The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Curtis J Donskey - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of a hand-held far-ultraviolet radiation device for Decontamination of Clostridium difficile and other healthcare-associated pathogens
BMC Infectious Diseases, 2012Co-Authors: Michelle M. Nerandzic, Kevin E Eckart, Jennifer L Cadnum, Curtis J DonskeyAbstract:BackgroundEnvironmental surfaces play an important role in transmission of healthcare-associated pathogens. There is a need for new disinfection methods that are effective against Clostridium difficile spores, but also safe and rapid. The Sterilray™ Disinfection Wand device is a hand-held room Decontamination Technology that utilizes far-ultraviolet radiation (185-230 nm) to kill pathogens.MethodsWe examined the efficacy of disinfection using the Sterilray device in the laboratory, in rooms of hospitalized patients, and on surfaces outside of patient rooms (i.e. keyboards and portable medical equipment). Cultures for C. difficile , methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococcus (VRE) were collected from commonly-touched surfaces before and after use of the Sterilray device.ResultsOn inoculated surfaces in the laboratory, application of the Sterilray device at a radiant dose of 100 mJ/cm^2 for ~ 5 seconds consistently reduced recovery of C. difficile spores by 4.4 CFU log_10, MRSA by 5.4 log_10CFU and of VRE by 6.9 log_10CFU. A >3 log_10 reduction of MRSA and VRE was achieved in ~2 seconds at a lower radiant dose, but killing of C. difficile spores was significantly reduced. On keyboards and portable medical equipment that were inoculated with C. difficile spores, application of the Sterilray device at a radiant dose of 100 mJ/cm^2 for ~ 5 seconds reduced contamination by 3.2 log_10CFU. However, the presence of organic material reduced the lethal effect of the far-UV radiation. In hospital rooms that were not pre-cleaned, disinfection with the Sterilray device significantly reduced the frequency of positive C. difficile and MRSA cultures ( P =0.007).ConclusionsThe Sterilray™ Disinfection Wand is a novel environmental disinfection Technology that rapidly kills C. difficile spores and other healthcare-associated pathogens on surfaces. However, the presence of organic matter reduces the efficacy of far-UV radiation, possibly explaining the more modest results observed on surfaces in hospital rooms that were not pre-cleaned.
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Evaluation of an automated ultraviolet radiation device for Decontamination of Clostridium difficile and other healthcare-associated pathogens in hospital rooms
BMC Infectious Diseases, 2010Co-Authors: Michelle M. Nerandzic, Michael J Pultz, Jennifer L Cadnum, Curtis J DonskeyAbstract:BackgroundEnvironmental surfaces play an important role in transmission of healthcare-associated pathogens. There is a need for new disinfection methods that are effective against Clostridium difficile spores, but also safe, rapid, and automated.MethodsThe Tru-D™ Rapid Room Disinfection device is a mobile, fully-automated room Decontamination Technology that utilizes ultraviolet-C irradiation to kill pathogens. We examined the efficacy of environmental disinfection using the Tru-D device in the laboratory and in rooms of hospitalized patients. Cultures for C. difficile , methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococcus (VRE) were collected from commonly touched surfaces before and after use of Tru-D.ResultsOn inoculated surfaces, application of Tru-D at a reflected dose of 22,000 μWs/cm^2 for ~45 minutes consistently reduced recovery of C. difficile spores and MRSA by >2-3 log_10 colony forming units (CFU)/cm^2 and of VRE by >3-4 log_10 CFU/cm^2. Similar killing of MRSA and VRE was achieved in ~20 minutes at a reflected dose of 12,000 μWs/cm^2, but killing of C. difficile spores was reduced. Disinfection of hospital rooms with Tru-D reduced the frequency of positive MRSA and VRE cultures by 93% and of C. difficile cultures by 80%. After routine hospital cleaning of the rooms of MRSA carriers, 18% of sites under the edges of bedside tables (i.e., a frequently touched site not easily amenable to manual application of disinfectant) were contaminated with MRSA, versus 0% after Tru-D ( P < 0.001). The system required
Michelle M. Nerandzic - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of a hand-held far-ultraviolet radiation device for Decontamination of Clostridium difficile and other healthcare-associated pathogens
BMC Infectious Diseases, 2012Co-Authors: Michelle M. Nerandzic, Kevin E Eckart, Jennifer L Cadnum, Curtis J DonskeyAbstract:BackgroundEnvironmental surfaces play an important role in transmission of healthcare-associated pathogens. There is a need for new disinfection methods that are effective against Clostridium difficile spores, but also safe and rapid. The Sterilray™ Disinfection Wand device is a hand-held room Decontamination Technology that utilizes far-ultraviolet radiation (185-230 nm) to kill pathogens.MethodsWe examined the efficacy of disinfection using the Sterilray device in the laboratory, in rooms of hospitalized patients, and on surfaces outside of patient rooms (i.e. keyboards and portable medical equipment). Cultures for C. difficile , methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococcus (VRE) were collected from commonly-touched surfaces before and after use of the Sterilray device.ResultsOn inoculated surfaces in the laboratory, application of the Sterilray device at a radiant dose of 100 mJ/cm^2 for ~ 5 seconds consistently reduced recovery of C. difficile spores by 4.4 CFU log_10, MRSA by 5.4 log_10CFU and of VRE by 6.9 log_10CFU. A >3 log_10 reduction of MRSA and VRE was achieved in ~2 seconds at a lower radiant dose, but killing of C. difficile spores was significantly reduced. On keyboards and portable medical equipment that were inoculated with C. difficile spores, application of the Sterilray device at a radiant dose of 100 mJ/cm^2 for ~ 5 seconds reduced contamination by 3.2 log_10CFU. However, the presence of organic material reduced the lethal effect of the far-UV radiation. In hospital rooms that were not pre-cleaned, disinfection with the Sterilray device significantly reduced the frequency of positive C. difficile and MRSA cultures ( P =0.007).ConclusionsThe Sterilray™ Disinfection Wand is a novel environmental disinfection Technology that rapidly kills C. difficile spores and other healthcare-associated pathogens on surfaces. However, the presence of organic matter reduces the efficacy of far-UV radiation, possibly explaining the more modest results observed on surfaces in hospital rooms that were not pre-cleaned.
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Evaluation of an automated ultraviolet radiation device for Decontamination of Clostridium difficile and other healthcare-associated pathogens in hospital rooms
BMC Infectious Diseases, 2010Co-Authors: Michelle M. Nerandzic, Michael J Pultz, Jennifer L Cadnum, Curtis J DonskeyAbstract:BackgroundEnvironmental surfaces play an important role in transmission of healthcare-associated pathogens. There is a need for new disinfection methods that are effective against Clostridium difficile spores, but also safe, rapid, and automated.MethodsThe Tru-D™ Rapid Room Disinfection device is a mobile, fully-automated room Decontamination Technology that utilizes ultraviolet-C irradiation to kill pathogens. We examined the efficacy of environmental disinfection using the Tru-D device in the laboratory and in rooms of hospitalized patients. Cultures for C. difficile , methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococcus (VRE) were collected from commonly touched surfaces before and after use of Tru-D.ResultsOn inoculated surfaces, application of Tru-D at a reflected dose of 22,000 μWs/cm^2 for ~45 minutes consistently reduced recovery of C. difficile spores and MRSA by >2-3 log_10 colony forming units (CFU)/cm^2 and of VRE by >3-4 log_10 CFU/cm^2. Similar killing of MRSA and VRE was achieved in ~20 minutes at a reflected dose of 12,000 μWs/cm^2, but killing of C. difficile spores was reduced. Disinfection of hospital rooms with Tru-D reduced the frequency of positive MRSA and VRE cultures by 93% and of C. difficile cultures by 80%. After routine hospital cleaning of the rooms of MRSA carriers, 18% of sites under the edges of bedside tables (i.e., a frequently touched site not easily amenable to manual application of disinfectant) were contaminated with MRSA, versus 0% after Tru-D ( P < 0.001). The system required
Ellen Raber - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of liquid and foam Decontamination technologies for chemical warfare agents on indoor surfaces.
Journal of Hazardous Materials, 2011Co-Authors: Adam H. Love, M. Leslie Hanna, Alex K. Vu, Dennis J. Reutter, Christopher G. Bailey, Ellen RaberAbstract:Abstract Bench-scale testing was used to evaluate the efficacy of four Decontamination formulations on typical indoor surfaces following exposure to the liquid chemical warfare agents sarin (GB), soman (GD), sulfur mustard (HD), and VX. Residual surface contamination on coupons was periodically measured for up to 24 h after applying one of four selected Decontamination technologies [0.5% bleach solution with trisodium phosphate, Allen Vanguard Surface Decontamination Foam (SDF™), U.S. military Decon Green™, and Modec Inc. and EnviroFoam Technologies Sandia Decontamination Foam (DF-200)]. All Decontamination technologies tested, except for the bleach solution, performed well on nonporous and nonpermeable glass and stainless-steel surfaces. However, chemical agent residual contamination typically remained on porous and permeable surfaces, especially for the more persistent agents, HD and VX. Solvent-based Decon Green™ performed better than aqueous-based bleach or foams on polymeric surfaces, possibly because the solvent is able to penetrate the polymer matrix. Bleach and foams out-performed Decon Green for penetrating the highly polar concrete surface. Results suggest that the different characteristics needed for an ideal and universal Decontamination Technology may be incompatible in a single formulation and a strategy for decontaminating a complex facility will require a range of technologies.
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Efficacy of liquid and foam Decontamination technologies for chemical warfare agents on indoor surfaces
Journal of Hazardous Materials, 2011Co-Authors: Adam H. Love, M. Leslie Hanna, Saphon Hok, Alex K. Vu, Dennis J. Reutter, Christopher G. Bailey, Ellen RaberAbstract:Bench-scale testing was used to evaluate the efficacy of four Decontamination formulations on typical indoor surfaces following exposure to the liquid chemical warfare agents sarin (GB), soman (GD), sulfur mustard (HD), and VX. Residual surface contamination on coupons was periodically measured for up to 24 h after applying one of four selected Decontamination technologies [0.5% bleach solution with trisodium phosphate, Allen Vanguard Surface Decontamination Foam (SDF™), U.S. military Decon Green™, and Modec Inc. and EnviroFoam Technologies Sandia Decontamination Foam (DF-200)]. All Decontamination technologies tested, except for the bleach solution, performed well on nonporous and nonpermeable glass and stainless-steel surfaces. However, chemical agent residual contamination typically remained on porous and permeable surfaces, especially for the more persistent agents, HD and VX. Solvent-based Decon Green™ performed better than aqueous-based bleach or foams on polymeric surfaces, possibly because the solvent is able to penetrate the polymer matrix. Bleach and foams out-performed Decon Green for penetrating the highly polar concrete surface. Results suggest that the different characteristics needed for an ideal and universal Decontamination Technology may be incompatible in a single formulation and a strategy for decontaminating a complex facility will require a range of technologies. © 2011 Elsevier B.V.
Ronit Mandal - One of the best experts on this subject based on the ideXlab platform.
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Applications of Pulsed Light Decontamination Technology in Food Processing: An Overview
Applied Sciences, 2020Co-Authors: Ronit Mandal, Anika Singh, Xanyar Mohammadi, Artur Wiktor, Anubhav Pratap SinghAbstract:Consumers of the 21st century tend to be more aware and demand safe as well as nutritionally balanced food. Unfortunately, conventional thermal processing makes food safe at the cost of hampering nutritional value. The food industry is trying to develop non-thermal processes for food preservation. Pulsed light (PL) is one such emerging non-thermal food processing method that can decontaminate food products or food contact surfaces using white light. Exposure to intense light pulses (in infrared, visible, and ultraviolet (UV) regions) causes the death of microbial cells, rendering the food safe at room temperature. PL Technology is an excellent and rapid method of disinfection of product surfaces and is increasingly being used for food surfaces and packaging Decontamination, enabling the minimal processing of food. This paper aims to give an overview of the latest trends in pulsed light research, discuss principles of pulse generation, and review applications of various PL systems for the inactivation of microorganisms in vitro, in various food products, and on food contact surfaces. Effects of PL on food quality, challenges of the process, and its prospects are presented.
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recent developments in cold plasma Decontamination Technology in the food industry
Trends in Food Science and Technology, 2018Co-Authors: Ronit Mandal, Anika Singh, Anubhav Pratap SinghAbstract:Abstract Background The advent of the 21st century has witnessed a growing demand of safe and nutritious foods. The food industry is adopting novel non-thermal food processing technologies. Cold plasma is one such promising non-thermal food processing method which uses charged, highly reactive gaseous molecules and species to inactivate contaminating microorganisms on foods and packaging materials. Scope and approach The paper gives the reader an overview of the cold plasma Technology in food industry. It reviews principles of plasma generation, including mechanisms of action of the process on microorganisms. It also highlights different plasma generation systems, various published results of plasma application to inactivate microorganisms in vitro and in various food products, food packages and equipment surfaces. The challenges of the process, its effects on food quality and the future prospects are highlighted. Key findings and conclusions This article aims to review and apprise readers about the important fundamentals and latest trends in the Cold Plasma Technology. The on-going studies on plasma Technology prove that cold plasma is strongly effective for surface Decontamination, with efforts in-progress for liquid processing. The short time of application causes no significant deterioration in food products. Thus, it is an apt alternative processing Technology which could also help to counter food allergenicity, seed germination, packaging material printing, waste-water treatment, modify food functionality, extract bio-actives etc. Further research is needed for scaling-up of this process for future commercialization.
Jennifer L Cadnum - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of a hand-held far-ultraviolet radiation device for Decontamination of Clostridium difficile and other healthcare-associated pathogens
BMC Infectious Diseases, 2012Co-Authors: Michelle M. Nerandzic, Kevin E Eckart, Jennifer L Cadnum, Curtis J DonskeyAbstract:BackgroundEnvironmental surfaces play an important role in transmission of healthcare-associated pathogens. There is a need for new disinfection methods that are effective against Clostridium difficile spores, but also safe and rapid. The Sterilray™ Disinfection Wand device is a hand-held room Decontamination Technology that utilizes far-ultraviolet radiation (185-230 nm) to kill pathogens.MethodsWe examined the efficacy of disinfection using the Sterilray device in the laboratory, in rooms of hospitalized patients, and on surfaces outside of patient rooms (i.e. keyboards and portable medical equipment). Cultures for C. difficile , methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococcus (VRE) were collected from commonly-touched surfaces before and after use of the Sterilray device.ResultsOn inoculated surfaces in the laboratory, application of the Sterilray device at a radiant dose of 100 mJ/cm^2 for ~ 5 seconds consistently reduced recovery of C. difficile spores by 4.4 CFU log_10, MRSA by 5.4 log_10CFU and of VRE by 6.9 log_10CFU. A >3 log_10 reduction of MRSA and VRE was achieved in ~2 seconds at a lower radiant dose, but killing of C. difficile spores was significantly reduced. On keyboards and portable medical equipment that were inoculated with C. difficile spores, application of the Sterilray device at a radiant dose of 100 mJ/cm^2 for ~ 5 seconds reduced contamination by 3.2 log_10CFU. However, the presence of organic material reduced the lethal effect of the far-UV radiation. In hospital rooms that were not pre-cleaned, disinfection with the Sterilray device significantly reduced the frequency of positive C. difficile and MRSA cultures ( P =0.007).ConclusionsThe Sterilray™ Disinfection Wand is a novel environmental disinfection Technology that rapidly kills C. difficile spores and other healthcare-associated pathogens on surfaces. However, the presence of organic matter reduces the efficacy of far-UV radiation, possibly explaining the more modest results observed on surfaces in hospital rooms that were not pre-cleaned.
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Evaluation of an automated ultraviolet radiation device for Decontamination of Clostridium difficile and other healthcare-associated pathogens in hospital rooms
BMC Infectious Diseases, 2010Co-Authors: Michelle M. Nerandzic, Michael J Pultz, Jennifer L Cadnum, Curtis J DonskeyAbstract:BackgroundEnvironmental surfaces play an important role in transmission of healthcare-associated pathogens. There is a need for new disinfection methods that are effective against Clostridium difficile spores, but also safe, rapid, and automated.MethodsThe Tru-D™ Rapid Room Disinfection device is a mobile, fully-automated room Decontamination Technology that utilizes ultraviolet-C irradiation to kill pathogens. We examined the efficacy of environmental disinfection using the Tru-D device in the laboratory and in rooms of hospitalized patients. Cultures for C. difficile , methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococcus (VRE) were collected from commonly touched surfaces before and after use of Tru-D.ResultsOn inoculated surfaces, application of Tru-D at a reflected dose of 22,000 μWs/cm^2 for ~45 minutes consistently reduced recovery of C. difficile spores and MRSA by >2-3 log_10 colony forming units (CFU)/cm^2 and of VRE by >3-4 log_10 CFU/cm^2. Similar killing of MRSA and VRE was achieved in ~20 minutes at a reflected dose of 12,000 μWs/cm^2, but killing of C. difficile spores was reduced. Disinfection of hospital rooms with Tru-D reduced the frequency of positive MRSA and VRE cultures by 93% and of C. difficile cultures by 80%. After routine hospital cleaning of the rooms of MRSA carriers, 18% of sites under the edges of bedside tables (i.e., a frequently touched site not easily amenable to manual application of disinfectant) were contaminated with MRSA, versus 0% after Tru-D ( P < 0.001). The system required
