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Lihua Peng - One of the best experts on this subject based on the ideXlab platform.
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Efficacy and safety of Mobi-C cervical artificial Disc versus anterior Discectomy and fusion in patients with symptomatic Degenerative Disc Disease: A meta-analysis
Medicine, 2017Co-Authors: Lihua PengAbstract:Background: Total Disc replacement (TDR) using Mobi-C cervical artificial Disc might be promising to treat symptomatic Degenerative Disc Disease. However, the results remained controversial. We conducted a systematic review and meta-analysis to compare the efficacy and safety of Mobi-C cervical artificial Disc and anterior cervical Discectomy and fusion (ACDF) in patients with symptomatic Degenerative Disc Disease.
Chester E. Sutterlin - One of the best experts on this subject based on the ideXlab platform.
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The effect of pedicle screw/plate fixation on lumbar/lumbosacral autogenous bone graft fusions in patients with Degenerative Disc Disease.
Spine, 1995Co-Authors: George W. Wood, Robert J. Boyd, Thomas A. Carothers, Frederick L. Mansfield, Glenn R. Rechtine, Michael J. Rozen, Chester E. SutterlinAbstract:Study Design A prospective, multi-center Investigational Device Exemption Study was carried out in the United States using a pedicle screw and plate system to performe a fusion in patients with Degenerative Disc Disease or spondylolisthesis. The patients' pain, function, complications, and fusion status were evaluated and compared with literature controls. Objectives To study the safety and efficacy of the ISF pedicle screw/plate system. This article focuses only on those study patients with Degenerative Disc Disease treated with autogenous bone grafts and compares the results to those of similar patients treated without instrumentation, as reported in the literature. Summary of Background Data Twenty-eight patients were in the subgroup studied-patients with Degenerative Disc Disease who had fusions with autogenous bone graft. This study was conducted at four clinical sites with a 2-year follow-up. Patient follow-up was greater than 95% at all time points. Methods To be considered a patient with Degenerative Disc Disease, radiographs had to demonstrate a collapse of the Disc, the presence of bone erosion, or the compression of the vertebrae as the primary spinal abnormality. Spinal fusion must have been the recommended surgical treatment for Discogenic pain. The fusion status was evaluated by the operating surgeon and an independent reviewer. Results After 2 years, this subset of patients (n=28) with Degenerative Disc Disease who had lumbar/lumbosacral fusion with autogenous bone graft was found to have a pseudarthrosis rate of 0%. Eight articles in the literature were found to be valid noninstrumented literature controls with which this subgroup could be compared. The average pseudarthosis rate in the control group was 32%. Conclusions A statistical analysis showed that patients with Degenerative Disc Disease who underwent fusion without pedicle screw instrumentation were over 24 times more likely to have a pseudarthrosis than comparable patients implanted with a pedicle screw/plate system. Regarding the most important goal in performing a spinal fusion-fusion of the spine-the pedicle screw/plate system used in this study was shown to be a safe and efficacious method of facilitating fusion with autogenous bone graft for this patient population.
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the effect of pedicle screw plate fixation on lumbar lumbosacral autogenous bone graft fusions in patients with Degenerative Disc Disease
Spine, 1995Co-Authors: George W. Wood, Robert J. Boyd, Thomas A. Carothers, Frederick L. Mansfield, Glenn R. Rechtine, Michael J. Rozen, Chester E. SutterlinAbstract:Study Design A prospective, multi-center Investigational Device Exemption Study was carried out in the United States using a pedicle screw and plate system to performe a fusion in patients with Degenerative Disc Disease or spondylolisthesis. The patients' pain, function, complications, and fusion status were evaluated and compared with literature controls. Objectives To study the safety and efficacy of the ISF pedicle screw/plate system. This article focuses only on those study patients with Degenerative Disc Disease treated with autogenous bone grafts and compares the results to those of similar patients treated without instrumentation, as reported in the literature. Summary of Background Data Twenty-eight patients were in the subgroup studied-patients with Degenerative Disc Disease who had fusions with autogenous bone graft. This study was conducted at four clinical sites with a 2-year follow-up. Patient follow-up was greater than 95% at all time points. Methods To be considered a patient with Degenerative Disc Disease, radiographs had to demonstrate a collapse of the Disc, the presence of bone erosion, or the compression of the vertebrae as the primary spinal abnormality. Spinal fusion must have been the recommended surgical treatment for Discogenic pain. The fusion status was evaluated by the operating surgeon and an independent reviewer. Results After 2 years, this subset of patients (n=28) with Degenerative Disc Disease who had lumbar/lumbosacral fusion with autogenous bone graft was found to have a pseudarthrosis rate of 0%. Eight articles in the literature were found to be valid noninstrumented literature controls with which this subgroup could be compared. The average pseudarthosis rate in the control group was 32%. Conclusions A statistical analysis showed that patients with Degenerative Disc Disease who underwent fusion without pedicle screw instrumentation were over 24 times more likely to have a pseudarthrosis than comparable patients implanted with a pedicle screw/plate system. Regarding the most important goal in performing a spinal fusion-fusion of the spine-the pedicle screw/plate system used in this study was shown to be a safe and efficacious method of facilitating fusion with autogenous bone graft for this patient population.
A F Ozer - One of the best experts on this subject based on the ideXlab platform.
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A Rehabilitation Protocol for Patients with Lumbar Degenerative Disc Disease Treated with Posterior Transpedicular Dynamic Stabilization.
Turkish neurosurgery, 2017Co-Authors: N Canbulat, T Oktenoglu, M Sasani, O Ercelen, Yaprak Ataker, Tuncer Suzer, Onder Cerezci, A F OzerAbstract:AIM To evaluate the efficacy of the rehabilitation protocol on patients with lumbar Degenerative Disc Disease after posterior transpedicular dynamic stabilization (PTDS) surgery. MATERIAL AND METHODS Patients (n=50) with single level lumbar Degenerative Disc Disease were recruited for this study. Patients had PTDS surgery with hinged screws. A rehabilitation program was applied for all patients. Phase 1 was the preoperative evaluation phase. Phase 2 (active rest phase) was the first 6 weeks after surgery. During phase 3 (minimal movement phase, 6-12 weeks) pelvic tilt exercises initiated. In phase 4 (dynamic phase, 3-6 months) dynamic lumbar stabilization exercises were started. Phase 5 (return to sports phase) began after the 6th month. The primary outcome criteria were the Visual Analogue Pain Score (VAS) and the Oswestry Disability Index (ODI). Patients were evaluated preoperatively, postoperative 3rd, 12th and 24th months. RESULTS The mean preoperative VAS and ODI scores were 7.52±0.97 and 60.96±8.74, respectively. During the 3rd month, VAS and ODI scores decreased to 2.62±1.05 and 26.2±7.93, respectively. VAS and ODI scores continued to decrease during the 12th month after surgery to 1.4±0.81 and 13.72±6.68, respectively. At the last follow-up (mean 34.1 months) the VAS and ODI scores were found to be 0.68±0.62 and 7.88±3.32, respectively. (p=0.0001). CONCLUSION The protocol was designed for a postoperative rehabilitation program after PTDS surgery for patients with lumbar Degenerative Disc Disease. The good outcomes are the result of a combination of very careful and restrictive patient selection, surgical technique, and the presented rehabilitation program.
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dynamic stabilisation in the treatment of Degenerative Disc Disease with modic changes
Advances in orthopedics, 2013Co-Authors: Olcay Eser, T Oktenoglu, M Sasani, Cengiz Gomleksiz, Ahmet Levent Aydin, Yaprak Ataker, Tuncer Suzer, A F OzerAbstract:Objective. Posterior dynamic stabilization is an effective alternative to fusion in the treatment of chronic instability and Degenerative Disc Disease (DDD) of the lumbar spine. This study was undertaken to investigate the efficacy of dynamic stabilization in chronic Degenerative Disc Disease with Modic types 1 and 2. Modic types 1 and 2 degeneration can be painful. Classic approach in such cases is spine fusion. We operated 88 DDD patients with Modic types 1 and 2 via posterior dynamic stabilization. Good results were obtained after 2 years of followup. Methods. A total of 88 DDD patients with Modic types 1 and 2 were selected for this study. The patients were included in the study between 2004 and 2010. All of them were examined with lumbar anteroposterior (AP) and lateral X-rays. Lordosis of the lumbar spine, segmental lordosis, and ratio of the height of the intervertebral Disc spaces (IVSs) were measured preoperatively and at 3, 12, and 24 months after surgery. Magnetic resonance imaging (MRI) analysis was carried out, and according to the data obtained, the grade of Disc degeneration was classified. The quality of life and pain scores were evaluated by visual analog scale (VAS) score and Oswestry Disability Index (ODI) preoperatively and at 3, 12, and 24 months after surgery. Appropriate statistical method was chosen. Results. The mean 3- and 12-month postoperative IVS ratio was significantly greater than that of the preoperative group (P 0.05). Furthermore, the mean preoperative and 1 and 2 postoperative angles of lumbar lordosis and segmental lordosis were not significantly different (P > 0.05). The mean VAS score and ODI, 3, 12, and 24 months after surgery, decreased significantly, when compared with the preoperative scores in the groups (P = 0.000). Conclusion. Dynamic stabilization in chronic Degenerative Disc Disease with Modic types 1 and 2 was effective.
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Posterior dynamic stabilization for the treatment of patients with lumbar Degenerative Disc Disease: long-term clinical and radiological results.
Turkish neurosurgery, 2013Co-Authors: Suat Canbay, M Sasani, Ahmet Levent Aydin, Elif Aktas, Serhat Fuat Erten, Mehmet Basmaci, A F OzerAbstract:AIM Comparison of long-term preoperative and postoperative clinical and radiological results for patients diagnosed with Degenerative Disc Disease that underwent posterior dynamic stabilization. Lumbar Disc degeneration is caused by a variety of factors. Disruptions in the vertebral endplate result in defects in Disc nutrition and, thus, Disc degeneration. The aims of dynamic stabilization are to unload the Disc/facet joints, preserve motion under mechanical load, and restrict abnormal motion in the spinal segment. MATERIAL AND METHODS Twenty-five patients diagnosed with lumbar Degenerative Disc Disease were enrolled. Totally, 25 vertebral segments were subjected to posterior dynamic stabilization. Patients were clinically evaluated in the preoperative and postoperative periods using the Oswestry Disability Index (ODI) and Visual Analog Scale (VAS). Segmental movement was evaluated radiologically in the late postoperative period by measuring the segmental angles during flexion and extension. RESULTS Significant postoperative improvements were observed in the ODI and VAS measurements (P < 0.01). During the long postoperative period (averaging 5 years and 2 months), lumbar lordosis angles, intervertebral space ratio and segmental ratio were measured and compared statistically. Adjacent segment Disease developed in two patients. Both patients received L5-S1 Discectomy. CONCLUSION Good clinical outcomes were observed in the treatment of lumbar Degenerative Disc Disease with a posterior dynamic system.
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Posterior dynamic stabilization in the treatment of lumbar Degenerative Disc Disease: 2-year follow-up.
Minimally invasive neurosurgery : MIN, 2010Co-Authors: T Oktenoglu, A F Ozer, M Sasani, T Kaner, N Canbulat, O Ercelen, A C SariogluAbstract:A prospective pilot study was designed to evaluate the role of a posterior dynamic stabilization technique in the surgical treatment of Degenerative Disc Disease. Posterior dynamic stabilization with a hinged screw is a new concept in the surgical treatment of Degenerative Disc Disease of the lumbar spine. The traditional surgical treatment is to apply a fusion procedure. However, numerous reports showed unsatisfactory clinical outcomes even when patients have satisfactory radiological outcomes following fusion procedures. The study included patients who were surgically treated with a dynamic stabilization technique due to painful Degenerative Disc Disease. Clinical and radiological findings for the 20 participating patients were analyzed in a 2-year follow-up study. Preoperative and postoperative data at the 3 (rd), 12 (th) and 24 (th) month were collected for both clinical and radiological outcomes. Statistical analyses between preoperative and postoperative data were performed using the Wilcoxon test. The clinical outcome measurements (VAS, ODI) showed significant improvement in all postoperative measurements compared to preoperative values. The mean preoperative visual analogue score (VAS, 7.9) and Oswestry Disability Index (ODI 59.2) significantly decreased to 0.8 for VAS and 9.2 for ODI, at 2 years post-operation (p<0.05). The radiological studies showed no significant changes between pre- and postoperative values, in all parameters. There was no mortality or morbidity. The results of this pilot study are encouraging. Dynamic stabilization may be an effective technique in the surgical treatment of painful Degenerative Disc Disease. A larger series study, with longer follow-up periods and with control groups is needed to determine the success and safety of posterior dynamic stabilization in the surgical treatment of Degenerative Disc Disease. Georg Thieme Verlag KG Stuttgart . New York.
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Posterior dynamic stabilization in the treatment of lumbar Degenerative Disc Disease: 2-year follow-up.
Minimally Invasive Neurosurgery, 2010Co-Authors: T Oktenoglu, A F Ozer, M Sasani, T Kaner, N Canbulat, O Ercelen, A C SariogluAbstract:BACKGROUND: A prospective pilot study was designed to evaluate the role of a posterior dynamic stabilization technique in the surgical treatment of Degenerative Disc Disease. Posterior dynamic stabilization with a hinged screw is a new concept in the surgical treatment of Degenerative Disc Disease of the lumbar spine. The traditional surgical treatment is to apply a fusion procedure. However, numerous reports showed unsatisfactory clinical outcomes even when patients have satisfactory radiological outcomes following fusion procedures. MATERIAL AND METHODS: The study included patients who were surgically treated with a dynamic stabilization technique due to painful Degenerative Disc Disease. Clinical and radiological findings for the 20 participating patients were analyzed in a 2-year follow-up study. Preoperative and postoperative data at the 3 rd , 12 th and 24 th month were collected for both clinical and radiological outcomes. Statistical analyses between preoperative and postoperative data were performed using the Wilcoxon test. RESULTS: The clinical outcome measurements (VAS, ODI) showed significant improvement in all postoperative measurements compared to preoperative values. The mean preoperative visual analogue score (VAS, 7.9) and Oswestry Disability Index (ODI 59.2) significantly decreased to 0.8 for VAS and 9.2 for ODI, at 2 years post-operation (p
Ming Liu - One of the best experts on this subject based on the ideXlab platform.
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total Disc replacement versus fusion for lumbar Degenerative Disc Disease a systematic review of overlapping meta analyses
European Spine Journal, 2017Co-Authors: Fan Ding, Zhiwei Jia, Zhigang Zhao, Lin Xie, Xinfeng Gao, Ming LiuAbstract:Purpose Although many meta-analyses have been performed to compare total Disc replacement (TDR) and fusion for treating lumbar Degenerative Disc Disease (LDDD), their findings are inconsistent. This study aimed to conduct a systematic review of overlapping meta-analyses comparing TDR with fusion for treating LDDD, to assist decision makers in selection among conflicting meta-analyses, and to provide treatment recommendations based on the best available evidence.
George W. Wood - One of the best experts on this subject based on the ideXlab platform.
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The effect of pedicle screw/plate fixation on lumbar/lumbosacral autogenous bone graft fusions in patients with Degenerative Disc Disease.
Spine, 1995Co-Authors: George W. Wood, Robert J. Boyd, Thomas A. Carothers, Frederick L. Mansfield, Glenn R. Rechtine, Michael J. Rozen, Chester E. SutterlinAbstract:Study Design A prospective, multi-center Investigational Device Exemption Study was carried out in the United States using a pedicle screw and plate system to performe a fusion in patients with Degenerative Disc Disease or spondylolisthesis. The patients' pain, function, complications, and fusion status were evaluated and compared with literature controls. Objectives To study the safety and efficacy of the ISF pedicle screw/plate system. This article focuses only on those study patients with Degenerative Disc Disease treated with autogenous bone grafts and compares the results to those of similar patients treated without instrumentation, as reported in the literature. Summary of Background Data Twenty-eight patients were in the subgroup studied-patients with Degenerative Disc Disease who had fusions with autogenous bone graft. This study was conducted at four clinical sites with a 2-year follow-up. Patient follow-up was greater than 95% at all time points. Methods To be considered a patient with Degenerative Disc Disease, radiographs had to demonstrate a collapse of the Disc, the presence of bone erosion, or the compression of the vertebrae as the primary spinal abnormality. Spinal fusion must have been the recommended surgical treatment for Discogenic pain. The fusion status was evaluated by the operating surgeon and an independent reviewer. Results After 2 years, this subset of patients (n=28) with Degenerative Disc Disease who had lumbar/lumbosacral fusion with autogenous bone graft was found to have a pseudarthrosis rate of 0%. Eight articles in the literature were found to be valid noninstrumented literature controls with which this subgroup could be compared. The average pseudarthosis rate in the control group was 32%. Conclusions A statistical analysis showed that patients with Degenerative Disc Disease who underwent fusion without pedicle screw instrumentation were over 24 times more likely to have a pseudarthrosis than comparable patients implanted with a pedicle screw/plate system. Regarding the most important goal in performing a spinal fusion-fusion of the spine-the pedicle screw/plate system used in this study was shown to be a safe and efficacious method of facilitating fusion with autogenous bone graft for this patient population.
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the effect of pedicle screw plate fixation on lumbar lumbosacral autogenous bone graft fusions in patients with Degenerative Disc Disease
Spine, 1995Co-Authors: George W. Wood, Robert J. Boyd, Thomas A. Carothers, Frederick L. Mansfield, Glenn R. Rechtine, Michael J. Rozen, Chester E. SutterlinAbstract:Study Design A prospective, multi-center Investigational Device Exemption Study was carried out in the United States using a pedicle screw and plate system to performe a fusion in patients with Degenerative Disc Disease or spondylolisthesis. The patients' pain, function, complications, and fusion status were evaluated and compared with literature controls. Objectives To study the safety and efficacy of the ISF pedicle screw/plate system. This article focuses only on those study patients with Degenerative Disc Disease treated with autogenous bone grafts and compares the results to those of similar patients treated without instrumentation, as reported in the literature. Summary of Background Data Twenty-eight patients were in the subgroup studied-patients with Degenerative Disc Disease who had fusions with autogenous bone graft. This study was conducted at four clinical sites with a 2-year follow-up. Patient follow-up was greater than 95% at all time points. Methods To be considered a patient with Degenerative Disc Disease, radiographs had to demonstrate a collapse of the Disc, the presence of bone erosion, or the compression of the vertebrae as the primary spinal abnormality. Spinal fusion must have been the recommended surgical treatment for Discogenic pain. The fusion status was evaluated by the operating surgeon and an independent reviewer. Results After 2 years, this subset of patients (n=28) with Degenerative Disc Disease who had lumbar/lumbosacral fusion with autogenous bone graft was found to have a pseudarthrosis rate of 0%. Eight articles in the literature were found to be valid noninstrumented literature controls with which this subgroup could be compared. The average pseudarthosis rate in the control group was 32%. Conclusions A statistical analysis showed that patients with Degenerative Disc Disease who underwent fusion without pedicle screw instrumentation were over 24 times more likely to have a pseudarthrosis than comparable patients implanted with a pedicle screw/plate system. Regarding the most important goal in performing a spinal fusion-fusion of the spine-the pedicle screw/plate system used in this study was shown to be a safe and efficacious method of facilitating fusion with autogenous bone graft for this patient population.