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Sheikh Raisuddin - One of the best experts on this subject based on the ideXlab platform.
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genotoxic and oxidative stress inducing effects of Deltamethrin in the erythrocytes of a freshwater biomarker fish species channa punctata bloch
Environmental Toxicology, 2009Co-Authors: Rizwan A Ansari, Sheikh Raisuddin, Manpreet Kaur, Firoz Ahmad, Shakilur Rahman, Hina Rashid, Fakhrul IslamAbstract:Deltamethrin, an α-cyano class of pyrethroid insecticide is used in insect pest control and antimalaria programs in several countries including India. Although various toxic manifestations of Deltamethrin are reported in mammals, its ecotoxicologic dimensions are not adequately researched in ecologically and commercially important fishes. In this study, we report genotoxic effect of Deltamethrin in a biomarker fish Channa punctata (Bloch). Adult fish were exposed to three concentrations of technical grade Deltamethrin (0.4, 0.8, and 1.2 μg/L) for 48 and 72 h. Ethyl methane sulfonate was used as a positive control. Fish were analyzed for induction of micronucleus (MN), nuclear abnormalities (NAs), and oxidative stress biomarkers in erythrocytes. Deltamethrin significantly induced MN and NAs accompanied by increased lipid peroxidation. Activity of antioxidant enzyme superoxide dismutase was significantly decreased but an increase was observed in reduced glutathione level after 72 h of exposure. The NAs in exposed fish included blebbed, lobed and notched nuclei, and binucleated erythrocytes. Our findings suggest that oxidative stress may, in part, be contributing to Deltamethrin-induced genotoxic damage to erythrocytes. Although MN induction is a nonspecific biomarker, it may provide an indication of pollution load of Deltamethrin in the affected fish population when used as part of suite of other biomarkers. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2009.
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copper modulates non enzymatic antioxidants in the freshwater fish channa punctata bloch exposed to Deltamethrin
Chemosphere, 2006Co-Authors: Suhel Parvez, Sheikh RaisuddinAbstract:The assessment of the ecotoxicological risks caused by pesticides to ecosystems are based on data on the toxicity and effects of pesticide preparations to non-target organisms like fish. Deltamethrin is a widely used pesticide based on pyrethroids, which is reported to be extremely toxic to fish species. Modulatory effect of copper pre-exposure (10 ppb) on Deltamethrin (0.75 μg l−1)-induced oxidative stress was investigated in freshwater fish Channa punctata (Bloch). Non-enzymatic antioxidants were studied as biomarkers of exposure to Deltamethrin and possible protection afforded by copper pre-exposure. Glutathione levels were reduced significantly (P < 0.05) in liver of copper-acclimatized Deltamethrin-exposed group when compared with Deltamethrin-exposed groups. The total thiol levels of copper-acclimatized Deltamethrin-exposed group was significantly lowered (P < 0.01) in liver when compared with Deltamethrin-exposed group, while non-protein thiol levels recorded a significant (P < 0.01) increase in liver of copper-acclimatized Deltamethrin-exposed group when compared with Deltamethrin-exposed group. The lipid peroxidation levels of copper-acclimatized Deltamethrin-exposed groups were significantly lowered (P < 0.01) in liver when compared with Deltamethrin-exposed group. Deltamethrin is known to induce toxic responses by generating reactive oxygen species and to neutralize its toxic effect various non-enzymatic antioxidants were found to be modulated thus implicating their role as biomarkers in pollution control programmes.
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oxidative stress biomarkers of exposure to Deltamethrin in freshwater fish channa punctatus bloch
Ecotoxicology and Environmental Safety, 2003Co-Authors: Iqbal Sayeed, Suhel Parvez, Suwarna Pandey, Bilal Binhafeez, Rizwanul Haque, Sheikh RaisuddinAbstract:The pyrethroid class of insecticides, including Deltamethrin, are being used as substitutes for organochlorines and organophosphates in pest-control programs because of their low environmental persistence and toxicity. Ecotoxicological consequences of Deltamethrin, particularly its effects on antioxidants in fish and other aquatic organisms, are not well understood. We investigated the effect of Deltamethrin (0.75 μg/L) on antioxidants in a freshwater fish, Channa punctatus Bloch, using standard laboratory conditions. A single exposure for 48 h caused induction of various antioxidant enzymes and nonenzymatic antioxidants in kidney and liver. The induction of these antioxidants was not very prominent in gills. In fact, certain antioxidants were found to be depleted in gills. Catalase activity was decreased in all the tissues. Deltamethrin also induced lipid peroxidation in all the tissues, gills showing the highest levels. Glutathione, which is an established nonenzymatic antioxidant in fish, was significantly (P<0.001) increased in all the tissues. Ascorbic acid content increased in kidney and liver while it decreased in gills. The findings of the present investigation show that Deltamethrin has oxidative-stress-inducing potential in fish, and gills are the most sensitive organs. It is also interesting to note that gills are the primary sites of Deltamethrin absorption and their antioxidant potential is also very poor. The various parameters studied in this investigation can also be used as biomarkers of exposure to Deltamethrin. It is suggested that appropriate ecotoxicological risk assessment should be made in the areas where Deltamethrin is proposed to be used in pest control activities.
Oner Kocak - One of the best experts on this subject based on the ideXlab platform.
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acute toxicity behavioral changes and histopathological effects of Deltamethrin on tissues gills liver brain spleen kidney muscle skin of nile tilapia oreochromis niloticus l fingerlings
Environmental Toxicology, 2006Co-Authors: Ziynet M Yildirim, Caglan Karasu A Benli, Mahmut Selvi, Ayhan Ozkul, Figen Erkoc, Oner KocakAbstract:Deltamethrin, a synthetic pyrethroid contaminating aquatic ecosystems as a potential toxic pollutant, was investigated in the present study for acute toxicity. The purpose of this study was to evaluate LC(50) values of Deltamethrin on Nile tilapia (Oreochromis niloticus L.) fingerlings and investigate histopathological responses of fish exposed to Deltamethrin. The 48 h LC(50) value for Nile tilapia fingerlings was estimated as 4.85 microg/L using static test system. In addition, behavioral changes at each Deltamethrin concentration were observed closely. All fish, exposed to 5 microg/L Deltamethrin revealed severe morphological alterations in the gills and liver. In the gills hyperemia, fusion of secondary lamellae and telangiectasis were observed; whereas hydropic degenerations in liver were observed in all examined fish. The results are significant for reporting acute Deltamethrin toxicity in terms of behavioral and histopathological changes: Deltamethrin is highly toxic to fingerlings.
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acute toxicity behavioral changes and histopathological effects of Deltamethrin on tissues gills liver brain spleen kidney muscle skin of nile tilapia oreochromis niloticus l fingerlings
Environmental Toxicology, 2006Co-Authors: Ziynet M Yildirim, Caglan Karasu A Benli, Mahmut Selvi, Ayhan Ozkul, Figen Erkoc, Oner KocakAbstract:Deltamethrin, a synthetic pyrethroid contaminating aquatic ecosystems as a potential toxic pollutant, was investigated in the present study for acute toxicity. The purpose of this study was to evaluate LC50 values of Deltamethrin on Nile tilapia (Oreochromis niloticus L.) fingerlings and investigate histopathological responses of fish exposed to Deltamethrin. The 48 h LC50 value for Nile tilapia fingerlings was estimated as 4.85 μg/L using static test system. In addition, behavioral changes at each Deltamethrin concentration were observed closely. All fish, exposed to 5 μg/L Deltamethrin revealed severe morphological alterations in the gills and liver. In the gills hyperemia, fusion of secondary lamellae and telangiectasis were observed; whereas hydropic degenerations in liver were observed in all examined fish. The results are significant for reporting acute Deltamethrin toxicity in terms of behavioral and histopathological changes: Deltamethrin is highly toxic to fingerlings. © 2006 Wiley Periodicals, Inc. Environ Toxicol 21: 614–620, 2006.
Ziynet M Yildirim - One of the best experts on this subject based on the ideXlab platform.
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acute toxicity behavioral changes and histopathological effects of Deltamethrin on tissues gills liver brain spleen kidney muscle skin of nile tilapia oreochromis niloticus l fingerlings
Environmental Toxicology, 2006Co-Authors: Ziynet M Yildirim, Caglan Karasu A Benli, Mahmut Selvi, Ayhan Ozkul, Figen Erkoc, Oner KocakAbstract:Deltamethrin, a synthetic pyrethroid contaminating aquatic ecosystems as a potential toxic pollutant, was investigated in the present study for acute toxicity. The purpose of this study was to evaluate LC(50) values of Deltamethrin on Nile tilapia (Oreochromis niloticus L.) fingerlings and investigate histopathological responses of fish exposed to Deltamethrin. The 48 h LC(50) value for Nile tilapia fingerlings was estimated as 4.85 microg/L using static test system. In addition, behavioral changes at each Deltamethrin concentration were observed closely. All fish, exposed to 5 microg/L Deltamethrin revealed severe morphological alterations in the gills and liver. In the gills hyperemia, fusion of secondary lamellae and telangiectasis were observed; whereas hydropic degenerations in liver were observed in all examined fish. The results are significant for reporting acute Deltamethrin toxicity in terms of behavioral and histopathological changes: Deltamethrin is highly toxic to fingerlings.
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acute toxicity behavioral changes and histopathological effects of Deltamethrin on tissues gills liver brain spleen kidney muscle skin of nile tilapia oreochromis niloticus l fingerlings
Environmental Toxicology, 2006Co-Authors: Ziynet M Yildirim, Caglan Karasu A Benli, Mahmut Selvi, Ayhan Ozkul, Figen Erkoc, Oner KocakAbstract:Deltamethrin, a synthetic pyrethroid contaminating aquatic ecosystems as a potential toxic pollutant, was investigated in the present study for acute toxicity. The purpose of this study was to evaluate LC50 values of Deltamethrin on Nile tilapia (Oreochromis niloticus L.) fingerlings and investigate histopathological responses of fish exposed to Deltamethrin. The 48 h LC50 value for Nile tilapia fingerlings was estimated as 4.85 μg/L using static test system. In addition, behavioral changes at each Deltamethrin concentration were observed closely. All fish, exposed to 5 μg/L Deltamethrin revealed severe morphological alterations in the gills and liver. In the gills hyperemia, fusion of secondary lamellae and telangiectasis were observed; whereas hydropic degenerations in liver were observed in all examined fish. The results are significant for reporting acute Deltamethrin toxicity in terms of behavioral and histopathological changes: Deltamethrin is highly toxic to fingerlings. © 2006 Wiley Periodicals, Inc. Environ Toxicol 21: 614–620, 2006.
Fabrice Chandre - One of the best experts on this subject based on the ideXlab platform.
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efficacy of six neonicotinoid insecticides alone and in combination with Deltamethrin and piperonyl butoxide against pyrethroid resistant aedes aegypti and anopheles gambiae diptera culicidae
Pest Management Science, 2013Co-Authors: Frederic Darriet, Fabrice ChandreAbstract:BACKGROUND In this study, carried out on pyrethroid-resistant Aedes aegypti and Anopheles gambiae, different combinations containing pyrethroid Deltamethrin, piperonyl butoxide (PBO) synergist and six neonicotinoid insecticides (acetamiprid, nitenpyram, thiamethoxam, clothianidin, imidacloprid and thiacloprid) were tested. The bioassays were carried out by tarsal contact on impregnated paper on Ae. aegypti and with impregnated pieces of netting on An. gambiae. RESULTS The combination of Deltamethrin and PBO was synergistic against pyrethroid-resistant Ae. aegypti (LHP) and An. gambiae (VKPR) strains, with 43 and 57% mortality respectively, versus 17 and 12% with Deltamethrin alone. On LHP Ae. aegypti, the Deltamethrin + PBO + neonicotinoid mixtures generated insecticide efficacies that were either greater (group 1) or lower (group 2) than the Deltamethrin + PBO mixture. The tricomponent mixtures made with thiamethoxam, nitenpyram and thiacloprid (70.7, 64.9 and 55.9% mortality respectively) belong to group 1. Group 2 consists of mixtures made with imidacloprid, clothianidin and acetamiprid (28.9, 32.9 and 34.3% mortality respectively). The nettings impregnated with the three tricomponent mixtures of group 1 confirmed the excellent efficacy of these mixtures against An. gambiae VKPR (87–89% mortality). CONCLUSION Deltamethrin + PBO + neonicotinoid (group 1) mixtures induce interesting, efficient synergies, most valuable for the management of mosquito resistance to insecticides.© 2012 Society of Chemical Industry
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combining piperonyl butoxide and dinotefuran restores the efficacy of Deltamethrin mosquito nets against resistant anopheles gambiae diptera culicidae
Journal of Medical Entomology, 2011Co-Authors: Frederic Darriet, Fabrice ChandreAbstract:ABSTRACT One strategy suggested for the management of mosquito insecticide resistance consists of combining a pyrethroid with an insecticide that has a different mode of action. To restore the efficacy of Deltamethrin (pyrethroid) against pyrethroid-resistant strain of Anopheles gambiae Giles (VKPR: homozygous Kdr), Deltamethrin was combined with the neonicotinoid insecticide dinotefuran and piperonyl butoxide (PBO). Bednets impregnated with Deltamethrin, dinotefuran, and PBO alone and in combination were tested in the laboratory. Knockdown (KD) and mortality were measured using WHO cone tests on susceptible and pyrethroid-resistant adult mosquitoes. The combination of Deltamethrin and PBO was synergistic against resistant female An. gambiae (58.2% mortality). Both mortality and knockdown time (KDt50/95 values) of the tricomponent mixture on the VKPR strain were similar to the insecticidal activity of Deltamethrin on the pyrethroid-susceptible KIS strain (98.8 and 100% mortality, respectively). The three-...
Mahmut Selvi - One of the best experts on this subject based on the ideXlab platform.
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acute toxicity behavioral changes and histopathological effects of Deltamethrin on tissues gills liver brain spleen kidney muscle skin of nile tilapia oreochromis niloticus l fingerlings
Environmental Toxicology, 2006Co-Authors: Ziynet M Yildirim, Caglan Karasu A Benli, Mahmut Selvi, Ayhan Ozkul, Figen Erkoc, Oner KocakAbstract:Deltamethrin, a synthetic pyrethroid contaminating aquatic ecosystems as a potential toxic pollutant, was investigated in the present study for acute toxicity. The purpose of this study was to evaluate LC(50) values of Deltamethrin on Nile tilapia (Oreochromis niloticus L.) fingerlings and investigate histopathological responses of fish exposed to Deltamethrin. The 48 h LC(50) value for Nile tilapia fingerlings was estimated as 4.85 microg/L using static test system. In addition, behavioral changes at each Deltamethrin concentration were observed closely. All fish, exposed to 5 microg/L Deltamethrin revealed severe morphological alterations in the gills and liver. In the gills hyperemia, fusion of secondary lamellae and telangiectasis were observed; whereas hydropic degenerations in liver were observed in all examined fish. The results are significant for reporting acute Deltamethrin toxicity in terms of behavioral and histopathological changes: Deltamethrin is highly toxic to fingerlings.
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acute toxicity behavioral changes and histopathological effects of Deltamethrin on tissues gills liver brain spleen kidney muscle skin of nile tilapia oreochromis niloticus l fingerlings
Environmental Toxicology, 2006Co-Authors: Ziynet M Yildirim, Caglan Karasu A Benli, Mahmut Selvi, Ayhan Ozkul, Figen Erkoc, Oner KocakAbstract:Deltamethrin, a synthetic pyrethroid contaminating aquatic ecosystems as a potential toxic pollutant, was investigated in the present study for acute toxicity. The purpose of this study was to evaluate LC50 values of Deltamethrin on Nile tilapia (Oreochromis niloticus L.) fingerlings and investigate histopathological responses of fish exposed to Deltamethrin. The 48 h LC50 value for Nile tilapia fingerlings was estimated as 4.85 μg/L using static test system. In addition, behavioral changes at each Deltamethrin concentration were observed closely. All fish, exposed to 5 μg/L Deltamethrin revealed severe morphological alterations in the gills and liver. In the gills hyperemia, fusion of secondary lamellae and telangiectasis were observed; whereas hydropic degenerations in liver were observed in all examined fish. The results are significant for reporting acute Deltamethrin toxicity in terms of behavioral and histopathological changes: Deltamethrin is highly toxic to fingerlings. © 2006 Wiley Periodicals, Inc. Environ Toxicol 21: 614–620, 2006.