The Experts below are selected from a list of 9360 Experts worldwide ranked by ideXlab platform

Weidong Tian - One of the best experts on this subject based on the ideXlab platform.

  • three dimensional printing biotechnology for the Regeneration of the tooth and tooth supporting tissues
    Biotechnology and Bioengineering, 2019
    Co-Authors: Li Xie, Bo Yang, Weidong Tian
    Abstract:

    The tooth and its supporting tissues are organized with complex three-dimensional (3D) architecture, including the Dental pulp with a blood supply and nerve tissues, complex multilayer periodontium, and highly aligned periodontal ligament (PDL). Mimicking such 3D complexity and the multicellular interactions naturally existing in Dental structures represents great challenges in Dental Regeneration. Attempts to construct the complex system of the tooth and tooth-supporting apparatus (i.e., the PDL, alveolar bone, and cementum) have made certain progress owing to 3D printing biotechnology. Recent advances have enabled the 3D printing of biocompatible materials, seed cells, and supporting components into complex 3D functional living tissue. Furthermore, 3D bioprinting is driving major innovations in regenerative medicine, giving the field of regenerative dentistry a boost. The fabrication of scaffolds via 3D printing is already being performed extensively at the laboratory bench and in clinical trials; however, printing living cells and matrix materials together to produce tissue constructs by 3D bioprinting remains limited to the Regeneration of Dental pulp and the tooth germ. This review summarizes the application of scaffolds for cell seeding and biofabricated tissues via 3D printing and bioprinting, respectively, in the tooth and its supporting tissues. Additionally, the key advantages and prospects of 3D bioprinting in regenerative dentistry are highlighted, providing new ideas for Dental Regeneration.

Qiuchan Xiong - One of the best experts on this subject based on the ideXlab platform.

  • three dimensional printing with biomaterials in craniofacial and Dental tissue engineering
    PeerJ, 2019
    Co-Authors: Wen Liao, Lin Xu, Kaijuan Wangrao, Yu Du, Qiuchan Xiong
    Abstract:

    : With the development of technology, tissue engineering (TE) has been widely applied in the medical field. In recent years, due to its accuracy and the demands of solid freeform fabrication in TE, three-dimensional printing, also known as additive manufacturing (AM), has been applied for biological scaffold fabrication in craniofacial and Dental Regeneration. In this review, we have compared several types of AM techniques and summarized their advantages and limitations. The range of printable materials used in craniofacial and Dental tissue includes all the biomaterials. Thus, basic and clinical studies were discussed in this review to present the application of AM techniques in craniofacial and Dental tissue and their advances during these years, which might provide information for further AM studies in craniofacial and Dental TE.

Yan Jin - One of the best experts on this subject based on the ideXlab platform.

  • stem cell based bone and Dental Regeneration a view of microenvironmental modulation
    International Journal of Oral Science, 2019
    Co-Authors: Chenxi Zheng, Ji Chen, Shiyu Liu, Yan Jin
    Abstract:

    In modern medicine, bone and Dental loss and defects are common and widespread morbidities, for which regenerative therapy has shown great promise. Mesenchymal stem cells, obtained from various sources and playing an essential role in organ development and postnatal repair, have exhibited enormous potential for regenerating bone and Dental tissue. Currently, mesenchymal stem cells (MSCs)-based bone and Dental Regeneration mainly includes two strategies: the rescue or mobilization of endogenous MSCs and the application of exogenous MSCs in cytotherapy or tissue engineering. Nevertheless, the efficacy of MSC-based Regeneration is not always fulfilled, especially in diseased microenvironments. Specifically, the diseased microenvironment not only impairs the regenerative potential of resident MSCs but also controls the therapeutic efficacy of exogenous MSCs, both as donors and recipients. Accordingly, approaches targeting a diseased microenvironment have been established, including improving the diseased niche to restore endogenous MSCs, enhancing MSC resistance to a diseased microenvironment and renormalizing the microenvironment to guarantee MSC-mediated therapies. Moreover, the application of extracellular vesicles (EVs) as cell-free therapy has emerged as a promising therapeutic strategy. In this review, we summarize current knowledge regarding the tactics of MSC-based bone and Dental Regeneration and the decisive role of the microenvironment, emphasizing the therapeutic potential of microenvironment-targeting strategies in bone and Dental regenerative medicine.

Li Xie - One of the best experts on this subject based on the ideXlab platform.

  • three dimensional printing biotechnology for the Regeneration of the tooth and tooth supporting tissues
    Biotechnology and Bioengineering, 2019
    Co-Authors: Li Xie, Bo Yang, Weidong Tian
    Abstract:

    The tooth and its supporting tissues are organized with complex three-dimensional (3D) architecture, including the Dental pulp with a blood supply and nerve tissues, complex multilayer periodontium, and highly aligned periodontal ligament (PDL). Mimicking such 3D complexity and the multicellular interactions naturally existing in Dental structures represents great challenges in Dental Regeneration. Attempts to construct the complex system of the tooth and tooth-supporting apparatus (i.e., the PDL, alveolar bone, and cementum) have made certain progress owing to 3D printing biotechnology. Recent advances have enabled the 3D printing of biocompatible materials, seed cells, and supporting components into complex 3D functional living tissue. Furthermore, 3D bioprinting is driving major innovations in regenerative medicine, giving the field of regenerative dentistry a boost. The fabrication of scaffolds via 3D printing is already being performed extensively at the laboratory bench and in clinical trials; however, printing living cells and matrix materials together to produce tissue constructs by 3D bioprinting remains limited to the Regeneration of Dental pulp and the tooth germ. This review summarizes the application of scaffolds for cell seeding and biofabricated tissues via 3D printing and bioprinting, respectively, in the tooth and its supporting tissues. Additionally, the key advantages and prospects of 3D bioprinting in regenerative dentistry are highlighted, providing new ideas for Dental Regeneration.

Wen Liao - One of the best experts on this subject based on the ideXlab platform.

  • three dimensional printing with biomaterials in craniofacial and Dental tissue engineering
    PeerJ, 2019
    Co-Authors: Wen Liao, Lin Xu, Kaijuan Wangrao, Yu Du, Qiuchan Xiong
    Abstract:

    : With the development of technology, tissue engineering (TE) has been widely applied in the medical field. In recent years, due to its accuracy and the demands of solid freeform fabrication in TE, three-dimensional printing, also known as additive manufacturing (AM), has been applied for biological scaffold fabrication in craniofacial and Dental Regeneration. In this review, we have compared several types of AM techniques and summarized their advantages and limitations. The range of printable materials used in craniofacial and Dental tissue includes all the biomaterials. Thus, basic and clinical studies were discussed in this review to present the application of AM techniques in craniofacial and Dental tissue and their advances during these years, which might provide information for further AM studies in craniofacial and Dental TE.