The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Torkil Menné - One of the best experts on this subject based on the ideXlab platform.

  • Deodorants are the leading cause of allergic contact dermatitis to fragrance ingredients
    Contact Dermatitis, 2011
    Co-Authors: Maria V Heisterberg, Torkil Menné, Klaus Ejner Andersen, Christian Avnstorp, Berit I Kristensen, Ove Kristensen, Knud Kaaber, Grete Laurberg, N H Nielsen, Mette Sommerlund
    Abstract:

    Background. Fragrances frequently cause contact allergy, and cosmetic products are the main causes of fragrance contact allergy. As the various products have distinctive forms of application and composition of ingredients, some product groups are potentially more likely to play a part in allergic reactions than others. Aim. To determine which cosmetic product groups cause fragrance allergy among Danish eczema patients. Method. This was a retrospective study based on data collected by members of the Danish Contact Dermatitis Group. Participants (N = 17716) were consecutively patch tested with fragrance markers from the European baseline series (2005–2009). Results. Of the participants, 10.1% had fragrance allergy, of which 42.1% was caused by a cosmetic product: Deodorants accounted for 25%, and scented lotions 24.4%. A sex difference was apparent, as Deodorants were significantly more likely to be listed as the cause of fragrance allergy in men (odds ratio 2.2) than in women. Correlation was observed between Deodorants listed as the cause of allergy and allergy detected with fragrance mix II (FM II) and hydroxyisohexyl 3-cyclohexene carboxaldehyde. Conclusion. Deodorants were the leading causes of fragrance allergy, especially among men. Seemingly, Deodorants have an ‘unhealthy’ composition of the fragrance chemicals present in FM II.

  • Deodorants: an experimental provocation study with isoeugenol.
    Contact dermatitis, 2005
    Co-Authors: Magnus Bruze, Jean-pierre Lepoittevin, Suresh Chandra Rastogi, Jeanne D Johansen, Ian R. White, Klaus Ejner Andersen, An Goossens, Peter J. Frosch, Torkil Menné
    Abstract:

    Axillary dermatitis is common and overrepresented in people with contact allergy to fragrances. Many people suspect their Deodorants to be the incriminating products. In order to investigate the significance of isoeugenol in Deodorants for the development of axillary dermatitis when used by people with and without contact allergy to isoeugenol, patch tests with Deodorants and ethanol solutions with isoeugenol, as well as repeated open application tests (ROAT) with roll-on Deodorants with and without isoeugenol at various concentrations, were performed in 35 dermatitis patients, 10 without and 25 with contact allergy to isoeugenol. A positive ROAT was observed only in patients hypersensitive to isoeugenol (P < 0.001) and only in the axilla to which the Deodorants containing isoeugenol had been applied (P < 0.001). Deodorants containing isoeugenol in the concentration range of 0.0063–0.2% used 2 times daily on healthy skin can thus elicit axillary dermatitis within a few weeks in people with contact allergy to isoeugenol.

  • Deodorants an experimental provocation study with hydroxycitronellal
    Contact Dermatitis, 2003
    Co-Authors: Cecilia Svedman, Jean-pierre Lepoittevin, P J Frosch, Suresh Chandra Rastogi, Jeanne D Johansen, Magnus Bruze, Ian R. White, Klaus Ejner Andersen, An Goossens, Torkil Menné
    Abstract:

    Axillary dermatitis is a common problem, particularly in individuals with contact allergy to fragrances. Many individuals suspect their deodorant to be the causal product of their fragrance allergy. It has been shown that Deodorants containing cinnamic aldehyde (cinnamal) can elicit axillary dermatitis in patients sensitized to this substance. The aim of the present investigation was to evaluate the importance of hydroxycitronellal used in Deodorants for the development of axillary dermatitis, when applied by individuals with and without contact allergy to this fragrance chemical. Patch tests with Deodorants and ethanolic solutions containing hydroxycitronellal, as well as repeated open application tests (ROAT) with roll-on Deodorants with and without hydroxycitronellal at different concentrations, were performed in 14 dermatitis patients, 7 with and 7 without contact allergy to hydroxycitronellal. A positive ROAT was noted only in the patients hypersensitive to hydroxycitronellal (P < 0·001) and only in the axilla to which the Deodorants containing hydroxycitronellal had been applied (P < 0·001). Deodorants containing hydroxycitronellal in the concentration range of 0·032–0·32% used twice daily on healthy skin in individuals hypersensitive to hydroxycitronellal can elicit axillary dermatitis in a few weeks. (Less)

  • Deodorants an experimental provocation study with cinnamic aldehyde
    Journal of The American Academy of Dermatology, 2003
    Co-Authors: M Bruze, Jean-pierre Lepoittevin, P J Frosch, Suresh Chandra Rastogi, Jeanne D Johansen, Klaus Ejner Andersen, I R White, S Wakelin, Torkil Menné
    Abstract:

    Abstract Background: Axillary dermatitis is common and overrepresented in individuals with contact allergy to fragrances. Many individuals suspect their Deodorants to be the incriminating products. Objective: Our aim was to investigate the significance of cinnamic aldehyde in Deodorants for the development of axillary dermatitis when used by individuals with and without contact allergy to cinnamic aldehyde. Methods: Patch tests with Deodorants and ethanol solutions with cinnamic aldehyde, and repeated open application tests with roll-on Deodorants without and with cinnamic aldehyde at different concentrations, were performed in 37 patients with dermatitis, 20 without and 17 with contact allergy to cinnamic aldehyde. Results: A repeated open application test with positive findings was noted only in patients hypersensitive to cinnamic aldehyde ( P P Conclusion: Deodorants containing cinnamic aldehyde in the concentration range 0.01% to 0.32%, used twice daily on healthy skin, can elicit axillary dermatitis within a few weeks. (J Am Acad Dermatol 2003;48:194-200.)

  • fragrances and other materials in Deodorants search for potentially sensitizing molecules using combined gc ms and structure activity relationship sar analysis
    Contact Dermatitis, 1998
    Co-Authors: Suresh Chandra Rastogi, Jean-pierre Lepoittevin, P J Frosch, Jeanne D Johansen, Torkil Menné, Klaus Ejner Andersen, M Bruze, B Dreier, I R White
    Abstract:

    Deodorants are one of the most frequently-used types of cosmetics and are a source of allergic contact dermatitis. Therefore, a gas chromatography - mass spectrometric analysis of 71 Deodorants was performed for identification of fragrance and non-fragrance materials present in marketed Deodorants. Futhermore, the sensitizing potential of these molecules was evaluated using structure activity relationships (SARs) analysis. This was based on the presence of 1 or more chemically reactive site(s), in the chemical structure, associated with sensitizing potential. Among the many different substances used to formulate cosmetic products (over 3500), 226 chemicals were identified in a sample of 71 Deodorants. 84 molecules were found to contain at least 1 structural alert, and 70 to belong to, or be susceptible to being metabolized into, the chemical group of aldehydes, ketones and alpha,beta-unsaturated aldehydes, ketone or esters. The combination of GC-MS and SARs analysis could be helpful in the selection of substances for supplementary investigations regarding sensitizing properties. Thus, it may be a valuable tool in the management of contact allergy to Deodorants and for producing new Deodorants with decreased propensity to cause contact allergy.

Jeanne D Johansen - One of the best experts on this subject based on the ideXlab platform.

  • experimental elicitation with hydroxyisohexyl 3 cyclohexene carboxaldehyde containing Deodorants
    Contact Dermatitis, 2007
    Co-Authors: Pia Haslund Jorgensen, Suresh Chandra Rastogi, Klaus Ejner Andersen, Charlotte D Jensen, Jeanne D Johansen
    Abstract:

    Hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC) known as Lyral is a frequent allergen. It is used in more than 50% of marketed Deodorants. The aim of the present study was to determine elicitation thresholds for HICC under simulated conditions of deodorant use. 15 patients with previously diagnosed contact allergy to HICC were patch tested with 5 solutions of HICC-scented and HICC-unscented Deodorants. Patients and 10 healthy controls performed a use test in the axillae using Deodorants scented with HICC in increasing concentrations and unscented Deodorants as control. The concentration of HICC was increased every second week (200, 600, and 1800 p.p.m.) until either a reaction developed or for 6 weeks. 14 patients completed the study, and all developed unilateral eczema from the HICC-containing deodorant, while controls were all negative (P= 0.004). In 9/14 patients, a positive use test developed during the first 2 weeks to the deodorant containing 200 p.p.m. HICC. Positive correlations were found between the day of positive use and patch test threshold concentration of the HICC solutions (r= 0.71, P= 0.01) as well as the patch test thresholds of the HICC-scented Deodorants (r= 0.74, P= 0.007). In conclusion, HICC elicits allergic contact dermatitis in a high proportion of sensitized individuals at common usage concentrations in Deodorants.

  • Deodorants: an experimental provocation study with isoeugenol.
    Contact dermatitis, 2005
    Co-Authors: Magnus Bruze, Jean-pierre Lepoittevin, Suresh Chandra Rastogi, Jeanne D Johansen, Ian R. White, Klaus Ejner Andersen, An Goossens, Peter J. Frosch, Torkil Menné
    Abstract:

    Axillary dermatitis is common and overrepresented in people with contact allergy to fragrances. Many people suspect their Deodorants to be the incriminating products. In order to investigate the significance of isoeugenol in Deodorants for the development of axillary dermatitis when used by people with and without contact allergy to isoeugenol, patch tests with Deodorants and ethanol solutions with isoeugenol, as well as repeated open application tests (ROAT) with roll-on Deodorants with and without isoeugenol at various concentrations, were performed in 35 dermatitis patients, 10 without and 25 with contact allergy to isoeugenol. A positive ROAT was observed only in patients hypersensitive to isoeugenol (P < 0.001) and only in the axilla to which the Deodorants containing isoeugenol had been applied (P < 0.001). Deodorants containing isoeugenol in the concentration range of 0.0063–0.2% used 2 times daily on healthy skin can thus elicit axillary dermatitis within a few weeks in people with contact allergy to isoeugenol.

  • Deodorants an experimental provocation study with hydroxycitronellal
    Contact Dermatitis, 2003
    Co-Authors: Cecilia Svedman, Jean-pierre Lepoittevin, P J Frosch, Suresh Chandra Rastogi, Jeanne D Johansen, Magnus Bruze, Ian R. White, Klaus Ejner Andersen, An Goossens, Torkil Menné
    Abstract:

    Axillary dermatitis is a common problem, particularly in individuals with contact allergy to fragrances. Many individuals suspect their deodorant to be the causal product of their fragrance allergy. It has been shown that Deodorants containing cinnamic aldehyde (cinnamal) can elicit axillary dermatitis in patients sensitized to this substance. The aim of the present investigation was to evaluate the importance of hydroxycitronellal used in Deodorants for the development of axillary dermatitis, when applied by individuals with and without contact allergy to this fragrance chemical. Patch tests with Deodorants and ethanolic solutions containing hydroxycitronellal, as well as repeated open application tests (ROAT) with roll-on Deodorants with and without hydroxycitronellal at different concentrations, were performed in 14 dermatitis patients, 7 with and 7 without contact allergy to hydroxycitronellal. A positive ROAT was noted only in the patients hypersensitive to hydroxycitronellal (P < 0·001) and only in the axilla to which the Deodorants containing hydroxycitronellal had been applied (P < 0·001). Deodorants containing hydroxycitronellal in the concentration range of 0·032–0·32% used twice daily on healthy skin in individuals hypersensitive to hydroxycitronellal can elicit axillary dermatitis in a few weeks. (Less)

  • Deodorants an experimental provocation study with cinnamic aldehyde
    Journal of The American Academy of Dermatology, 2003
    Co-Authors: M Bruze, Jean-pierre Lepoittevin, P J Frosch, Suresh Chandra Rastogi, Jeanne D Johansen, Klaus Ejner Andersen, I R White, S Wakelin, Torkil Menné
    Abstract:

    Abstract Background: Axillary dermatitis is common and overrepresented in individuals with contact allergy to fragrances. Many individuals suspect their Deodorants to be the incriminating products. Objective: Our aim was to investigate the significance of cinnamic aldehyde in Deodorants for the development of axillary dermatitis when used by individuals with and without contact allergy to cinnamic aldehyde. Methods: Patch tests with Deodorants and ethanol solutions with cinnamic aldehyde, and repeated open application tests with roll-on Deodorants without and with cinnamic aldehyde at different concentrations, were performed in 37 patients with dermatitis, 20 without and 17 with contact allergy to cinnamic aldehyde. Results: A repeated open application test with positive findings was noted only in patients hypersensitive to cinnamic aldehyde ( P P Conclusion: Deodorants containing cinnamic aldehyde in the concentration range 0.01% to 0.32%, used twice daily on healthy skin, can elicit axillary dermatitis within a few weeks. (J Am Acad Dermatol 2003;48:194-200.)

  • fragrance contact allergy a clinical review
    American Journal of Clinical Dermatology, 2003
    Co-Authors: Jeanne D Johansen
    Abstract:

    Most people in modern society are exposed daily to fragrance ingredients from one or more sources. Fragrance ingredients are also one of the most frequent causes of contact allergic reactions. The diagnosis is made by patch testing with a mixture of fragrance ingredients, the fragrance mix. This gives a positive patch-test reaction in about 10% of tested patients with eczema, and the most recent estimates show that 1.7-4.1% of the general population are sensitized to ingredients of the fragrance mix. Fragrance allergy occurs predominantly in women with facial or hand eczema. These women typically have a history of rash to a fine fragrance or scented Deodorants. Chemical analysis has revealed that well known allergens from the fragrance mix are present in 15-100% of cosmetic products, including Deodorants and fine fragrances, and most often in combinations of three to four allergens in the same products. This means that it is difficult to avoid exposure, as products labelled as 'fragrance free' have also been shown to contain fragrance ingredients, either because of the use of fragrance ingredients as preservatives or masking perfumes, or the use of botanicals. About 2500 different fragrance ingredients are currently used in the composition of perfumes and at least 100 of these are known contact allergens. Therefore, it is advisable to supplement standard patch testing with the patient's own stay-on cosmetic products, as well as the fragrance chemical hydroxyisohexyl-3-cyclohexane carboxaldehyde, which on its own gives responses in 1-3% of tested patients. The focus in recent years on the ingredients of the fragrance mix will probably result in the fragrance industry changing the composition of perfumes, and thus make the current diagnostic test less useful. New diagnostic tests are under development to identify contact allergy to new allergens, reflecting the continuous developments and trends in exposure.

Klaus Ejner Andersen - One of the best experts on this subject based on the ideXlab platform.

  • Deodorants are the leading cause of allergic contact dermatitis to fragrance ingredients
    Contact Dermatitis, 2011
    Co-Authors: Maria V Heisterberg, Torkil Menné, Klaus Ejner Andersen, Christian Avnstorp, Berit I Kristensen, Ove Kristensen, Knud Kaaber, Grete Laurberg, N H Nielsen, Mette Sommerlund
    Abstract:

    Background. Fragrances frequently cause contact allergy, and cosmetic products are the main causes of fragrance contact allergy. As the various products have distinctive forms of application and composition of ingredients, some product groups are potentially more likely to play a part in allergic reactions than others. Aim. To determine which cosmetic product groups cause fragrance allergy among Danish eczema patients. Method. This was a retrospective study based on data collected by members of the Danish Contact Dermatitis Group. Participants (N = 17716) were consecutively patch tested with fragrance markers from the European baseline series (2005–2009). Results. Of the participants, 10.1% had fragrance allergy, of which 42.1% was caused by a cosmetic product: Deodorants accounted for 25%, and scented lotions 24.4%. A sex difference was apparent, as Deodorants were significantly more likely to be listed as the cause of fragrance allergy in men (odds ratio 2.2) than in women. Correlation was observed between Deodorants listed as the cause of allergy and allergy detected with fragrance mix II (FM II) and hydroxyisohexyl 3-cyclohexene carboxaldehyde. Conclusion. Deodorants were the leading causes of fragrance allergy, especially among men. Seemingly, Deodorants have an ‘unhealthy’ composition of the fragrance chemicals present in FM II.

  • experimental elicitation with hydroxyisohexyl 3 cyclohexene carboxaldehyde containing Deodorants
    Contact Dermatitis, 2007
    Co-Authors: Pia Haslund Jorgensen, Suresh Chandra Rastogi, Klaus Ejner Andersen, Charlotte D Jensen, Jeanne D Johansen
    Abstract:

    Hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC) known as Lyral is a frequent allergen. It is used in more than 50% of marketed Deodorants. The aim of the present study was to determine elicitation thresholds for HICC under simulated conditions of deodorant use. 15 patients with previously diagnosed contact allergy to HICC were patch tested with 5 solutions of HICC-scented and HICC-unscented Deodorants. Patients and 10 healthy controls performed a use test in the axillae using Deodorants scented with HICC in increasing concentrations and unscented Deodorants as control. The concentration of HICC was increased every second week (200, 600, and 1800 p.p.m.) until either a reaction developed or for 6 weeks. 14 patients completed the study, and all developed unilateral eczema from the HICC-containing deodorant, while controls were all negative (P= 0.004). In 9/14 patients, a positive use test developed during the first 2 weeks to the deodorant containing 200 p.p.m. HICC. Positive correlations were found between the day of positive use and patch test threshold concentration of the HICC solutions (r= 0.71, P= 0.01) as well as the patch test thresholds of the HICC-scented Deodorants (r= 0.74, P= 0.007). In conclusion, HICC elicits allergic contact dermatitis in a high proportion of sensitized individuals at common usage concentrations in Deodorants.

  • Deodorants: an experimental provocation study with isoeugenol.
    Contact dermatitis, 2005
    Co-Authors: Magnus Bruze, Jean-pierre Lepoittevin, Suresh Chandra Rastogi, Jeanne D Johansen, Ian R. White, Klaus Ejner Andersen, An Goossens, Peter J. Frosch, Torkil Menné
    Abstract:

    Axillary dermatitis is common and overrepresented in people with contact allergy to fragrances. Many people suspect their Deodorants to be the incriminating products. In order to investigate the significance of isoeugenol in Deodorants for the development of axillary dermatitis when used by people with and without contact allergy to isoeugenol, patch tests with Deodorants and ethanol solutions with isoeugenol, as well as repeated open application tests (ROAT) with roll-on Deodorants with and without isoeugenol at various concentrations, were performed in 35 dermatitis patients, 10 without and 25 with contact allergy to isoeugenol. A positive ROAT was observed only in patients hypersensitive to isoeugenol (P < 0.001) and only in the axilla to which the Deodorants containing isoeugenol had been applied (P < 0.001). Deodorants containing isoeugenol in the concentration range of 0.0063–0.2% used 2 times daily on healthy skin can thus elicit axillary dermatitis within a few weeks in people with contact allergy to isoeugenol.

  • Deodorants an experimental provocation study with hydroxycitronellal
    Contact Dermatitis, 2003
    Co-Authors: Cecilia Svedman, Jean-pierre Lepoittevin, P J Frosch, Suresh Chandra Rastogi, Jeanne D Johansen, Magnus Bruze, Ian R. White, Klaus Ejner Andersen, An Goossens, Torkil Menné
    Abstract:

    Axillary dermatitis is a common problem, particularly in individuals with contact allergy to fragrances. Many individuals suspect their deodorant to be the causal product of their fragrance allergy. It has been shown that Deodorants containing cinnamic aldehyde (cinnamal) can elicit axillary dermatitis in patients sensitized to this substance. The aim of the present investigation was to evaluate the importance of hydroxycitronellal used in Deodorants for the development of axillary dermatitis, when applied by individuals with and without contact allergy to this fragrance chemical. Patch tests with Deodorants and ethanolic solutions containing hydroxycitronellal, as well as repeated open application tests (ROAT) with roll-on Deodorants with and without hydroxycitronellal at different concentrations, were performed in 14 dermatitis patients, 7 with and 7 without contact allergy to hydroxycitronellal. A positive ROAT was noted only in the patients hypersensitive to hydroxycitronellal (P < 0·001) and only in the axilla to which the Deodorants containing hydroxycitronellal had been applied (P < 0·001). Deodorants containing hydroxycitronellal in the concentration range of 0·032–0·32% used twice daily on healthy skin in individuals hypersensitive to hydroxycitronellal can elicit axillary dermatitis in a few weeks. (Less)

  • Deodorants an experimental provocation study with cinnamic aldehyde
    Journal of The American Academy of Dermatology, 2003
    Co-Authors: M Bruze, Jean-pierre Lepoittevin, P J Frosch, Suresh Chandra Rastogi, Jeanne D Johansen, Klaus Ejner Andersen, I R White, S Wakelin, Torkil Menné
    Abstract:

    Abstract Background: Axillary dermatitis is common and overrepresented in individuals with contact allergy to fragrances. Many individuals suspect their Deodorants to be the incriminating products. Objective: Our aim was to investigate the significance of cinnamic aldehyde in Deodorants for the development of axillary dermatitis when used by individuals with and without contact allergy to cinnamic aldehyde. Methods: Patch tests with Deodorants and ethanol solutions with cinnamic aldehyde, and repeated open application tests with roll-on Deodorants without and with cinnamic aldehyde at different concentrations, were performed in 37 patients with dermatitis, 20 without and 17 with contact allergy to cinnamic aldehyde. Results: A repeated open application test with positive findings was noted only in patients hypersensitive to cinnamic aldehyde ( P P Conclusion: Deodorants containing cinnamic aldehyde in the concentration range 0.01% to 0.32%, used twice daily on healthy skin, can elicit axillary dermatitis within a few weeks. (J Am Acad Dermatol 2003;48:194-200.)

Suresh Chandra Rastogi - One of the best experts on this subject based on the ideXlab platform.

  • experimental elicitation with hydroxyisohexyl 3 cyclohexene carboxaldehyde containing Deodorants
    Contact Dermatitis, 2007
    Co-Authors: Pia Haslund Jorgensen, Suresh Chandra Rastogi, Klaus Ejner Andersen, Charlotte D Jensen, Jeanne D Johansen
    Abstract:

    Hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC) known as Lyral is a frequent allergen. It is used in more than 50% of marketed Deodorants. The aim of the present study was to determine elicitation thresholds for HICC under simulated conditions of deodorant use. 15 patients with previously diagnosed contact allergy to HICC were patch tested with 5 solutions of HICC-scented and HICC-unscented Deodorants. Patients and 10 healthy controls performed a use test in the axillae using Deodorants scented with HICC in increasing concentrations and unscented Deodorants as control. The concentration of HICC was increased every second week (200, 600, and 1800 p.p.m.) until either a reaction developed or for 6 weeks. 14 patients completed the study, and all developed unilateral eczema from the HICC-containing deodorant, while controls were all negative (P= 0.004). In 9/14 patients, a positive use test developed during the first 2 weeks to the deodorant containing 200 p.p.m. HICC. Positive correlations were found between the day of positive use and patch test threshold concentration of the HICC solutions (r= 0.71, P= 0.01) as well as the patch test thresholds of the HICC-scented Deodorants (r= 0.74, P= 0.007). In conclusion, HICC elicits allergic contact dermatitis in a high proportion of sensitized individuals at common usage concentrations in Deodorants.

  • Deodorants: an experimental provocation study with isoeugenol.
    Contact dermatitis, 2005
    Co-Authors: Magnus Bruze, Jean-pierre Lepoittevin, Suresh Chandra Rastogi, Jeanne D Johansen, Ian R. White, Klaus Ejner Andersen, An Goossens, Peter J. Frosch, Torkil Menné
    Abstract:

    Axillary dermatitis is common and overrepresented in people with contact allergy to fragrances. Many people suspect their Deodorants to be the incriminating products. In order to investigate the significance of isoeugenol in Deodorants for the development of axillary dermatitis when used by people with and without contact allergy to isoeugenol, patch tests with Deodorants and ethanol solutions with isoeugenol, as well as repeated open application tests (ROAT) with roll-on Deodorants with and without isoeugenol at various concentrations, were performed in 35 dermatitis patients, 10 without and 25 with contact allergy to isoeugenol. A positive ROAT was observed only in patients hypersensitive to isoeugenol (P < 0.001) and only in the axilla to which the Deodorants containing isoeugenol had been applied (P < 0.001). Deodorants containing isoeugenol in the concentration range of 0.0063–0.2% used 2 times daily on healthy skin can thus elicit axillary dermatitis within a few weeks in people with contact allergy to isoeugenol.

  • Deodorants an experimental provocation study with hydroxycitronellal
    Contact Dermatitis, 2003
    Co-Authors: Cecilia Svedman, Jean-pierre Lepoittevin, P J Frosch, Suresh Chandra Rastogi, Jeanne D Johansen, Magnus Bruze, Ian R. White, Klaus Ejner Andersen, An Goossens, Torkil Menné
    Abstract:

    Axillary dermatitis is a common problem, particularly in individuals with contact allergy to fragrances. Many individuals suspect their deodorant to be the causal product of their fragrance allergy. It has been shown that Deodorants containing cinnamic aldehyde (cinnamal) can elicit axillary dermatitis in patients sensitized to this substance. The aim of the present investigation was to evaluate the importance of hydroxycitronellal used in Deodorants for the development of axillary dermatitis, when applied by individuals with and without contact allergy to this fragrance chemical. Patch tests with Deodorants and ethanolic solutions containing hydroxycitronellal, as well as repeated open application tests (ROAT) with roll-on Deodorants with and without hydroxycitronellal at different concentrations, were performed in 14 dermatitis patients, 7 with and 7 without contact allergy to hydroxycitronellal. A positive ROAT was noted only in the patients hypersensitive to hydroxycitronellal (P < 0·001) and only in the axilla to which the Deodorants containing hydroxycitronellal had been applied (P < 0·001). Deodorants containing hydroxycitronellal in the concentration range of 0·032–0·32% used twice daily on healthy skin in individuals hypersensitive to hydroxycitronellal can elicit axillary dermatitis in a few weeks. (Less)

  • Deodorants an experimental provocation study with cinnamic aldehyde
    Journal of The American Academy of Dermatology, 2003
    Co-Authors: M Bruze, Jean-pierre Lepoittevin, P J Frosch, Suresh Chandra Rastogi, Jeanne D Johansen, Klaus Ejner Andersen, I R White, S Wakelin, Torkil Menné
    Abstract:

    Abstract Background: Axillary dermatitis is common and overrepresented in individuals with contact allergy to fragrances. Many individuals suspect their Deodorants to be the incriminating products. Objective: Our aim was to investigate the significance of cinnamic aldehyde in Deodorants for the development of axillary dermatitis when used by individuals with and without contact allergy to cinnamic aldehyde. Methods: Patch tests with Deodorants and ethanol solutions with cinnamic aldehyde, and repeated open application tests with roll-on Deodorants without and with cinnamic aldehyde at different concentrations, were performed in 37 patients with dermatitis, 20 without and 17 with contact allergy to cinnamic aldehyde. Results: A repeated open application test with positive findings was noted only in patients hypersensitive to cinnamic aldehyde ( P P Conclusion: Deodorants containing cinnamic aldehyde in the concentration range 0.01% to 0.32%, used twice daily on healthy skin, can elicit axillary dermatitis within a few weeks. (J Am Acad Dermatol 2003;48:194-200.)

  • fragrances and other materials in Deodorants search for potentially sensitizing molecules using combined gc ms and structure activity relationship sar analysis
    Contact Dermatitis, 1998
    Co-Authors: Suresh Chandra Rastogi, Jean-pierre Lepoittevin, P J Frosch, Jeanne D Johansen, Torkil Menné, Klaus Ejner Andersen, M Bruze, B Dreier, I R White
    Abstract:

    Deodorants are one of the most frequently-used types of cosmetics and are a source of allergic contact dermatitis. Therefore, a gas chromatography - mass spectrometric analysis of 71 Deodorants was performed for identification of fragrance and non-fragrance materials present in marketed Deodorants. Futhermore, the sensitizing potential of these molecules was evaluated using structure activity relationships (SARs) analysis. This was based on the presence of 1 or more chemically reactive site(s), in the chemical structure, associated with sensitizing potential. Among the many different substances used to formulate cosmetic products (over 3500), 226 chemicals were identified in a sample of 71 Deodorants. 84 molecules were found to contain at least 1 structural alert, and 70 to belong to, or be susceptible to being metabolized into, the chemical group of aldehydes, ketones and alpha,beta-unsaturated aldehydes, ketone or esters. The combination of GC-MS and SARs analysis could be helpful in the selection of substances for supplementary investigations regarding sensitizing properties. Thus, it may be a valuable tool in the management of contact allergy to Deodorants and for producing new Deodorants with decreased propensity to cause contact allergy.

Jean-pierre Lepoittevin - One of the best experts on this subject based on the ideXlab platform.

  • Deodorants: an experimental provocation study with isoeugenol.
    Contact dermatitis, 2005
    Co-Authors: Magnus Bruze, Jean-pierre Lepoittevin, Suresh Chandra Rastogi, Jeanne D Johansen, Ian R. White, Klaus Ejner Andersen, An Goossens, Peter J. Frosch, Torkil Menné
    Abstract:

    Axillary dermatitis is common and overrepresented in people with contact allergy to fragrances. Many people suspect their Deodorants to be the incriminating products. In order to investigate the significance of isoeugenol in Deodorants for the development of axillary dermatitis when used by people with and without contact allergy to isoeugenol, patch tests with Deodorants and ethanol solutions with isoeugenol, as well as repeated open application tests (ROAT) with roll-on Deodorants with and without isoeugenol at various concentrations, were performed in 35 dermatitis patients, 10 without and 25 with contact allergy to isoeugenol. A positive ROAT was observed only in patients hypersensitive to isoeugenol (P < 0.001) and only in the axilla to which the Deodorants containing isoeugenol had been applied (P < 0.001). Deodorants containing isoeugenol in the concentration range of 0.0063–0.2% used 2 times daily on healthy skin can thus elicit axillary dermatitis within a few weeks in people with contact allergy to isoeugenol.

  • Deodorants an experimental provocation study with hydroxycitronellal
    Contact Dermatitis, 2003
    Co-Authors: Cecilia Svedman, Jean-pierre Lepoittevin, P J Frosch, Suresh Chandra Rastogi, Jeanne D Johansen, Magnus Bruze, Ian R. White, Klaus Ejner Andersen, An Goossens, Torkil Menné
    Abstract:

    Axillary dermatitis is a common problem, particularly in individuals with contact allergy to fragrances. Many individuals suspect their deodorant to be the causal product of their fragrance allergy. It has been shown that Deodorants containing cinnamic aldehyde (cinnamal) can elicit axillary dermatitis in patients sensitized to this substance. The aim of the present investigation was to evaluate the importance of hydroxycitronellal used in Deodorants for the development of axillary dermatitis, when applied by individuals with and without contact allergy to this fragrance chemical. Patch tests with Deodorants and ethanolic solutions containing hydroxycitronellal, as well as repeated open application tests (ROAT) with roll-on Deodorants with and without hydroxycitronellal at different concentrations, were performed in 14 dermatitis patients, 7 with and 7 without contact allergy to hydroxycitronellal. A positive ROAT was noted only in the patients hypersensitive to hydroxycitronellal (P < 0·001) and only in the axilla to which the Deodorants containing hydroxycitronellal had been applied (P < 0·001). Deodorants containing hydroxycitronellal in the concentration range of 0·032–0·32% used twice daily on healthy skin in individuals hypersensitive to hydroxycitronellal can elicit axillary dermatitis in a few weeks. (Less)

  • Deodorants an experimental provocation study with cinnamic aldehyde
    Journal of The American Academy of Dermatology, 2003
    Co-Authors: M Bruze, Jean-pierre Lepoittevin, P J Frosch, Suresh Chandra Rastogi, Jeanne D Johansen, Klaus Ejner Andersen, I R White, S Wakelin, Torkil Menné
    Abstract:

    Abstract Background: Axillary dermatitis is common and overrepresented in individuals with contact allergy to fragrances. Many individuals suspect their Deodorants to be the incriminating products. Objective: Our aim was to investigate the significance of cinnamic aldehyde in Deodorants for the development of axillary dermatitis when used by individuals with and without contact allergy to cinnamic aldehyde. Methods: Patch tests with Deodorants and ethanol solutions with cinnamic aldehyde, and repeated open application tests with roll-on Deodorants without and with cinnamic aldehyde at different concentrations, were performed in 37 patients with dermatitis, 20 without and 17 with contact allergy to cinnamic aldehyde. Results: A repeated open application test with positive findings was noted only in patients hypersensitive to cinnamic aldehyde ( P P Conclusion: Deodorants containing cinnamic aldehyde in the concentration range 0.01% to 0.32%, used twice daily on healthy skin, can elicit axillary dermatitis within a few weeks. (J Am Acad Dermatol 2003;48:194-200.)

  • fragrances and other materials in Deodorants search for potentially sensitizing molecules using combined gc ms and structure activity relationship sar analysis
    Contact Dermatitis, 1998
    Co-Authors: Suresh Chandra Rastogi, Jean-pierre Lepoittevin, P J Frosch, Jeanne D Johansen, Torkil Menné, Klaus Ejner Andersen, M Bruze, B Dreier, I R White
    Abstract:

    Deodorants are one of the most frequently-used types of cosmetics and are a source of allergic contact dermatitis. Therefore, a gas chromatography - mass spectrometric analysis of 71 Deodorants was performed for identification of fragrance and non-fragrance materials present in marketed Deodorants. Futhermore, the sensitizing potential of these molecules was evaluated using structure activity relationships (SARs) analysis. This was based on the presence of 1 or more chemically reactive site(s), in the chemical structure, associated with sensitizing potential. Among the many different substances used to formulate cosmetic products (over 3500), 226 chemicals were identified in a sample of 71 Deodorants. 84 molecules were found to contain at least 1 structural alert, and 70 to belong to, or be susceptible to being metabolized into, the chemical group of aldehydes, ketones and alpha,beta-unsaturated aldehydes, ketone or esters. The combination of GC-MS and SARs analysis could be helpful in the selection of substances for supplementary investigations regarding sensitizing properties. Thus, it may be a valuable tool in the management of contact allergy to Deodorants and for producing new Deodorants with decreased propensity to cause contact allergy.

  • Deodorants a clinical provocation study in fragrance sensitive individuals
    Contact Dermatitis, 1998
    Co-Authors: Jeanne D Johansen, Jean-pierre Lepoittevin, Suresh Chandra Rastogi, Klaus Ejner Andersen, Peter J. Frosch, M Bruze, B Dreier, I R White, Torkil Menné
    Abstract:

    Deodorants are one of the most marketed types of cosmetics and are frequently reported as a cause of dermatitis, particularly among fragrance-sensitive persons. The aim of this study was to investigate the ability of Deodorants, which had previously caused axillary dermatitis in fragrance-mix-sensitive eczema patients, to provoke reactions on repeated open application tests on the upper arm and in the axillae, and to relate the findings to the content of fragrance-mix constituents in those Deodorants. 14 eczema patients performed a 7-day use test with 1 or 2 Deodorants that had caused a rash within the last 12 months. 2 applications per day were made in the axilla and simultaneously on a 25 cm2 area on the upper arm. A total of 20 Deodorants were tested among the 14 patients. Afterwards, the Deodorants were subjected to quantitative chemical analysis identifying constituents of the fragrance mix. 12/20 (60%) Deodorants elicited eczema on use testing in the axilla. 8/12 Deodorants were positive in the axilla on day (D) 7 and 4 both in the axilla and on the upper arm. 2 of the 4 developed a reaction in the axilla before it developed on the upper arm. Chemical analysis revealed that 18/19 Deodorants contained between 1 and 6 of the fragrance-mix constituents, on average 3 being found. The mean concentration of fragrance-mix constituents was generally higher in the Deodorants causing a positive use test, as compared with those giving a negative reaction, indicating that the differences between the Deodorants in terms of elicitation potential were more related to quantitative aspects of allergen content than of a qualitative nature. It is recommended that Deodorants are tested in the axilla in the case of a negative use test on the upper arm and a strong clinical suspicion.