The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform

Bernhard Bogerts - One of the best experts on this subject based on the ideXlab platform.

  • increased densities of nitric oxide synthase expressing neurons in the temporal cortex and the hypothalamic paraventricular nucleus of polytoxicomanic heroin overdose victims possible implications for heroin neurotoxicity
    Acta Histochemica, 2014
    Co-Authors: Hansgert Bernstein, Kurt Trubner, Philipp Krebs, Henrik Dobrowolny, Hendrik Bielau, Johann Steiner, Bernhard Bogerts
    Abstract:

    Heroin is one of the most dangerous drugs of abuse, which may exert various neurotoxic actions on the brain (such as gray matter loss, neuronal apoptosis, mitochondrial dysfunction, synaptic defects, Depression of Adult neurogenensis, as well as development of spongiform leucoencephalopathy). Some of these toxic effects are probably mediated by the gas nitric oxide (NO). We studied by morphometric analysis the numerical density of neurons expressing neuronal nitric oxide synthase (nNOS) in cortical and hypothalamic areas of eight heroin overdose victims and nine matched controls. Heroin addicts showed significantly increased numerical densities of nNOS immunoreactive cells in the right temporal cortex and the left paraventricular nucleus. Remarkably, in heroin abusers, but not in controls, we observed not only immunostained interneurons, but also cortical pyramidal cells. Given that increased cellular expression of nNOS was accompanied by elevated NO generation in brains of heroin addicts, these elevated levels of NO might have contributed to some of the known toxic effects of heroin (for example, reduced Adult neurogenesis, mitochondrial pathology or disturbances in synaptic functioning).

Hansgert Bernstein - One of the best experts on this subject based on the ideXlab platform.

  • increased densities of nitric oxide synthase expressing neurons in the temporal cortex and the hypothalamic paraventricular nucleus of polytoxicomanic heroin overdose victims possible implications for heroin neurotoxicity
    Acta Histochemica, 2014
    Co-Authors: Hansgert Bernstein, Kurt Trubner, Philipp Krebs, Henrik Dobrowolny, Hendrik Bielau, Johann Steiner, Bernhard Bogerts
    Abstract:

    Heroin is one of the most dangerous drugs of abuse, which may exert various neurotoxic actions on the brain (such as gray matter loss, neuronal apoptosis, mitochondrial dysfunction, synaptic defects, Depression of Adult neurogenensis, as well as development of spongiform leucoencephalopathy). Some of these toxic effects are probably mediated by the gas nitric oxide (NO). We studied by morphometric analysis the numerical density of neurons expressing neuronal nitric oxide synthase (nNOS) in cortical and hypothalamic areas of eight heroin overdose victims and nine matched controls. Heroin addicts showed significantly increased numerical densities of nNOS immunoreactive cells in the right temporal cortex and the left paraventricular nucleus. Remarkably, in heroin abusers, but not in controls, we observed not only immunostained interneurons, but also cortical pyramidal cells. Given that increased cellular expression of nNOS was accompanied by elevated NO generation in brains of heroin addicts, these elevated levels of NO might have contributed to some of the known toxic effects of heroin (for example, reduced Adult neurogenesis, mitochondrial pathology or disturbances in synaptic functioning).

Kurt Trubner - One of the best experts on this subject based on the ideXlab platform.

  • increased densities of nitric oxide synthase expressing neurons in the temporal cortex and the hypothalamic paraventricular nucleus of polytoxicomanic heroin overdose victims possible implications for heroin neurotoxicity
    Acta Histochemica, 2014
    Co-Authors: Hansgert Bernstein, Kurt Trubner, Philipp Krebs, Henrik Dobrowolny, Hendrik Bielau, Johann Steiner, Bernhard Bogerts
    Abstract:

    Heroin is one of the most dangerous drugs of abuse, which may exert various neurotoxic actions on the brain (such as gray matter loss, neuronal apoptosis, mitochondrial dysfunction, synaptic defects, Depression of Adult neurogenensis, as well as development of spongiform leucoencephalopathy). Some of these toxic effects are probably mediated by the gas nitric oxide (NO). We studied by morphometric analysis the numerical density of neurons expressing neuronal nitric oxide synthase (nNOS) in cortical and hypothalamic areas of eight heroin overdose victims and nine matched controls. Heroin addicts showed significantly increased numerical densities of nNOS immunoreactive cells in the right temporal cortex and the left paraventricular nucleus. Remarkably, in heroin abusers, but not in controls, we observed not only immunostained interneurons, but also cortical pyramidal cells. Given that increased cellular expression of nNOS was accompanied by elevated NO generation in brains of heroin addicts, these elevated levels of NO might have contributed to some of the known toxic effects of heroin (for example, reduced Adult neurogenesis, mitochondrial pathology or disturbances in synaptic functioning).

Philipp Krebs - One of the best experts on this subject based on the ideXlab platform.

  • increased densities of nitric oxide synthase expressing neurons in the temporal cortex and the hypothalamic paraventricular nucleus of polytoxicomanic heroin overdose victims possible implications for heroin neurotoxicity
    Acta Histochemica, 2014
    Co-Authors: Hansgert Bernstein, Kurt Trubner, Philipp Krebs, Henrik Dobrowolny, Hendrik Bielau, Johann Steiner, Bernhard Bogerts
    Abstract:

    Heroin is one of the most dangerous drugs of abuse, which may exert various neurotoxic actions on the brain (such as gray matter loss, neuronal apoptosis, mitochondrial dysfunction, synaptic defects, Depression of Adult neurogenensis, as well as development of spongiform leucoencephalopathy). Some of these toxic effects are probably mediated by the gas nitric oxide (NO). We studied by morphometric analysis the numerical density of neurons expressing neuronal nitric oxide synthase (nNOS) in cortical and hypothalamic areas of eight heroin overdose victims and nine matched controls. Heroin addicts showed significantly increased numerical densities of nNOS immunoreactive cells in the right temporal cortex and the left paraventricular nucleus. Remarkably, in heroin abusers, but not in controls, we observed not only immunostained interneurons, but also cortical pyramidal cells. Given that increased cellular expression of nNOS was accompanied by elevated NO generation in brains of heroin addicts, these elevated levels of NO might have contributed to some of the known toxic effects of heroin (for example, reduced Adult neurogenesis, mitochondrial pathology or disturbances in synaptic functioning).

Henrik Dobrowolny - One of the best experts on this subject based on the ideXlab platform.

  • increased densities of nitric oxide synthase expressing neurons in the temporal cortex and the hypothalamic paraventricular nucleus of polytoxicomanic heroin overdose victims possible implications for heroin neurotoxicity
    Acta Histochemica, 2014
    Co-Authors: Hansgert Bernstein, Kurt Trubner, Philipp Krebs, Henrik Dobrowolny, Hendrik Bielau, Johann Steiner, Bernhard Bogerts
    Abstract:

    Heroin is one of the most dangerous drugs of abuse, which may exert various neurotoxic actions on the brain (such as gray matter loss, neuronal apoptosis, mitochondrial dysfunction, synaptic defects, Depression of Adult neurogenensis, as well as development of spongiform leucoencephalopathy). Some of these toxic effects are probably mediated by the gas nitric oxide (NO). We studied by morphometric analysis the numerical density of neurons expressing neuronal nitric oxide synthase (nNOS) in cortical and hypothalamic areas of eight heroin overdose victims and nine matched controls. Heroin addicts showed significantly increased numerical densities of nNOS immunoreactive cells in the right temporal cortex and the left paraventricular nucleus. Remarkably, in heroin abusers, but not in controls, we observed not only immunostained interneurons, but also cortical pyramidal cells. Given that increased cellular expression of nNOS was accompanied by elevated NO generation in brains of heroin addicts, these elevated levels of NO might have contributed to some of the known toxic effects of heroin (for example, reduced Adult neurogenesis, mitochondrial pathology or disturbances in synaptic functioning).