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Brenda W J H Penninx - One of the best experts on this subject based on the ideXlab platform.
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the mental health impact of the covid 19 pandemic on people with and without Depressive Anxiety or obsessive compulsive disorders a longitudinal study of three dutch case control cohorts
The Lancet Psychiatry, 2021Co-Authors: Kuan Yu Pan, Almar A L Kok, Merijn Eikelenboom, Melany Horsfall, Frederike Jorg, Rob A Luteijn, Didi Rhebergen, Patricia Van Oppen, Erik J Giltay, Brenda W J H PenninxAbstract:Summary Background The impact of the COVID-19 pandemic on mental health in people with pre-existing mental health disorders is unclear. In three psychiatry case-control cohorts, we compared the perceived mental health impact and coping and changes in Depressive symptoms, Anxiety, worry, and loneliness before and during the COVID-19 pandemic between people with and without lifetime Depressive, Anxiety, or obsessive-compulsive disorders. Methods Between April 1 and May 13, 2020, online questionnaires were distributed among the Netherlands Study of Depression and Anxiety, Netherlands Study of Depression in Older Persons, and Netherlands Obsessive Compulsive Disorder Association cohorts, including people with (n=1181) and without (n=336) Depressive, Anxiety, or obsessive-compulsive disorders. The questionnaire contained questions on perceived mental health impact, fear of COVID-19, coping, and four validated scales assessing Depressive symptoms, Anxiety, worry, and loneliness used in previous waves during 2006–16. Number and chronicity of disorders were based on diagnoses in previous waves. Linear regression and mixed models were done. Findings The number and chronicity of disorders showed a positive graded dose–response relation, with greater perceived impact on mental health, fear, and poorer coping. Although people with Depressive, Anxiety, or obsessive-compulsive disorders scored higher on all four symptom scales than did individuals without these mental health disorders, both before and during the COVID-19 pandemic, they did not report a greater increase in symptoms during the pandemic. In fact, people without Depressive, Anxiety, or obsessive-compulsive disorders showed a greater increase in symptoms during the COVID-19 pandemic, whereas individuals with the greatest burden on their mental health tended to show a slight symptom decrease. Interpretation People with Depressive, Anxiety, or obsessive-compulsive disorders are experiencing a detrimental impact on their mental health from the COVID-19 pandemic, which requires close monitoring in clinical practice. Yet, the COVID-19 pandemic does not seem to have further increased symptom severity compared with their prepandemic levels. Funding Dutch Research Council.
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sleep circadian rhythm and physical activity patterns in Depressive and Anxiety disorders a 2 week ambulatory assessment study
Depression and Anxiety, 2019Co-Authors: Sonia Difrancesco, Femke Lamers, Aartjan T F Beekman, Harriette Riese, Kathleen R Merikangas, Albert M Van Hemert, Robert A Schoevers, Brenda W J H PenninxAbstract:BACKGROUND: Actigraphy may provide a more valid assessment of sleep, circadian rhythm (CR), and physical activity (PA) than self-reported questionnaires, but has not been used widely to study the association with depression/Anxiety and their clinical characteristics. METHODS: Fourteen-day actigraphy data of 359 participants with current (n = 93), remitted (n = 176), or no (n = 90) composite international diagnostic interview depression/Anxiety diagnoses were obtained from the Netherlands Study of Depression and Anxiety. Objective estimates included sleep duration (SD), sleep efficiency, relative amplitude (RA) between day-time and night-time activity, mid sleep on free days (MSF), gross motor activity (GMA), and moderate-to-vigorous PA (MVPA). Self-reported measures included insomnia rating scale, SD, MSF, metabolic equivalent total, and MVPA. RESULTS: Compared to controls, individuals with current depression/Anxiety had a significantly different objective, but not self-reported, PA and CR: lower GMA (23.83 vs. 27.4 milli-gravity/day, p = .022), lower MVPA (35.32 vs. 47.64 min/day, p = .023), lower RA (0.82 vs. 0.83, p = .033). In contrast, self-reported, but not objective, sleep differed between people with current depression/Anxiety compared to those without current disorders; people with current depression/Anxiety reported both shorter and longer SD and more insomnia. More Depressive/Anxiety symptoms and number of Depressive/Anxiety diagnoses were associated with larger disturbances of the actigraphy measures. CONCLUSION: Actigraphy provides ecologically valid information on sleep, CR, and PA that enhances data from self-reported questionnaires. As those with more severe or comorbid forms showed the lowest PA and most CR disruptions, the potential for adjunctive behavioral and chronotherapy interventions should be explored, as well as the potential of actigraphy to monitor treatment response to such interventions.
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Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval
Frontiers Media S.A., 2018Co-Authors: Femke Lamers, Brenda W J H Penninx, Eco J C De GeusAbstract:Objectives: Cardiac repolarization may be affected by psychiatric disorders and/or antidepressant use, but evidence for this is inconclusive. This study examined the relationship between Depressive and Anxiety disorder and use of antidepressants with T-wave amplitude (TWA) and QT-interval.Methods: Data was obtained from the Netherlands Study of Depression and Anxiety (n = 1,383). Depression/Anxiety was diagnosed with the DSM-IV based Composite International Diagnostic Interview. The use of tricyclic antidepressants (TCAs), selective serotonin and noradrenalin reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs) was established. T-wave amplitude and QT-interval corrected for heart rate (QTc) were obtained from an ECG measured in a type II axis configuration.Results: Compared to controls, persons with depression or Anxiety disorders did not show a significantly different TWA (p = 0.58; Cohen's d = 0.046) or QTc (p = 0.48; Cohen's d = −0.057). In spite of known sympathomimetic effects, TCA use (p = 0.26; Cohen's d = −0.162) and SNRI use (p = 0.70; Cohen's d = −0.055) were not significantly associated with a lower TWA. TCA use (p = 0.12; Cohen's d = 0.225) and SNRI use (p = 0.11; Cohen's d = 0.227) were also not significantly associated with a prolonged QTc.Conclusion: We did not find evidence that either Depressive/Anxiety disorder or antidepressant use is associated with abnormalities in TWA or QTc. Earlier found sympathomimetic effects of TCAs and SNRIs are not evident in these measures of cardiac repolarization
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common rather than unique aspects of repetitive negative thinking are related to Depressive and Anxiety disorders and symptoms
Journal of Anxiety Disorders, 2015Co-Authors: Brenda W J H Penninx, Philip Spinhoven, Jolijn Drost, Bert Van HemertAbstract:Repetitive Negative Thinking (RNT) is assumed to be a transdiagnostic factor in Depressive and Anxiety disorders. We hypothesized that an underlying common dimension of RNT will be more strongly associated with each of the Anxiety and Depressive disorders, with comorbidity among disorders and with symptom severity than unique aspects of rumination and worry. In a cross-sectional study, 2143 adults diagnosed according to DSM-IV criteria completed questionnaires for content-independent RNT, rumination and worry. 84% of the shared variance of worry and rumination overlapped with content-independent RNT. The common dimension of RNT was significantly associated with each of the Depressive and Anxiety disorders, comorbidity among emotional disorders and the common core of Depressive, Anxiety and avoidance symptoms. The unique portion of rumination showed a significant relationship with Major Depressive Disorder and Depressive comorbidity and the unique portion of worry with Generalized Anxiety Disorder. These findings are particularly relevant for clinical practice as generic interventions to reduce RNT are currently being tested.
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the role of negative emotionality and impulsivity in Depressive Anxiety disorders and alcohol dependence
Psychological Medicine, 2013Co-Authors: Lynn Boschloo, Nicole Vogelzangs, W Van Den Brink, J H Smit, Aartjan T F Beekman, Brenda W J H PenninxAbstract:BACKGROUND: Much is still unclear about the role of personality in the structure of common psychiatric disorders such as Depressive/Anxiety disorders and alcohol dependence. This study will therefore examine whether various traits of negative emotionality and impulsivity showed shared or specific associations with these disorders. Method Cross-sectional data were used from the Netherlands Study of Depression and Anxiety (NESDA), including individuals with no DSM-IV psychiatric disorder (n = 460), Depressive/Anxiety disorder only (i.e. Depressive and/or Anxiety disorder; n = 1398), alcohol dependence only (n = 32) and co-morbid Depressive/Anxiety disorder plus alcohol dependence (n = 358). Aspects of negative emotionality were neuroticism, hopelessness, rumination, worry and Anxiety sensitivity, whereas aspects of impulsivity included disinhibition, thrill/adventure seeking, experience seeking and boredom susceptibility. RESULTS: Aspects of negative emotionality formed a homogeneous dimension, which was unrelated to the more heterogeneous construct of impulsivity. Although all aspects of negative emotionality were associated with alcohol dependence only, associations were much stronger for Depressive/Anxiety disorder only and co-morbid Depressive/Anxiety disorder with alcohol dependence. The results for impulsivity traits were less profound and more variable, with disinhibition and boredom susceptibility showing modest associations with both Depressive/Anxiety disorder and alcohol dependence, whereas low thrill/adventure seeking and high disinhibition were more strongly related with the first and the latter, respectively. CONCLUSIONS: Our results suggest that Depressive/Anxiety disorder and alcohol dependence result from shared as well as specific aetiological pathways as they showed the same associations with all aspects of negative emotionality, disinhibition and boredom susceptibility as well as specific associations with thrill/adventure seeking and disinhibition.
Manuela Martinez - One of the best experts on this subject based on the ideXlab platform.
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recovery from Depressive symptoms state Anxiety and post traumatic stress disorder in women exposed to physical and psychological but not to psychological intimate partner violence alone a longitudinal study
BMC Psychiatry, 2010Co-Authors: Concepcion Blascoros, Segunda Sanchezlorente, Manuela MartinezAbstract:Background It is well established that intimate male partner violence (IPV) has a high impact on women's mental health. It is necessary to further investigate this impact longitudinally to assess the factors that contribute to its recovery or deterioration. The objective of this study was to assess the course of Depressive, Anxiety and post-traumatic stress disorder (PTSD) symptoms and suicidal behavior over a three-year follow-up in female victims of IPV.
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recovery from Depressive symptoms state Anxiety and post traumatic stress disorder in women exposed to physical and psychological but not to psychological intimate partner violence alone a longitudinal study
BMC Psychiatry, 2010Co-Authors: Concepcion Blascoros, Segunda Sanchezlorente, Manuela MartinezAbstract:It is well established that intimate male partner violence (IPV) has a high impact on women's mental health. It is necessary to further investigate this impact longitudinally to assess the factors that contribute to its recovery or deterioration. The objective of this study was to assess the course of Depressive, Anxiety and post-traumatic stress disorder (PTSD) symptoms and suicidal behavior over a three-year follow-up in female victims of IPV. Women (n = 91) who participated in our previous cross-sectional study, and who had been either physically/psychologically (n = 33) or psychologically abused (n = 23) by their male partners, were evaluated three years later. A nonabused control group of women (n = 35) was included for comparison. Information about mental health status and lifestyle variables was obtained through face-to-face structured interviews. Results of the follow-up study indicated that while women exposed to physical/psychological IPV recovered their mental health status with a significant decrease in Depressive, Anxiety and PTSD symptoms, no recovery occurred in women exposed to psychological IPV alone. The evolution of IPV was also different: while it continued across both time points in 65.21% of psychologically abused women, it continued in only 12.12% of physically/psychologically abused women while it was reduced to psychological IPV in 51.5%. Hierarchical multiple regression analyses indicated that cessation of physical IPV and perceived social support contributed to mental health recovery, while a high perception of lifetime events predicted the continuation of PTSD symptoms. This study shows that the pattern of mental health recovery depends on the type of IPV that the women had been exposed to. While those experiencing physical/psychological IPV have a higher likelihood of undergoing a cessation or reduction of IPV over time and, therefore, could recover, women exposed to psychological IPV alone have a high probability of continued exposure to the same type of IPV with a low possibility of recovery. Thus, women exposed to psychological IPV alone need more help to escape from IPV and to recuperate their mental health. Longitudinal studies are needed to improve knowledge of factors promoting or impeding health recovery to guide the formulation of policy at individual, social and criminal justice levels.
Mitchell G Weiss - One of the best experts on this subject based on the ideXlab platform.
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cultural dimensions of psychiatric diagnosis a comparison of dsm iii r and illness explanatory models in south india
British Journal of Psychiatry, 1995Co-Authors: Mitchell G Weiss, R Raguram, S M ChannabasavannaAbstract:BACKGROUND Cross-cultural research to examine the cultural validity of diagnostic categories and underlying concepts requires methods that integrate epidemiological and anthropological frameworks. METHOD The Explanatory Model Interview Catalogue (EMIC) and Structured Clinical Interview for DSM-III-R (SCID) were used to study 80 psychiatric out-patients with Depressive neurosis at a clinic in south India. RESULTS Summary kappa values of 0.75 for the EMIC and 0.68 for the SCID confirmed interrater reliability. Comparison of patient explanatory models and SCID diagnoses showed that patients emphasised somatic experience while clinicians emphasised Depressive diagnoses. More than half the patients (55%) received a non-specific or dual diagnosis. CONCLUSIONS These findings raise questions about the distinctiveness of Depressive, Anxiety, and somatoform (DAS) disorders for this population.
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the explanatory model interview catalogue emic contribution to cross cultural research methods from a study of leprosy and mental health
British Journal of Psychiatry, 1992Co-Authors: Mitchell G Weiss, D R Doongaji, S Siddhartha, David Wypij, S Pathare, M Bhatawdekar, A Bhave, A Sheth, Richard FernandesAbstract:The Explanatory Model Interview Catalogue (EMIC) has been developed to elicit illness-related perceptions, beliefs, and practices in a cultural study of leprosy and mental health in Bombay. Leprosy is an especially appropriate disorder for studying the inter-relationship of culture, mental health and medical illness because of deeply rooted cultural meanings, the emotional burden, and underuse of effective therapy. Fifty per cent of 56 recently diagnosed leprosy out-patients, 37% of 19 controls with another stigmatised dermatological condition (vitiligo), but only 8% of 12 controls with a comparable non-stigmatised condition (tinea versicolor) met DSM-III-R criteria for an axis I Depressive, Anxiety or somatoform disorder. Belief in a humoral (traditional) cause of illness predicted better attendance at clinic.
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the explanatory model interview catalogue emic contribution to cross cultural research methods from a study of leprosy and mental health
British Journal of Psychiatry, 1992Co-Authors: Mitchell G Weiss, D R Doongaji, S Siddhartha, David Wypij, S Pathare, M Bhatawdekar, A Bhave, A Sheth, Richard FernandesAbstract:The Explanatory Model Interview Catalogue (EMIC) has been developed to elicit illness-related perceptions, beliefs, and practices in a cultural study of leprosy and mental health in Bombay. Leprosy is an especially appropriate disorder for studying the inter-relationship of culture, mental health and medical illness because of deeply rooted cultural meanings, the emotional burden, and underuse of effective therapy. Fifty per cent of 56 recently diagnosed leprosy out-patients, 37% of 19 controls with another stigmatised dermatological condition (vitiligo), but only 8% of 12 controls with a comparable non-stigmatised condition (tinea versicolor) met DSM-III-R criteria for an axis I Depressive, Anxiety or somatoform disorder. Belief in a humoral (traditional) cause of illness predicted better attendance at clinic.
Richard Fernandes - One of the best experts on this subject based on the ideXlab platform.
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the explanatory model interview catalogue emic contribution to cross cultural research methods from a study of leprosy and mental health
British Journal of Psychiatry, 1992Co-Authors: Mitchell G Weiss, D R Doongaji, S Siddhartha, David Wypij, S Pathare, M Bhatawdekar, A Bhave, A Sheth, Richard FernandesAbstract:The Explanatory Model Interview Catalogue (EMIC) has been developed to elicit illness-related perceptions, beliefs, and practices in a cultural study of leprosy and mental health in Bombay. Leprosy is an especially appropriate disorder for studying the inter-relationship of culture, mental health and medical illness because of deeply rooted cultural meanings, the emotional burden, and underuse of effective therapy. Fifty per cent of 56 recently diagnosed leprosy out-patients, 37% of 19 controls with another stigmatised dermatological condition (vitiligo), but only 8% of 12 controls with a comparable non-stigmatised condition (tinea versicolor) met DSM-III-R criteria for an axis I Depressive, Anxiety or somatoform disorder. Belief in a humoral (traditional) cause of illness predicted better attendance at clinic.
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the explanatory model interview catalogue emic contribution to cross cultural research methods from a study of leprosy and mental health
British Journal of Psychiatry, 1992Co-Authors: Mitchell G Weiss, D R Doongaji, S Siddhartha, David Wypij, S Pathare, M Bhatawdekar, A Bhave, A Sheth, Richard FernandesAbstract:The Explanatory Model Interview Catalogue (EMIC) has been developed to elicit illness-related perceptions, beliefs, and practices in a cultural study of leprosy and mental health in Bombay. Leprosy is an especially appropriate disorder for studying the inter-relationship of culture, mental health and medical illness because of deeply rooted cultural meanings, the emotional burden, and underuse of effective therapy. Fifty per cent of 56 recently diagnosed leprosy out-patients, 37% of 19 controls with another stigmatised dermatological condition (vitiligo), but only 8% of 12 controls with a comparable non-stigmatised condition (tinea versicolor) met DSM-III-R criteria for an axis I Depressive, Anxiety or somatoform disorder. Belief in a humoral (traditional) cause of illness predicted better attendance at clinic.
Concepcion Blascoros - One of the best experts on this subject based on the ideXlab platform.
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recovery from Depressive symptoms state Anxiety and post traumatic stress disorder in women exposed to physical and psychological but not to psychological intimate partner violence alone a longitudinal study
BMC Psychiatry, 2010Co-Authors: Concepcion Blascoros, Segunda Sanchezlorente, Manuela MartinezAbstract:Background It is well established that intimate male partner violence (IPV) has a high impact on women's mental health. It is necessary to further investigate this impact longitudinally to assess the factors that contribute to its recovery or deterioration. The objective of this study was to assess the course of Depressive, Anxiety and post-traumatic stress disorder (PTSD) symptoms and suicidal behavior over a three-year follow-up in female victims of IPV.
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recovery from Depressive symptoms state Anxiety and post traumatic stress disorder in women exposed to physical and psychological but not to psychological intimate partner violence alone a longitudinal study
BMC Psychiatry, 2010Co-Authors: Concepcion Blascoros, Segunda Sanchezlorente, Manuela MartinezAbstract:It is well established that intimate male partner violence (IPV) has a high impact on women's mental health. It is necessary to further investigate this impact longitudinally to assess the factors that contribute to its recovery or deterioration. The objective of this study was to assess the course of Depressive, Anxiety and post-traumatic stress disorder (PTSD) symptoms and suicidal behavior over a three-year follow-up in female victims of IPV. Women (n = 91) who participated in our previous cross-sectional study, and who had been either physically/psychologically (n = 33) or psychologically abused (n = 23) by their male partners, were evaluated three years later. A nonabused control group of women (n = 35) was included for comparison. Information about mental health status and lifestyle variables was obtained through face-to-face structured interviews. Results of the follow-up study indicated that while women exposed to physical/psychological IPV recovered their mental health status with a significant decrease in Depressive, Anxiety and PTSD symptoms, no recovery occurred in women exposed to psychological IPV alone. The evolution of IPV was also different: while it continued across both time points in 65.21% of psychologically abused women, it continued in only 12.12% of physically/psychologically abused women while it was reduced to psychological IPV in 51.5%. Hierarchical multiple regression analyses indicated that cessation of physical IPV and perceived social support contributed to mental health recovery, while a high perception of lifetime events predicted the continuation of PTSD symptoms. This study shows that the pattern of mental health recovery depends on the type of IPV that the women had been exposed to. While those experiencing physical/psychological IPV have a higher likelihood of undergoing a cessation or reduction of IPV over time and, therefore, could recover, women exposed to psychological IPV alone have a high probability of continued exposure to the same type of IPV with a low possibility of recovery. Thus, women exposed to psychological IPV alone need more help to escape from IPV and to recuperate their mental health. Longitudinal studies are needed to improve knowledge of factors promoting or impeding health recovery to guide the formulation of policy at individual, social and criminal justice levels.