The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Luca Borradori - One of the best experts on this subject based on the ideXlab platform.
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superficial neutrophilic dermatoses from subcorneal pustular Dermatosis sneddon wilkinson disease to intercellular iga dermatoses
2018Co-Authors: Laurence Feldmeyer, T Hashimoto, Luca BorradoriAbstract:Since the initial description of the subcorneal pustular Dermatosis by Sneddon and Wilkinson in 1956 [1], our understanding of the pathophysiology of diseases associated with the accumulation of neutrophils in the epidermis and intraepidermal blistering has significantly evolved. Sneddon-Wilkinson disease is now regarded as condition belonging to the spectrum of neutrophilic dermatoses characterized by neutrophilic infiltration of the skin and potential extracutaneous involvement, such as Sweet syndrome and pyoderma gangrenosum [2–4]. This group of inflammatory conditions, which show considerable clinical and histological overlap, is frequently associated with systemic diseases. Recently, it has been suggested to use the term of superficial neutrophilic dermatoses for all neutrophilic diseases associated with intraepidermal neutrophil accumulation [5]. Intriguingly, there is a group of patients who develop a superficial neutrophilic disease very similar to Sneddon-Wilkinson disease, showing either subcorneal or intraepidermal pustule formation. However, in contrast to Sneddon-Wilkinson disease, these patients show characteristically IgA deposits on the cell surface of epidermal keratinocyte in a pemphigus-like pattern or more rarely linear deposits in the subcorneal zone.
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giant cellulitis like sweet syndrome a new variant of neutrophilic Dermatosis
JAMA Dermatology, 2013Co-Authors: Andre M Surovy, Nedzmidin Pelivani, Ivan Hegyi, Urs Buettiker, Helmut Beltraminelli, Luca BorradoriAbstract:Background:Neutrophilic dermatoses comprise a wide spectrumofinflammatorydiseaseswithoverlappingfeatures characterized histologically by the presence of an aseptic neutrophilic infiltrate in the epidermis, dermis, and/or hypodermis and are often associated with systemic inflammatory and neoplastic disorders. Observations: We describe 3 patients with an unusual neutrophilic Dermatosis characterized by relapsingepisodesoffever,widespreadinfiltratedplaqueswith bullousappearance,andvariableinvolvementofthearms, legs, abdomen, and/or trunk. Light microscopy studies showed marked edema of the papillary dermis with an inflammatoryinfiltrateconsistingmainlyofmatureneu
H Bergoend - One of the best experts on this subject based on the ideXlab platform.
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subcorneal pustular Dermatosis in a patient with crohn s disease
Acta Dermato-venereologica, 1992Co-Authors: Emmanuel Delaporte, C Nguyenmailfer, Ferdinand Piette, Alexis Cortot, Jean-frederic Colombel, H BergoendAbstract:: A case of subcorneal pustular Dermatosis (Sneddon-Wilkinson disease) is reported in a patient with a one-year history of Crohn's disease. Subcorneal pustular Dermatosis has been described in association with monoclonal gammopathy, but to our knowledge it has not been associated with Crohn's disease. This new association reinforces the hypothesis of a possible common pathogenesis for neutrophilic dermatoses and inflammatory bowel diseases.
Emmanuel Delaporte - One of the best experts on this subject based on the ideXlab platform.
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subcorneal pustular Dermatosis in a patient with crohn s disease
Acta Dermato-venereologica, 1992Co-Authors: Emmanuel Delaporte, C Nguyenmailfer, Ferdinand Piette, Alexis Cortot, Jean-frederic Colombel, H BergoendAbstract:: A case of subcorneal pustular Dermatosis (Sneddon-Wilkinson disease) is reported in a patient with a one-year history of Crohn's disease. Subcorneal pustular Dermatosis has been described in association with monoclonal gammopathy, but to our knowledge it has not been associated with Crohn's disease. This new association reinforces the hypothesis of a possible common pathogenesis for neutrophilic dermatoses and inflammatory bowel diseases.
T Hashimoto - One of the best experts on this subject based on the ideXlab platform.
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superficial neutrophilic dermatoses from subcorneal pustular Dermatosis sneddon wilkinson disease to intercellular iga dermatoses
2018Co-Authors: Laurence Feldmeyer, T Hashimoto, Luca BorradoriAbstract:Since the initial description of the subcorneal pustular Dermatosis by Sneddon and Wilkinson in 1956 [1], our understanding of the pathophysiology of diseases associated with the accumulation of neutrophils in the epidermis and intraepidermal blistering has significantly evolved. Sneddon-Wilkinson disease is now regarded as condition belonging to the spectrum of neutrophilic dermatoses characterized by neutrophilic infiltration of the skin and potential extracutaneous involvement, such as Sweet syndrome and pyoderma gangrenosum [2–4]. This group of inflammatory conditions, which show considerable clinical and histological overlap, is frequently associated with systemic diseases. Recently, it has been suggested to use the term of superficial neutrophilic dermatoses for all neutrophilic diseases associated with intraepidermal neutrophil accumulation [5]. Intriguingly, there is a group of patients who develop a superficial neutrophilic disease very similar to Sneddon-Wilkinson disease, showing either subcorneal or intraepidermal pustule formation. However, in contrast to Sneddon-Wilkinson disease, these patients show characteristically IgA deposits on the cell surface of epidermal keratinocyte in a pemphigus-like pattern or more rarely linear deposits in the subcorneal zone.
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rapid response of iga pemphigus of subcorneal pustular Dermatosis type to treatment with isotretinoin
Journal of The American Academy of Dermatology, 2000Co-Authors: Claudia Gruss, M Kroiss, Markus Landthaler, T. Vogt, T Hashimoto, Detlef Zillikens, Masayuki Amagai, W StolzAbstract:Abstract Diagnosing IgA pemphigus and distinguishing between its 2 subtypes, intraepidermal neutrophilic IgA Dermatosis type and subcorneal pustular Dermatosis type, is important because treatment of IgA pemphigus has to be different from treatment of other blistering autoimmune dermatoses. We present a patient with subcorneal pustular Dermatosis type of IgA pemphigus who rapidly responded to systemic treatment with isotretinoin. Specific diagnosis was established by detecting IgA serum activity to desmocollin 1 by indirect immunofluorescence microscopy on unfixed COS7 cells transfected with desmocollin 1. No IgA or IgG serum reactivity was found to recombinant forms of desmogleins 1 and 3 by an antigen-specific enzyme-linked immunosorbent assay. The disease was not effectively controlled by conventional therapeutic regimens. Systemic treatment with isotretinoin 20 mg daily led to complete clearance of skin lesions within 3 weeks. Assaying IgA serum reactivity to desmocollin 1, desmoglein 1, and desmoglein 3 as a valuable method for establishing the diagnosis and differentiating the 2 subtypes of IgA pemphigus. Isotretinoin was an effective drug in the treatment of subcorneal pustular Dermatosis type of IgA pemphigus in this patient. (J Am Acad Dermatol 2000;43:923-6.)
Muzeyyen Gonul - One of the best experts on this subject based on the ideXlab platform.
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a case of subcorneal pustular Dermatosis successfully treated with acitretin
Journal of Allergy & Inflammation, 2016Co-Authors: Havva Ozge Keseroglu, Necip Enis Kaya, Aysun Gokce, Muzeyyen GonulAbstract:Subcorneal pustular Dermatosis is a rare, chronic neutrophilic dermatoses characterized by recurrent, sterile pustules localized to the trunk, intertriginous regions and flexural surfaces of extremities. The diagnosis of disease is made by demonstration of subcorneal pustules containing neutrophils histopathologically and negative immunofluorescence staining. We reported a 68-year-old male patient with subcorneal pustular Dermatosis, who was misdiagnosed as dermatitis herpetiformis without performing direct immunofluorescence examination and had been treated with dapsone with partial benefit for 20 years. He was admitted to our clinic because of the increasing complaints after the cessation of dapsone treatment 2 months before due to development of anemia. The diagnosis of subcorneal pustular Dermatosis was made clinically and histopathologically. Complete remission was achieved with systemic acitretin treatment. With this case, we want to emphasize that direct immunofluorescence examination is necessary in order to distinguish subcorneal pustular Dermatosis from dermatitis herpetiformis and IgA pemphigus. Acitretin can be a safe and effective treatment option for these patients.