The Experts below are selected from a list of 591 Experts worldwide ranked by ideXlab platform
Jun Cao - One of the best experts on this subject based on the ideXlab platform.
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two phase systems developed with hydrophilic and hydrophobic deep eutectic Solvents for simultaneously extracting various bioactive compounds with different polarities
Green Chemistry, 2018Co-Authors: Jun Cao, Fuliang Cao, Luyao Chen, Linguo ZhaoAbstract:Two-phase systems developed with hydrophilic deep eutectic Solvents (DESs) and hydrophobic DESs were prepared in this study for the first time. Ginkgo biloba leaves containing several bioactive compounds were chosen as the model plant material to evaluate the possibility of the two-phase DES system as a Designer Solvent for the simultaneous extraction of the various bioactive compounds with different polarities. After tailoring, a two-phase DES system prepared with two hydrophilic DESs and one hydrophobic DES at a volume ratio of 35 : 5 : 40 could effectively extract flavonoids, terpene trilactones (TTLs), procyanidine (PAC) and polyprenyl acetates (PPAs) simultaneously from the Ginkgo biloba leaves. The extraction conditions were further optimized using the response surface methodology. When the two-phase DES system was employed in the extraction under the optimal conditions, the PPAs moved into the hydrophobic phase, and the flavonoids, TTLs, and PAC were enriched into the hydrophilic phase. The first extraction rates for PAC, flavonoids, TTLs and PPAs were 86.07%, 77.72%, 93.29% and 94.63%, respectively. After extraction, the hydrophilic and hydrophobic phases containing different bioactive compounds could be easily separated for different preparations. Extraction with the two-phase DES system is a new application trial of DESs, which has the potential to be widely used for the extraction of bioactive compounds from plant materials or removal of different polar impurities from specific extracts.
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tailor made hydrophobic deep eutectic Solvents for cleaner extraction of polyprenyl acetates from ginkgo biloba leaves
Journal of Cleaner Production, 2017Co-Authors: Jun Cao, Meng Yang, Fuliang Cao, Jiahong WangAbstract:Abstract Deep eutectic Solvents (DESs), especially hydrophilic DESs, have been considered green substitutes to conventional organic Solvents for bioactive compounds extraction. This study provided a practical example demonstrating the efficiency of hydrophobic DESs as Designer Solvent to extract polyprenyl acetates from Ginkgo biloba leaves. A hydrophobic ternary DES named as MCO gave the highest extraction yield for polyprenyl acetates during the initial screening. It was tailor-made from methyl trioctyl ammonium chloride, capryl alcohol and octylic acid at a molar ratio of 1:2:3 by systematically optimizing the DES component type, molar ratio and number. With MCO-based extraction, the operational factors influencing the extraction yield were further optimized by statistical method. The model for the extraction of polyprenyl acetates was well established and verified. Extraction yield of 84.11 ± 0.7366 was obtained at the optimal conditions, which was much higher than those of conventional hydrophobic organic Solvents (petroleum ether and n-hexane). Moreover, excellent recovery of polyprenyl acetates from MCO extraction solution was obtained by macroporous resin AB-8 or DM130 adsorption. This study demonstrated that not only hydrophilic DESs but also hydrophobic DESs can be adopted as Solvents for bioactive compounds extraction from biomass.
Marcos R Mafra - One of the best experts on this subject based on the ideXlab platform.
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Designer Solvent ability of alcohols in aqueous biphasic systems composed of deep eutectic Solvents and potassium phosphate
Separation and Purification Technology, 2018Co-Authors: Fabiane Oliveira Farias, Helena Passos, Matheus Gomes Sanglard, Luciana Igarashimafra, Joao A P Coutinho, Marcos R MafraAbstract:Abstract Deep eutectic Solvents (DES) have been proposed as phase forming components of aqueous biphasic systems (ABS). However, the DES hydrogen bonding complexes are not stable in the high concentrations of water present in this type of systems. Therefore, as previously shown, DES-based ABS should be treated as quaternary systems. This confers DES-based ABS with an extra degree of freedom for the design of separation processes since while one of the DES components acts as a phase forming component, the other could induce the modification of the ABS phase properties and, consequently, the control of the partition of various biomolecules. In this context, the Designer Solvent effect of the hydrogen bond donor (HBD), using four different alcohols – ethanol, n-propanol 1,2-propanediol and ethylene glycol – mixed at three different molar fractions (2:1; 1:1 and 1:2) with cholinium chloride (the hydrogen bond acceptor, HBA) in quaternary systems composed of K2HPO4 and water, was evaluated in this work. The results show that the presence of the HBD has an impact upon the liquid–liquid equilibrium, and these changes are dependent on the alcohol nature. The NRTL model was correlated to the tie-line experimental data with a low mean deviation. Moreover, several biomolecules (phenolic compounds, alkaloids, and amino acids) were use as molecular probes to evaluate the ability of alcohols to tune the partition in the studied systems. The alcohol presence changes the properties of the ABS’s phases and it is here shown that the HBD of the DES can indeed be used to modulate the partition behavior of target molecules.
M B Deshmukh - One of the best experts on this subject based on the ideXlab platform.
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low melting mixture glycerol proline as an innovative Designer Solvent for the synthesis of novel chromeno fused thiazolopyrimidinone derivatives an excellent correlation with green chemistry metrics
Journal of Molecular Liquids, 2019Co-Authors: Priyanka P Mohire, Dattatray Chandam, Reshma B Patil, Ajinkya A Patravale, Jai S Ghosh, M B DeshmukhAbstract:Abstract The expansion of proficient and environmentally benign synthetic protocols has engrossed increasing attention in recent organic syntheses in view of the mounting concern over the environment. As part of this green concept, our group designed novel LTTM by using Glycerol and proline (1:1) at reflux condition, and effectiveness of novel DES or LTTM has been studied for the synthesis of 7-(aryl)-10-methyl-6H,7H-chromeno[4,3-d]thiazolo[3,2-a]pyrimidin-6-one derivatives via Multicomponent reaction. The synthetic methodology with the use of novel LTTM as green Solvent and inexpensive, biodegradable, plays a dual role (recyclable catalyst and Solvent) with its operational simplicity and maximum greener synthetic efficiency with green chemistry metrics calculations will be attractive for academic and industrial research. The synthesized derivatives have been evaluated for mosquito larvicidal bioassay using two mosquito species namely Aedes aegypti and Culex quinquefasciatus.
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oxalic acid dihydrate proline as a new recyclable Designer Solvent a sustainable green avenue for the synthesis of spirooxindole
Research on Chemical Intermediates, 2016Co-Authors: Dattatray Chandam, Abhijeet Mulik, D R Patil, M B DeshmukhAbstract:The quest to develop an environmentally friendly, sustainable protocol for immensely bioactive spirooxindole derivatives has encouraged to explore oxalic acid dihydrate: proline low transition temperature mixture as a new Designer Solvent for the said synthesis at room temperature. It has been successfully applied for the three component reaction of isatin, malononitrile or ethyl cyanoacetate and 1,3–dicarbonyl compounds for the first time. Moderate to good yield of the products, shorter reaction time, energy efficiency, chromatography-free purification process, recyclability and high atom economy are the captivating feature of this protocol which will find applications in multi-component, diversity-oriented synthesis.
Fuliang Cao - One of the best experts on this subject based on the ideXlab platform.
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two phase systems developed with hydrophilic and hydrophobic deep eutectic Solvents for simultaneously extracting various bioactive compounds with different polarities
Green Chemistry, 2018Co-Authors: Jun Cao, Fuliang Cao, Luyao Chen, Linguo ZhaoAbstract:Two-phase systems developed with hydrophilic deep eutectic Solvents (DESs) and hydrophobic DESs were prepared in this study for the first time. Ginkgo biloba leaves containing several bioactive compounds were chosen as the model plant material to evaluate the possibility of the two-phase DES system as a Designer Solvent for the simultaneous extraction of the various bioactive compounds with different polarities. After tailoring, a two-phase DES system prepared with two hydrophilic DESs and one hydrophobic DES at a volume ratio of 35 : 5 : 40 could effectively extract flavonoids, terpene trilactones (TTLs), procyanidine (PAC) and polyprenyl acetates (PPAs) simultaneously from the Ginkgo biloba leaves. The extraction conditions were further optimized using the response surface methodology. When the two-phase DES system was employed in the extraction under the optimal conditions, the PPAs moved into the hydrophobic phase, and the flavonoids, TTLs, and PAC were enriched into the hydrophilic phase. The first extraction rates for PAC, flavonoids, TTLs and PPAs were 86.07%, 77.72%, 93.29% and 94.63%, respectively. After extraction, the hydrophilic and hydrophobic phases containing different bioactive compounds could be easily separated for different preparations. Extraction with the two-phase DES system is a new application trial of DESs, which has the potential to be widely used for the extraction of bioactive compounds from plant materials or removal of different polar impurities from specific extracts.
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tailor made hydrophobic deep eutectic Solvents for cleaner extraction of polyprenyl acetates from ginkgo biloba leaves
Journal of Cleaner Production, 2017Co-Authors: Jun Cao, Meng Yang, Fuliang Cao, Jiahong WangAbstract:Abstract Deep eutectic Solvents (DESs), especially hydrophilic DESs, have been considered green substitutes to conventional organic Solvents for bioactive compounds extraction. This study provided a practical example demonstrating the efficiency of hydrophobic DESs as Designer Solvent to extract polyprenyl acetates from Ginkgo biloba leaves. A hydrophobic ternary DES named as MCO gave the highest extraction yield for polyprenyl acetates during the initial screening. It was tailor-made from methyl trioctyl ammonium chloride, capryl alcohol and octylic acid at a molar ratio of 1:2:3 by systematically optimizing the DES component type, molar ratio and number. With MCO-based extraction, the operational factors influencing the extraction yield were further optimized by statistical method. The model for the extraction of polyprenyl acetates was well established and verified. Extraction yield of 84.11 ± 0.7366 was obtained at the optimal conditions, which was much higher than those of conventional hydrophobic organic Solvents (petroleum ether and n-hexane). Moreover, excellent recovery of polyprenyl acetates from MCO extraction solution was obtained by macroporous resin AB-8 or DM130 adsorption. This study demonstrated that not only hydrophilic DESs but also hydrophobic DESs can be adopted as Solvents for bioactive compounds extraction from biomass.
Linguo Zhao - One of the best experts on this subject based on the ideXlab platform.
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two phase systems developed with hydrophilic and hydrophobic deep eutectic Solvents for simultaneously extracting various bioactive compounds with different polarities
Green Chemistry, 2018Co-Authors: Jun Cao, Fuliang Cao, Luyao Chen, Linguo ZhaoAbstract:Two-phase systems developed with hydrophilic deep eutectic Solvents (DESs) and hydrophobic DESs were prepared in this study for the first time. Ginkgo biloba leaves containing several bioactive compounds were chosen as the model plant material to evaluate the possibility of the two-phase DES system as a Designer Solvent for the simultaneous extraction of the various bioactive compounds with different polarities. After tailoring, a two-phase DES system prepared with two hydrophilic DESs and one hydrophobic DES at a volume ratio of 35 : 5 : 40 could effectively extract flavonoids, terpene trilactones (TTLs), procyanidine (PAC) and polyprenyl acetates (PPAs) simultaneously from the Ginkgo biloba leaves. The extraction conditions were further optimized using the response surface methodology. When the two-phase DES system was employed in the extraction under the optimal conditions, the PPAs moved into the hydrophobic phase, and the flavonoids, TTLs, and PAC were enriched into the hydrophilic phase. The first extraction rates for PAC, flavonoids, TTLs and PPAs were 86.07%, 77.72%, 93.29% and 94.63%, respectively. After extraction, the hydrophilic and hydrophobic phases containing different bioactive compounds could be easily separated for different preparations. Extraction with the two-phase DES system is a new application trial of DESs, which has the potential to be widely used for the extraction of bioactive compounds from plant materials or removal of different polar impurities from specific extracts.