The Experts below are selected from a list of 5565 Experts worldwide ranked by ideXlab platform
Benjamin A Alman - One of the best experts on this subject based on the ideXlab platform.
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predominance of beta catenin mutations and beta catenin dysregulation in sporadic aggressive fibromatosis Desmoid Tumor
Oncogene, 1999Co-Authors: Sabine Tejpar, Friedel Nollet, Catherine Li, Jay S Wunder, G Michils, Eric Van Cutsem, Bharati Bapat, Jean Jacques Cassiman, Benjamin A AlmanAbstract:Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (Desmoid Tumor)
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aggressive fibromatosis Desmoid Tumor is a monoclonal disorder
Diagnostic Molecular Pathology, 1997Co-Authors: Benjamin A Alman, Mandy E Pajerski, Salvador J Diazcano, Kerry Corboy, Hubert J WolfeAbstract:Aggressive fibromatosis (also called deep fibromatosis or Desmoid Tumor) is a proliferation of cytologically benign-appearing fibrocytes, often resulting in significant functional loss. The nature of the lesion is controversial: some evidence suggests that it is a reactive process, whereas other evi
Adam I Riker - One of the best experts on this subject based on the ideXlab platform.
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palliative resection of a giant mesenteric Desmoid Tumor
The Ochsner journal, 2015Co-Authors: Jeremy Sugrue, Stephanie Cohen, Roland M Marshall, Adam I RikerAbstract:Background: Desmoid Tumors are relatively uncommon Tumors, and those occurring sporadically and in an intraabdominal location are especially rare. Although Desmoid Tumors have a benign histologic appearance and lack the ability to metastasize, they can invade locally, often aggressively, grow to large sizes, and recur repeatedly. Case Report: We present the case of a symptomatic, giant mesenteric Desmoid Tumor discovered incidentally during workup for the patient's previous history of lung cancer. The patient elected to undergo palliative resection of the Tumor because of persistent and unrelenting abdominal pain. Conclusion: Because of the rarity of the disease, no clear evidence-based guidelines exist for the treatment of sporadic mesenteric Desmoid Tumors. Review of the available literature suggests that surgical resection with negative margins is a reasonable approach for patients with symptomatic Tumors.
Morito Monden - One of the best experts on this subject based on the ideXlab platform.
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dacarbazine doxorubicin therapy ameliorated an extremely aggressive mesenteric Desmoid Tumor associated with familial adenomatous polyposis report of a case
Japanese Journal of Clinical Oncology, 2008Co-Authors: Koji Ezumi, Hirofumi Yamamoto, Ichiro Takemasa, Masaya Nomura, Masataka Ikeda, Mitsugu Sekimoto, Morito MondenAbstract:A 30-year-old man with familial adenomatous polyposis (FAP) underwent prophylactic proctocolectomy by laparoscopy-assisted surgery. After 10 months, we found an intra-abdominal Tumor, which grew rapidly to 25 cm in diameter. We performed an emergency operation, which revealed that it was a Desmoid Tumor derived mainly from colorectal mesenterium. The Tumor was removed with three short segments of intestine and the left ureter. A computed tomography (CT) scan done 3 months later showed a 10 cm mesenteric Desmoid Tumor at the beginning of jejunum, approaching the root of the superior mesenteric artery (SMA). Fortunately, we were able to remove the Tumor without injuring the SMA. To our distress, however, another recurrent mesenteric Desmoid Tumor was discovered in the pelvis one month later, which grew rapidly from 5 cm to 16 cm within 4 months. During this period, we gave the patient several regimens, including antiestrogen (tamoxifen), a nonsteroidal antiinflammtory drug and imatinib mesylate (Gleevec), which had little or no effect. Finally, when the Desmoid occupied the pelvic space, we gave the patient dacarbazine (DTIC) and doxorubicin (DOX). After seven courses, the mesenteric Tumor showed an almost complete response (CR). The chemotherapy caused grade 3 to 4 leukocytopenia, but without any hazardous events. No evidence of further recurrence of mesenteric Desmoid has been seen for 4 years. This combination chemotherapy is a promising strategy, even against an extremely aggressive, life-threatening mesenteric Desmoid associated with FAP.
William L Heimer - One of the best experts on this subject based on the ideXlab platform.
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extraabdominal Desmoid Tumor
Journal of The American Academy of Dermatology, 1996Co-Authors: Neville G Pereyo, William L HeimerAbstract:An extraabdominal Desmoid Tumor of the shoulder occurring in a middle-aged woman without Gardner's syndrome is described. Two punch biopsy specimens from the Tumor were initially interpreted as representing scar tissue; a third incisional biopsy specimen demonstrated the characteristic features of a Desmoid Tumor. Because Desmoid Tumors are locally aggressive, early diagnosis and treatment are crucial to minimize morbidity and mortality. Typical clinical and histologic findings characteristic of an extraabdominal Desmoid Tumor are described, and treatment options are reviewed.
Khadra Maysa - One of the best experts on this subject based on the ideXlab platform.
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abdominal wall Desmoid Tumor mimicking a subserosal uterine leiomyoma
International Journal of General Medicine, 2011Co-Authors: Moamar Aljefout, Alabed Walid, Abomayale Esam, Alqaisi Amin, Hawa Nather, Nawayse Sultan, Khadra MaysaAbstract:Desmoid Tumors are cytologically bland fibrous neoplasms originating from musculoaponeurotic structures throughout the body. The cause of Desmoid Tumors is uncertain, but may be related to trauma or hormonal factors, or may have a genetic association. These Tumors can be found in some young women during pregnancy or just after giving birth. We report herein a case of Desmoid Tumor on the inner aspect of the abdominal wall that mimicked a large subserosal uterine leiomyoma. Initial clinical examination of the patient suggested a large abdominal wall Tumor, while the imaging techniques including transabdominal ultrasound and magnetic resonance imaging suggested a large subserosal uterine leiomyoma as the initial diagnosis. This case emphasizes the importance of clinical examination during the diagnostic process.