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Heather Gamble - One of the best experts on this subject based on the ideXlab platform.

  • Effect of Swirling Desolvation Gas Flow in an Atmospheric Pressure Ion Source
    Journal of The American Society for Mass Spectrometry, 2014
    Co-Authors: Serguei Savtchenko, Nasser Ashgriz, Chuck Jolliffe, Lisa Cousins, Heather Gamble
    Abstract:

    A numerical study is performed to examine the effect of introducing a swirling Desolvation gas flow on the flow transport characteristics in an electrospray and an atmospheric pressure chemical ionization (APCI) system. An ion source having three coaxial tubes is considered: (1) an inner capillary tube to inject the liquid sample, (2) a center coaxial tube to provide a room temperature gas flow to nebulize the liquid, referred to as the nebulizing gas flow, and (3) an outer coaxial tube having a converging exit to supply a high temperature gas for droplet Desolvation, referred to as the Desolvation gas flow. The results show that a swirling Desolvation gas flow reduces the dispersion of the nebulizing gas and suppresses turbulent diffusion. The effect of swirling Desolvation flow on the trajectory of a range of droplet sizes emitted from a source is also considered. Figure ᅟ

  • effect of swirling Desolvation gas flow in an atmospheric pressure ion source
    Journal of the American Society for Mass Spectrometry, 2014
    Co-Authors: Serguei Savtchenko, Nasser Ashgriz, Chuck Jolliffe, Lisa Woodbridge Cousins, Heather Gamble
    Abstract:

    A numerical study is performed to examine the effect of introducing a swirling Desolvation gas flow on the flow transport characteristics in an electrospray and an atmospheric pressure chemical ionization (APCI) system. An ion source having three coaxial tubes is considered: (1) an inner capillary tube to inject the liquid sample, (2) a center coaxial tube to provide a room temperature gas flow to nebulize the liquid, referred to as the nebulizing gas flow, and (3) an outer coaxial tube having a converging exit to supply a high temperature gas for droplet Desolvation, referred to as the Desolvation gas flow. The results show that a swirling Desolvation gas flow reduces the dispersion of the nebulizing gas and suppresses turbulent diffusion. The effect of swirling Desolvation flow on the trajectory of a range of droplet sizes emitted from a source is also considered.

Serguei Savtchenko - One of the best experts on this subject based on the ideXlab platform.

  • Effect of Swirling Desolvation Gas Flow in an Atmospheric Pressure Ion Source
    Journal of The American Society for Mass Spectrometry, 2014
    Co-Authors: Serguei Savtchenko, Nasser Ashgriz, Chuck Jolliffe, Lisa Cousins, Heather Gamble
    Abstract:

    A numerical study is performed to examine the effect of introducing a swirling Desolvation gas flow on the flow transport characteristics in an electrospray and an atmospheric pressure chemical ionization (APCI) system. An ion source having three coaxial tubes is considered: (1) an inner capillary tube to inject the liquid sample, (2) a center coaxial tube to provide a room temperature gas flow to nebulize the liquid, referred to as the nebulizing gas flow, and (3) an outer coaxial tube having a converging exit to supply a high temperature gas for droplet Desolvation, referred to as the Desolvation gas flow. The results show that a swirling Desolvation gas flow reduces the dispersion of the nebulizing gas and suppresses turbulent diffusion. The effect of swirling Desolvation flow on the trajectory of a range of droplet sizes emitted from a source is also considered. Figure ᅟ

  • effect of swirling Desolvation gas flow in an atmospheric pressure ion source
    Journal of the American Society for Mass Spectrometry, 2014
    Co-Authors: Serguei Savtchenko, Nasser Ashgriz, Chuck Jolliffe, Lisa Woodbridge Cousins, Heather Gamble
    Abstract:

    A numerical study is performed to examine the effect of introducing a swirling Desolvation gas flow on the flow transport characteristics in an electrospray and an atmospheric pressure chemical ionization (APCI) system. An ion source having three coaxial tubes is considered: (1) an inner capillary tube to inject the liquid sample, (2) a center coaxial tube to provide a room temperature gas flow to nebulize the liquid, referred to as the nebulizing gas flow, and (3) an outer coaxial tube having a converging exit to supply a high temperature gas for droplet Desolvation, referred to as the Desolvation gas flow. The results show that a swirling Desolvation gas flow reduces the dispersion of the nebulizing gas and suppresses turbulent diffusion. The effect of swirling Desolvation flow on the trajectory of a range of droplet sizes emitted from a source is also considered.

Chuck Jolliffe - One of the best experts on this subject based on the ideXlab platform.

  • Effect of Swirling Desolvation Gas Flow in an Atmospheric Pressure Ion Source
    Journal of The American Society for Mass Spectrometry, 2014
    Co-Authors: Serguei Savtchenko, Nasser Ashgriz, Chuck Jolliffe, Lisa Cousins, Heather Gamble
    Abstract:

    A numerical study is performed to examine the effect of introducing a swirling Desolvation gas flow on the flow transport characteristics in an electrospray and an atmospheric pressure chemical ionization (APCI) system. An ion source having three coaxial tubes is considered: (1) an inner capillary tube to inject the liquid sample, (2) a center coaxial tube to provide a room temperature gas flow to nebulize the liquid, referred to as the nebulizing gas flow, and (3) an outer coaxial tube having a converging exit to supply a high temperature gas for droplet Desolvation, referred to as the Desolvation gas flow. The results show that a swirling Desolvation gas flow reduces the dispersion of the nebulizing gas and suppresses turbulent diffusion. The effect of swirling Desolvation flow on the trajectory of a range of droplet sizes emitted from a source is also considered. Figure ᅟ

  • effect of swirling Desolvation gas flow in an atmospheric pressure ion source
    Journal of the American Society for Mass Spectrometry, 2014
    Co-Authors: Serguei Savtchenko, Nasser Ashgriz, Chuck Jolliffe, Lisa Woodbridge Cousins, Heather Gamble
    Abstract:

    A numerical study is performed to examine the effect of introducing a swirling Desolvation gas flow on the flow transport characteristics in an electrospray and an atmospheric pressure chemical ionization (APCI) system. An ion source having three coaxial tubes is considered: (1) an inner capillary tube to inject the liquid sample, (2) a center coaxial tube to provide a room temperature gas flow to nebulize the liquid, referred to as the nebulizing gas flow, and (3) an outer coaxial tube having a converging exit to supply a high temperature gas for droplet Desolvation, referred to as the Desolvation gas flow. The results show that a swirling Desolvation gas flow reduces the dispersion of the nebulizing gas and suppresses turbulent diffusion. The effect of swirling Desolvation flow on the trajectory of a range of droplet sizes emitted from a source is also considered.

Nasser Ashgriz - One of the best experts on this subject based on the ideXlab platform.

  • Effect of Swirling Desolvation Gas Flow in an Atmospheric Pressure Ion Source
    Journal of The American Society for Mass Spectrometry, 2014
    Co-Authors: Serguei Savtchenko, Nasser Ashgriz, Chuck Jolliffe, Lisa Cousins, Heather Gamble
    Abstract:

    A numerical study is performed to examine the effect of introducing a swirling Desolvation gas flow on the flow transport characteristics in an electrospray and an atmospheric pressure chemical ionization (APCI) system. An ion source having three coaxial tubes is considered: (1) an inner capillary tube to inject the liquid sample, (2) a center coaxial tube to provide a room temperature gas flow to nebulize the liquid, referred to as the nebulizing gas flow, and (3) an outer coaxial tube having a converging exit to supply a high temperature gas for droplet Desolvation, referred to as the Desolvation gas flow. The results show that a swirling Desolvation gas flow reduces the dispersion of the nebulizing gas and suppresses turbulent diffusion. The effect of swirling Desolvation flow on the trajectory of a range of droplet sizes emitted from a source is also considered. Figure ᅟ

  • effect of swirling Desolvation gas flow in an atmospheric pressure ion source
    Journal of the American Society for Mass Spectrometry, 2014
    Co-Authors: Serguei Savtchenko, Nasser Ashgriz, Chuck Jolliffe, Lisa Woodbridge Cousins, Heather Gamble
    Abstract:

    A numerical study is performed to examine the effect of introducing a swirling Desolvation gas flow on the flow transport characteristics in an electrospray and an atmospheric pressure chemical ionization (APCI) system. An ion source having three coaxial tubes is considered: (1) an inner capillary tube to inject the liquid sample, (2) a center coaxial tube to provide a room temperature gas flow to nebulize the liquid, referred to as the nebulizing gas flow, and (3) an outer coaxial tube having a converging exit to supply a high temperature gas for droplet Desolvation, referred to as the Desolvation gas flow. The results show that a swirling Desolvation gas flow reduces the dispersion of the nebulizing gas and suppresses turbulent diffusion. The effect of swirling Desolvation flow on the trajectory of a range of droplet sizes emitted from a source is also considered.

Douglas R. Flanagan - One of the best experts on this subject based on the ideXlab platform.

  • Desolvation Kinetics of Sulfameter Solvates
    Journal of pharmaceutical sciences, 2008
    Co-Authors: Ammar Khawam, Douglas R. Flanagan
    Abstract:

    Solvates are often encountered in pharmaceutical solids and knowledge of their physical stability is necessary for their effective formulation. This work investigates the solid-state stability of five structurally related solvates of sulfameter (5-methoxysulfadiazine) by studying the kinetics of their Desolvation reaction with thermogravimetric analysis, both isothermally and nonisothermally. Desolvation kinetic analysis was done isothermally by conventional model-fitting and nonisothermally by the complementary method. Calculated kinetic parameters (model, A and Ea) were compared and related to the crystal structure of these solvates. A relationship was established between Desolvation activation energy from isothermal results and solvent size; the larger the solvent molecule, the higher its solvate's Desolvation activation energy. The best fitting solid-state reaction model correlated to single crystal structural features of sulfameter-solvates where solvent molecules occupied cavities in the unit cell. Finally, it was found that kinetic parameters obtained isothermally and nonisothermally were at variance. Therefore, kinetic results obtained from one method may not be extended to results form the other.

  • Solid-state non-isothermal kinetics of sulfonamide-ammonia adduct Desolvation
    Thermochimica Acta, 1992
    Co-Authors: Christy M. Wyandt, Douglas R. Flanagan
    Abstract:

    Abstract A general differential technique is proposed for obtaining non-isothermal kinetic information from thermogravimetric data. This method uses a differential form of the general non-isothermal kinetic expression and fits Desolvation data to rate laws corresponding to each of 11 solid-state mechanisms. The correct mechanism is determined to be the one the data fit most closely and the activation energy is calculated for this rate law. The method was used to evaluate the Desolvation of six sulfonamide-ammonia adducts. A correlation was found between the calculated isothermal activation energies for a drug and its p K a . Sulfonamides with higher p K a values had lower Desolvation activation energies and those with lower p K a values had higher Desolvation activation energies.