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V W V Jaddoe - One of the best experts on this subject based on the ideXlab platform.

  • body fat distribution overweight and cardiac structures in school age children a population based cardiac magnetic resonance imaging study
    Journal of the American Heart Association, 2020
    Co-Authors: Liza Toemen, A A Roest, G Jelic, J F Felix, W A Helbing, R Gaillard, Susana Santos, Aad Van Der Lugt, V W V Jaddoe
    Abstract:

    Background Adiposity is associated with larger left ventricular mass in children and adults. The role of body fat distribution in these associations is not clear. We examined the associations of body fat distribution and overweight with cardiac measures obtained by cardiac magnetic resonance imaging in school-age children. Methods and Results In a population-based cohort study including 2836 children, 10 years of age, we used anthropometric measures, dual-energy X-ray absorptiometry, and magnetic resonance imaging to collect information on body mass index, lean mass index, fat mass index, and abdominal visceral adipose tissue index. Indexes were standardized by height. Cardiac measures included right and left ventricular end-diastolic volume, left ventricular mass, and mass-to-volume ratio as a marker for concentricity. All body fat measures were positively associated with right and left ventricular end-diastolic volumes and left ventricular mass, with the strongest associations for lean mass index (all P<0.05). Obese children had a 1.12 standard Deviation Score (95% CI, 0.94-1.30) larger left ventricular mass and a 0.35 standard Deviation Score (95% CI, 0.14-0.57) higher left ventricular mass-to-volume ratio than normal weight children. Conditional on body mass index, higher lean mass index was associated with higher right and left ventricular end-diastolic volume and left ventricular mass, whereas higher fat mass measures were inversely associated with these cardiac measures (all P<0.05). Conclusions Higher childhood body mass index is associated with a larger right and left ventricular size. This association is influenced by higher lean mass. In childhood, lean mass may be a stronger determinant of heart growth than fat mass. Fat mass may influence cardiac structures at older ages.

  • body fat distribution overweight and cardiac structures in school age children a population based cardiac magnetic resonance imaging study
    Stroke, 2020
    Co-Authors: Liza Toemen, S M S Santos, A A Roest, G Jelic, A Van Delugt, J F Felix, W A Helbing, R Gaillard, V W V Jaddoe
    Abstract:

    BACKGROUND: Adiposity is associated with larger left ventricular mass in children and adults. The role of body fat distribution in these associations is not clear. We examined the associations of body fat distribution and overweight with cardiac measures obtained by cardiac magnetic resonance imaging in school-age children. METHODS AND RESULTS: In a population-based cohort study including 2836 children, 10 years of age, we used anthropometric measures, dual-energy X-ray absorptiometry, and magnetic resonance imaging to collect information on body mass index, lean mass index, fat mass index, and abdominal visceral adipose tissue index. Indexes were standardized by height. Cardiac measures included right and left ventricular end-diastolic volume, left ventricular mass, and mass-to-volume ratio as a marker for concentricity. All body fat measures were positively associated with right and left ventricular end-diastolic volumes and left ventricular mass, with the strongest associations for lean mass index (all P<0.05). Obese children had a 1.12 standard Deviation Score (95% CI, 0.94–1.30) larger left ventricular mass and a 0.35 standard Deviation Score (95% CI, 0.14–0.57) higher left ventricular mass-to-volume ratio than normal weight children. Conditional on body mass index, higher lean mass index was associated with higher right and left ventricular end-diastolic volume and left ventricular mass, whereas higher fat mass measures were inversely associated with these cardiac measures (all P<0.05). CONCLUSIONS: Higher c

  • fetal and infant growth and asthma symptoms in preschool children the generation r study
    American Journal of Respiratory and Critical Care Medicine, 2012
    Co-Authors: Agnes Sonnenscheinvan Der M M Voort, V W V Jaddoe, Hein Raat, Henriette A Moll, Albert Hofman, Johan C De Jongste, Liesbeth Duijts
    Abstract:

    Rationale: Low birth weight is associated with an increased risk of wheezing in childhood.Objectives: We examined the associations of longitudinally measured fetal and infant growth patterns with the risks of asthma symptoms in preschool children.Methods: This study was embedded in a population-based prospective cohort study among 5,125 children. Second- and third-trimester fetal growth characteristics (head circumference, femur length, abdominal circumference, and weight) were estimated by repeated ultrasounds. Infant growth (head circumference, length, and weight) was measured at birth and at the ages of 3, 6, and 12 months. Parental report of asthma symptoms until the age of 4 years was yearly obtained by questionnaires.Measurements and Main Results: Both fetal restricted and accelerated growth, defined as a negative or positive change of more than 0.67 standard Deviation Score, were not associated with asthma symptoms until the age of 4 years. Accelerated weight gain from birth to 3 months following n...

  • risk factors and outcomes associated with first trimester fetal growth restriction
    JAMA, 2010
    Co-Authors: Dennis O Mookkanamori, Hein Raat, Albert Hofman, Eric A P Steegers, Paul H C Eilers, V W V Jaddoe
    Abstract:

    Context Adverse environmental exposures lead to developmental adaptations in fetal life. The influences of maternal physical characteristics and lifestyle habits on first-trimester fetal adaptations and the postnatal consequences are not known. Objective To determine the risk factors and outcomes associated with first-trimester growth restriction. Design, Setting, and Participants Prospective evaluation of the associations of maternal physical characteristics and lifestyle habits with first-trimester fetal crown to rump length in 1631 mothers with a known and reliable first day of their last menstrual period and a regular menstrual cycle. Subsequently, we assessed the associations of first-trimester fetal growth restriction with the risks of adverse birth outcomes and postnatal growth acceleration until the age of 2 years. The study was based in Rotterdam, the Netherlands. Mothers were enrolled between 2001 and 2005. Main Outcome Measures First-trimester fetal growth was measured as fetal crown to rump length by ultrasound between the gestational age of 10 weeks 0 days and 13 weeks 6 days. Main birth outcomes were preterm birth (gestational age Results In the multivariate analysis, maternal age was positively associated with first-trimester fetal crown to rump length (difference per maternal year of age, 0.79 mm; 95% confidence interval [CI], 0.41 to 1.18 per standard Deviation Score increase). Higher diastolic blood pressure and higher hematocrit levels were associated with a shorter crown to rump length (differences, −0.40 mm; 95% CI, −0.74 to −0.06 and −0.52 mm; 95% CI, −0.90 to −0.14 per standard Deviation increase, respectively). Compared with mothers who were nonsmokers and optimal users of folic acid supplements, those who both smoked and did not use folic acid supplements had shorter fetal crown to rump lengths (difference, −3.84 mm; 95% CI, −5.71 to −1.98). Compared with normal first-trimester fetal growth, first-trimester growth restriction was associated with increased risks of preterm birth (4.0% vs 7.2%; adjusted odds ratio [OR], 2.12; 95% CI, 1.24 to 3.61), low birth weight (3.5% vs 7.5%; adjusted OR, 2.42; 95% CI, 1.41 to 4.16), and small size for gestational age at birth (4.0% vs 10.6%; adjusted OR, 2.64; 95% CI, 1.64 to 4.25). Each standard Deviation decrease in first-trimester fetal crown to rump length was associated with a postnatal growth acceleration until the age of 2 years (standard Deviation Score increase, 0.139 per 2 years; 95% CI, 0.097 to 0.181). Conclusions Maternal physical characteristics and lifestyle habits were independently associated with early fetal growth. First-trimester fetal growth restriction was associated with an increased risk of adverse birth outcomes and growth acceleration in early childhood.

Moshe Phillip - One of the best experts on this subject based on the ideXlab platform.

  • Growth hormone therapy in children with idiopathic short stature – the effect on appetite and appetite-regulating hormones: a pilot study
    2018
    Co-Authors: Michal Yackobovitch-gavan, Moshe Phillip, Galia Gat-yablonski, Biana Shtaif, Shir Hadani, Shiran Abargil, Liora Lazar
    Abstract:

    Aim: To investigate the effect of growth hormone (GH) therapy on appetite-regulating hormones and to examine the association between these hormones and the response to GH, body composition, and resting energy expenditure (REE). Methods: Nine pre-pubertal children with idiopathic short stature underwent a standard meal test before and 4 months following initiation of GH treatment. Ghrelin, GLP-1, leptin, and insulin levels were measured; area under the curve (AUC) was calculated. Height, weight, body composition, REE, and insulin-like growth factor levels were recorded at baseline and after 4 and 12 months. Results: Following 4 months of GH therapy, food intake increased, with increased height-standard Deviation Score (SDS), weight-SDS, and REE (p 

  • premature thelarche age at presentation affects clinical course but not clinical characteristics or risk to progress to precocious puberty
    The Journal of Pediatrics, 2010
    Co-Authors: Liat De Vries, Moshe Phillip, Liora Lazar, Anat Guzmark, Adi Reches
    Abstract:

    Objectives To determine whether age at premature thelarche (PT) onset affects the clinical characteristics, course, and risk of progression to precocious puberty (PP). Study design Data regarding course of growth and puberty were retrieved from the medical files of 139 girls with PT followed up from 1995 to 2005. Analysis was based on age at PT appearance (birth, 1-24 months, and 2-8 years); course was categorized as regressive, persistent, progressive, or cyclic. Results At diagnosis, height standard Deviation Score, bone age-chronological age ratio, and hormonal values were comparable in the 3 age groups. PT regressed in 50.8%, persisted in 36.3%, progressed in 3.2% and had a cyclic course in 9.7%. A progressive or cyclic course was significantly more prevalent among girls presenting after 2 years (52.6%) compared with girls presenting at birth (13.0%) or at 1 to 24 months (3.8%) ( P Conclusions Clinical and anthropometric characteristics at admission and risk of PP were similar in all girls with PT, regardless of age at onset. There are currently no clinical or laboratory tests that can predict the risk of progression to PP at presentation.

  • once versus twice daily injections of growth hormone in children with idiopathic short stature
    Acta Paediatrica, 2007
    Co-Authors: Moshe Phillip, Eli Hershkovitz, O Belotserkovsky, E Leiberman, Y Limoni, Zvi Zadik
    Abstract:

    The aim of this study was to compare the growth response of 22 short pre-pubertal children without growth hormone deficiency, treated with a single daily growth hormone injection (group A), to the growth response of 27 similar children, treated with the same daily dose divided into 2 subcutaneous injections per day (group B), for 1 y, in a randomized study. GH treatment significantly promoted growth parameters, height standard Deviation Score and height velocity standard Deviation Score in both groups. Serum insulin-like growth factor I was also increased. There were no significant differences in growth response, serum IGF-I levels, or the advance in bone age between the two study groups after 1 y of GH therapy. We conclude that twice daily s.c. growth hormone injections provide no advantages over once daily injection of the same dose in promoting the linear growth of short children without growth hormone deficiency.

Hector Jasper - One of the best experts on this subject based on the ideXlab platform.

  • effects of deflazacort immunosuppression on long term growth and growth factors after renal transplantation
    Pediatric Nephrology, 1997
    Co-Authors: Jorge R Ferraris, Patricia Pennisi, Titania Pasqualini, Hector Jasper
    Abstract:

    Deflazacort is an oxazoline compound derived from prednisolone. We studied changes in kidney function, growth velocity, weight/height ratio, insulin-like growth factor (IGF-I), and IGF binding proteins before and after substitution of deflazacort for methylprednisone in 27 transplanted patients aged 3.1 – 20 years. Methylprednisone (mean±SEM 0.17±0.01 mg/kg per day) was replaced by deflazacort (0.29±0.01 mg/kg per day) for a period of 1 – 5 years. Calculated creatinine clearance did not change significantly during deflazacort treatment. Growth velocity increased from 2.6±0.5 cm/year to 5.2±0.7 cm/year (1st year) in 14 prepubertal patients. After 4 years of deflazacort treatment, height standard Deviation Score for chronological age did not change in 7 prepubertal patients. Mean weight/height ratio decreased by 50% (1st year) and remained reduced during follow-up. Serum IGF-I, IGF binding protein -3 (IGFBP3), IGF/IGFBP3 molar ratio, and IGF-I and -II binding capacities showed no significant change; however in 5 of 6 patients IGFBP2 decreased during deflazacort therapy. Our findings suggest that immunosuppressive treatment with deflazacort is as effective as methylprednisone and may lead to an improvement in the growth prognosis of children with renal transplantation.

Toshio Hirohata - One of the best experts on this subject based on the ideXlab platform.

  • urinary growth hormone level and insulin like growth factor 1 standard Deviation Score igf sds can discriminate adult patients with severe growth hormone deficiency
    Endocrine Journal, 2013
    Co-Authors: Toshio Hirohata, Nobuhito Saito, Koji Takano, So Yamada, Jaehyun Son, Shoko M Yamada, Hiroshi Nakaguchi, Katsumi Hoya, Mineko Murakami
    Abstract:

    Adult growth hormone (GH) deficiency (AGHD) in Japan is diagnosed based on peak GH concentrations during GH provocative tests such as GHRP-2 stimulation test. In this study, we aimed to evaluate the ability of serum insulin-like growth factor-1 (sIGF-1) and urinary GH (uGH) at the time of awakening to diagnose AGHD. Fifty-nine patients with pituitary disease (32 men and 27 women; age 20-85 y (57.5 ± 15.5, mean ± SD) underwent GHRP-2 stimulation and sIGF-1 testing. Thirty-six and 23 patients were diagnosed with and without severe AGHD, respectively based on a peak GH response of -1.4. IGF-1 SDS discriminated AGHD more effectively in patients aged ≤60 years. The χ2 test revealed a statistical relationship between uGH and AGHD (test statistic: 7.0104 ≥ χ2 (1; 0.01) = 6.6349). When IGF-1 SDS is < -1.4 or uGH is below the sensitivity limit, AGHD can be detected with high sensitivity.

Liza Toemen - One of the best experts on this subject based on the ideXlab platform.

  • body fat distribution overweight and cardiac structures in school age children a population based cardiac magnetic resonance imaging study
    Journal of the American Heart Association, 2020
    Co-Authors: Liza Toemen, A A Roest, G Jelic, J F Felix, W A Helbing, R Gaillard, Susana Santos, Aad Van Der Lugt, V W V Jaddoe
    Abstract:

    Background Adiposity is associated with larger left ventricular mass in children and adults. The role of body fat distribution in these associations is not clear. We examined the associations of body fat distribution and overweight with cardiac measures obtained by cardiac magnetic resonance imaging in school-age children. Methods and Results In a population-based cohort study including 2836 children, 10 years of age, we used anthropometric measures, dual-energy X-ray absorptiometry, and magnetic resonance imaging to collect information on body mass index, lean mass index, fat mass index, and abdominal visceral adipose tissue index. Indexes were standardized by height. Cardiac measures included right and left ventricular end-diastolic volume, left ventricular mass, and mass-to-volume ratio as a marker for concentricity. All body fat measures were positively associated with right and left ventricular end-diastolic volumes and left ventricular mass, with the strongest associations for lean mass index (all P<0.05). Obese children had a 1.12 standard Deviation Score (95% CI, 0.94-1.30) larger left ventricular mass and a 0.35 standard Deviation Score (95% CI, 0.14-0.57) higher left ventricular mass-to-volume ratio than normal weight children. Conditional on body mass index, higher lean mass index was associated with higher right and left ventricular end-diastolic volume and left ventricular mass, whereas higher fat mass measures were inversely associated with these cardiac measures (all P<0.05). Conclusions Higher childhood body mass index is associated with a larger right and left ventricular size. This association is influenced by higher lean mass. In childhood, lean mass may be a stronger determinant of heart growth than fat mass. Fat mass may influence cardiac structures at older ages.

  • body fat distribution overweight and cardiac structures in school age children a population based cardiac magnetic resonance imaging study
    Stroke, 2020
    Co-Authors: Liza Toemen, S M S Santos, A A Roest, G Jelic, A Van Delugt, J F Felix, W A Helbing, R Gaillard, V W V Jaddoe
    Abstract:

    BACKGROUND: Adiposity is associated with larger left ventricular mass in children and adults. The role of body fat distribution in these associations is not clear. We examined the associations of body fat distribution and overweight with cardiac measures obtained by cardiac magnetic resonance imaging in school-age children. METHODS AND RESULTS: In a population-based cohort study including 2836 children, 10 years of age, we used anthropometric measures, dual-energy X-ray absorptiometry, and magnetic resonance imaging to collect information on body mass index, lean mass index, fat mass index, and abdominal visceral adipose tissue index. Indexes were standardized by height. Cardiac measures included right and left ventricular end-diastolic volume, left ventricular mass, and mass-to-volume ratio as a marker for concentricity. All body fat measures were positively associated with right and left ventricular end-diastolic volumes and left ventricular mass, with the strongest associations for lean mass index (all P<0.05). Obese children had a 1.12 standard Deviation Score (95% CI, 0.94–1.30) larger left ventricular mass and a 0.35 standard Deviation Score (95% CI, 0.14–0.57) higher left ventricular mass-to-volume ratio than normal weight children. Conditional on body mass index, higher lean mass index was associated with higher right and left ventricular end-diastolic volume and left ventricular mass, whereas higher fat mass measures were inversely associated with these cardiac measures (all P<0.05). CONCLUSIONS: Higher c