The Experts below are selected from a list of 119118 Experts worldwide ranked by ideXlab platform

Raymond W J G Ostelo - One of the best experts on this subject based on the ideXlab platform.

  • magnetic resonance imaging for diagnosing lumbar spinal pathology in adult patients with low back pain or sciatica a Diagnostic systematic review
    European Spine Journal, 2012
    Co-Authors: Merel Wassenaar, Rogier M Van Rijn, Maurits W Van Tulder, Arianne P Verhagen, Danielle A W M Van Der Windt, Bart W Koes, Michiel R De Boer, Abida Z Ginai, Raymond W J G Ostelo
    Abstract:

    Purpose In about 5% of all cases LBP is associated with serious underlying pathology requiring Diagnostic confirmation and directed treatment. Magnetic resonance imaging (MRI) is often used for this Diagnostic Purpose yet its role remains controversial. Consequently, this review aimed to summarize the available evidence on the Diagnostic accuracy of MRI for identifying lumbar spinal pathology in adult low back pain (LPB) or sciatica patients.

  • Magnetic resonance imaging for diagnosing lumbar spinal pathology in adult patients with low back pain or sciatica: a Diagnostic systematic review
    European Spine Journal, 2012
    Co-Authors: Merel Wassenaar, Arianne P Verhagen, Bart W Koes, Michiel R De Boer, Abida Z Ginai, Rogier M. Rijn, Maurits W. Tulder, Danielle A. W. M. Windt, Raymond W J G Ostelo
    Abstract:

    Purpose In about 5% of all cases LBP is associated with serious underlying pathology requiring Diagnostic confirmation and directed treatment. Magnetic resonance imaging (MRI) is often used for this Diagnostic Purpose yet its role remains controversial. Consequently, this review aimed to summarize the available evidence on the Diagnostic accuracy of MRI for identifying lumbar spinal pathology in adult low back pain (LPB) or sciatica patients. Methods MEDLINE, EMBASE and CINAHL were searched (until December 2009) for observational studies assessing the Diagnostic accuracy of MRI compared to a reference test for the identification of lumbar spinal pathology. Two reviewers independently selected studies for inclusion, extracted data and assessed methodological quality. Pooled summary estimates of sensitivity and specificity with 95% confidence intervals were calculated for homogenous subsets of studies. Results Eight studies were included in this review. Strata were defined for separate pathologies i.e. lumbar disc herniation (HNP) and spinal stenosis. Five studies comparing MRI to findings at the surgery for identifying HNP were included in a meta-analysis. Pooled analysis resulted in a summary estimate of sensitivity of 75% (95% CI 65–83%) and specificity of 77% (95% CI 61–88%). For spinal stenosis pooling was not possible. Conclusions The results suggest that a considerable proportion of patients may be classified incorrectly by MRI for HNP and spinal stenosis. However, the evidence for the Diagnostic accuracy of MRI found by this review is not conclusive, since the results could be distorted due to the limited number of studies and large heterogeneity.

Gabrio Bassotti - One of the best experts on this subject based on the ideXlab platform.

  • Mucosal tissue transglutaminase expression in celiac disease.
    Journal of Cellular and Molecular Medicine, 2008
    Co-Authors: Vincenzo Villanacci, Tiziano Gaiotto, Anna Galletti, Daniele Sblattero, Fernando Gabriel Chirdo, Gabrio Bassotti
    Abstract:

    Tissue transglutaminase (tTG) plays an important role in celiac disease pathogenesis and antibodies to tTG are a Diagnostic marker of gluten-sensitive enteropathy. The aim of this study was to investigate the localization of tTG in the duodenal mucosa in control tissues and in different histological stages of celiac disease by using a commercial and a novel set of anti-tTG monoclonal antibodies, to see whether this assessment can be useful for Diagnostic Purpose. The distribution of tTG was firstly evaluated in 18 untreated celiac patients by using a commercial monoclonal antibody (CUB7402) against tissue transglutaminase enzyme and directed against the loop-core region of the enzyme. Thereafter, in further 30 untreated celiac patients we employed three newly characterized anti-tTG monoclonal antibodies produced against recombinant human-tTG. The epitopes recognized are located in three distinct domains of the protein corresponding to the core, C1 and C2 protein structure. Eleven age- and sex-matched patients with chronic duodenitis acted as controls. All subjects underwent upper endoscopy to obtain biopsy samples from the duodenum. Overall, we found that (i) tTG is equally expressed in CD at different stages of disease; (ii) tTG is expressed, at similar level, in CD and controls with duodenitis. Assessment of tTG level in biopsy samples by immunohistochemical methods is not useful in the clinical Diagnostic work-up of CD.

Merel Wassenaar - One of the best experts on this subject based on the ideXlab platform.

  • magnetic resonance imaging for diagnosing lumbar spinal pathology in adult patients with low back pain or sciatica a Diagnostic systematic review
    European Spine Journal, 2012
    Co-Authors: Merel Wassenaar, Rogier M Van Rijn, Maurits W Van Tulder, Arianne P Verhagen, Danielle A W M Van Der Windt, Bart W Koes, Michiel R De Boer, Abida Z Ginai, Raymond W J G Ostelo
    Abstract:

    Purpose In about 5% of all cases LBP is associated with serious underlying pathology requiring Diagnostic confirmation and directed treatment. Magnetic resonance imaging (MRI) is often used for this Diagnostic Purpose yet its role remains controversial. Consequently, this review aimed to summarize the available evidence on the Diagnostic accuracy of MRI for identifying lumbar spinal pathology in adult low back pain (LPB) or sciatica patients.

  • Magnetic resonance imaging for diagnosing lumbar spinal pathology in adult patients with low back pain or sciatica: a Diagnostic systematic review
    European Spine Journal, 2012
    Co-Authors: Merel Wassenaar, Arianne P Verhagen, Bart W Koes, Michiel R De Boer, Abida Z Ginai, Rogier M. Rijn, Maurits W. Tulder, Danielle A. W. M. Windt, Raymond W J G Ostelo
    Abstract:

    Purpose In about 5% of all cases LBP is associated with serious underlying pathology requiring Diagnostic confirmation and directed treatment. Magnetic resonance imaging (MRI) is often used for this Diagnostic Purpose yet its role remains controversial. Consequently, this review aimed to summarize the available evidence on the Diagnostic accuracy of MRI for identifying lumbar spinal pathology in adult low back pain (LPB) or sciatica patients. Methods MEDLINE, EMBASE and CINAHL were searched (until December 2009) for observational studies assessing the Diagnostic accuracy of MRI compared to a reference test for the identification of lumbar spinal pathology. Two reviewers independently selected studies for inclusion, extracted data and assessed methodological quality. Pooled summary estimates of sensitivity and specificity with 95% confidence intervals were calculated for homogenous subsets of studies. Results Eight studies were included in this review. Strata were defined for separate pathologies i.e. lumbar disc herniation (HNP) and spinal stenosis. Five studies comparing MRI to findings at the surgery for identifying HNP were included in a meta-analysis. Pooled analysis resulted in a summary estimate of sensitivity of 75% (95% CI 65–83%) and specificity of 77% (95% CI 61–88%). For spinal stenosis pooling was not possible. Conclusions The results suggest that a considerable proportion of patients may be classified incorrectly by MRI for HNP and spinal stenosis. However, the evidence for the Diagnostic accuracy of MRI found by this review is not conclusive, since the results could be distorted due to the limited number of studies and large heterogeneity.

Vincenzo Villanacci - One of the best experts on this subject based on the ideXlab platform.

  • Mucosal tissue transglutaminase expression in celiac disease.
    Journal of Cellular and Molecular Medicine, 2008
    Co-Authors: Vincenzo Villanacci, Tiziano Gaiotto, Anna Galletti, Daniele Sblattero, Fernando Gabriel Chirdo, Gabrio Bassotti
    Abstract:

    Tissue transglutaminase (tTG) plays an important role in celiac disease pathogenesis and antibodies to tTG are a Diagnostic marker of gluten-sensitive enteropathy. The aim of this study was to investigate the localization of tTG in the duodenal mucosa in control tissues and in different histological stages of celiac disease by using a commercial and a novel set of anti-tTG monoclonal antibodies, to see whether this assessment can be useful for Diagnostic Purpose. The distribution of tTG was firstly evaluated in 18 untreated celiac patients by using a commercial monoclonal antibody (CUB7402) against tissue transglutaminase enzyme and directed against the loop-core region of the enzyme. Thereafter, in further 30 untreated celiac patients we employed three newly characterized anti-tTG monoclonal antibodies produced against recombinant human-tTG. The epitopes recognized are located in three distinct domains of the protein corresponding to the core, C1 and C2 protein structure. Eleven age- and sex-matched patients with chronic duodenitis acted as controls. All subjects underwent upper endoscopy to obtain biopsy samples from the duodenum. Overall, we found that (i) tTG is equally expressed in CD at different stages of disease; (ii) tTG is expressed, at similar level, in CD and controls with duodenitis. Assessment of tTG level in biopsy samples by immunohistochemical methods is not useful in the clinical Diagnostic work-up of CD.

Abida Z Ginai - One of the best experts on this subject based on the ideXlab platform.

  • magnetic resonance imaging for diagnosing lumbar spinal pathology in adult patients with low back pain or sciatica a Diagnostic systematic review
    European Spine Journal, 2012
    Co-Authors: Merel Wassenaar, Rogier M Van Rijn, Maurits W Van Tulder, Arianne P Verhagen, Danielle A W M Van Der Windt, Bart W Koes, Michiel R De Boer, Abida Z Ginai, Raymond W J G Ostelo
    Abstract:

    Purpose In about 5% of all cases LBP is associated with serious underlying pathology requiring Diagnostic confirmation and directed treatment. Magnetic resonance imaging (MRI) is often used for this Diagnostic Purpose yet its role remains controversial. Consequently, this review aimed to summarize the available evidence on the Diagnostic accuracy of MRI for identifying lumbar spinal pathology in adult low back pain (LPB) or sciatica patients.

  • Magnetic resonance imaging for diagnosing lumbar spinal pathology in adult patients with low back pain or sciatica: a Diagnostic systematic review
    European Spine Journal, 2012
    Co-Authors: Merel Wassenaar, Arianne P Verhagen, Bart W Koes, Michiel R De Boer, Abida Z Ginai, Rogier M. Rijn, Maurits W. Tulder, Danielle A. W. M. Windt, Raymond W J G Ostelo
    Abstract:

    Purpose In about 5% of all cases LBP is associated with serious underlying pathology requiring Diagnostic confirmation and directed treatment. Magnetic resonance imaging (MRI) is often used for this Diagnostic Purpose yet its role remains controversial. Consequently, this review aimed to summarize the available evidence on the Diagnostic accuracy of MRI for identifying lumbar spinal pathology in adult low back pain (LPB) or sciatica patients. Methods MEDLINE, EMBASE and CINAHL were searched (until December 2009) for observational studies assessing the Diagnostic accuracy of MRI compared to a reference test for the identification of lumbar spinal pathology. Two reviewers independently selected studies for inclusion, extracted data and assessed methodological quality. Pooled summary estimates of sensitivity and specificity with 95% confidence intervals were calculated for homogenous subsets of studies. Results Eight studies were included in this review. Strata were defined for separate pathologies i.e. lumbar disc herniation (HNP) and spinal stenosis. Five studies comparing MRI to findings at the surgery for identifying HNP were included in a meta-analysis. Pooled analysis resulted in a summary estimate of sensitivity of 75% (95% CI 65–83%) and specificity of 77% (95% CI 61–88%). For spinal stenosis pooling was not possible. Conclusions The results suggest that a considerable proportion of patients may be classified incorrectly by MRI for HNP and spinal stenosis. However, the evidence for the Diagnostic accuracy of MRI found by this review is not conclusive, since the results could be distorted due to the limited number of studies and large heterogeneity.