The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Harinantenaina L Rakotondraibe - One of the best experts on this subject based on the ideXlab platform.
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semi synthetic cinnamodial analogues structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito aedes aegypti
PLOS Neglected Tropical Diseases, 2020Co-Authors: Preston K Manwill, Megha Kalsi, Erick Martinez J Rodriguez, Xiaolin Cheng, Peter M Piermarini, Harinantenaina L RakotondraibeAbstract:The Aedes aegypti mosquito serves as a major vector for viral diseases, such as dengue, chikungunya, and Zika, which are spreading across the globe and threatening public health. In addition to increased vector transmission, the prevalence of insecticide-resistant mosquitoes is also on the rise, thus solidifying the need for new, safe and effective insecticides to control mosquito populations. We recently discovered that cinnamodial, a unique drimane sesquiterpene Dialdehyde of the Malagasy medicinal plant Cinnamosma fragrans, exhibited significant larval and adult toxicity to Ae. aegypti and was more efficacious than DEET–the gold standard for insect repellents–at repelling adult female Ae. aegypti from blood feeding. In this study several semi-synthetic analogues of cinnamodial were prepared to probe the structure-activity relationship (SAR) for larvicidal, adulticidal and antifeedant activity against Ae. aegypti. Initial efforts were focused on modification of the Dialdehyde functionality to produce more stable active analogues and to understand the importance of the 1,4-Dialdehyde and the α,s-unsaturated carbonyl in the observed bioactivity of cinnamodial against mosquitoes. This study represents the first investigation into the SAR of cinnamodial as an insecticide and antifeedant against the medically important Ae. aegypti mosquito.
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semi synthetic cinnamodial analogues structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito aedes aegypti
bioRxiv, 2019Co-Authors: Preston K Manwill, Megha Kalsi, Xiaolin Cheng, Peter M Piermarini, Harinantenaina L RakotondraibeAbstract:The Aedes aegypti mosquito serves as a major vector for viral diseases, such as dengue, chikungunya, and Zika, which are spreading across the globe and threatening public health. In addition to increased vector transmission, the prevalence of insecticide-resistant mosquitoes is also on the rise, thus solidifying the need for new, safe and effective insecticides to control mosquito populations. We recently discovered that cinnamodial, a unique drimane sesquiterpene Dialdehyde of the Malagasy medicinal plant Cinnamosma fragrans, exhibited significant larval and adult toxicity to Ae. aegypti and was more efficacious than DEET-the gold standard for insect repellents - at repelling adult female Ae. aegypti from blood feeding. In this study several semisynthetic analogues of cinnamodial were prepared to probe the structure-activity relationship (SAR) for larvicidal, adulticidal and antifeedant activity against Ae. aegypti. Initial efforts were focused on modification of the Dialdehyde functionality to produce more stable active analogues and to understand the importance of the 1,4-Dialdehyde and the alpha,beta-unsaturated carbonyl in the observed bioactivity of cinnamodial against mosquitoes. This study represents the first investigation into the SAR of cinnamodial as an insecticide and repellent against the medically important Ae. aegypti mosquito.
Preston K Manwill - One of the best experts on this subject based on the ideXlab platform.
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semi synthetic cinnamodial analogues structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito aedes aegypti
PLOS Neglected Tropical Diseases, 2020Co-Authors: Preston K Manwill, Megha Kalsi, Erick Martinez J Rodriguez, Xiaolin Cheng, Peter M Piermarini, Harinantenaina L RakotondraibeAbstract:The Aedes aegypti mosquito serves as a major vector for viral diseases, such as dengue, chikungunya, and Zika, which are spreading across the globe and threatening public health. In addition to increased vector transmission, the prevalence of insecticide-resistant mosquitoes is also on the rise, thus solidifying the need for new, safe and effective insecticides to control mosquito populations. We recently discovered that cinnamodial, a unique drimane sesquiterpene Dialdehyde of the Malagasy medicinal plant Cinnamosma fragrans, exhibited significant larval and adult toxicity to Ae. aegypti and was more efficacious than DEET–the gold standard for insect repellents–at repelling adult female Ae. aegypti from blood feeding. In this study several semi-synthetic analogues of cinnamodial were prepared to probe the structure-activity relationship (SAR) for larvicidal, adulticidal and antifeedant activity against Ae. aegypti. Initial efforts were focused on modification of the Dialdehyde functionality to produce more stable active analogues and to understand the importance of the 1,4-Dialdehyde and the α,s-unsaturated carbonyl in the observed bioactivity of cinnamodial against mosquitoes. This study represents the first investigation into the SAR of cinnamodial as an insecticide and antifeedant against the medically important Ae. aegypti mosquito.
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semi synthetic cinnamodial analogues structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito aedes aegypti
bioRxiv, 2019Co-Authors: Preston K Manwill, Megha Kalsi, Xiaolin Cheng, Peter M Piermarini, Harinantenaina L RakotondraibeAbstract:The Aedes aegypti mosquito serves as a major vector for viral diseases, such as dengue, chikungunya, and Zika, which are spreading across the globe and threatening public health. In addition to increased vector transmission, the prevalence of insecticide-resistant mosquitoes is also on the rise, thus solidifying the need for new, safe and effective insecticides to control mosquito populations. We recently discovered that cinnamodial, a unique drimane sesquiterpene Dialdehyde of the Malagasy medicinal plant Cinnamosma fragrans, exhibited significant larval and adult toxicity to Ae. aegypti and was more efficacious than DEET-the gold standard for insect repellents - at repelling adult female Ae. aegypti from blood feeding. In this study several semisynthetic analogues of cinnamodial were prepared to probe the structure-activity relationship (SAR) for larvicidal, adulticidal and antifeedant activity against Ae. aegypti. Initial efforts were focused on modification of the Dialdehyde functionality to produce more stable active analogues and to understand the importance of the 1,4-Dialdehyde and the alpha,beta-unsaturated carbonyl in the observed bioactivity of cinnamodial against mosquitoes. This study represents the first investigation into the SAR of cinnamodial as an insecticide and repellent against the medically important Ae. aegypti mosquito.
Kálmán J. Szabó - One of the best experts on this subject based on the ideXlab platform.
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stereoselective synthesis of 1 4 diols by a tandem allylboration allenylboration sequence
Organic Letters, 2015Co-Authors: Tony S. N. Zhao, Jian Zhao, Kálmán J. SzabóAbstract:The reaction of mono- and Dialdehydes with bis-borodienes (incorporating an allylboronate unit) has been studied. It was found that the initial allylboration reaction results in an allenylboronate, which has two stereogenic units: one of them has axial chirality and the other one is a stereogenic carbon center. This reaction proceeds with high diastereoselectivity. The allenylboronate formed in the allylboration reacts with an additional aldehyde with fair to high stereoselectivity depending on the aldehyde substrate. Aromatic Dialdehydes react with bis-boro-butadienes creating three new stereocenters with usually high diastereoselectivity.
Xiaolin Cheng - One of the best experts on this subject based on the ideXlab platform.
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semi synthetic cinnamodial analogues structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito aedes aegypti
PLOS Neglected Tropical Diseases, 2020Co-Authors: Preston K Manwill, Megha Kalsi, Erick Martinez J Rodriguez, Xiaolin Cheng, Peter M Piermarini, Harinantenaina L RakotondraibeAbstract:The Aedes aegypti mosquito serves as a major vector for viral diseases, such as dengue, chikungunya, and Zika, which are spreading across the globe and threatening public health. In addition to increased vector transmission, the prevalence of insecticide-resistant mosquitoes is also on the rise, thus solidifying the need for new, safe and effective insecticides to control mosquito populations. We recently discovered that cinnamodial, a unique drimane sesquiterpene Dialdehyde of the Malagasy medicinal plant Cinnamosma fragrans, exhibited significant larval and adult toxicity to Ae. aegypti and was more efficacious than DEET–the gold standard for insect repellents–at repelling adult female Ae. aegypti from blood feeding. In this study several semi-synthetic analogues of cinnamodial were prepared to probe the structure-activity relationship (SAR) for larvicidal, adulticidal and antifeedant activity against Ae. aegypti. Initial efforts were focused on modification of the Dialdehyde functionality to produce more stable active analogues and to understand the importance of the 1,4-Dialdehyde and the α,s-unsaturated carbonyl in the observed bioactivity of cinnamodial against mosquitoes. This study represents the first investigation into the SAR of cinnamodial as an insecticide and antifeedant against the medically important Ae. aegypti mosquito.
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semi synthetic cinnamodial analogues structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito aedes aegypti
bioRxiv, 2019Co-Authors: Preston K Manwill, Megha Kalsi, Xiaolin Cheng, Peter M Piermarini, Harinantenaina L RakotondraibeAbstract:The Aedes aegypti mosquito serves as a major vector for viral diseases, such as dengue, chikungunya, and Zika, which are spreading across the globe and threatening public health. In addition to increased vector transmission, the prevalence of insecticide-resistant mosquitoes is also on the rise, thus solidifying the need for new, safe and effective insecticides to control mosquito populations. We recently discovered that cinnamodial, a unique drimane sesquiterpene Dialdehyde of the Malagasy medicinal plant Cinnamosma fragrans, exhibited significant larval and adult toxicity to Ae. aegypti and was more efficacious than DEET-the gold standard for insect repellents - at repelling adult female Ae. aegypti from blood feeding. In this study several semisynthetic analogues of cinnamodial were prepared to probe the structure-activity relationship (SAR) for larvicidal, adulticidal and antifeedant activity against Ae. aegypti. Initial efforts were focused on modification of the Dialdehyde functionality to produce more stable active analogues and to understand the importance of the 1,4-Dialdehyde and the alpha,beta-unsaturated carbonyl in the observed bioactivity of cinnamodial against mosquitoes. This study represents the first investigation into the SAR of cinnamodial as an insecticide and repellent against the medically important Ae. aegypti mosquito.
Megha Kalsi - One of the best experts on this subject based on the ideXlab platform.
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semi synthetic cinnamodial analogues structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito aedes aegypti
PLOS Neglected Tropical Diseases, 2020Co-Authors: Preston K Manwill, Megha Kalsi, Erick Martinez J Rodriguez, Xiaolin Cheng, Peter M Piermarini, Harinantenaina L RakotondraibeAbstract:The Aedes aegypti mosquito serves as a major vector for viral diseases, such as dengue, chikungunya, and Zika, which are spreading across the globe and threatening public health. In addition to increased vector transmission, the prevalence of insecticide-resistant mosquitoes is also on the rise, thus solidifying the need for new, safe and effective insecticides to control mosquito populations. We recently discovered that cinnamodial, a unique drimane sesquiterpene Dialdehyde of the Malagasy medicinal plant Cinnamosma fragrans, exhibited significant larval and adult toxicity to Ae. aegypti and was more efficacious than DEET–the gold standard for insect repellents–at repelling adult female Ae. aegypti from blood feeding. In this study several semi-synthetic analogues of cinnamodial were prepared to probe the structure-activity relationship (SAR) for larvicidal, adulticidal and antifeedant activity against Ae. aegypti. Initial efforts were focused on modification of the Dialdehyde functionality to produce more stable active analogues and to understand the importance of the 1,4-Dialdehyde and the α,s-unsaturated carbonyl in the observed bioactivity of cinnamodial against mosquitoes. This study represents the first investigation into the SAR of cinnamodial as an insecticide and antifeedant against the medically important Ae. aegypti mosquito.
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semi synthetic cinnamodial analogues structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito aedes aegypti
bioRxiv, 2019Co-Authors: Preston K Manwill, Megha Kalsi, Xiaolin Cheng, Peter M Piermarini, Harinantenaina L RakotondraibeAbstract:The Aedes aegypti mosquito serves as a major vector for viral diseases, such as dengue, chikungunya, and Zika, which are spreading across the globe and threatening public health. In addition to increased vector transmission, the prevalence of insecticide-resistant mosquitoes is also on the rise, thus solidifying the need for new, safe and effective insecticides to control mosquito populations. We recently discovered that cinnamodial, a unique drimane sesquiterpene Dialdehyde of the Malagasy medicinal plant Cinnamosma fragrans, exhibited significant larval and adult toxicity to Ae. aegypti and was more efficacious than DEET-the gold standard for insect repellents - at repelling adult female Ae. aegypti from blood feeding. In this study several semisynthetic analogues of cinnamodial were prepared to probe the structure-activity relationship (SAR) for larvicidal, adulticidal and antifeedant activity against Ae. aegypti. Initial efforts were focused on modification of the Dialdehyde functionality to produce more stable active analogues and to understand the importance of the 1,4-Dialdehyde and the alpha,beta-unsaturated carbonyl in the observed bioactivity of cinnamodial against mosquitoes. This study represents the first investigation into the SAR of cinnamodial as an insecticide and repellent against the medically important Ae. aegypti mosquito.