The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Thomas Lecourt - One of the best experts on this subject based on the ideXlab platform.
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straightforward entry toward highly substituted 2 3 dihydrobenz b oxepines by ring expansion of benzopyryliums with donor acceptor Diazo Compounds
Organic Letters, 2018Co-Authors: Thibaut Courant, Morgane Pasco, Thomas LecourtAbstract:Ylide-type reactivity of Diazo Compounds is exploited in a new way to prepare benzo[b]oxepines thanks to the formation of three chemical bonds and two contiguous and highly substituted stereocenters in a single pot. This cationic reaction cascade first involves addition of a donor–acceptor-substituted Diazo Compound to a benzopyrylium. Selective 1,2 migration of the endocyclic C–C bond then results in a ring-expansion and generates a second oxocarbenium that is trapped by a nucleophile added sequentially.
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Straightforward Entry toward Highly Substituted 2,3-Dihydrobenz[b]oxepines by Ring Expansion of Benzopyryliums with Donor–Acceptor Diazo Compounds
Organic Letters, 2018Co-Authors: Thibaut Courant, Morgane Pasco, Thomas LecourtAbstract:Ylide-type reactivity of Diazo Compounds is exploited in a new way to prepare benzo[b]oxepines thanks to the formation of three chemical bonds and two contiguous and highly substituted stereocenters in a single pot. This cationic reaction cascade first involves addition of a donor–acceptor-substituted Diazo Compound to a benzopyrylium. Selective 1,2 migration of the endocyclic C–C bond then results in a ring-expansion and generates a second oxocarbenium that is trapped by a nucleophile added sequentially.
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Straightforward Entry toward Highly Substituted 2,3-Dihydrobenz[b]oxepines by Ring Expansion of Benzopyryliums with Donor–Acceptor Diazo Compounds
2018Co-Authors: Thibaut Courant, Morgane Pasco, Thomas LecourtAbstract:Ylide-type reactivity of Diazo Compounds is exploited in a new way to prepare benzo[b]oxepines thanks to the formation of three chemical bonds and two contiguous and highly substituted stereocenters in a single pot. This cationic reaction cascade first involves addition of a donor–acceptor-substituted Diazo Compound to a benzopyrylium. Selective 1,2 migration of the endocyclic C–C bond then results in a ring-expansion and generates a second oxocarbenium that is trapped by a nucleophile added sequentially
Hong Liu - One of the best experts on this subject based on the ideXlab platform.
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Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzo[ de]chromenes.
Organic letters, 2018Co-Authors: Feifei Fang, Chunmei Zhang, Chaofan Zhou, Yu Zhou, Hong LiuAbstract:Rh (III)-catalyzed C-H activation of benzoylacetonitriles in coupling with Diazo Compounds was developed to synthesize diversified substituted benzo[ de]chromenes via a formal (4 + 2) cycloaddition with a Diazo Compound and subsequent tandem (4 + 2) cycloaddition with another Diazo Compound. Intriguingly, synthesis of substituted benzo[ de]chromenes and their decarboxylation products could be realized by controlling the reaction conditions. These reactions have a broad range of substrates, moderate to good yields, and high regioselectivity.
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Rh(III)-Catalyzed C–H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzo[de]chromenes
2018Co-Authors: Feifei Fang, Chunmei Zhang, Chaofan Zhou, Yu Zhou, Hong LiuAbstract:Rh (III)-catalyzed C–H activation of benzoylacetonitriles in coupling with Diazo Compounds was developed to synthesize diversified substituted benzo[de]chromenes via a formal (4 + 2) cycloaddition with a Diazo Compound and subsequent tandem (4 + 2) cycloaddition with another Diazo Compound. Intriguingly, synthesis of substituted benzo[de]chromenes and their decarboxylation products could be realized by controlling the reaction conditions. These reactions have a broad range of substrates, moderate to good yields, and high regioselectivity
Thibaut Courant - One of the best experts on this subject based on the ideXlab platform.
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straightforward entry toward highly substituted 2 3 dihydrobenz b oxepines by ring expansion of benzopyryliums with donor acceptor Diazo Compounds
Organic Letters, 2018Co-Authors: Thibaut Courant, Morgane Pasco, Thomas LecourtAbstract:Ylide-type reactivity of Diazo Compounds is exploited in a new way to prepare benzo[b]oxepines thanks to the formation of three chemical bonds and two contiguous and highly substituted stereocenters in a single pot. This cationic reaction cascade first involves addition of a donor–acceptor-substituted Diazo Compound to a benzopyrylium. Selective 1,2 migration of the endocyclic C–C bond then results in a ring-expansion and generates a second oxocarbenium that is trapped by a nucleophile added sequentially.
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Straightforward Entry toward Highly Substituted 2,3-Dihydrobenz[b]oxepines by Ring Expansion of Benzopyryliums with Donor–Acceptor Diazo Compounds
Organic Letters, 2018Co-Authors: Thibaut Courant, Morgane Pasco, Thomas LecourtAbstract:Ylide-type reactivity of Diazo Compounds is exploited in a new way to prepare benzo[b]oxepines thanks to the formation of three chemical bonds and two contiguous and highly substituted stereocenters in a single pot. This cationic reaction cascade first involves addition of a donor–acceptor-substituted Diazo Compound to a benzopyrylium. Selective 1,2 migration of the endocyclic C–C bond then results in a ring-expansion and generates a second oxocarbenium that is trapped by a nucleophile added sequentially.
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Straightforward Entry toward Highly Substituted 2,3-Dihydrobenz[b]oxepines by Ring Expansion of Benzopyryliums with Donor–Acceptor Diazo Compounds
2018Co-Authors: Thibaut Courant, Morgane Pasco, Thomas LecourtAbstract:Ylide-type reactivity of Diazo Compounds is exploited in a new way to prepare benzo[b]oxepines thanks to the formation of three chemical bonds and two contiguous and highly substituted stereocenters in a single pot. This cationic reaction cascade first involves addition of a donor–acceptor-substituted Diazo Compound to a benzopyrylium. Selective 1,2 migration of the endocyclic C–C bond then results in a ring-expansion and generates a second oxocarbenium that is trapped by a nucleophile added sequentially
Jianbo Wang - One of the best experts on this subject based on the ideXlab platform.
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When Diazo Compounds meet with organoboron Compounds
Pure and Applied Chemistry, 2017Co-Authors: Jianbo WangAbstract:Abstract Transition-metal free reactions of Diazo Compounds with organoboron Compounds provide some unique approaches for the formation of C–C, C–B and C–Si bonds. With N-tosylhydrazones as the precursors for non-stabilized Diazo Compound, this type of reaction becomes practically useful in organic synthesis. Transition-metal-free synthetic methodologies for borylation, gem-diborylation, gem-silylborylation arylation, 2,2,2-trifluoroethylation and gem-difluorovinylation have been successfully developed.
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Reaction of Diazo Compounds with Organoboron Compounds
Synthesis, 2013Co-Authors: Yan Zhang, Jianbo WangAbstract:The transition-metal-free reactions of Diazo Compounds with organoboron Compounds are reviewed. This type of reaction provides an alternative approach for the formation of C–C, C–B, and C–Si bonds. Moreover, by using tosylhydrazones as Diazo Compound precursors and boronic acids/esters as the boron substrates, this type of reaction becomes of practical use in organic synthesis. This short review covers the recent developments of this area with an introduction to the historical background. 1 Introduction 2 Reaction of Diazo Compounds with Organoboranes 3 Reactions of Diazo Compounds with Boronic Acids and Related Organoborons 4 Reaction of Diazo Compounds with Boronic Esters 5 Concluding Remarks
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Nucleophilic Addition to C=O and C=N Bonds by Nucleophiles Containing a Diazo Group
Synlett, 2005Co-Authors: Yonghua Zhao, Jianbo WangAbstract:This account summarizes recent developments in the nucleophilic addition reaction of Diazo Compound derived anion or enolate with electrophilic C=O and C=N bonds. Subsequent reaction of the addition products under transition-metal-catalyzed conditions, as well as their synthetic utility, are also presented.
Feifei Fang - One of the best experts on this subject based on the ideXlab platform.
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Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzo[ de]chromenes.
Organic letters, 2018Co-Authors: Feifei Fang, Chunmei Zhang, Chaofan Zhou, Yu Zhou, Hong LiuAbstract:Rh (III)-catalyzed C-H activation of benzoylacetonitriles in coupling with Diazo Compounds was developed to synthesize diversified substituted benzo[ de]chromenes via a formal (4 + 2) cycloaddition with a Diazo Compound and subsequent tandem (4 + 2) cycloaddition with another Diazo Compound. Intriguingly, synthesis of substituted benzo[ de]chromenes and their decarboxylation products could be realized by controlling the reaction conditions. These reactions have a broad range of substrates, moderate to good yields, and high regioselectivity.
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Rh(III)-Catalyzed C–H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzo[de]chromenes
2018Co-Authors: Feifei Fang, Chunmei Zhang, Chaofan Zhou, Yu Zhou, Hong LiuAbstract:Rh (III)-catalyzed C–H activation of benzoylacetonitriles in coupling with Diazo Compounds was developed to synthesize diversified substituted benzo[de]chromenes via a formal (4 + 2) cycloaddition with a Diazo Compound and subsequent tandem (4 + 2) cycloaddition with another Diazo Compound. Intriguingly, synthesis of substituted benzo[de]chromenes and their decarboxylation products could be realized by controlling the reaction conditions. These reactions have a broad range of substrates, moderate to good yields, and high regioselectivity