The Experts below are selected from a list of 2277 Experts worldwide ranked by ideXlab platform
Paul Knochel - One of the best experts on this subject based on the ideXlab platform.
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stereoselective migration of sterically hindered Organoboranes in cyclic and acyclic systems a stereoselective allylic c h activation reaction
Tetrahedron, 2003Co-Authors: Eike Hupe, Dmitri Denisenko, Paul KnochelAbstract:The thermal migration of cyclic and acyclic Organoboranes were studied. In most cases, a stereoselective 1,2-dyotropic migration was observed, allowing the stereocontrol of three contiguous chiral centers. Scope and limitations of this thermal migration are presented.
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Stereoselective migration of sterically hindered Organoboranes in cyclic and acyclic systems. A stereoselective allylic C–H activation reaction
Tetrahedron, 2003Co-Authors: Eike Hupe, Dmitri Denisenko, Paul KnochelAbstract:The thermal migration of cyclic and acyclic Organoboranes were studied. In most cases, a stereoselective 1,2-dyotropic migration was observed, allowing the stereocontrol of three contiguous chiral centers. Scope and limitations of this thermal migration are presented.
Eike Hupe - One of the best experts on this subject based on the ideXlab platform.
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stereoselective migration of sterically hindered Organoboranes in cyclic and acyclic systems a stereoselective allylic c h activation reaction
Tetrahedron, 2003Co-Authors: Eike Hupe, Dmitri Denisenko, Paul KnochelAbstract:The thermal migration of cyclic and acyclic Organoboranes were studied. In most cases, a stereoselective 1,2-dyotropic migration was observed, allowing the stereocontrol of three contiguous chiral centers. Scope and limitations of this thermal migration are presented.
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Stereoselective migration of sterically hindered Organoboranes in cyclic and acyclic systems. A stereoselective allylic C–H activation reaction
Tetrahedron, 2003Co-Authors: Eike Hupe, Dmitri Denisenko, Paul KnochelAbstract:The thermal migration of cyclic and acyclic Organoboranes were studied. In most cases, a stereoselective 1,2-dyotropic migration was observed, allowing the stereocontrol of three contiguous chiral centers. Scope and limitations of this thermal migration are presented.
Jean-luc Boucher - One of the best experts on this subject based on the ideXlab platform.
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Aminoboronic acids and esters: from synthetic challenges to the discovery of unique classes of enzyme inhibitors.
Chemical Society Reviews, 2011Co-Authors: Sabrina Touchet, François Carreaux, Bertrand Carboni, Alexandre Bouillon, Jean-luc BoucherAbstract:Although boronic acids have attracted considerable interest as versatile intermediates in organic synthesis, their contributions in chemical biology and drug discovery programs have long been underestimated. This situation is changing since the beginning of the 2000s, mainly due to significant advances in modern organoborane chemistry and the recent FDA approval of Velcade®, a boropeptide used for multiple myeloma treatment. There is now a significant renewed interest in the design and synthesis of new boron-containing compounds. Due to their close analogy to their carbon counterparts, aminoboronic acids, alone or incorporated at the C-terminal position of a peptide, represent one of the major classes of Organoboranes evaluated as potential drug candidates. This critical review aims to provide an overview of the current state of the art in their synthesis and their most relevant biological properties (156 references).
James R. Mccarthy - One of the best experts on this subject based on the ideXlab platform.
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New methods for the synthesis of fluoroolefins via the palladium catalyzed cross-coupling reaction of 1-fluorovinyl halides with Organoboranes and organostannanes
Journal of Fluorine Chemistry, 2000Co-Authors: Chen Chen, Keith Wilcoxen, Nathalie Strack, Charles Q. Huang, James R. MccarthyAbstract:Abstract The palladium catalyzed cross-coupling reaction of 1-fluorovinyl halides with Organoboranes and organostannanes provide two new facile methods to 1-substituted 1-fluoroolefins. The reactions proceed with retention of configuration in good to excellent yields.
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SYNTHESIS OF FLUORINATED OLEFINS VIA THE PALLADIUM CATALYZED CROSS-COUPLING REACTION OF 1-FLUOROVINYL HALIDES WITH Organoboranes
Tetrahedron Letters, 1999Co-Authors: Chen Chen, Keith Wilcoxen, Nathalie Strack, James R. MccarthyAbstract:Abstract The palladium catalyzed cross-coupling reaction of 1-fluorovinyl halides 1–4 with Organoboranes proceeds under Suzuki conditions with retention on configuration to give 1-substituted 1-fluoroolefins 6–8 in good to excellent yields.
George W. Kabalka - One of the best experts on this subject based on the ideXlab platform.
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Sodium perborate: A mild and convenient reagent for efficiently oxidizing trialkylboranes
Tetrahedron Letters, 2001Co-Authors: George W. Kabalka, Timothy M. Shoup, Naganna M. GoudgaonAbstract:Abstract Sodium perborate, a readily available and inexpensive reagent, efficiently oxidizes Organoboranes. The reagent permits the oxidation of a wide variety of functionally substituted Organoboranes. In nearly every instance, the product yields exceed those obtained using standard oxidation procedures.
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Evidence for the Formation of Acylboronate Intermediates in the Carbonylation Reactions of Organoboranes
Organometallics, 1994Co-Authors: George W. Kabalka, J. T. Gotsick, R. D. PaceAbstract:Trialkylboranes react with acyllithium reagents to yield ketones after oxidation with hydrogen peroxide. The ketones contain one alkyl group supplied by the alkyllithium reagent and one alkyl group supplied by the organoborane. The experimental results support the hypothesis that an acylboronate is an intermediate in the reactions of Organoboranes with carbon monoxide. The yields are modest due to an apparent competition between carbon monoxide and organoborane for the alkyllithium needed to generate the acyl anion. 13 refs., 2 tabs.
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Oxidation of Organoboranes with sodium percarbonate
Organometallics, 1990Co-Authors: George W. Kabalka, Prakash P. Wadgaonkar, Timothy M. ShoupAbstract:Sodium percarbonate, a readily available, inexpensive, and easily handled reagent, efficiently oxidizes a variety of Organoboranes. The product yields compare favorably with those obtained by use of the standard sodium hydroxide/hydrogen peroxide oxidation procedure