The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform

Azizollah Nezhadali - One of the best experts on this subject based on the ideXlab platform.

  • Mechanistic study of in vitro chemical interaction of trimipramine drug with barbituric Derivative after its oxidation: Electrochemical synthesis of new Dibenzazepine Derivative.
    Materials science & engineering. C Materials for biological applications, 2017
    Co-Authors: Shahram Lotfi, Esmail Tammari, Azizollah Nezhadali
    Abstract:

    Abstract Electrochemical oxidation of trimipramine in the absence and presence of 1,3 dimethyl barbituric acid as a nucleophile in aqueous solution has been studied using cyclic voltammetry and controlled-potential coulometry electrolysis. Voltammetric studies of electro-oxidation of trimipramine were realized in a range of pH 1.0 to 8.0 in the absence and presence of 1,3 dimethyl barbituric acid. Based on the obtained electrochemical results, dimerization is the main reaction of electro-oxidation of trimipramine in the absence of nucleophile. The voltammetric data indicate that the 1,3 dimethyl barbituric acid participation in Michael addition reaction with the oxidized dimeric form of trimipramine via an ECEC electrochemical mechanisms. On the other hand the results indicate existence of a catalytic (EC’) electrochemical mechanism in parallel with ECEC electrochemical mechanism. This method provides a facile and one-pot procedure for the synthesis of new Dibenzazepine Derivative. Finally, a possible mechanism is proposed for the electrode process, on the basis of the present and previous investigations. The product has been characterized by IR, 1 H NMR, 13 CNMR and MS methods.

Shahram Lotfi - One of the best experts on this subject based on the ideXlab platform.

  • Mechanistic study of in vitro chemical interaction of trimipramine drug with barbituric Derivative after its oxidation: Electrochemical synthesis of new Dibenzazepine Derivative.
    Materials science & engineering. C Materials for biological applications, 2017
    Co-Authors: Shahram Lotfi, Esmail Tammari, Azizollah Nezhadali
    Abstract:

    Abstract Electrochemical oxidation of trimipramine in the absence and presence of 1,3 dimethyl barbituric acid as a nucleophile in aqueous solution has been studied using cyclic voltammetry and controlled-potential coulometry electrolysis. Voltammetric studies of electro-oxidation of trimipramine were realized in a range of pH 1.0 to 8.0 in the absence and presence of 1,3 dimethyl barbituric acid. Based on the obtained electrochemical results, dimerization is the main reaction of electro-oxidation of trimipramine in the absence of nucleophile. The voltammetric data indicate that the 1,3 dimethyl barbituric acid participation in Michael addition reaction with the oxidized dimeric form of trimipramine via an ECEC electrochemical mechanisms. On the other hand the results indicate existence of a catalytic (EC’) electrochemical mechanism in parallel with ECEC electrochemical mechanism. This method provides a facile and one-pot procedure for the synthesis of new Dibenzazepine Derivative. Finally, a possible mechanism is proposed for the electrode process, on the basis of the present and previous investigations. The product has been characterized by IR, 1 H NMR, 13 CNMR and MS methods.

Esmail Tammari - One of the best experts on this subject based on the ideXlab platform.

  • Mechanistic study of in vitro chemical interaction of trimipramine drug with barbituric Derivative after its oxidation: Electrochemical synthesis of new Dibenzazepine Derivative.
    Materials science & engineering. C Materials for biological applications, 2017
    Co-Authors: Shahram Lotfi, Esmail Tammari, Azizollah Nezhadali
    Abstract:

    Abstract Electrochemical oxidation of trimipramine in the absence and presence of 1,3 dimethyl barbituric acid as a nucleophile in aqueous solution has been studied using cyclic voltammetry and controlled-potential coulometry electrolysis. Voltammetric studies of electro-oxidation of trimipramine were realized in a range of pH 1.0 to 8.0 in the absence and presence of 1,3 dimethyl barbituric acid. Based on the obtained electrochemical results, dimerization is the main reaction of electro-oxidation of trimipramine in the absence of nucleophile. The voltammetric data indicate that the 1,3 dimethyl barbituric acid participation in Michael addition reaction with the oxidized dimeric form of trimipramine via an ECEC electrochemical mechanisms. On the other hand the results indicate existence of a catalytic (EC’) electrochemical mechanism in parallel with ECEC electrochemical mechanism. This method provides a facile and one-pot procedure for the synthesis of new Dibenzazepine Derivative. Finally, a possible mechanism is proposed for the electrode process, on the basis of the present and previous investigations. The product has been characterized by IR, 1 H NMR, 13 CNMR and MS methods.

Prasanna A Datar - One of the best experts on this subject based on the ideXlab platform.

  • quantitative bioanalytical and analytical method development of Dibenzazepine Derivative carbamazepine a review
    Journal of Pharmaceutical Analysis, 2015
    Co-Authors: Prasanna A Datar
    Abstract:

    Abstract Bioanalytical methods are widely used for quantitative estimation of drugs and their metabolites in physiological matrices. These methods could be applied to studies in areas of human clinical pharmacology and toxicology. The major bioanalytical services are method development, method validation and sample analysis (method application). Various methods such as GC, LC–MS/MS, HPLC, HPTLC, micellar electrokinetic chromatography, and UFLC have been used in laboratories for the qualitative and quantitative analysis of carbamazepine in biological samples throughout all phases of clinical research and quality control. The article incorporates various reported methods developed to help analysts in choosing crucial parameters for new method development of carbamazepine and its Derivatives and also enumerates metabolites, and impurities reported so far.

Department Of Health - One of the best experts on this subject based on the ideXlab platform.

  • I IT
    2016
    Co-Authors: Balkr Ishena Kau L, Bab Ington Quame, Bernard Davidow, City Of New York, Department Of Health
    Abstract:

    Antisera to nortriptyline and desipramine were produced in ~ z ~ rabbits against their succinylated Derivatives conjugated to bovine serum albumin and bovine thyroglobulin, respect- Nortriptyline: R = CH(CH2)2NHCH 3 Oesipramine:R = (CH2)3NHCH 3 ively. The antibodies thus produced were shown to be specific for tricyclic antidepressant group of drugs. Some of the Arnitriptyline:R = CH(CH2)2N{CH3) 2 Irnipramine: R = (CH2)3N(CH3) 2 phenothiazines cross-reacted in higher concentrations. The assay was useful when either antibody was combined with generally or specifically tritium-labelled amitriptyline and nortriptyline. The sensitivity of the assay is in 2-5 nanogram range and is usful in screening for use and abuse of trlcyclics by man. Comparison of RIA results with thin-layer and gas chromatography have been made, and good agreement is reported. Combined with a thin-layer and/or gas-chromato-graphic confirmation, the test is well suited for detection and exclusion of these compounds in biological specimens. I ntroduct ion]mipramine (a Dibenzazepine Derivative), amitriptyline (a dibenzocyloheptadiene Derivative), and doxepin (a dibenzo-xepin Derivative), and their desmethyl Derivatives (metabo-lites) are the drugs currently most widely used in the treat-.ment of depression. Because of their structure, (Figure 1) they are often referred to as the tricyclic antidepressants. On account of large individual variation in steady state concentra-tions of tricyclic antidepressants in patients receiving the same therapeutic dose and a correlation between the blood levels and clinical response in psychotic patients, their monitoring in blood is becoming more and more important (1-3). Clinical use of antidepressants is increasing and a number of overdose cases are being reported (4). We have laboratory evidence to show that the use of tricyclic antide-pressa.nts among the patients on methadone maintenance treatment program is extremely high. (Unpublished ata, B