The Experts below are selected from a list of 267 Experts worldwide ranked by ideXlab platform
Yusuf Yagci - One of the best experts on this subject based on the ideXlab platform.
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n acyl Dibenzazepine chemistry as versatile approach for photoreversible thiol ene networks
Macromolecular Rapid Communications, 2020Co-Authors: Semira Bener, Yusuf Yagci, Cansu AydoganAbstract:It is herein reported that a facile application of N-acyl Dibenzazepine (ADBA) photochemistry for preparing photoreversible ADBA based thiol-ene networks. Crosslinking of the ADBA thiol-ene networks is successfully achieved by UV induced dimerization of ADBA groups at wavelengths above 300 nm while a subsequent deep UV exposure (λ = 250 nm) results in a well-defined cleavage of the crosslinks. The photochemical bonding and cleavage of the process has been determined and studied in detail by spectroscopic measurements.
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N‐Acyl Dibenzazepine Chemistry as Versatile Approach for Photoreversible Thiol‐Ene Networks
Macromolecular rapid communications, 2020Co-Authors: Semira Bener, Cansu Aydogan, Yusuf YagciAbstract:It is herein reported that a facile application of N-acyl Dibenzazepine (ADBA) photochemistry for preparing photoreversible ADBA based thiol-ene networks. Crosslinking of the ADBA thiol-ene networks is successfully achieved by UV induced dimerization of ADBA groups at wavelengths above 300 nm while a subsequent deep UV exposure (λ = 250 nm) results in a well-defined cleavage of the crosslinks. The photochemical bonding and cleavage of the process has been determined and studied in detail by spectroscopic measurements.
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Synthesis and reactions of polymers with photoactive terminal groups—4. the use of oxocarbenium polymerization for the synthesis of poly(α-methylstyrene) with N-acyl dibenz[b,f]azepine terminal units
European Polymer Journal, 1992Co-Authors: Yusuf Yagci, Metin H. Acar, Anthony LedwithAbstract:Abstract N -chlorocarbonyl dibenz[b,f]azepine in conjunction with AgSbF 6 initiated the cationic polymerization of α-methylstyrene in methylene chloride. Polymer samples obtained this way contained terminal Dibenzazepine units. Chain extension occurred upon irradiating these polymers with u.v. in benzene solution containing benzophenone or benzil, via cyclobutane formation.
Semira Bener - One of the best experts on this subject based on the ideXlab platform.
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N‐Acyl Dibenzazepine Chemistry as Versatile Approach for Photoreversible Thiol‐Ene Networks
Macromolecular rapid communications, 2020Co-Authors: Semira Bener, Cansu Aydogan, Yusuf YagciAbstract:It is herein reported that a facile application of N-acyl Dibenzazepine (ADBA) photochemistry for preparing photoreversible ADBA based thiol-ene networks. Crosslinking of the ADBA thiol-ene networks is successfully achieved by UV induced dimerization of ADBA groups at wavelengths above 300 nm while a subsequent deep UV exposure (λ = 250 nm) results in a well-defined cleavage of the crosslinks. The photochemical bonding and cleavage of the process has been determined and studied in detail by spectroscopic measurements.
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n acyl Dibenzazepine chemistry as versatile approach for photoreversible thiol ene networks
Macromolecular Rapid Communications, 2020Co-Authors: Semira Bener, Yusuf Yagci, Cansu AydoganAbstract:It is herein reported that a facile application of N-acyl Dibenzazepine (ADBA) photochemistry for preparing photoreversible ADBA based thiol-ene networks. Crosslinking of the ADBA thiol-ene networks is successfully achieved by UV induced dimerization of ADBA groups at wavelengths above 300 nm while a subsequent deep UV exposure (λ = 250 nm) results in a well-defined cleavage of the crosslinks. The photochemical bonding and cleavage of the process has been determined and studied in detail by spectroscopic measurements.
Cansu Aydogan - One of the best experts on this subject based on the ideXlab platform.
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N‐Acyl Dibenzazepine Chemistry as Versatile Approach for Photoreversible Thiol‐Ene Networks
Macromolecular rapid communications, 2020Co-Authors: Semira Bener, Cansu Aydogan, Yusuf YagciAbstract:It is herein reported that a facile application of N-acyl Dibenzazepine (ADBA) photochemistry for preparing photoreversible ADBA based thiol-ene networks. Crosslinking of the ADBA thiol-ene networks is successfully achieved by UV induced dimerization of ADBA groups at wavelengths above 300 nm while a subsequent deep UV exposure (λ = 250 nm) results in a well-defined cleavage of the crosslinks. The photochemical bonding and cleavage of the process has been determined and studied in detail by spectroscopic measurements.
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n acyl Dibenzazepine chemistry as versatile approach for photoreversible thiol ene networks
Macromolecular Rapid Communications, 2020Co-Authors: Semira Bener, Yusuf Yagci, Cansu AydoganAbstract:It is herein reported that a facile application of N-acyl Dibenzazepine (ADBA) photochemistry for preparing photoreversible ADBA based thiol-ene networks. Crosslinking of the ADBA thiol-ene networks is successfully achieved by UV induced dimerization of ADBA groups at wavelengths above 300 nm while a subsequent deep UV exposure (λ = 250 nm) results in a well-defined cleavage of the crosslinks. The photochemical bonding and cleavage of the process has been determined and studied in detail by spectroscopic measurements.
Olga García Mancheño - One of the best experts on this subject based on the ideXlab platform.
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Oxidative CH Bond Functionalization and Ring Expansion with TMSCHN2: A Copper(I)‐Catalyzed Approach to Dibenzoxepines and Dibenzoazepines
Angewandte Chemie, 2015Co-Authors: Tobias Stopka, Mercedes Zurro, Simon Janich, Ernst-ulrich Würthwein, Leyre Marzo, Jose Aleman, Constantin G Daniliuc, Olga García MancheñoAbstract:: Tricyclic dibenzoxepines and Dibenzazepines are important therapeutic agents for the pharmaceutical industry and academic research. However, their syntheses are generally rather tedious, requiring several steps that involve a Wagner-Meerwein-type rearrangement under harsh conditions. Herein, we present the first copper(I)-catalyzed oxidative CH bond functionalization and ring expansion with TMSCHN2 to yield these important derivatives in a facile and straightforward way.
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Oxidative C-H bond functionalization and ring expansion with TMSCHN2 : a copper(I)-catalyzed approach to dibenzoxepines and dibenzoazepines.
Angewandte Chemie (International ed. in English), 2015Co-Authors: Tobias Stopka, Mercedes Zurro, Simon Janich, Ernst-ulrich Würthwein, Leyre Marzo, Jose Aleman, Constantin G Daniliuc, Olga García MancheñoAbstract:Tricyclic dibenzoxepines and Dibenzazepines are important therapeutic agents for the pharmaceutical industry and academic research. However, their syntheses are generally rather tedious, requiring several steps that involve a Wagner-Meerwein-type rearrangement under harsh conditions. Herein, we present the first copper(I)-catalyzed oxidative CH bond functionalization and ring expansion with TMSCHN2 to yield these important derivatives in a facile and straightforward way.
M.p. Sadashiva - One of the best experts on this subject based on the ideXlab platform.
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Synthesis, antimalarial activity, and target binding of Dibenzazepine-tethered isoxazolines
RSC Advances, 2015Co-Authors: Koravangala S. Vinay Kumar, Gejjalagere S. Lingaraju, Yadaganahalli K. Bommegowda, Ajjampura C. Vinayaka, Pritesh Bhat, Challanayakanahally S. Pradeepa Kumara, Kanchugarakoppal S. Rangappa, D. Channe Gowda, M.p. SadashivaAbstract:Malaria, a complex and deadly parasitic infectious disease, is a huge public health problem in many endemic countries around the globe. The prevailing extensive resistance of malaria parasites to traditional drugs and emergence of resistance to the currently used frontline artemisinin-based chemotherapy calls for the development of new drugs. Towards this objective and since compounds containing the Dibenzazepine moiety are effective in treating both gametocyte and asexual stage malaria parasites, including multi drug resistant parasites, a library of Dibenzazepine tethered 3,5-disubstituted isoxazolines was synthesised via 1,3-dipolar cycloaddition reaction. An additional diversified group of Dibenzazepine derivatives were accessed by Suzuki coupling of one of the above Dibenzazepine derivatives with various organoboronic acids. All compounds were structurally characterized and were evaluated for their antimalarial activity. They exhibited good to excellent inhibitory activity against the growth of drug-sensitive Plasmodium falciparum 3D7 strain with IC50 values ranging from 0.2 to 7.7 μM. About 50% of the compounds were either minimally or not toxic to human cell lines. Five of the compounds (6j, 6k, 8c, 8k and 8l) that highly inhibited the parasite growth were further assessed for antimalarial activity using an additional chloroquine-sensitive (D6) and two chloroquine-resistant (W2 and 7G8) P. falciparum strains. These compounds were effective against all four strains (3D7, D6, W2 and 7G8), exhibiting IC50 values of 0.1 to 1.75 μM. The Dibenzazepines were identified to target the metalloamino-peptidase of parasites. Molecular docking and dynamics simulation studies were performed to understand the binding mode and binding strengths of the selected compounds with the enzyme. In agreement with their excellent antimalarial activity, the data suggested that the compounds can strongly bind to the active site of the enzyme.
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Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives
BMC Chemical Biology, 2012Co-Authors: M.p. Sadashiva, Basappa, Shivananju Nanjundaswamy, Kanjoormana Aryan Manu, D. S. Prasanna, Nirvanappa C. Anilkumar, Gautam Sethi, Murugan Sengottuvelan, Feng Li, Kazuyuki SugaharaAbstract:Background Dibenzoazepine (DB) derivatives are important and valuable compounds in medicinal chemistry. The synthesis and chemotherapeutic properties of naturally occurring DBs and different heterocyclic moiety tethered DBs are reported. Herein, we report the DB-fused hybrid structure that containing isoxazolines (DBIs) and their anti-cancer activity, which could throw light on the structural and functional features of new molecules.