The Experts below are selected from a list of 201 Experts worldwide ranked by ideXlab platform
Pragati Rai - One of the best experts on this subject based on the ideXlab platform.
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moo2cl2 dmf 2 catalyzed microwave assisted reductive cyclization of nitroaromatics into Dibenzodiazepines
ChemInform, 2015Co-Authors: I R Siddiqui, Anushree Srivastava, Archana Singh, Shayna Shamim, Pragati RaiAbstract:A mild, convenient, and efficient method for the synthesis of a wide range of the title compounds (III) from cost effective and easily available starting materials is developed.
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moo2cl2 dmf 2 catalyzed microwave assisted reductive cyclisation of nitroaromatics into Dibenzodiazepines
RSC Advances, 2015Co-Authors: I R Siddiqui, Anushree Srivastava, Archana Singh, Shayna Shamim, Pragati RaiAbstract:The paper describes a gentle and highly efficient protocol for the synthesis of Dibenzodiazepines by reductive cyclisation of nitroaniline to Dibenzodiazepines under microwave irradiation catalyzed by MoO2Cl2(DMF)2 involving Ph3P as reducing agent. This synergic approach results in the transformation of nitroaromatics into Dibenzodiazepines in high yield and is applicable to the construction of a wide variety of dibenzo(di/ox)azepines and other structurally related heterocycles.
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moo cl dmf catalyzed microwave assisted reductive cyclisation of nitroaromatics into Dibenzodiazepines
RSC Advances, 2014Co-Authors: I R Siddiqui, Anushree Srivastava, Archana Singh, Shayna Shamim, Pragati RaiAbstract:The paper describes a gentle and highly efficient protocol for the synthesis of Dibenzodiazepines by reductive cyclisation of nitroaniline to Dibenzodiazepines under microwave irradiation catalyzed by MoO₂Cl₂(DMF)₂ involving Ph₃P as reducing agent. This synergic approach results in the transformation of nitroaromatics into Dibenzodiazepines in high yield and is applicable to the construction of a wide variety of dibenzo(di/ox)azepines and other structurally related heterocycles.
Iwan J. P. De Esch - One of the best experts on this subject based on the ideXlab platform.
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Characterization of the Histamine H4 Receptor Binding Site. Part 1. Synthesis and Pharmacological Evaluation of Dibenzodiazepine Derivatives
Journal of medicinal chemistry, 2006Co-Authors: Rogier A. Smits, Herman D. Lim, Remko A. Bakker, Bart Stegink, Iwan J. P. De EschAbstract:A series of Dibenzodiazepine derivatives was synthesized to probe the binding site of the recently discovered histamine H4 receptor (H4R). Optimization of the lead structure clozapine (2) resulted in (E)-7-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine (7j), a potent H4R agonist (H4R, pKi = 7.6). Pharmacological data suggests that the series of nonimidazole compounds can be used to describe the orthosteric binding site of the H4R because both 2 and 7j displace [3H]histamine in a competitive manner. Furthermore, it is demonstrated that the effects of 7j are competitively antagonized by the selective H4R antagonist JNJ 7777120 (1), indicating considerable overlap of their binding sites. On the basis of the derived structure−activity relationships and additional pharmacological results, a pharmacophore model was constructed, which will be the premise for the design of novel H4R ligands.
Yinlong Guo - One of the best experts on this subject based on the ideXlab platform.
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the n aryl aminocarbonyl ortho substituent effect in cu catalyzed aryl amination and its application in the synthesis of 5 substituted 11 oxo Dibenzodiazepines
ChemInform, 2012Co-Authors: Xiaoqiong Diao, Wei Zhu, Yongwen Jiang, Haoyang Wang, Yinlong GuoAbstract:A variety of biologically important 11-oxoDibenzodiazepines is prepared tolerating a wide range of functional groups in the amine partner and substitution at both aromatic rings.
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the n aryl aminocarbonyl ortho substituent effect in cu catalyzed aryl amination and its application in the synthesis of 5 substituted 11 oxo Dibenzodiazepines
Organic Letters, 2011Co-Authors: Xiaoqiong Diao, Wei Zhu, Yongwen Jiang, Haoyang Wang, Yinlong GuoAbstract:Double amination of ortho-substituted aryl bromides proceeded under mild conditions to afford 5-substituted 11-oxo-Dibenzodiazepines, which revealed that there is a strong ortho-substituent effect caused by N-aryl aminocarbonyl groups during copper-catalyzed aryl amination.
I R Siddiqui - One of the best experts on this subject based on the ideXlab platform.
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moo2cl2 dmf 2 catalyzed microwave assisted reductive cyclization of nitroaromatics into Dibenzodiazepines
ChemInform, 2015Co-Authors: I R Siddiqui, Anushree Srivastava, Archana Singh, Shayna Shamim, Pragati RaiAbstract:A mild, convenient, and efficient method for the synthesis of a wide range of the title compounds (III) from cost effective and easily available starting materials is developed.
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moo2cl2 dmf 2 catalyzed microwave assisted reductive cyclisation of nitroaromatics into Dibenzodiazepines
RSC Advances, 2015Co-Authors: I R Siddiqui, Anushree Srivastava, Archana Singh, Shayna Shamim, Pragati RaiAbstract:The paper describes a gentle and highly efficient protocol for the synthesis of Dibenzodiazepines by reductive cyclisation of nitroaniline to Dibenzodiazepines under microwave irradiation catalyzed by MoO2Cl2(DMF)2 involving Ph3P as reducing agent. This synergic approach results in the transformation of nitroaromatics into Dibenzodiazepines in high yield and is applicable to the construction of a wide variety of dibenzo(di/ox)azepines and other structurally related heterocycles.
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moo cl dmf catalyzed microwave assisted reductive cyclisation of nitroaromatics into Dibenzodiazepines
RSC Advances, 2014Co-Authors: I R Siddiqui, Anushree Srivastava, Archana Singh, Shayna Shamim, Pragati RaiAbstract:The paper describes a gentle and highly efficient protocol for the synthesis of Dibenzodiazepines by reductive cyclisation of nitroaniline to Dibenzodiazepines under microwave irradiation catalyzed by MoO₂Cl₂(DMF)₂ involving Ph₃P as reducing agent. This synergic approach results in the transformation of nitroaromatics into Dibenzodiazepines in high yield and is applicable to the construction of a wide variety of dibenzo(di/ox)azepines and other structurally related heterocycles.
Rogier A. Smits - One of the best experts on this subject based on the ideXlab platform.
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Characterization of the Histamine H4 Receptor Binding Site. Part 1. Synthesis and Pharmacological Evaluation of Dibenzodiazepine Derivatives
Journal of medicinal chemistry, 2006Co-Authors: Rogier A. Smits, Herman D. Lim, Remko A. Bakker, Bart Stegink, Iwan J. P. De EschAbstract:A series of Dibenzodiazepine derivatives was synthesized to probe the binding site of the recently discovered histamine H4 receptor (H4R). Optimization of the lead structure clozapine (2) resulted in (E)-7-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine (7j), a potent H4R agonist (H4R, pKi = 7.6). Pharmacological data suggests that the series of nonimidazole compounds can be used to describe the orthosteric binding site of the H4R because both 2 and 7j displace [3H]histamine in a competitive manner. Furthermore, it is demonstrated that the effects of 7j are competitively antagonized by the selective H4R antagonist JNJ 7777120 (1), indicating considerable overlap of their binding sites. On the basis of the derived structure−activity relationships and additional pharmacological results, a pharmacophore model was constructed, which will be the premise for the design of novel H4R ligands.