The Experts below are selected from a list of 153 Experts worldwide ranked by ideXlab platform
Wolfgang Steglich - One of the best experts on this subject based on the ideXlab platform.
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esterification of carboxylic acids with Dicyclohexylcarbodiimide 4 dimethylaminopyridine tert butyl ethyl fumarate
Organic Syntheses, 2003Co-Authors: B Neises, Wolfgang SteglichAbstract:Esterification of carboxylic acids with Dicyclohexylcarbodiimide/4-dimethylaminopyridine: tert-butyl ethyl fumarate reactant: 45.59 g (0.22 mol) of Dicyclohexylcarbodiimide product: tert-butyl ethyl fumarate Keywords: esterification, of dicarboxylic acids; dichloromethane (methylene chloride); Dicyclohexylcarbodiimide; Dicyclohexylcarbodiimide
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Organic Syntheses - Esterification of Carboxylic Acids with Dicyclohexylcarbodiimide/4‐Dimethylaminopyridine: tert‐Butyl Ethyl Fumarate
Organic Syntheses, 2003Co-Authors: B Neises, Wolfgang SteglichAbstract:Esterification of carboxylic acids with Dicyclohexylcarbodiimide/4-dimethylaminopyridine: tert-butyl ethyl fumarate reactant: 45.59 g (0.22 mol) of Dicyclohexylcarbodiimide product: tert-butyl ethyl fumarate Keywords: esterification, of dicarboxylic acids; dichloromethane (methylene chloride); Dicyclohexylcarbodiimide; Dicyclohexylcarbodiimide
Peter T.m. Kenny - One of the best experts on this subject based on the ideXlab platform.
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the synthesis and structural characterization of novel n meta ferrocenyl benzoyl dipeptide esters the x ray crystal structure and in vitro anti cancer activity of n meta ferrocenyl benzoyl l alanine glycine ethyl ester
Journal of Organometallic Chemistry, 2007Co-Authors: Alok Goel, David Savage, Steven Alley, Paula N Kelly, Dermot Osullivan, Helge Muellerbunz, Peter T.m. KennyAbstract:Abstract A series of N - meta -ferrocenyl benzoyl dipeptide esters 2 – 5 have been prepared by coupling meta -ferrocenyl benzoic acid 1b to the dipeptide ethyl esters using the conventional 1,3-Dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBt) protocol. The dipeptides employed in the synthesis were AlaGly(OEt) ( 2 ), AlaAla(OEt) ( 3 ), AlaLeu(OEt) ( 4 ) and AlaPhe(OEt) ( 5 ). The compounds were fully characterized by a range of NMR spectroscopic techniques, mass spectrometry (MALDI-MS, ESI-MS), and cyclic voltammetry (CV). In addition, the X-ray crystal structure and cytotoxicity of N -{ meta -(ferrocenyl)-benzoyl}- l -alanine-glycine ethyl ester ( 2 ) towards lung cancer cells has been determined.
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the synthesis and structural characterization of n ortho ferrocenyl benzoyl amino acid esters the x ray crystal structure of n ortho ferrocenyl benzoyl l phenylalanine ethyl ester
Journal of Organometallic Chemistry, 2006Co-Authors: David Savage, Alok Goel, Steven Alley, Paula N Kelly, Helge Muellerbunz, Gwen Malone, John F Gallagher, Peter T.m. KennyAbstract:Abstract A series of N - ortho -ferrocenyl benzoyl amino acid ethyl esters 3 – 9 have been prepared by coupling ortho -ferrocenyl benzoic acid 2 to the amino acid ethyl esters of glycine, l -alanine, l -leucine, l -phenylalanine, β-alanine, 4-aminobutyric acid and (±)-2-aminobutyric acid using the conventional 1,3-Dicyclohexylcarbodiimide, 1-hydroxybenzotriazole protocol. The compounds were fully characterized by a range of NMR spectroscopic techniques and by mass spectrometry (MALDI-MS, ESI-MS). The X-ray crystal structure of the l -phenylalanine derivative 6 has been determined.
B Neises - One of the best experts on this subject based on the ideXlab platform.
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esterification of carboxylic acids with Dicyclohexylcarbodiimide 4 dimethylaminopyridine tert butyl ethyl fumarate
Organic Syntheses, 2003Co-Authors: B Neises, Wolfgang SteglichAbstract:Esterification of carboxylic acids with Dicyclohexylcarbodiimide/4-dimethylaminopyridine: tert-butyl ethyl fumarate reactant: 45.59 g (0.22 mol) of Dicyclohexylcarbodiimide product: tert-butyl ethyl fumarate Keywords: esterification, of dicarboxylic acids; dichloromethane (methylene chloride); Dicyclohexylcarbodiimide; Dicyclohexylcarbodiimide
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Organic Syntheses - Esterification of Carboxylic Acids with Dicyclohexylcarbodiimide/4‐Dimethylaminopyridine: tert‐Butyl Ethyl Fumarate
Organic Syntheses, 2003Co-Authors: B Neises, Wolfgang SteglichAbstract:Esterification of carboxylic acids with Dicyclohexylcarbodiimide/4-dimethylaminopyridine: tert-butyl ethyl fumarate reactant: 45.59 g (0.22 mol) of Dicyclohexylcarbodiimide product: tert-butyl ethyl fumarate Keywords: esterification, of dicarboxylic acids; dichloromethane (methylene chloride); Dicyclohexylcarbodiimide; Dicyclohexylcarbodiimide
Lars Ernster - One of the best experts on this subject based on the ideXlab platform.
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a study of the Dicyclohexylcarbodiimide binding component of the mitochondrial atpase complex from beef heart
FEBS Journal, 2005Co-Authors: Elzbieta Glaser, Birgitta Norling, Lars ErnsterAbstract:1 The binding of [14C]Dicyclohexylcarbodiimide to membrane proteins of beef heart mitochondria has been investigated using dodecylsulphate/polyacrylamide gel electrophoresis. Upon incubation of submitochondrial particles with low concentrations of Dicyclohexylcarbodiimide (5 nmol/mg protein) radioactivity was incorporated into three components with apparent molecular weights of 30000, 18000 and less than 6500. Only the two smaller components were found to be extracted into chloroform/methanol. The same two components were labelled when the isolated ATPase complex or a reconstituted F0F1 system was incubated with low concentrations of Dicyclohexylcarbodiimide. High concentrations of Dicyclohexylcarbodiimide (20–100 nmol/mg protein) resulted in binding to several mitochondrial proteins. 2 The maximal amount of Dicyclohexylcarbodiimide which can bind to submitochondrial particles, the isolated ATPase complex, and the reconstituted F0F1 system was found to exceed the amount required for maximal inhibition of the ATPase activity by several-fold. The distribution of the bound [14C]Dicyclohexylcarbodiimide between the different Dicyclohexylcarbodiimide-binding components was investigated as a function of Dicyclohexylcarbodiimide concentration. The smallest and largest components revealed a high affinity for Dicyclohexylcarbodiimidebinding which paralleled the inhibition of ATPase activity. The intermediate component had a markedly lower affinity for Dicyclohexylcarbodiimide-binding. 3 The larger Dicyclohexylcarbodiimide-binding component of the isolated ATPase complex can be converted into the smaller component by treatment of the ATPase complex with performic acid. Partial conversion can also be achieved by extraction of the band from the dodecylsulphate-polyacrylamide gel after electrophoresis, followed by re-electrophoresis. The observations suggest that the larger component may be an oligomer of the smaller one. 4 Using concentrations of oligomycin and Dicyclohexylcarbodiimide which were equal to or greater than those required for maximal inhibition of the ATPase activity, oligomycin was found to diminish the binding of [14C]Dicyclohexylcarbodiimide to both Dicyclohexylcarbodiimide-binding components of the isolated ATPase complex.
David Savage - One of the best experts on this subject based on the ideXlab platform.
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the synthesis and structural characterization of novel n meta ferrocenyl benzoyl dipeptide esters the x ray crystal structure and in vitro anti cancer activity of n meta ferrocenyl benzoyl l alanine glycine ethyl ester
Journal of Organometallic Chemistry, 2007Co-Authors: Alok Goel, David Savage, Steven Alley, Paula N Kelly, Dermot Osullivan, Helge Muellerbunz, Peter T.m. KennyAbstract:Abstract A series of N - meta -ferrocenyl benzoyl dipeptide esters 2 – 5 have been prepared by coupling meta -ferrocenyl benzoic acid 1b to the dipeptide ethyl esters using the conventional 1,3-Dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBt) protocol. The dipeptides employed in the synthesis were AlaGly(OEt) ( 2 ), AlaAla(OEt) ( 3 ), AlaLeu(OEt) ( 4 ) and AlaPhe(OEt) ( 5 ). The compounds were fully characterized by a range of NMR spectroscopic techniques, mass spectrometry (MALDI-MS, ESI-MS), and cyclic voltammetry (CV). In addition, the X-ray crystal structure and cytotoxicity of N -{ meta -(ferrocenyl)-benzoyl}- l -alanine-glycine ethyl ester ( 2 ) towards lung cancer cells has been determined.
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the synthesis and structural characterization of n ortho ferrocenyl benzoyl amino acid esters the x ray crystal structure of n ortho ferrocenyl benzoyl l phenylalanine ethyl ester
Journal of Organometallic Chemistry, 2006Co-Authors: David Savage, Alok Goel, Steven Alley, Paula N Kelly, Helge Muellerbunz, Gwen Malone, John F Gallagher, Peter T.m. KennyAbstract:Abstract A series of N - ortho -ferrocenyl benzoyl amino acid ethyl esters 3 – 9 have been prepared by coupling ortho -ferrocenyl benzoic acid 2 to the amino acid ethyl esters of glycine, l -alanine, l -leucine, l -phenylalanine, β-alanine, 4-aminobutyric acid and (±)-2-aminobutyric acid using the conventional 1,3-Dicyclohexylcarbodiimide, 1-hydroxybenzotriazole protocol. The compounds were fully characterized by a range of NMR spectroscopic techniques and by mass spectrometry (MALDI-MS, ESI-MS). The X-ray crystal structure of the l -phenylalanine derivative 6 has been determined.