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Dieter Lutjohann - One of the best experts on this subject based on the ideXlab platform.

  • plant sterol ester Diet Supplementation increases serum plant sterols and markers of cholesterol synthesis but has no effect on total cholesterol levels
    The Journal of Steroid Biochemistry and Molecular Biology, 2017
    Co-Authors: Oliver Weingartner, Ivan Bogeski, Carsten Kummerow, Stephan H Schirmer, Constanze Husche, Tim Vanmierlo, Gudrun Wagenpfeil, Markus Hoth, Michael Bohm, Dieter Lutjohann
    Abstract:

    This double-blind, randomized, placebo-controlled, cross-over intervention-study was conducted in healthy volunteers to evaluate the effects of plant sterol ester supplemented margarine on cholesterol, non-cholesterol sterols and oxidative stress in serum and monocytes. Sixteen volunteers, average age 34 years, with no or mild hypercholesterolemia were subjected to a 4 week period of daily intake of 3g plant sterols per day supplied via a supplemented margarine on top of regular eating habits. After a wash-out period of one week, volunteers switched groups. Compared to placebo, a Diet Supplementation with plant sterols increased serum levels of plant sterols such as campesterol (+0.16±0.19mg/dL, p=0.005) and sitosterol (+0.27±0.18mg/dL, p<0.001) and increased markers of cholesterol synthesis such as desmosterol (+0.05±0.07mg/dL, p=0.006) as well as lathosterol (+0.11±0.16mg/dL, p=0.012). Cholesterol serum levels, however, were not changed significantly (+18.68±32.6mg/dL, p=0.052). These findings could not be verified in isolated circulating monocytes. Moreover, there was no effect on monocyte activation and no differences with regard to redox state after plant sterol supplemented Diet. Therefore, in a population of healthy volunteers with no or mild hypercholesterolemia, consumption of plant sterol ester supplemented margarine results in increased concentrations of plant sterols and cholesterol synthesis markers without affecting total cholesterol in the serum, activation of circulating monocytes or redox state.

  • Plant sterol ester Diet Supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels.
    The Journal of steroid biochemistry and molecular biology, 2016
    Co-Authors: Oliver Weingartner, Ivan Bogeski, Carsten Kummerow, Stephan H Schirmer, Constanze Husche, Tim Vanmierlo, Gudrun Wagenpfeil, Markus Hoth, Michael Bohm, Dieter Lutjohann
    Abstract:

    This double-blind, randomized, placebo-controlled, cross-over intervention-study was conducted in healthy volunteers to evaluate the effects of plant sterol ester supplemented margarine on cholesterol, non-cholesterol sterols and oxidative stress in serum and monocytes. Sixteen volunteers, average age 34 years, with no or mild hypercholesterolemia were subjected to a 4 week period of daily intake of 3g plant sterols per day supplied via a supplemented margarine on top of regular eating habits. After a wash-out period of one week, volunteers switched groups. Compared to placebo, a Diet Supplementation with plant sterols increased serum levels of plant sterols such as campesterol (+0.16±0.19mg/dL, p=0.005) and sitosterol (+0.27±0.18mg/dL, p

  • vascular effects of Diet Supplementation with plant sterols
    Journal of the American College of Cardiology, 2008
    Co-Authors: Oliver Weingartner, Dieter Lutjohann, Shengbo Ji, Nicole Weisshoff, Franka List, Thomas Sudhop, Klaus Von Bergmann, Karen Gertz, Jochem Konig, Hansjoachim Schafers
    Abstract:

    Objectives The purpose of this study was to evaluate vascular effects of Diet Supplementation with plant sterol esters (PSE). Background Plant sterol esters are used as food supplements to reduce cholesterol levels. Their effects on endothelial function, stroke, or atherogenesis are not known. Methods In mice, plasma sterol concentrations were correlated with endothelial function, cerebral lesion size, and atherosclerosis. Plasma and tissue sterol concentrations were measured by gas-liquid chromatography-mass spectrometry in 82 consecutive patients with aortic stenosis. Results Compared with those fed with normal chow (NC), wild-type mice fed with NC supplemented with 2% PSE showed increased plant sterol but equal cholesterol plasma concentrations. The PSE Supplementation impaired endothelium-dependent vasorelaxation and increased cerebral lesion size after middle cerebral artery occlusion. To test the effects of cholesterol-lowering by PSE, apolipoprotein E (ApoE)−/− mice were randomized to Western-type Diet (WTD) with the addition of PSE or ezetimibe (EZE). Compared with WTD, both interventions reduced plaque sizes; however, WTD + PSE showed larger plaques compared with WTD + EZE (20.4 ± 2.1% vs. 10.0 ± 1.5%). Plant sterol plasma concentration strongly correlated with increased atherosclerotic lesion formation (r = 0.50). Furthermore, we examined plasma and aortic valve concentrations of plant sterol in 82 consecutive patients with aortic stenosis. Patients eating PSE-supplemented margarine (n = 10) showed increased plasma concentrations and 5-fold higher sterol concentrations in aortic valve tissue. Conclusions Food Supplementation with PSE impairs endothelial function, aggravates ischemic brain injury, effects atherogenesis in mice, and leads to increased tissue sterol concentrations in humans. Therefore, prospective studies are warranted that evaluate not only effects on cholesterol reduction, but also on clinical endpoints. (Concentration of Plant Sterols in Serum and Aortic Valve Cusps; NCT00222950 )

Oliver Weingartner - One of the best experts on this subject based on the ideXlab platform.

  • plant sterol ester Diet Supplementation increases serum plant sterols and markers of cholesterol synthesis but has no effect on total cholesterol levels
    The Journal of Steroid Biochemistry and Molecular Biology, 2017
    Co-Authors: Oliver Weingartner, Ivan Bogeski, Carsten Kummerow, Stephan H Schirmer, Constanze Husche, Tim Vanmierlo, Gudrun Wagenpfeil, Markus Hoth, Michael Bohm, Dieter Lutjohann
    Abstract:

    This double-blind, randomized, placebo-controlled, cross-over intervention-study was conducted in healthy volunteers to evaluate the effects of plant sterol ester supplemented margarine on cholesterol, non-cholesterol sterols and oxidative stress in serum and monocytes. Sixteen volunteers, average age 34 years, with no or mild hypercholesterolemia were subjected to a 4 week period of daily intake of 3g plant sterols per day supplied via a supplemented margarine on top of regular eating habits. After a wash-out period of one week, volunteers switched groups. Compared to placebo, a Diet Supplementation with plant sterols increased serum levels of plant sterols such as campesterol (+0.16±0.19mg/dL, p=0.005) and sitosterol (+0.27±0.18mg/dL, p<0.001) and increased markers of cholesterol synthesis such as desmosterol (+0.05±0.07mg/dL, p=0.006) as well as lathosterol (+0.11±0.16mg/dL, p=0.012). Cholesterol serum levels, however, were not changed significantly (+18.68±32.6mg/dL, p=0.052). These findings could not be verified in isolated circulating monocytes. Moreover, there was no effect on monocyte activation and no differences with regard to redox state after plant sterol supplemented Diet. Therefore, in a population of healthy volunteers with no or mild hypercholesterolemia, consumption of plant sterol ester supplemented margarine results in increased concentrations of plant sterols and cholesterol synthesis markers without affecting total cholesterol in the serum, activation of circulating monocytes or redox state.

  • Plant sterol ester Diet Supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels.
    The Journal of steroid biochemistry and molecular biology, 2016
    Co-Authors: Oliver Weingartner, Ivan Bogeski, Carsten Kummerow, Stephan H Schirmer, Constanze Husche, Tim Vanmierlo, Gudrun Wagenpfeil, Markus Hoth, Michael Bohm, Dieter Lutjohann
    Abstract:

    This double-blind, randomized, placebo-controlled, cross-over intervention-study was conducted in healthy volunteers to evaluate the effects of plant sterol ester supplemented margarine on cholesterol, non-cholesterol sterols and oxidative stress in serum and monocytes. Sixteen volunteers, average age 34 years, with no or mild hypercholesterolemia were subjected to a 4 week period of daily intake of 3g plant sterols per day supplied via a supplemented margarine on top of regular eating habits. After a wash-out period of one week, volunteers switched groups. Compared to placebo, a Diet Supplementation with plant sterols increased serum levels of plant sterols such as campesterol (+0.16±0.19mg/dL, p=0.005) and sitosterol (+0.27±0.18mg/dL, p

  • vascular effects of Diet Supplementation with plant sterols
    Journal of the American College of Cardiology, 2008
    Co-Authors: Oliver Weingartner, Dieter Lutjohann, Shengbo Ji, Nicole Weisshoff, Franka List, Thomas Sudhop, Klaus Von Bergmann, Karen Gertz, Jochem Konig, Hansjoachim Schafers
    Abstract:

    Objectives The purpose of this study was to evaluate vascular effects of Diet Supplementation with plant sterol esters (PSE). Background Plant sterol esters are used as food supplements to reduce cholesterol levels. Their effects on endothelial function, stroke, or atherogenesis are not known. Methods In mice, plasma sterol concentrations were correlated with endothelial function, cerebral lesion size, and atherosclerosis. Plasma and tissue sterol concentrations were measured by gas-liquid chromatography-mass spectrometry in 82 consecutive patients with aortic stenosis. Results Compared with those fed with normal chow (NC), wild-type mice fed with NC supplemented with 2% PSE showed increased plant sterol but equal cholesterol plasma concentrations. The PSE Supplementation impaired endothelium-dependent vasorelaxation and increased cerebral lesion size after middle cerebral artery occlusion. To test the effects of cholesterol-lowering by PSE, apolipoprotein E (ApoE)−/− mice were randomized to Western-type Diet (WTD) with the addition of PSE or ezetimibe (EZE). Compared with WTD, both interventions reduced plaque sizes; however, WTD + PSE showed larger plaques compared with WTD + EZE (20.4 ± 2.1% vs. 10.0 ± 1.5%). Plant sterol plasma concentration strongly correlated with increased atherosclerotic lesion formation (r = 0.50). Furthermore, we examined plasma and aortic valve concentrations of plant sterol in 82 consecutive patients with aortic stenosis. Patients eating PSE-supplemented margarine (n = 10) showed increased plasma concentrations and 5-fold higher sterol concentrations in aortic valve tissue. Conclusions Food Supplementation with PSE impairs endothelial function, aggravates ischemic brain injury, effects atherogenesis in mice, and leads to increased tissue sterol concentrations in humans. Therefore, prospective studies are warranted that evaluate not only effects on cholesterol reduction, but also on clinical endpoints. (Concentration of Plant Sterols in Serum and Aortic Valve Cusps; NCT00222950 )

Gudrun Wagenpfeil - One of the best experts on this subject based on the ideXlab platform.

  • plant sterol ester Diet Supplementation increases serum plant sterols and markers of cholesterol synthesis but has no effect on total cholesterol levels
    The Journal of Steroid Biochemistry and Molecular Biology, 2017
    Co-Authors: Oliver Weingartner, Ivan Bogeski, Carsten Kummerow, Stephan H Schirmer, Constanze Husche, Tim Vanmierlo, Gudrun Wagenpfeil, Markus Hoth, Michael Bohm, Dieter Lutjohann
    Abstract:

    This double-blind, randomized, placebo-controlled, cross-over intervention-study was conducted in healthy volunteers to evaluate the effects of plant sterol ester supplemented margarine on cholesterol, non-cholesterol sterols and oxidative stress in serum and monocytes. Sixteen volunteers, average age 34 years, with no or mild hypercholesterolemia were subjected to a 4 week period of daily intake of 3g plant sterols per day supplied via a supplemented margarine on top of regular eating habits. After a wash-out period of one week, volunteers switched groups. Compared to placebo, a Diet Supplementation with plant sterols increased serum levels of plant sterols such as campesterol (+0.16±0.19mg/dL, p=0.005) and sitosterol (+0.27±0.18mg/dL, p<0.001) and increased markers of cholesterol synthesis such as desmosterol (+0.05±0.07mg/dL, p=0.006) as well as lathosterol (+0.11±0.16mg/dL, p=0.012). Cholesterol serum levels, however, were not changed significantly (+18.68±32.6mg/dL, p=0.052). These findings could not be verified in isolated circulating monocytes. Moreover, there was no effect on monocyte activation and no differences with regard to redox state after plant sterol supplemented Diet. Therefore, in a population of healthy volunteers with no or mild hypercholesterolemia, consumption of plant sterol ester supplemented margarine results in increased concentrations of plant sterols and cholesterol synthesis markers without affecting total cholesterol in the serum, activation of circulating monocytes or redox state.

  • Plant sterol ester Diet Supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels.
    The Journal of steroid biochemistry and molecular biology, 2016
    Co-Authors: Oliver Weingartner, Ivan Bogeski, Carsten Kummerow, Stephan H Schirmer, Constanze Husche, Tim Vanmierlo, Gudrun Wagenpfeil, Markus Hoth, Michael Bohm, Dieter Lutjohann
    Abstract:

    This double-blind, randomized, placebo-controlled, cross-over intervention-study was conducted in healthy volunteers to evaluate the effects of plant sterol ester supplemented margarine on cholesterol, non-cholesterol sterols and oxidative stress in serum and monocytes. Sixteen volunteers, average age 34 years, with no or mild hypercholesterolemia were subjected to a 4 week period of daily intake of 3g plant sterols per day supplied via a supplemented margarine on top of regular eating habits. After a wash-out period of one week, volunteers switched groups. Compared to placebo, a Diet Supplementation with plant sterols increased serum levels of plant sterols such as campesterol (+0.16±0.19mg/dL, p=0.005) and sitosterol (+0.27±0.18mg/dL, p

Constanze Husche - One of the best experts on this subject based on the ideXlab platform.

  • plant sterol ester Diet Supplementation increases serum plant sterols and markers of cholesterol synthesis but has no effect on total cholesterol levels
    The Journal of Steroid Biochemistry and Molecular Biology, 2017
    Co-Authors: Oliver Weingartner, Ivan Bogeski, Carsten Kummerow, Stephan H Schirmer, Constanze Husche, Tim Vanmierlo, Gudrun Wagenpfeil, Markus Hoth, Michael Bohm, Dieter Lutjohann
    Abstract:

    This double-blind, randomized, placebo-controlled, cross-over intervention-study was conducted in healthy volunteers to evaluate the effects of plant sterol ester supplemented margarine on cholesterol, non-cholesterol sterols and oxidative stress in serum and monocytes. Sixteen volunteers, average age 34 years, with no or mild hypercholesterolemia were subjected to a 4 week period of daily intake of 3g plant sterols per day supplied via a supplemented margarine on top of regular eating habits. After a wash-out period of one week, volunteers switched groups. Compared to placebo, a Diet Supplementation with plant sterols increased serum levels of plant sterols such as campesterol (+0.16±0.19mg/dL, p=0.005) and sitosterol (+0.27±0.18mg/dL, p<0.001) and increased markers of cholesterol synthesis such as desmosterol (+0.05±0.07mg/dL, p=0.006) as well as lathosterol (+0.11±0.16mg/dL, p=0.012). Cholesterol serum levels, however, were not changed significantly (+18.68±32.6mg/dL, p=0.052). These findings could not be verified in isolated circulating monocytes. Moreover, there was no effect on monocyte activation and no differences with regard to redox state after plant sterol supplemented Diet. Therefore, in a population of healthy volunteers with no or mild hypercholesterolemia, consumption of plant sterol ester supplemented margarine results in increased concentrations of plant sterols and cholesterol synthesis markers without affecting total cholesterol in the serum, activation of circulating monocytes or redox state.

  • Plant sterol ester Diet Supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels.
    The Journal of steroid biochemistry and molecular biology, 2016
    Co-Authors: Oliver Weingartner, Ivan Bogeski, Carsten Kummerow, Stephan H Schirmer, Constanze Husche, Tim Vanmierlo, Gudrun Wagenpfeil, Markus Hoth, Michael Bohm, Dieter Lutjohann
    Abstract:

    This double-blind, randomized, placebo-controlled, cross-over intervention-study was conducted in healthy volunteers to evaluate the effects of plant sterol ester supplemented margarine on cholesterol, non-cholesterol sterols and oxidative stress in serum and monocytes. Sixteen volunteers, average age 34 years, with no or mild hypercholesterolemia were subjected to a 4 week period of daily intake of 3g plant sterols per day supplied via a supplemented margarine on top of regular eating habits. After a wash-out period of one week, volunteers switched groups. Compared to placebo, a Diet Supplementation with plant sterols increased serum levels of plant sterols such as campesterol (+0.16±0.19mg/dL, p=0.005) and sitosterol (+0.27±0.18mg/dL, p

Markus Hoth - One of the best experts on this subject based on the ideXlab platform.

  • plant sterol ester Diet Supplementation increases serum plant sterols and markers of cholesterol synthesis but has no effect on total cholesterol levels
    The Journal of Steroid Biochemistry and Molecular Biology, 2017
    Co-Authors: Oliver Weingartner, Ivan Bogeski, Carsten Kummerow, Stephan H Schirmer, Constanze Husche, Tim Vanmierlo, Gudrun Wagenpfeil, Markus Hoth, Michael Bohm, Dieter Lutjohann
    Abstract:

    This double-blind, randomized, placebo-controlled, cross-over intervention-study was conducted in healthy volunteers to evaluate the effects of plant sterol ester supplemented margarine on cholesterol, non-cholesterol sterols and oxidative stress in serum and monocytes. Sixteen volunteers, average age 34 years, with no or mild hypercholesterolemia were subjected to a 4 week period of daily intake of 3g plant sterols per day supplied via a supplemented margarine on top of regular eating habits. After a wash-out period of one week, volunteers switched groups. Compared to placebo, a Diet Supplementation with plant sterols increased serum levels of plant sterols such as campesterol (+0.16±0.19mg/dL, p=0.005) and sitosterol (+0.27±0.18mg/dL, p<0.001) and increased markers of cholesterol synthesis such as desmosterol (+0.05±0.07mg/dL, p=0.006) as well as lathosterol (+0.11±0.16mg/dL, p=0.012). Cholesterol serum levels, however, were not changed significantly (+18.68±32.6mg/dL, p=0.052). These findings could not be verified in isolated circulating monocytes. Moreover, there was no effect on monocyte activation and no differences with regard to redox state after plant sterol supplemented Diet. Therefore, in a population of healthy volunteers with no or mild hypercholesterolemia, consumption of plant sterol ester supplemented margarine results in increased concentrations of plant sterols and cholesterol synthesis markers without affecting total cholesterol in the serum, activation of circulating monocytes or redox state.

  • Plant sterol ester Diet Supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels.
    The Journal of steroid biochemistry and molecular biology, 2016
    Co-Authors: Oliver Weingartner, Ivan Bogeski, Carsten Kummerow, Stephan H Schirmer, Constanze Husche, Tim Vanmierlo, Gudrun Wagenpfeil, Markus Hoth, Michael Bohm, Dieter Lutjohann
    Abstract:

    This double-blind, randomized, placebo-controlled, cross-over intervention-study was conducted in healthy volunteers to evaluate the effects of plant sterol ester supplemented margarine on cholesterol, non-cholesterol sterols and oxidative stress in serum and monocytes. Sixteen volunteers, average age 34 years, with no or mild hypercholesterolemia were subjected to a 4 week period of daily intake of 3g plant sterols per day supplied via a supplemented margarine on top of regular eating habits. After a wash-out period of one week, volunteers switched groups. Compared to placebo, a Diet Supplementation with plant sterols increased serum levels of plant sterols such as campesterol (+0.16±0.19mg/dL, p=0.005) and sitosterol (+0.27±0.18mg/dL, p