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  • modulation effects of black vinegar based supplement against a high fat Dietary Habit antiobesity hypolipidemic antioxidative and energy metabolism effects
    Journal of the Science of Food and Agriculture, 2020
    Co-Authors: Mingen Liu, Yiling Lin, Chunghsi Chou, Yichen Chen
    Abstract:

    BACKGROUND An imbalanced fat or excess energy intake always results in obesity and increased serum/liver lipids, thus leading to metabolic syndromes. Given the bioactive components in black vinegar (BV), such as branched amino acids, phenolic profile, and mineral contents, we investigated the antiobesity effects of BV-based supplements in rats fed a high-fat diet (HFD). RESULTS HFD (30% fat, w/w) feeding increased (P < 0.05) body weight, weight gains, weights of livers and mesenteric, epididymal, and perirenal adipose tissues, and serum/liver triglyceride levels relative to those of rats fed a normal diet (4% fat, w/w; CON). These increased values were ameliorated (P < 0.05) by supplementing with BV-based supplements but were still higher (P < 0.05) than those of CON rats. The increased areas of perirenal adipocytes in rats fed with an HFD were also decreased (P < 0.05) by supplementing with BV-based supplements, which might result from an upregulation (P < 0.05) of 5'-adenosine monophosphate-activated protein kinase (AMPK), carnitine palmitoyltransferase-1 (CPT1), and uncoupling protein-2 (UCP2) in the perirenal adipose tissues. A similar effect was observed for AMPK, peroxisome proliferator-activated receptor alpha, retinoid X receptor alpha, CPT1, and UCP2 gene and protein levels in livers (P < 0.05). Generally, BV-based supplements increased the fecal triglyceride, cholesterol, and bile acid levels of rats fed with an HFD, which partially contribute to the lipid-lowering effects. Furthermore, BV-based supplements increased (P < 0.05) hepatic Trolox equivalent antioxidant capacity and lowered (P < 0.05) serum/liver thiobarbituric acid reactive substances values in HFD-fed rats. CONCLUSION In a chronic high-fat Dietary Habit, the food-grade BV-based supplement is a good daily choice to ameliorate obesity and its associated comorbidities. © 2020 Society of Chemical Industry.

  • preventive effects of taurine on development of hepatic steatosis induced by a high fat cholesterol Dietary Habit
    Journal of Agricultural and Food Chemistry, 2011
    Co-Authors: Yuanyen Chang, Chunghsi O Chou, Chihhsien O Chiu, Kuotai Yang, Yiling Lin, Weilien Weng, Yichen Chen
    Abstract:

    Nonalcoholic fatty liver (NAFL) is also called hepatic steatosis and has become an emergent liver disease in developed and developing nations. This study was to exam the preventive effects of taurine (Tau) on the development of hepatic steatosis via a hamster model. Although hepatic steatosis of hamsters was induced by feeding a high-fat/cholesterol diet, drinking water containing 0.35 and 0.7% Tau improved (p < 0.05) the serum lipid profile. Meanwhile, the smaller (p < 0.05) liver sizes and lower (p < 0.05) hepatic lipids in high-fat/cholesterol Dietary hamsters drinking Tau may be partially due to higher (p < 0.05) fecal cholesterol, triacylglycerol, and bile acid outputs. In the regulation of lipid homeostasis, drinking a Tau solution upregulated (p < 0.05) low-density lipoprotein receptor and CYP7A1 gene expressions in high-fat/cholesterol Dietary hamsters, which result in increased fecal cholesterol and bile acid outputs. Drinking a Tau solution also upregulated (p < 0.05) peroxisome proliferator-activated receptor-α (PPAR-α) and uncoupling protein 2 (UPC2) gene expressions in high-fat/cholesterol Dietary hamsters, thus increasing energy expenditure. Besides, Tau also enhanced (p < 0.05) liver antioxidant capacities (GSH, TEAC, SOD, and CAT) and decreased (p < 0.05) lipid peroxidation (MDA), which alleviated liver damage in the high-fat/cholesterol Dietary hamsters. Therefore, Tau shows preventive effects on the development of hepatic steatosis induced by a high-fat/cholesterol Dietary Habit.

  • preventive effects of taurine on development of hepatic steatosis induced by a high fat cholesterol Dietary Habit
    Journal of Agricultural and Food Chemistry, 2011
    Co-Authors: Yuanyen Chang, Chunghsi O Chou, Chihhsien O Chiu, Kuotai Yang, Weilien Weng, Yichen Chen
    Abstract:

    Nonalcoholic fatty liver (NAFL) is also called hepatic steatosis and has become an emergent liver disease in developed and developing nations. This study was to exam the preventive effects of taurine (Tau) on the development of hepatic steatosis via a hamster model. Although hepatic steatosis of hamsters was induced by feeding a high-fat/cholesterol diet, drinking water containing 0.35 and 0.7% Tau improved (p < 0.05) the serum lipid profile. Meanwhile, the smaller (p < 0.05) liver sizes and lower (p < 0.05) hepatic lipids in high-fat/cholesterol Dietary hamsters drinking Tau may be partially due to higher (p < 0.05) fecal cholesterol, triacylglycerol, and bile acid outputs. In the regulation of lipid homeostasis, drinking a Tau solution upregulated (p < 0.05) low-density lipoprotein receptor and CYP7A1 gene expressions in high-fat/cholesterol Dietary hamsters, which result in increased fecal cholesterol and bile acid outputs. Drinking a Tau solution also upregulated (p < 0.05) peroxisome proliferator-act...

  • taurine alleviates dyslipidemia and liver damage induced by a high fat cholesterol Dietary Habit
    Food Chemistry, 2010
    Co-Authors: Shunfa Yang, Yuanyen Chang, Kuotai Yang, Borshow Tzang, Yuanchao Hsiao, Chiho Chan, Yichen Chen
    Abstract:

    Eight male hamsters per group were assigned randomly to one of the following diets: chow diet (Control); high-fat/cholesterol diet (HFCD); HFCD supplemented with 1% Tau (HFCD/1% Tau); HFCD supplemented with 2% Tau (HFCD/2% Tau). Tau supplementation improved (P 0.05) changed by Tau supplementation, faecal cholesterol and bile acid outputs were increased (P < 0.05). Two percent Tau supplementation unregulated (P < 0.05) HMG-CoA reductase and cholesterol 7-a hydroxylase (CYP7A1) expressions in the high-fat/cholesterol-Dietary hamsters. Besides, Tau supplementation also increased (P < 0.05) LDL receptor mRNA expressions in high-fat/cholesterol-Dietary hamsters. Tau supplementation also reduced serum GPT and GOT values and C-reactive protein (CRP) levels in the high-fat/cholesterol-Dietary hamsters. Results clearly indicated that Tau could alleviate blood lipids and hepatic damage induced by a high-fat/cholesterol-Dietary diet.

Yuanyen Chang - One of the best experts on this subject based on the ideXlab platform.

  • preventive effects of taurine on development of hepatic steatosis induced by a high fat cholesterol Dietary Habit
    Journal of Agricultural and Food Chemistry, 2011
    Co-Authors: Yuanyen Chang, Chunghsi O Chou, Chihhsien O Chiu, Kuotai Yang, Yiling Lin, Weilien Weng, Yichen Chen
    Abstract:

    Nonalcoholic fatty liver (NAFL) is also called hepatic steatosis and has become an emergent liver disease in developed and developing nations. This study was to exam the preventive effects of taurine (Tau) on the development of hepatic steatosis via a hamster model. Although hepatic steatosis of hamsters was induced by feeding a high-fat/cholesterol diet, drinking water containing 0.35 and 0.7% Tau improved (p < 0.05) the serum lipid profile. Meanwhile, the smaller (p < 0.05) liver sizes and lower (p < 0.05) hepatic lipids in high-fat/cholesterol Dietary hamsters drinking Tau may be partially due to higher (p < 0.05) fecal cholesterol, triacylglycerol, and bile acid outputs. In the regulation of lipid homeostasis, drinking a Tau solution upregulated (p < 0.05) low-density lipoprotein receptor and CYP7A1 gene expressions in high-fat/cholesterol Dietary hamsters, which result in increased fecal cholesterol and bile acid outputs. Drinking a Tau solution also upregulated (p < 0.05) peroxisome proliferator-activated receptor-α (PPAR-α) and uncoupling protein 2 (UPC2) gene expressions in high-fat/cholesterol Dietary hamsters, thus increasing energy expenditure. Besides, Tau also enhanced (p < 0.05) liver antioxidant capacities (GSH, TEAC, SOD, and CAT) and decreased (p < 0.05) lipid peroxidation (MDA), which alleviated liver damage in the high-fat/cholesterol Dietary hamsters. Therefore, Tau shows preventive effects on the development of hepatic steatosis induced by a high-fat/cholesterol Dietary Habit.

  • preventive effects of taurine on development of hepatic steatosis induced by a high fat cholesterol Dietary Habit
    Journal of Agricultural and Food Chemistry, 2011
    Co-Authors: Yuanyen Chang, Chunghsi O Chou, Chihhsien O Chiu, Kuotai Yang, Weilien Weng, Yichen Chen
    Abstract:

    Nonalcoholic fatty liver (NAFL) is also called hepatic steatosis and has become an emergent liver disease in developed and developing nations. This study was to exam the preventive effects of taurine (Tau) on the development of hepatic steatosis via a hamster model. Although hepatic steatosis of hamsters was induced by feeding a high-fat/cholesterol diet, drinking water containing 0.35 and 0.7% Tau improved (p < 0.05) the serum lipid profile. Meanwhile, the smaller (p < 0.05) liver sizes and lower (p < 0.05) hepatic lipids in high-fat/cholesterol Dietary hamsters drinking Tau may be partially due to higher (p < 0.05) fecal cholesterol, triacylglycerol, and bile acid outputs. In the regulation of lipid homeostasis, drinking a Tau solution upregulated (p < 0.05) low-density lipoprotein receptor and CYP7A1 gene expressions in high-fat/cholesterol Dietary hamsters, which result in increased fecal cholesterol and bile acid outputs. Drinking a Tau solution also upregulated (p < 0.05) peroxisome proliferator-act...

  • taurine alleviates dyslipidemia and liver damage induced by a high fat cholesterol Dietary Habit
    Food Chemistry, 2010
    Co-Authors: Shunfa Yang, Yuanyen Chang, Kuotai Yang, Borshow Tzang, Yuanchao Hsiao, Chiho Chan, Yichen Chen
    Abstract:

    Eight male hamsters per group were assigned randomly to one of the following diets: chow diet (Control); high-fat/cholesterol diet (HFCD); HFCD supplemented with 1% Tau (HFCD/1% Tau); HFCD supplemented with 2% Tau (HFCD/2% Tau). Tau supplementation improved (P 0.05) changed by Tau supplementation, faecal cholesterol and bile acid outputs were increased (P < 0.05). Two percent Tau supplementation unregulated (P < 0.05) HMG-CoA reductase and cholesterol 7-a hydroxylase (CYP7A1) expressions in the high-fat/cholesterol-Dietary hamsters. Besides, Tau supplementation also increased (P < 0.05) LDL receptor mRNA expressions in high-fat/cholesterol-Dietary hamsters. Tau supplementation also reduced serum GPT and GOT values and C-reactive protein (CRP) levels in the high-fat/cholesterol-Dietary hamsters. Results clearly indicated that Tau could alleviate blood lipids and hepatic damage induced by a high-fat/cholesterol-Dietary diet.

Kuotai Yang - One of the best experts on this subject based on the ideXlab platform.

  • preventive effects of taurine on development of hepatic steatosis induced by a high fat cholesterol Dietary Habit
    Journal of Agricultural and Food Chemistry, 2011
    Co-Authors: Yuanyen Chang, Chunghsi O Chou, Chihhsien O Chiu, Kuotai Yang, Yiling Lin, Weilien Weng, Yichen Chen
    Abstract:

    Nonalcoholic fatty liver (NAFL) is also called hepatic steatosis and has become an emergent liver disease in developed and developing nations. This study was to exam the preventive effects of taurine (Tau) on the development of hepatic steatosis via a hamster model. Although hepatic steatosis of hamsters was induced by feeding a high-fat/cholesterol diet, drinking water containing 0.35 and 0.7% Tau improved (p < 0.05) the serum lipid profile. Meanwhile, the smaller (p < 0.05) liver sizes and lower (p < 0.05) hepatic lipids in high-fat/cholesterol Dietary hamsters drinking Tau may be partially due to higher (p < 0.05) fecal cholesterol, triacylglycerol, and bile acid outputs. In the regulation of lipid homeostasis, drinking a Tau solution upregulated (p < 0.05) low-density lipoprotein receptor and CYP7A1 gene expressions in high-fat/cholesterol Dietary hamsters, which result in increased fecal cholesterol and bile acid outputs. Drinking a Tau solution also upregulated (p < 0.05) peroxisome proliferator-activated receptor-α (PPAR-α) and uncoupling protein 2 (UPC2) gene expressions in high-fat/cholesterol Dietary hamsters, thus increasing energy expenditure. Besides, Tau also enhanced (p < 0.05) liver antioxidant capacities (GSH, TEAC, SOD, and CAT) and decreased (p < 0.05) lipid peroxidation (MDA), which alleviated liver damage in the high-fat/cholesterol Dietary hamsters. Therefore, Tau shows preventive effects on the development of hepatic steatosis induced by a high-fat/cholesterol Dietary Habit.

  • preventive effects of taurine on development of hepatic steatosis induced by a high fat cholesterol Dietary Habit
    Journal of Agricultural and Food Chemistry, 2011
    Co-Authors: Yuanyen Chang, Chunghsi O Chou, Chihhsien O Chiu, Kuotai Yang, Weilien Weng, Yichen Chen
    Abstract:

    Nonalcoholic fatty liver (NAFL) is also called hepatic steatosis and has become an emergent liver disease in developed and developing nations. This study was to exam the preventive effects of taurine (Tau) on the development of hepatic steatosis via a hamster model. Although hepatic steatosis of hamsters was induced by feeding a high-fat/cholesterol diet, drinking water containing 0.35 and 0.7% Tau improved (p < 0.05) the serum lipid profile. Meanwhile, the smaller (p < 0.05) liver sizes and lower (p < 0.05) hepatic lipids in high-fat/cholesterol Dietary hamsters drinking Tau may be partially due to higher (p < 0.05) fecal cholesterol, triacylglycerol, and bile acid outputs. In the regulation of lipid homeostasis, drinking a Tau solution upregulated (p < 0.05) low-density lipoprotein receptor and CYP7A1 gene expressions in high-fat/cholesterol Dietary hamsters, which result in increased fecal cholesterol and bile acid outputs. Drinking a Tau solution also upregulated (p < 0.05) peroxisome proliferator-act...

  • taurine alleviates dyslipidemia and liver damage induced by a high fat cholesterol Dietary Habit
    Food Chemistry, 2010
    Co-Authors: Shunfa Yang, Yuanyen Chang, Kuotai Yang, Borshow Tzang, Yuanchao Hsiao, Chiho Chan, Yichen Chen
    Abstract:

    Eight male hamsters per group were assigned randomly to one of the following diets: chow diet (Control); high-fat/cholesterol diet (HFCD); HFCD supplemented with 1% Tau (HFCD/1% Tau); HFCD supplemented with 2% Tau (HFCD/2% Tau). Tau supplementation improved (P 0.05) changed by Tau supplementation, faecal cholesterol and bile acid outputs were increased (P < 0.05). Two percent Tau supplementation unregulated (P < 0.05) HMG-CoA reductase and cholesterol 7-a hydroxylase (CYP7A1) expressions in the high-fat/cholesterol-Dietary hamsters. Besides, Tau supplementation also increased (P < 0.05) LDL receptor mRNA expressions in high-fat/cholesterol-Dietary hamsters. Tau supplementation also reduced serum GPT and GOT values and C-reactive protein (CRP) levels in the high-fat/cholesterol-Dietary hamsters. Results clearly indicated that Tau could alleviate blood lipids and hepatic damage induced by a high-fat/cholesterol-Dietary diet.

Young A Kim - One of the best experts on this subject based on the ideXlab platform.

Kiyoshi Tanaka - One of the best experts on this subject based on the ideXlab platform.

  • intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis
    PLOS ONE, 2020
    Co-Authors: I Murakami, Kosaku Murakami, Motomu Hashimoto, M Torii, Kaori Ikeda, Akiko Kuwabara, Masao Tanaka, Hiromu Ito, Takao Fujii, Kiyoshi Tanaka
    Abstract:

    Objective To clarify the relationship between Dietary Habit and disease activity of rheumatoid arthritis (RA). Methods This study enrolled RA patients who met the ACR/EULAR 2010 classification criteria from Kyoto University Rheumatoid Arthritis Management Alliance (KURAMA) cohort in 2015. 22-item food frequency questionnaire (FFQ) was taken for the measurement of Dietary Habit in a single-institution cohort of RA (Kyoto University Rheumatoid Arthritis Management Alliance: KURAMA) in 2015. The disease activities of RA using the Disease Activity Score calculated based on the erythrocyte sedimentation rate (DAS28-ESR), Simplified Disease Activity Index (SDAI), Health Assessment Questionnaire (HAQ), and serum matrix metalloproteinase-3 (MMP-3) level, the use of disease-modifying anti-rheumatic drugs (DMARDs), disease duration, rheumatoid factor, anti-cyclic citrullinated antibody, and body mass index were also examined. All of them were combined and statistically analyzed. Results 441 RA patients (81% women; mean age 65 years; mean disease duration 15 years) were enrolled from the KURAMA cohort. Average Disease Activity Score-28 using the erythrocyte sedimentation rate (DAS28-ESR) was 2.7. Univariate analysis showed that intake frequency of vegetables had a statistically significant negative correlation with disease activity markers, such as DAS28-ESR (ρ = −0.11, p<0.01), Simplified Disease Activity Index (SDAI) (ρ = −0.16, p<0.001), matrix metalloproteinase-3 (MMP-3) (ρ = −0.21, p<0.0001), and Health Assessment Questionnaire (HAQ) (ρ = −0.13, p<0.01). Factor analysis with varimax rotation was done to simplify the relevance of disease activity to various food items. 22 foods were categorized into five Dietary patterns: “seafoods”, “vegetables/fruits”, “meats/fried foods”, “snacks”, and “processed foods”. The multivariate analysis adjusted for clinically significant confounders showed that “seafoods” had statistically significant negative correlations with DAS28-ESR (β = −0.15, p<0.01), SDAI (β = −0.18, p<0.001), MMP-3 (β = −0.15, p<0.01), and HAQ (β = −0.24, p<0.0001). “Vegetables/fruits” had statistically significant negative correlations with SDAI (β = −0.11 p<0.05), MMP-3 (β = −0.12, p<0.01), and HAQ (β = −0.11, p<0.05) Conclusions These results suggest that high intake frequency of vegetables/fruits and/or seafoods might correlate with low disease activity.

  • ab1133 high consumption of seafoods or vegetables negatively correlates with disease activity of rheumatoid arthritis
    Annals of the Rheumatic Diseases, 2017
    Co-Authors: I Murakami, Kosaku Murakami, Motomu Hashimoto, M Torii, Kaori Ikeda, Akiko Kuwabara, Kiyoshi Tanaka, Akiko Yoshida, Takashi Usui, Nobuo Kuramoto
    Abstract:

    Background Food intake is one of the important environmental factors of various diseases, and possibly influences the pathogenesis of RA. However, we have little knowledge about the impact of food intake on the pathogenesis of RA. Because each country has its own food culture, the study focused on the Dietary Habit in Japan is essential in order to clarify the clinical impact of food intake in Japanese RA patients. Objectives The aim of this study is to clarify the relationship between the Dietary Habit of RA patients and their disease status. Methods We took the questionnaire survey about Dietary Habit in 2015, in KURAMA (Kyoto University Rheumatoid Arthritis Management Alliance) cohort as single institute. Disease activity was also examined in this cohort. These data were combined and statistically analyzed. Results 563 RA patients were enrolled from KURAMA cohort; female: male 4:1, age 63 years old, disease duration 15.5 years, DAS28-ESR 2.8 on average. Multivariate analysis showed that the intake frequency of vegetables had statistically significant negative correlation with DAS28-ESR (β=−0.17, p Conclusions This study implicates that the disease activity of RA may be alleviated by high consumption of vegetables and fruits, or seafoods. Disclosure of Interest None declared