The Experts below are selected from a list of 219 Experts worldwide ranked by ideXlab platform
İmge Birman - One of the best experts on this subject based on the ideXlab platform.
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liquid phase equilibria of water formic acid Diethyl carbonate or Diethyl malonate or Diethyl Fumarate ternary systems at 298 15 k and atmospheric pressure
Fluid Phase Equilibria, 2011Co-Authors: Mehmet Bilgin, İmge BirmanAbstract:Abstract In the scope of investigating new solvents as potential replacements for chlorocarbons or aromatic hydrocarbons for separation of carboxylic acids from dilute aqueous solution, we have focused on the dibasic esters, which have perfect properties for industrial applications. For this purpose, liquid–liquid equilibrium data for water + formic acid + solvent (Diethyl carbonate or Diethyl malonate or Diethyl Fumarate) ternary systems were investigated at 298.15 K and atmospheric pressure. The equilibrium results consisted of solubility data and tie-lines were presented in ternary phase diagrams. The reliability of the experimental tie-lines was confirmed by using Othmer–Tobias correlation. The experimental tie-line data were correlated by UNIQUAC model, which gave satisfactory representation for the systems. It is concluded that Diethyl carbonate, Diethyl malonate and Diethyl Fumarate may be adequate solvents to extract formic acid from its dilute aqueous solutions.
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Liquid phase equilibria of (water + formic acid + Diethyl carbonate or Diethyl malonate or Diethyl Fumarate) ternary systems at 298.15 K and atmospheric pressure
Fluid Phase Equilibria, 2010Co-Authors: Mehmet Bilgin, İmge BirmanAbstract:Abstract In the scope of investigating new solvents as potential replacements for chlorocarbons or aromatic hydrocarbons for separation of carboxylic acids from dilute aqueous solution, we have focused on the dibasic esters, which have perfect properties for industrial applications. For this purpose, liquid–liquid equilibrium data for water + formic acid + solvent (Diethyl carbonate or Diethyl malonate or Diethyl Fumarate) ternary systems were investigated at 298.15 K and atmospheric pressure. The equilibrium results consisted of solubility data and tie-lines were presented in ternary phase diagrams. The reliability of the experimental tie-lines was confirmed by using Othmer–Tobias correlation. The experimental tie-line data were correlated by UNIQUAC model, which gave satisfactory representation for the systems. It is concluded that Diethyl carbonate, Diethyl malonate and Diethyl Fumarate may be adequate solvents to extract formic acid from its dilute aqueous solutions.
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Separation of propionic acid by Diethyl carbonate or Diethyl malonate or Diethyl Fumarate and the synergistic effect of phosphorus compounds and amines
Fluid Phase Equilibria, 2010Co-Authors: Mehmet Bilgin, İmge BirmanAbstract:Abstract The recovery of propionic acid from aqueous solutions such as fermentation broth and wastewater is an important problem where liquid extraction is the favorite process. Liquid–liquid equilibrium (LLE) data were investigated for mixtures of water + propionic acid + Diethyl carbonate or Diethyl malonate or Diethyl Fumarate at 298.15 K. The solubility curves and the tie-line end compositions of liquid phases at equilibrium were determined experimentally, and the tie-line results compared with the data correlated by means of UNIQUAC model. The phase diagrams for the ternary mixtures including both the experimental and correlated tie-lines are presented. The reliability of the experimental tie-lines was confirmed by using Othmer–Tobias correlation. The distribution coefficients and the separation factors for the immiscibility region are calculated. In order to boost the distribution of propionic acid between aqueous and organic phases, the distribution was investigated by using organic solutions composed of amine {tributylamine (TBA)} and phosphorus containing compounds {trioctylphosphine oxide (TOPO) or tributyl phosphate (TBP)} dissolved in Diethyl carbonate, Diethyl malonate and Diethyl Fumarate, in the concentration range of about 0.06–1.00 mol/l. It was observed that the used solvents may serve individually as adequate agents to extract propionic acid from its dilute aqueous solution; however, the extraction performance can be improved by using phosphorus containing compounds or amines, mostly by using tributylamine dissolved in Diethylmalonate.
Mojca Škerget - One of the best experts on this subject based on the ideXlab platform.
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Determination of Vapor–Liquid Equilibria of the Binary System of Sub- and Supercritical CO2 and Diethyl Fumarate
Journal of Chemical & Engineering Data, 2014Co-Authors: D. Čuček, Željko Knez, Mojca ŠkergetAbstract:High-pressure liquid–vapor phase equilibrium data (P–T–x–y) for the binary mixture of the ester Diethyl Fumarate with CO2 have been measured at temperatures of (373.2, 398.2, 423.2, and 453.2) K over the pressure range from (2.5 to 23) MPa using a static-analytic method. The results show that the molar fraction of CO2 in the liquid phase increases with increasing pressure at the studied temperatures and decreases with increasing temperature at constant pressure, while the composition of the light phase remains more or less unchanged. The experimental results were correlated using the Peng–Robinson equation of state in combination with one fluid mixing rule with two adjustable parameters, and the binary interaction parameters were calculated as functions of temperature. Overall, the absolute average relative deviations of the model from the data obtained for the light and heavy phases ranged from (8 to 10) % and (4 to 12) %, respectively.
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determination of vapor liquid equilibria of the binary system of sub and supercritical co2 and Diethyl Fumarate
Journal of Chemical & Engineering Data, 2014Co-Authors: D Cucek, Željko Knez, Mojca ŠkergetAbstract:High-pressure liquid–vapor phase equilibrium data (P–T–x–y) for the binary mixture of the ester Diethyl Fumarate with CO2 have been measured at temperatures of (373.2, 398.2, 423.2, and 453.2) K over the pressure range from (2.5 to 23) MPa using a static-analytic method. The results show that the molar fraction of CO2 in the liquid phase increases with increasing pressure at the studied temperatures and decreases with increasing temperature at constant pressure, while the composition of the light phase remains more or less unchanged. The experimental results were correlated using the Peng–Robinson equation of state in combination with one fluid mixing rule with two adjustable parameters, and the binary interaction parameters were calculated as functions of temperature. Overall, the absolute average relative deviations of the model from the data obtained for the light and heavy phases ranged from (8 to 10) % and (4 to 12) %, respectively.
Mehmet Bilgin - One of the best experts on this subject based on the ideXlab platform.
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liquid phase equilibria of water formic acid Diethyl carbonate or Diethyl malonate or Diethyl Fumarate ternary systems at 298 15 k and atmospheric pressure
Fluid Phase Equilibria, 2011Co-Authors: Mehmet Bilgin, İmge BirmanAbstract:Abstract In the scope of investigating new solvents as potential replacements for chlorocarbons or aromatic hydrocarbons for separation of carboxylic acids from dilute aqueous solution, we have focused on the dibasic esters, which have perfect properties for industrial applications. For this purpose, liquid–liquid equilibrium data for water + formic acid + solvent (Diethyl carbonate or Diethyl malonate or Diethyl Fumarate) ternary systems were investigated at 298.15 K and atmospheric pressure. The equilibrium results consisted of solubility data and tie-lines were presented in ternary phase diagrams. The reliability of the experimental tie-lines was confirmed by using Othmer–Tobias correlation. The experimental tie-line data were correlated by UNIQUAC model, which gave satisfactory representation for the systems. It is concluded that Diethyl carbonate, Diethyl malonate and Diethyl Fumarate may be adequate solvents to extract formic acid from its dilute aqueous solutions.
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Liquid phase equilibria of (water + formic acid + Diethyl carbonate or Diethyl malonate or Diethyl Fumarate) ternary systems at 298.15 K and atmospheric pressure
Fluid Phase Equilibria, 2010Co-Authors: Mehmet Bilgin, İmge BirmanAbstract:Abstract In the scope of investigating new solvents as potential replacements for chlorocarbons or aromatic hydrocarbons for separation of carboxylic acids from dilute aqueous solution, we have focused on the dibasic esters, which have perfect properties for industrial applications. For this purpose, liquid–liquid equilibrium data for water + formic acid + solvent (Diethyl carbonate or Diethyl malonate or Diethyl Fumarate) ternary systems were investigated at 298.15 K and atmospheric pressure. The equilibrium results consisted of solubility data and tie-lines were presented in ternary phase diagrams. The reliability of the experimental tie-lines was confirmed by using Othmer–Tobias correlation. The experimental tie-line data were correlated by UNIQUAC model, which gave satisfactory representation for the systems. It is concluded that Diethyl carbonate, Diethyl malonate and Diethyl Fumarate may be adequate solvents to extract formic acid from its dilute aqueous solutions.
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Separation of propionic acid by Diethyl carbonate or Diethyl malonate or Diethyl Fumarate and the synergistic effect of phosphorus compounds and amines
Fluid Phase Equilibria, 2010Co-Authors: Mehmet Bilgin, İmge BirmanAbstract:Abstract The recovery of propionic acid from aqueous solutions such as fermentation broth and wastewater is an important problem where liquid extraction is the favorite process. Liquid–liquid equilibrium (LLE) data were investigated for mixtures of water + propionic acid + Diethyl carbonate or Diethyl malonate or Diethyl Fumarate at 298.15 K. The solubility curves and the tie-line end compositions of liquid phases at equilibrium were determined experimentally, and the tie-line results compared with the data correlated by means of UNIQUAC model. The phase diagrams for the ternary mixtures including both the experimental and correlated tie-lines are presented. The reliability of the experimental tie-lines was confirmed by using Othmer–Tobias correlation. The distribution coefficients and the separation factors for the immiscibility region are calculated. In order to boost the distribution of propionic acid between aqueous and organic phases, the distribution was investigated by using organic solutions composed of amine {tributylamine (TBA)} and phosphorus containing compounds {trioctylphosphine oxide (TOPO) or tributyl phosphate (TBP)} dissolved in Diethyl carbonate, Diethyl malonate and Diethyl Fumarate, in the concentration range of about 0.06–1.00 mol/l. It was observed that the used solvents may serve individually as adequate agents to extract propionic acid from its dilute aqueous solution; however, the extraction performance can be improved by using phosphorus containing compounds or amines, mostly by using tributylamine dissolved in Diethylmalonate.
Antonios G Mikos - One of the best experts on this subject based on the ideXlab platform.
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photocrosslinking characteristics and mechanical properties of Diethyl Fumarate poly propylene Fumarate biomaterials
Biomaterials, 2002Co-Authors: John Fisher, David Dean, Antonios G MikosAbstract:The development of tissue engineered materials for the treatment of large bone defects would provide attractive alternatives to the autografts, allografts, non-degradable polymers, ceramics, and metals that are currently used in clinical settings. To this end, poly(propylene Fumarate) (PPF), a viscous polyester synthesized from Diethyl Fumarate (DEF), has been studied for use as an engineered bone graft. We have investigated the photocrosslinking of PPF dissolved in its precursor, DEF, using the photoinitiator bis(2,4,6-trimethylbenzoyl) phenylphosphine oxide (BAPO) and low levels of ultraviolet light exposure. A three factor, 2 x 2 x 4 factorial design was developed, studying the effects of PPF number average molecular weight, BAPO initiator content, and DEF content upon photocrosslinking characteristics and mechanical properties. Uncured DEF/PPF solution viscosity fell over three orders of magnitude as DEF content was increased from 0% to 75%. The exothermic photocrosslinking reaction released low levels of heat, with no more than 160J/g released from any formulation tested. As a result, the maximum photocrosslinking temperature remained below 47 degrees C for all samples. Both sol fraction and swelling degree generally increased with increasing DEF content. Compressive mechanical properties were within the range of trabecular bone, with the strongest samples possessing an elastic modulus of 195.3 +/- 17.5 MPa and a fracture strength of 68.8 +/- 9.4MPa. Finally, the results indicate that PPF crosslinking was facilitated at low DEF precursor concentrations, but hindered at higher precursor concentrations. These novel DEF/PPF solutions may be preferred over pure PPF as the basis for an engineered bone graft because they (1) exhibit reduced viscosity and thus are easily handled, (2) form polymer networks with compressive strength at fracture suitable for consideration for trabecular bone replacement, and (3) may be readily fabricated into solids with a wide range of structures.
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kinetics of poly propylene Fumarate synthesis by step polymerization of Diethyl Fumarate and propylene glycol using zinc chloride as a catalyst
Journal of Biomaterials Science-polymer Edition, 2002Co-Authors: Albert K Shung, Mark D Timmer, Seongbong Jo, Paul S Engel, Antonios G MikosAbstract:Diethyl Fumarate and propylene glycol were reacted in the presence of a zinc chloride catalyst to synthesize poly(propylene Fumarate) (PPF) over a period of 12 hours. The kinetics of the transester...
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Photocrosslinking characteristics and mechanical properties of Diethyl Fumarate/poly(propylene Fumarate) biomaterials.
Biomaterials, 2002Co-Authors: John Fisher, David Dean, Antonios G MikosAbstract:The development of tissue engineered materials for the treatment of large bone defects would provide attractive alternatives to the autografts, allografts, non-degradable polymers, ceramics, and metals that are currently used in clinical settings. To this end, poly(propylene Fumarate) (PPF), a viscous polyester synthesized from Diethyl Fumarate (DEF), has been studied for use as an engineered bone graft. We have investigated the photocrosslinking of PPF dissolved in its precursor, DEF, using the photoinitiator bis(2,4,6-trimethylbenzoyl) phenylphosphine oxide (BAPO) and low levels of ultraviolet light exposure. A three factor, 2 x 2 x 4 factorial design was developed, studying the effects of PPF number average molecular weight, BAPO initiator content, and DEF content upon photocrosslinking characteristics and mechanical properties. Uncured DEF/PPF solution viscosity fell over three orders of magnitude as DEF content was increased from 0% to 75%. The exothermic photocrosslinking reaction released low levels of heat, with no more than 160J/g released from any formulation tested. As a result, the maximum photocrosslinking temperature remained below 47 degrees C for all samples. Both sol fraction and swelling degree generally increased with increasing DEF content. Compressive mechanical properties were within the range of trabecular bone, with the strongest samples possessing an elastic modulus of 195.3 +/- 17.5 MPa and a fracture strength of 68.8 +/- 9.4MPa. Finally, the results indicate that PPF crosslinking was facilitated at low DEF precursor concentrations, but hindered at higher precursor concentrations. These novel DEF/PPF solutions may be preferred over pure PPF as the basis for an engineered bone graft because they (1) exhibit reduced viscosity and thus are easily handled, (2) form polymer networks with compressive strength at fracture suitable for consideration for trabecular bone replacement, and (3) may be readily fabricated into solids with a wide range of structures.
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kinetics of poly propylene Fumarate synthesis by step polymerization of Diethyl Fumarate and propylene glycol using zinc chloride as a catalyst
Journal of Biomaterials Science-polymer Edition, 2002Co-Authors: Albert K Shung, Mark D Timmer, Paul S Engel, Antonios G MikosAbstract:Diethyl Fumarate and propylene glycol were reacted in the presence of a zinc chloride catalyst to synthesize poly(propylene Fumarate) (PPF) over a period of 12 hours. The kinetics of the transesterification polymerization at 130 degrees C, 150 degrees C, and 200 degrees C were determined by gel permeation chromatography (GPC) analysis. The initial rate of polymerization at each temperature was quantified by calculating the rate of change of the number average molecular weight (Mn). At 200 degrees C, gelation of the PPF occurred after 4 h. GPC analysis of the reaction showed that PPF synthesized at 150 degrees C had a higher final Mn of 4600 (+/- 190) and a higher weight average molecular weight of 10500 (+/- 760) than at 130 degrees C (n = 3). The chemical structure of the PPF was verified by NMR and FT-IR analysis. This study demonstrated that the maximum Mn of PPF by a transesterification reaction is limited due to gelation of PPF at high temperature.
Michèle P. Bertrand - One of the best experts on this subject based on the ideXlab platform.
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Aminomethylation of Michael Acceptors: Complementary Radical and Polar Approaches Mediated by Dialkylzincs
Chemistry (Weinheim an der Bergstrasse Germany), 2012Co-Authors: Julien Maury, Laurence Feray, Dominique Mouysset, Sylvain R. A. Marque, Didier Siri, Michèle P. BertrandAbstract:Phtalimidomethyl iodide and substituted maleimidomethyl iodide were used as radical precursors in dialkylzinc-mediated radical addition to Diethyl Fumarate. The reactions led stereoselectively to functionalized pyrrolizidines. The radical mechanism was supported by spin-trapping experiments and rationalized by theoretical calculations. Radical additions, on the one hand, and carbozincation followed by transmetalation with copper(I), on the other, were shown to be complementary methods to achieve the formal aminomethylation of activated unsaturated compounds.
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A flexible, stereoselective dimethylzinc-mediated radical-anionic cascade: dramatic influence of additional Lewis acids.
Organic letters, 2010Co-Authors: Julien Maury, Laurence Feray, Patricia Perfetti, Michèle P. BertrandAbstract:Dimethylzinc-mediated addition of acyloxymethyl radicals to Diethyl Fumarate led to the highly stereoselective formation of disubstituted γ-lactones in mean to good yields; this cascade provides a ...
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A Flexible, Stereoselective Dimethylzinc-Mediated Radical-Anionic Cascade: Dramatic Influence of Additional Lewis Acids
Organic Letters, 2010Co-Authors: Julien Maury, Laurence Feray, Patricia Perfetti, Michèle P. BertrandAbstract:Dimethylzinc-mediated addition of acyloxymethyl radicals to Diethyl Fumarate led to the highly stereoselective formation of disubstituted gamma-lactones in mean to good yields; this cascade provides a new example of a one-pot process mediated by dimethylzinc involving a tandem radical-anionic reaction; the chemoselectivity of the reaction was totally modified by additional Lewis acids.