The Experts below are selected from a list of 78 Experts worldwide ranked by ideXlab platform
Howard A. Stone - One of the best experts on this subject based on the ideXlab platform.
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Cellular-scale hydrodynamics
Biomedical materials (Bristol England), 2008Co-Authors: Manouk Abkarian, Magalie Faivre, Renita E. Horton, Kristian Smistrup, Catherine Best-popescu, Howard A. StoneAbstract:Microfluidic tools are providing many new insights into the chemical, physical and physicochemical responses of cells. Both suspension-level and single-cell measurements have been studied. We review our studies of these kinds of problems for red blood cells with particular focus on the shapes of individual cells in confined geometries, the development and use of a 'Differential Manometer' for evaluating the mechanical response of individual cells or other objects flowing in confined geometries, and the cross-streamline drift of cells that pass through a constriction. In particular, we show how fluid mechanical effects on suspended cells can be studied systematically in small devices, and how these features can be exploited to develop methods for characterizing physicochemical responses and possibly for the diagnosis of cellular-scale changes to environmental factors.
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High-speed microfluidic Differential Manometer for cellular-scale hydrodynamics
Proceedings of the National Academy of Sciences of the United States of America, 2006Co-Authors: Manouk Abkarian, Magalie Faivre, Howard A. StoneAbstract:We propose a broadly applicable high-speed microfluidic approach for measuring dynamical pressure-drop variations along a micrometer-sized channel and illustrate the potential of the technique by presenting measurements of the additional pressure drop produced at the scale of individual flowing cells. The influence of drug-modified mechanical properties of the cell membrane is shown. Finally, single hemolysis events during flow are recorded simultaneously with the critical pressure drop for the rupture of the membrane. This scale-independent measurement approach can be applied to any dynamical process or event that changes the hydrodynamic resistance of micro- or nanochannels.
Manouk Abkarian - One of the best experts on this subject based on the ideXlab platform.
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Cellular-scale hydrodynamics
Biomedical materials (Bristol England), 2008Co-Authors: Manouk Abkarian, Magalie Faivre, Renita E. Horton, Kristian Smistrup, Catherine Best-popescu, Howard A. StoneAbstract:Microfluidic tools are providing many new insights into the chemical, physical and physicochemical responses of cells. Both suspension-level and single-cell measurements have been studied. We review our studies of these kinds of problems for red blood cells with particular focus on the shapes of individual cells in confined geometries, the development and use of a 'Differential Manometer' for evaluating the mechanical response of individual cells or other objects flowing in confined geometries, and the cross-streamline drift of cells that pass through a constriction. In particular, we show how fluid mechanical effects on suspended cells can be studied systematically in small devices, and how these features can be exploited to develop methods for characterizing physicochemical responses and possibly for the diagnosis of cellular-scale changes to environmental factors.
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Cellular-scale hydrodynamics
Biomedical Materials, 2008Co-Authors: Manouk Abkarian, Magalie Faivre, Kristian Smistrup, Catherine Best-popescu, Renita Horton, Howard StoneAbstract:Continuous and simultaneous measurement of the tank-treading motion of red blood cells and the surrounding flow using translational confocal micro-particle image velocimetry (micro-PIV) with sub-micron resolution M Oishi, K Utsubo, H Kinoshita et al. Abstract Microfluidic tools are providing many new insights into the chemical, physical and physicochemical responses of cells. Both suspension-level and single-cell measurements have been studied. We review our studies of these kinds of problems for red blood cells with particular focus on the shapes of individual cells in confined geometries, the development and use of a 'Differential Manometer' for evaluating the mechanical response of individual cells or other objects flowing in confined geometries, and the cross-streamline drift of cells that pass through a constriction. In particular, we show how fluid mechanical effects on suspended cells can be studied systematically in small devices, and how these features can be exploited to develop methods for characterizing physicochemical responses and possibly for the diagnosis of cellular-scale changes to environmental factors.
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High-speed microfluidic Differential Manometer for cellular-scale hydrodynamics
Proceedings of the National Academy of Sciences of the United States of America, 2006Co-Authors: Manouk Abkarian, Magalie Faivre, Howard A. StoneAbstract:We propose a broadly applicable high-speed microfluidic approach for measuring dynamical pressure-drop variations along a micrometer-sized channel and illustrate the potential of the technique by presenting measurements of the additional pressure drop produced at the scale of individual flowing cells. The influence of drug-modified mechanical properties of the cell membrane is shown. Finally, single hemolysis events during flow are recorded simultaneously with the critical pressure drop for the rupture of the membrane. This scale-independent measurement approach can be applied to any dynamical process or event that changes the hydrodynamic resistance of micro- or nanochannels.
Magalie Faivre - One of the best experts on this subject based on the ideXlab platform.
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Cellular-scale hydrodynamics
Biomedical materials (Bristol England), 2008Co-Authors: Manouk Abkarian, Magalie Faivre, Renita E. Horton, Kristian Smistrup, Catherine Best-popescu, Howard A. StoneAbstract:Microfluidic tools are providing many new insights into the chemical, physical and physicochemical responses of cells. Both suspension-level and single-cell measurements have been studied. We review our studies of these kinds of problems for red blood cells with particular focus on the shapes of individual cells in confined geometries, the development and use of a 'Differential Manometer' for evaluating the mechanical response of individual cells or other objects flowing in confined geometries, and the cross-streamline drift of cells that pass through a constriction. In particular, we show how fluid mechanical effects on suspended cells can be studied systematically in small devices, and how these features can be exploited to develop methods for characterizing physicochemical responses and possibly for the diagnosis of cellular-scale changes to environmental factors.
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Cellular-scale hydrodynamics
Biomedical Materials, 2008Co-Authors: Manouk Abkarian, Magalie Faivre, Kristian Smistrup, Catherine Best-popescu, Renita Horton, Howard StoneAbstract:Continuous and simultaneous measurement of the tank-treading motion of red blood cells and the surrounding flow using translational confocal micro-particle image velocimetry (micro-PIV) with sub-micron resolution M Oishi, K Utsubo, H Kinoshita et al. Abstract Microfluidic tools are providing many new insights into the chemical, physical and physicochemical responses of cells. Both suspension-level and single-cell measurements have been studied. We review our studies of these kinds of problems for red blood cells with particular focus on the shapes of individual cells in confined geometries, the development and use of a 'Differential Manometer' for evaluating the mechanical response of individual cells or other objects flowing in confined geometries, and the cross-streamline drift of cells that pass through a constriction. In particular, we show how fluid mechanical effects on suspended cells can be studied systematically in small devices, and how these features can be exploited to develop methods for characterizing physicochemical responses and possibly for the diagnosis of cellular-scale changes to environmental factors.
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High-speed microfluidic Differential Manometer for cellular-scale hydrodynamics
Proceedings of the National Academy of Sciences of the United States of America, 2006Co-Authors: Manouk Abkarian, Magalie Faivre, Howard A. StoneAbstract:We propose a broadly applicable high-speed microfluidic approach for measuring dynamical pressure-drop variations along a micrometer-sized channel and illustrate the potential of the technique by presenting measurements of the additional pressure drop produced at the scale of individual flowing cells. The influence of drug-modified mechanical properties of the cell membrane is shown. Finally, single hemolysis events during flow are recorded simultaneously with the critical pressure drop for the rupture of the membrane. This scale-independent measurement approach can be applied to any dynamical process or event that changes the hydrodynamic resistance of micro- or nanochannels.
G Tsipolitis - One of the best experts on this subject based on the ideXlab platform.
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a gas leak rate measurement system for the atlas muon bis monitored drift tubes
Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment, 2004Co-Authors: Theocharis Alexopoulos, R Avramidou, E Dris, T A Filippas, E N Gazis, E Katsoufis, S Maltezos, P Savva, George Stavropoulos, G TsipolitisAbstract:A low-cost and reliable system is presented which was developed for the gas leak rate measurement of the BIS-Monitored Drift Tubes (MDT) to be used for the Muon Spectrometer of the ATLAS experiment at LHC. In order to meet the ATLAS schedule, 100 MDTs are tested simultaneously each time by the developed setup. The method used is based on the measurement of the gas pressure drop in each MDT with respect to the pressure of a gas tight reference tube within a time interval of 48 h and is accomplished with a Differential Manometer. A high degree of temperature stability and homogeneity is achieved inside two thermally insulated boxes and leads to a satisfactory accuracy for the measurement of the gas leak rates. The developed system is appropriate within the ATLAS specifications for mass production. More than 18500 MDTs have been tested up to now and the obtained results are presented.
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A gas leak rate measurement system for the ATLAS MUON BIS-monitored drift tubes
Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment, 2004Co-Authors: Theocharis Alexopoulos, R Avramidou, E Dris, T A Filippas, E N Gazis, E Katsoufis, S Maltezos, P Savva, George Stavropoulos, G TsipolitisAbstract:A low-cost, reliable and precise system developed for the gas leak rate measurement of the BIS-Monitored Drift Tubes (MDTs) for the ATLAS Muon Spectrometer is presented. In order to meet the BIS-MDT mass production rate, a total number of 100 tubes are tested simultaneously in this setup. The pressure drop of each one of the MDT is measured, within a typical time interval of 48 hours, via a Differential Manometer comparing with the pressure of a gas tight reference tube. The precision of the method implemented is based on the system temperature homogeneity, with accuracy of ÄT = 0.3 oC. For this reason, two thermally isolated boxes are used testing 50 tubes each of them, to achieve high degree of temperature uniformity and stability. After measuring several thousands of the MDTs, the developed system is confirmed to be appropriate within the specifications for testing the MDTs during the mass production
Howard Stone - One of the best experts on this subject based on the ideXlab platform.
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Cellular-scale hydrodynamics
Biomedical Materials, 2008Co-Authors: Manouk Abkarian, Magalie Faivre, Kristian Smistrup, Catherine Best-popescu, Renita Horton, Howard StoneAbstract:Continuous and simultaneous measurement of the tank-treading motion of red blood cells and the surrounding flow using translational confocal micro-particle image velocimetry (micro-PIV) with sub-micron resolution M Oishi, K Utsubo, H Kinoshita et al. Abstract Microfluidic tools are providing many new insights into the chemical, physical and physicochemical responses of cells. Both suspension-level and single-cell measurements have been studied. We review our studies of these kinds of problems for red blood cells with particular focus on the shapes of individual cells in confined geometries, the development and use of a 'Differential Manometer' for evaluating the mechanical response of individual cells or other objects flowing in confined geometries, and the cross-streamline drift of cells that pass through a constriction. In particular, we show how fluid mechanical effects on suspended cells can be studied systematically in small devices, and how these features can be exploited to develop methods for characterizing physicochemical responses and possibly for the diagnosis of cellular-scale changes to environmental factors.