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He-sheng Luo - One of the best experts on this subject based on the ideXlab platform.

  • Retrospective analysis of correlative factors between Digestive System Injury and anticoagulant or antiplatelet-agents
    Zhonghua yi xue za zhi, 2014
    Co-Authors: Ning Cui, He-sheng Luo
    Abstract:

    Objective To explore the correlative factors and clinical characteristics of Digestive System Injury during the treatment of anticoagulant and (or) antiplatelet-agents. Methods A total of 1 443 hospitalized patients on anticoagulant and (or) antiplatelet-agents from January 2010 to December 2013 at Renmin Hospital of Wuhan University were analyzed retrospectively. Results Their length of hospital stay was from 5 to 27 days. Most of them were elderly males (n=880, 61.0%) with an average age of(62±6)years. 1 138 patients (78.9%) were farmers, workers or someone without a specific occupation. During the treatment of anticoagulant/antiplatelet-agents, statistical difference existed (P=0.01) between positively and negatively previous Digestive disease groups for actively newly occurring Digestive System Injury (16.0%(41/256) vs 15.9%(189/1 187)). After the dosing of anticoagulant and (or) antiplatelet-agents, 57 (66.3%, 57/86) patients were complicated by hemorrhage of Digestive tract, taking 62.9% (61/97) of all positive result patients for Helicobacter pylori test. Comparing preventive PPI group with no PPI group, there was no marked statistical differences (P=2.67) for Digestive System complication (including hemorrhage of Digestive tract) while receiving anticoagulant and (or) antiplatelet-agents (13.9%(74/533) vs 17.1%(156/910)). During anticoagulant and/or antiplatelet-agent therapy, 185 patients (12.8%) were complicated by peptic ulcer or peptic ulcer with bleeding, 40 patients (2.8%) had erosive gastritis and 5 (0.3%) developed acute gastric mucosal lesions. And 42 of 76 patients complicated by hemorrhage of Digestive tract underwent endoscopic hemostasis while 2 patients were operated. Ninety-seven patients(6.7%)died, including 61 (62.9%, 61/97) from hemorrhage of Digestive tract. The remainder became cured, improved and discharged. Moreover, no significant statistical differences existed (P=2.29) among three combination group (aspirin, clopidogrel, warfarin), two combination group (aspirin, clopidogrel), exclusive aspirin group and exclusive warfarin group in short-term (

  • retrospective analysis of correlative factors between Digestive System Injury and anticoagulant or antiplatelet agents
    National Medical Journal of China, 2014
    Co-Authors: Ning Cui, He-sheng Luo
    Abstract:

    Objective To explore the correlative factors and clinical characteristics of Digestive System Injury during the treatment of anticoagulant and (or) antiplatelet-agents. Methods A total of 1 443 hospitalized patients on anticoagulant and (or) antiplatelet-agents from January 2010 to December 2013 at Renmin Hospital of Wuhan University were analyzed retrospectively. Results Their length of hospital stay was from 5 to 27 days. Most of them were elderly males (n=880, 61.0%) with an average age of(62±6)years. 1 138 patients (78.9%) were farmers, workers or someone without a specific occupation. During the treatment of anticoagulant/antiplatelet-agents, statistical difference existed (P=0.01) between positively and negatively previous Digestive disease groups for actively newly occurring Digestive System Injury (16.0%(41/256) vs 15.9%(189/1 187)). After the dosing of anticoagulant and (or) antiplatelet-agents, 57 (66.3%, 57/86) patients were complicated by hemorrhage of Digestive tract, taking 62.9% (61/97) of all positive result patients for Helicobacter pylori test. Comparing preventive PPI group with no PPI group, there was no marked statistical differences (P=2.67) for Digestive System complication (including hemorrhage of Digestive tract) while receiving anticoagulant and (or) antiplatelet-agents (13.9%(74/533) vs 17.1%(156/910)). During anticoagulant and/or antiplatelet-agent therapy, 185 patients (12.8%) were complicated by peptic ulcer or peptic ulcer with bleeding, 40 patients (2.8%) had erosive gastritis and 5 (0.3%) developed acute gastric mucosal lesions. And 42 of 76 patients complicated by hemorrhage of Digestive tract underwent endoscopic hemostasis while 2 patients were operated. Ninety-seven patients(6.7%)died, including 61 (62.9%, 61/97) from hemorrhage of Digestive tract. The remainder became cured, improved and discharged. Moreover, no significant statistical differences existed (P=2.29) among three combination group (aspirin, clopidogrel, warfarin), two combination group (aspirin, clopidogrel), exclusive aspirin group and exclusive warfarin group in short-term (<27 d) mortality. Conclusions It is necessary to clearly dictate the details of medication to the patients not highly educated. Elder, male, history of Digestive System disease and Helicobacter pylori infection are possibly highly risk correlative factors for Digestive System complications during anticoagulant/antiplatelet-agent therapy. The short-term protective effect of routine dose of PPI is inconspicuous. No significant correlation exists between short-term mortality and the dosage (or type) of anticoagulant/antiplatelet-agents. Key words: Anticoagulants; Platelet aggregation inhibitors; Digestive System diseases; Hemorrhage

Ning Cui - One of the best experts on this subject based on the ideXlab platform.

  • Retrospective analysis of correlative factors between Digestive System Injury and anticoagulant or antiplatelet-agents
    Zhonghua yi xue za zhi, 2014
    Co-Authors: Ning Cui, He-sheng Luo
    Abstract:

    Objective To explore the correlative factors and clinical characteristics of Digestive System Injury during the treatment of anticoagulant and (or) antiplatelet-agents. Methods A total of 1 443 hospitalized patients on anticoagulant and (or) antiplatelet-agents from January 2010 to December 2013 at Renmin Hospital of Wuhan University were analyzed retrospectively. Results Their length of hospital stay was from 5 to 27 days. Most of them were elderly males (n=880, 61.0%) with an average age of(62±6)years. 1 138 patients (78.9%) were farmers, workers or someone without a specific occupation. During the treatment of anticoagulant/antiplatelet-agents, statistical difference existed (P=0.01) between positively and negatively previous Digestive disease groups for actively newly occurring Digestive System Injury (16.0%(41/256) vs 15.9%(189/1 187)). After the dosing of anticoagulant and (or) antiplatelet-agents, 57 (66.3%, 57/86) patients were complicated by hemorrhage of Digestive tract, taking 62.9% (61/97) of all positive result patients for Helicobacter pylori test. Comparing preventive PPI group with no PPI group, there was no marked statistical differences (P=2.67) for Digestive System complication (including hemorrhage of Digestive tract) while receiving anticoagulant and (or) antiplatelet-agents (13.9%(74/533) vs 17.1%(156/910)). During anticoagulant and/or antiplatelet-agent therapy, 185 patients (12.8%) were complicated by peptic ulcer or peptic ulcer with bleeding, 40 patients (2.8%) had erosive gastritis and 5 (0.3%) developed acute gastric mucosal lesions. And 42 of 76 patients complicated by hemorrhage of Digestive tract underwent endoscopic hemostasis while 2 patients were operated. Ninety-seven patients(6.7%)died, including 61 (62.9%, 61/97) from hemorrhage of Digestive tract. The remainder became cured, improved and discharged. Moreover, no significant statistical differences existed (P=2.29) among three combination group (aspirin, clopidogrel, warfarin), two combination group (aspirin, clopidogrel), exclusive aspirin group and exclusive warfarin group in short-term (

  • retrospective analysis of correlative factors between Digestive System Injury and anticoagulant or antiplatelet agents
    National Medical Journal of China, 2014
    Co-Authors: Ning Cui, He-sheng Luo
    Abstract:

    Objective To explore the correlative factors and clinical characteristics of Digestive System Injury during the treatment of anticoagulant and (or) antiplatelet-agents. Methods A total of 1 443 hospitalized patients on anticoagulant and (or) antiplatelet-agents from January 2010 to December 2013 at Renmin Hospital of Wuhan University were analyzed retrospectively. Results Their length of hospital stay was from 5 to 27 days. Most of them were elderly males (n=880, 61.0%) with an average age of(62±6)years. 1 138 patients (78.9%) were farmers, workers or someone without a specific occupation. During the treatment of anticoagulant/antiplatelet-agents, statistical difference existed (P=0.01) between positively and negatively previous Digestive disease groups for actively newly occurring Digestive System Injury (16.0%(41/256) vs 15.9%(189/1 187)). After the dosing of anticoagulant and (or) antiplatelet-agents, 57 (66.3%, 57/86) patients were complicated by hemorrhage of Digestive tract, taking 62.9% (61/97) of all positive result patients for Helicobacter pylori test. Comparing preventive PPI group with no PPI group, there was no marked statistical differences (P=2.67) for Digestive System complication (including hemorrhage of Digestive tract) while receiving anticoagulant and (or) antiplatelet-agents (13.9%(74/533) vs 17.1%(156/910)). During anticoagulant and/or antiplatelet-agent therapy, 185 patients (12.8%) were complicated by peptic ulcer or peptic ulcer with bleeding, 40 patients (2.8%) had erosive gastritis and 5 (0.3%) developed acute gastric mucosal lesions. And 42 of 76 patients complicated by hemorrhage of Digestive tract underwent endoscopic hemostasis while 2 patients were operated. Ninety-seven patients(6.7%)died, including 61 (62.9%, 61/97) from hemorrhage of Digestive tract. The remainder became cured, improved and discharged. Moreover, no significant statistical differences existed (P=2.29) among three combination group (aspirin, clopidogrel, warfarin), two combination group (aspirin, clopidogrel), exclusive aspirin group and exclusive warfarin group in short-term (<27 d) mortality. Conclusions It is necessary to clearly dictate the details of medication to the patients not highly educated. Elder, male, history of Digestive System disease and Helicobacter pylori infection are possibly highly risk correlative factors for Digestive System complications during anticoagulant/antiplatelet-agent therapy. The short-term protective effect of routine dose of PPI is inconspicuous. No significant correlation exists between short-term mortality and the dosage (or type) of anticoagulant/antiplatelet-agents. Key words: Anticoagulants; Platelet aggregation inhibitors; Digestive System diseases; Hemorrhage

Chen Rong - One of the best experts on this subject based on the ideXlab platform.

  • Analysis of Adverse Drug Reactions Induced by Cefixime
    China Pharmacy, 2012
    Co-Authors: Long Min, Chen Rong
    Abstract:

    OBJECTIVE:To investigate the characteristics and regularity of ADR induced by cefixime.METHODS:10 cefixime-induced ADR case reports were collected from domestic medical journals.79 cefixime-induced ADR cases reported by 3 hospitals during 2000-2010 were summarized.A total of 89 ADR cases were analyzed and evaluated.RESULTS:Of total 89 cases of ADR,lesion of skin and appendants took up the biggest proportion(accounting for 41.57%),followed by nervous System Injury(accounting for 19.10%) and Digestive System Injury(accounting for 15.73%).48.31% were occurred in children below 10 years old;46.07% were in sequential therapy.About 38.20% occurred after 48 hours.CONCLUSION:It is necessary to pay attention to ADR induced by cefixime and strengthen observation during medication in order to reduce the serious ADR.

Mu Hai-bi - One of the best experts on this subject based on the ideXlab platform.

Zhang Shao-hua - One of the best experts on this subject based on the ideXlab platform.

  • Retrospective analysis on adverse drug reactions in a Hospital of China in 2010
    Anhui Medical and Pharmaceutical Journal, 2011
    Co-Authors: Zhang Shao-hua
    Abstract:

    Aim To probe into the characteristics and regularity of adverse drug reactions(ADR) in our hospital and to promote clinical use of drugs.Methods 1031 ADR cases reported in our hospital in 2010 were collected and analyzed statistically.Results Of the 1 031 ADR cases,the ratio of male to female was 1.01:1.37.34% of the cases were collected from patients over the age of 60 and most were general in hospital induced by intravenous administration.50.53% of the cases were associated with anti-infective agents,among which 35.27% by quinolones and 32.17% by cephalosporins.The ADR cases were chiefly manifested as lesion of skin and its appendants and Digestive System Injury.89.04% of the symptom improved.Conclusion Creat attention should be paid to rational use of antibiotics and traditional Chinese medicine preparations.ADR monitoring should be strengthened to reduce or avoid the incidence of ADR.