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Dalal El M. Kaffash - One of the best experts on this subject based on the ideXlab platform.

  • Multiple Drug Resistant1 Gene C3435T Polymorphism and its Relation to Digoxin Blood Level in Cardiac Patients
    2015
    Co-Authors: Dalal El M. Kaffash, Salah Marzouk, Mohamed A. Abdelhady, Nermin H, Iman D
    Abstract:

    Background: The MDR1 gene was the first ABC transporter gene described. Genetic variations of MDR1 gene have over than 48 single nucleotide polymorphisms. Polymorphism in exon 26 C3435T results in 3 genotypes; homozygous genotype CC, homozygous genotype TT, and heterozygous genotype CT. It is a silent mutation, but is associated with altered P-glycoprotein expression, and subsequently its substrate drug pharmacokinetics. The objectives were detection of the MDR1 gene C3435T polymorphism at exon 26, the frequency of each genotype, and its relation to Digoxin Blood Level in cardiac patients under Digoxin therapy. Forty cardiac male patients were chosen after exclusion of factors affecting serum Digoxin Level or predisposing to Digoxin toxicity. Their ages ranged from 12 to 60 years. The patients were either newly diagnosed cases who received Digoxin for the first time or chronic cardiac cases on Digoxin therapy. Following selection of cases measurements of serum Digoxin Level after reaching the steady state concentration and PCR-RFLP for detection of MDR1 C3435T polymorphism were performed. The frequency of MDR1 C3435T genotypes was TT genotype in 20 cases (50%), CT genotype in 18 cases (45%) and CC genotype in 2 cases (5%). This frequency was in concordance with Hardy-Weinberg equilibrium. It was found that there was significant difference in serum Digoxin Levels between patients with TT and CT genotypes, and also between patients with TT and CC genotypes. The TT genotype was the mos

  • multiple drug resistant 1 gene c 3435 t polymorphism and its relation to Digoxin Blood Level in cardiac patients
    2006
    Co-Authors: Salah Marzouk, Dalal El M. Kaffash, Mohamed A. Abdelhady, H Nermin, D Iman
    Abstract:

    Background: The MDR 1 gene was the first ABC transporter gene described. Genetic variations of MDR1 gene have over than48 single nucleotide polymorphisms. Polymorphism in exon 26 C3435T results in3 genotypes; homozygous genotype CC, homozygous genotype TT, and heterozygous genotype CT. It is a silent mutation, but is associated with altered Pglycoprotein expression, and subsequently its substrate drug pharmacokinetics.The objectiveswere detection of the MDR1 gene C3435T polymorphism at exon 26,the frequency of each genotype,and its relation to Digoxin Blood Level in cardiac patients under Digoxin therapy. Forty cardiac male patients were chosen after exclusion of factors a ffecting serum Digoxin Level or predisposing to Digoxin toxicity .Their ages ranged from12 to60 years. The patients were either newly diagnosed cases who received Digoxin for the first time or chronic cardiac cases on Digoxin therapy. Following selectionof cases measurements of serum Digoxin Level after reaching the steady state concentration and PCR-RFLP for detection of MDR1 C3435T polymorphism were performed. The frequency of MDR 1 C3435T genotypes was TT genotype in 20 cases(50%),CT genotype in 18 cases(45%)and CC genotype in2 cases(5%).This frequency was in concordance with HardyWeinberg equilibrium. It was found that there was significant difference in serum Digoxin Levels between patients with TT and CT genotypes, and also between patients with TT and CC genotypes.The TT genotype was the most

Salah Marzouk - One of the best experts on this subject based on the ideXlab platform.

  • Multiple Drug Resistant1 Gene C3435T Polymorphism and its Relation to Digoxin Blood Level in Cardiac Patients
    2015
    Co-Authors: Dalal El M. Kaffash, Salah Marzouk, Mohamed A. Abdelhady, Nermin H, Iman D
    Abstract:

    Background: The MDR1 gene was the first ABC transporter gene described. Genetic variations of MDR1 gene have over than 48 single nucleotide polymorphisms. Polymorphism in exon 26 C3435T results in 3 genotypes; homozygous genotype CC, homozygous genotype TT, and heterozygous genotype CT. It is a silent mutation, but is associated with altered P-glycoprotein expression, and subsequently its substrate drug pharmacokinetics. The objectives were detection of the MDR1 gene C3435T polymorphism at exon 26, the frequency of each genotype, and its relation to Digoxin Blood Level in cardiac patients under Digoxin therapy. Forty cardiac male patients were chosen after exclusion of factors affecting serum Digoxin Level or predisposing to Digoxin toxicity. Their ages ranged from 12 to 60 years. The patients were either newly diagnosed cases who received Digoxin for the first time or chronic cardiac cases on Digoxin therapy. Following selection of cases measurements of serum Digoxin Level after reaching the steady state concentration and PCR-RFLP for detection of MDR1 C3435T polymorphism were performed. The frequency of MDR1 C3435T genotypes was TT genotype in 20 cases (50%), CT genotype in 18 cases (45%) and CC genotype in 2 cases (5%). This frequency was in concordance with Hardy-Weinberg equilibrium. It was found that there was significant difference in serum Digoxin Levels between patients with TT and CT genotypes, and also between patients with TT and CC genotypes. The TT genotype was the mos

  • multiple drug resistant 1 gene c 3435 t polymorphism and its relation to Digoxin Blood Level in cardiac patients
    2006
    Co-Authors: Salah Marzouk, Dalal El M. Kaffash, Mohamed A. Abdelhady, H Nermin, D Iman
    Abstract:

    Background: The MDR 1 gene was the first ABC transporter gene described. Genetic variations of MDR1 gene have over than48 single nucleotide polymorphisms. Polymorphism in exon 26 C3435T results in3 genotypes; homozygous genotype CC, homozygous genotype TT, and heterozygous genotype CT. It is a silent mutation, but is associated with altered Pglycoprotein expression, and subsequently its substrate drug pharmacokinetics.The objectiveswere detection of the MDR1 gene C3435T polymorphism at exon 26,the frequency of each genotype,and its relation to Digoxin Blood Level in cardiac patients under Digoxin therapy. Forty cardiac male patients were chosen after exclusion of factors a ffecting serum Digoxin Level or predisposing to Digoxin toxicity .Their ages ranged from12 to60 years. The patients were either newly diagnosed cases who received Digoxin for the first time or chronic cardiac cases on Digoxin therapy. Following selectionof cases measurements of serum Digoxin Level after reaching the steady state concentration and PCR-RFLP for detection of MDR1 C3435T polymorphism were performed. The frequency of MDR 1 C3435T genotypes was TT genotype in 20 cases(50%),CT genotype in 18 cases(45%)and CC genotype in2 cases(5%).This frequency was in concordance with HardyWeinberg equilibrium. It was found that there was significant difference in serum Digoxin Levels between patients with TT and CT genotypes, and also between patients with TT and CC genotypes.The TT genotype was the most

D Iman - One of the best experts on this subject based on the ideXlab platform.

  • multiple drug resistant 1 gene c 3435 t polymorphism and its relation to Digoxin Blood Level in cardiac patients
    2006
    Co-Authors: Salah Marzouk, Dalal El M. Kaffash, Mohamed A. Abdelhady, H Nermin, D Iman
    Abstract:

    Background: The MDR 1 gene was the first ABC transporter gene described. Genetic variations of MDR1 gene have over than48 single nucleotide polymorphisms. Polymorphism in exon 26 C3435T results in3 genotypes; homozygous genotype CC, homozygous genotype TT, and heterozygous genotype CT. It is a silent mutation, but is associated with altered Pglycoprotein expression, and subsequently its substrate drug pharmacokinetics.The objectiveswere detection of the MDR1 gene C3435T polymorphism at exon 26,the frequency of each genotype,and its relation to Digoxin Blood Level in cardiac patients under Digoxin therapy. Forty cardiac male patients were chosen after exclusion of factors a ffecting serum Digoxin Level or predisposing to Digoxin toxicity .Their ages ranged from12 to60 years. The patients were either newly diagnosed cases who received Digoxin for the first time or chronic cardiac cases on Digoxin therapy. Following selectionof cases measurements of serum Digoxin Level after reaching the steady state concentration and PCR-RFLP for detection of MDR1 C3435T polymorphism were performed. The frequency of MDR 1 C3435T genotypes was TT genotype in 20 cases(50%),CT genotype in 18 cases(45%)and CC genotype in2 cases(5%).This frequency was in concordance with HardyWeinberg equilibrium. It was found that there was significant difference in serum Digoxin Levels between patients with TT and CT genotypes, and also between patients with TT and CC genotypes.The TT genotype was the most

Mohamed A. Abdelhady - One of the best experts on this subject based on the ideXlab platform.

  • Multiple Drug Resistant1 Gene C3435T Polymorphism and its Relation to Digoxin Blood Level in Cardiac Patients
    2015
    Co-Authors: Dalal El M. Kaffash, Salah Marzouk, Mohamed A. Abdelhady, Nermin H, Iman D
    Abstract:

    Background: The MDR1 gene was the first ABC transporter gene described. Genetic variations of MDR1 gene have over than 48 single nucleotide polymorphisms. Polymorphism in exon 26 C3435T results in 3 genotypes; homozygous genotype CC, homozygous genotype TT, and heterozygous genotype CT. It is a silent mutation, but is associated with altered P-glycoprotein expression, and subsequently its substrate drug pharmacokinetics. The objectives were detection of the MDR1 gene C3435T polymorphism at exon 26, the frequency of each genotype, and its relation to Digoxin Blood Level in cardiac patients under Digoxin therapy. Forty cardiac male patients were chosen after exclusion of factors affecting serum Digoxin Level or predisposing to Digoxin toxicity. Their ages ranged from 12 to 60 years. The patients were either newly diagnosed cases who received Digoxin for the first time or chronic cardiac cases on Digoxin therapy. Following selection of cases measurements of serum Digoxin Level after reaching the steady state concentration and PCR-RFLP for detection of MDR1 C3435T polymorphism were performed. The frequency of MDR1 C3435T genotypes was TT genotype in 20 cases (50%), CT genotype in 18 cases (45%) and CC genotype in 2 cases (5%). This frequency was in concordance with Hardy-Weinberg equilibrium. It was found that there was significant difference in serum Digoxin Levels between patients with TT and CT genotypes, and also between patients with TT and CC genotypes. The TT genotype was the mos

  • multiple drug resistant 1 gene c 3435 t polymorphism and its relation to Digoxin Blood Level in cardiac patients
    2006
    Co-Authors: Salah Marzouk, Dalal El M. Kaffash, Mohamed A. Abdelhady, H Nermin, D Iman
    Abstract:

    Background: The MDR 1 gene was the first ABC transporter gene described. Genetic variations of MDR1 gene have over than48 single nucleotide polymorphisms. Polymorphism in exon 26 C3435T results in3 genotypes; homozygous genotype CC, homozygous genotype TT, and heterozygous genotype CT. It is a silent mutation, but is associated with altered Pglycoprotein expression, and subsequently its substrate drug pharmacokinetics.The objectiveswere detection of the MDR1 gene C3435T polymorphism at exon 26,the frequency of each genotype,and its relation to Digoxin Blood Level in cardiac patients under Digoxin therapy. Forty cardiac male patients were chosen after exclusion of factors a ffecting serum Digoxin Level or predisposing to Digoxin toxicity .Their ages ranged from12 to60 years. The patients were either newly diagnosed cases who received Digoxin for the first time or chronic cardiac cases on Digoxin therapy. Following selectionof cases measurements of serum Digoxin Level after reaching the steady state concentration and PCR-RFLP for detection of MDR1 C3435T polymorphism were performed. The frequency of MDR 1 C3435T genotypes was TT genotype in 20 cases(50%),CT genotype in 18 cases(45%)and CC genotype in2 cases(5%).This frequency was in concordance with HardyWeinberg equilibrium. It was found that there was significant difference in serum Digoxin Levels between patients with TT and CT genotypes, and also between patients with TT and CC genotypes.The TT genotype was the most

Iman D - One of the best experts on this subject based on the ideXlab platform.

  • Multiple Drug Resistant1 Gene C3435T Polymorphism and its Relation to Digoxin Blood Level in Cardiac Patients
    2015
    Co-Authors: Dalal El M. Kaffash, Salah Marzouk, Mohamed A. Abdelhady, Nermin H, Iman D
    Abstract:

    Background: The MDR1 gene was the first ABC transporter gene described. Genetic variations of MDR1 gene have over than 48 single nucleotide polymorphisms. Polymorphism in exon 26 C3435T results in 3 genotypes; homozygous genotype CC, homozygous genotype TT, and heterozygous genotype CT. It is a silent mutation, but is associated with altered P-glycoprotein expression, and subsequently its substrate drug pharmacokinetics. The objectives were detection of the MDR1 gene C3435T polymorphism at exon 26, the frequency of each genotype, and its relation to Digoxin Blood Level in cardiac patients under Digoxin therapy. Forty cardiac male patients were chosen after exclusion of factors affecting serum Digoxin Level or predisposing to Digoxin toxicity. Their ages ranged from 12 to 60 years. The patients were either newly diagnosed cases who received Digoxin for the first time or chronic cardiac cases on Digoxin therapy. Following selection of cases measurements of serum Digoxin Level after reaching the steady state concentration and PCR-RFLP for detection of MDR1 C3435T polymorphism were performed. The frequency of MDR1 C3435T genotypes was TT genotype in 20 cases (50%), CT genotype in 18 cases (45%) and CC genotype in 2 cases (5%). This frequency was in concordance with Hardy-Weinberg equilibrium. It was found that there was significant difference in serum Digoxin Levels between patients with TT and CT genotypes, and also between patients with TT and CC genotypes. The TT genotype was the mos