The Experts below are selected from a list of 3339 Experts worldwide ranked by ideXlab platform

Fang Geng - One of the best experts on this subject based on the ideXlab platform.

  • Sweet tea (Lithocarpus polystachyus rehd.) as a new natural source of bioactive Dihydrochalcones with multiple health benefits
    Critical reviews in food science and nutrition, 2020
    Co-Authors: Ao Shang, Hong-yan Liu, Min Luo, Yu Xia, Xiao Yang, Quancai Sun, Fang Geng
    Abstract:

    Sweet tea (Lithocarpus polystachyus Rehd.) has been consumed as herbal tea to prevent and manage diabetes for a long time. Recent studies indicate that sweet tea is rich in a variety of bioactive compounds, especially a class of nonclassical flavonoids, Dihydrochalcones. In order to provide a better understanding of sweet tea and its main Dihydrochalcones on human health, this review mainly summarizes related literature in the recent ten years, with the potential molecular mechanisms emphatically discussed. Phlorizin, phloretin, and trilobatin, three natural sweeteners, are the main Dihydrochalcones in sweet tea. In addition, sweet tea and its Dihydrochalcones exhibit plenty of health benefits, such as antioxidant, anti-inflammatory, antimicrobial, cardioprotective, hepatoprotective, antidiabetic, and anticancer effects, which are associated with the regulation of different molecular targets and signaling pathways. Therefore, sweet tea, as a rare natural source of Dihydrochalcones, can be processed and developed into nutraceuticals or functional foods, with the potential application in the prevention and management of certain chronic diseases.

Zhengbo Liu - One of the best experts on this subject based on the ideXlab platform.

  • Preparative isolation, quantification and antioxidant activity of Dihydrochalcones from Sweet Tea (Lithocarpus polystachyus Rehd.).
    Journal of chromatography. B Analytical technologies in the biomedical and life sciences, 2015
    Co-Authors: Yinshi Sun, Zhengbo Liu
    Abstract:

    Dihydrochalcones are the main active components of Lithocarpus polystachyus Rehd. (Sweet Tea), they are directly related to the sweet tonic beverage and traditional herb. In this work, two runs of preparative high-speed counter-current chromatography (HSCCC) with a two-phase solvent system composed of n-hexane/ethyl acetate/ethanol/water (1:4:3:4, v/v) were employed to separate three Dihydrochalcones (phloridzin, trilobatin and phloretin) from Sweet Tea. About 6.4mg of phloridzin, 48.4mg of trilobatin, and 4.7mg of phloretin with purities of 96.7%, 98.4% and 98.1% were obtained from 130mg of the crude Sweet Tea extract. Phloridzin, trilobatin, and phloretin had effective radical scavenging activities, with IC50 values of 866.80, 20.16 and 179.47μg/mL, respectively, in a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical method. The contents of phloridzin, trilobatin and phloretin in dried old leaves and tender leaves of tea were in the range of 10.1-18.0, 113.7-128.8, 3.6-4.3mg/g and 9.3-9.8, 82.9-103.1, 1.9-2.5mg/g, respectively. The results indicated that the HPLC had good precision, accuracy and repeatability for the determination of three Dihydrochalcones in samples.

Shili Hou - One of the best experts on this subject based on the ideXlab platform.

  • Facile synthesis of Dihydrochalcones via the AlCl3-promoted tandem Friedel–Crafts acylation and alkylation of arenes with 2-alkenoyl chlorides
    Journal of Molecular Catalysis A-chemical, 2012
    Co-Authors: Yang Zhou, Shili Hou
    Abstract:

    Abstract Tandem Friedel–Crafts acylation and alkylation of arenes with 2-alkenoyl chlorides were investigated under the catalysis of Lewis acids. The cascade reaction affords Dihydrochalcones in good yields accompanying 1-indanone derivatives in some cases, in the presence of anhydrous aluminum chloride. The scope, limitation, and mechanism of the tandem reaction were also explored. The intermolecular Friedel–Crafts alkylation for the formation of Dihydrochalcones is more favorable than the intramolecular one for the generation of 1-indanones in the tandem reaction due to a stable six-membered ring transition state. The sequent process was further studied by the DFT computations at the M06-2X/6-31G(d) level, which are in great agreement with the experimental observation and support the proposed mechanism. The current method provides a convenient and economic method to synthesis of Dihydrochalcones.

  • facile synthesis of Dihydrochalcones via the alcl3 promoted tandem friedel crafts acylation and alkylation of arenes with 2 alkenoyl chlorides
    Journal of Molecular Catalysis A-chemical, 2012
    Co-Authors: Yang Zhou, Shili Hou
    Abstract:

    Abstract Tandem Friedel–Crafts acylation and alkylation of arenes with 2-alkenoyl chlorides were investigated under the catalysis of Lewis acids. The cascade reaction affords Dihydrochalcones in good yields accompanying 1-indanone derivatives in some cases, in the presence of anhydrous aluminum chloride. The scope, limitation, and mechanism of the tandem reaction were also explored. The intermolecular Friedel–Crafts alkylation for the formation of Dihydrochalcones is more favorable than the intramolecular one for the generation of 1-indanones in the tandem reaction due to a stable six-membered ring transition state. The sequent process was further studied by the DFT computations at the M06-2X/6-31G(d) level, which are in great agreement with the experimental observation and support the proposed mechanism. The current method provides a convenient and economic method to synthesis of Dihydrochalcones.

Yu Wang - One of the best experts on this subject based on the ideXlab platform.

  • rapid structure based annotation and profiling of Dihydrochalcones in star fruit averrhoa carambola using uhplc q orbitrap ms and molecular networking
    Journal of Agricultural and Food Chemistry, 2021
    Co-Authors: Zhixin Wang, Alan H Chambers, Jonathan H Crane, Yu Wang
    Abstract:

    Dihydrochalcones are a subclass of flavonoids. There has been growing interest in Dihydrochalcones for their health benefits and potential to modulate flavor, but their comprehensive profile in diverse plant species is lacking. Star fruit is a tropical fruit rich in Dihydrochalcones. In this study, a systematic annotation using UHPLC/Q-Orbitrap-MS and molecular networking was established to rapidly identify Dihydrochalcones in 12 star fruit cultivars. A total of 53 Dihydrochalcones were characterized within a short retention time including one novel compound (phloretin-3'-C-(2-O-trans-p-coumaroyl)-β-d-fucopyranoside) and 23 compounds identified from the Averrhoa genus for the first time. 3-Hydroxyphloretin was the most abundant dihydrochalcone in star fruit. All the identified Dihydrochalcones had a higher abundance in leaves compared to fruits. This is the first report that systematically investigates Dihydrochalcones in star fruit of multiple cultivars, and the results could provide a useful reference for the future development and utilization of plant genetic resources.

  • Rapid Structure-Based Annotation and Profiling of Dihydrochalcones in Star Fruit (Averrhoa carambola) Using UHPLC/Q-Orbitrap-MS and Molecular Networking.
    Journal of agricultural and food chemistry, 2020
    Co-Authors: Zhixin Wang, Alan H Chambers, Jonathan H Crane, Yu Wang
    Abstract:

    Dihydrochalcones are a subclass of flavonoids. There has been growing interest in Dihydrochalcones for their health benefits and potential to modulate flavor, but their comprehensive profile in diverse plant species is lacking. Star fruit is a tropical fruit rich in Dihydrochalcones. In this study, a systematic annotation using UHPLC/Q-Orbitrap-MS and molecular networking was established to rapidly identify Dihydrochalcones in 12 star fruit cultivars. A total of 53 Dihydrochalcones were characterized within a short retention time including one novel compound (phloretin-3'-C-(2-O-trans-p-coumaroyl)-β-d-fucopyranoside) and 23 compounds identified from the Averrhoa genus for the first time. 3-Hydroxyphloretin was the most abundant dihydrochalcone in star fruit. All the identified Dihydrochalcones had a higher abundance in leaves compared to fruits. This is the first report that systematically investigates Dihydrochalcones in star fruit of multiple cultivars, and the results could provide a useful reference for the future development and utilization of plant genetic resources.

Ana R. Jesus - One of the best experts on this subject based on the ideXlab platform.

  • targeting type 2 diabetes with c glucosyl Dihydrochalcones as selective sodium glucose co transporter 2 sglt2 inhibitors synthesis and biological evaluation
    Journal of Medicinal Chemistry, 2017
    Co-Authors: Ana R. Jesus, Miguel Machuqueiro, Timothy M. Dore, Diogo Vilavicosa, Ana Marques, Amélia P. Rauter
    Abstract:

    Inhibiting glucose reabsorption by sodium glucose co-transporter proteins (SGLTs) in the kidneys is a relatively new strategy for treating type 2 diabetes. Selective inhibition of SGLT2 over SGLT1 is critical for minimizing adverse side effects associated with SGLT1 inhibition. A library of C-glucosyl Dihydrochalcones and their dihydrochalcone and chalcone precursors was synthesized and tested as SGLT1/SGLT2 inhibitors using a cell-based fluorescence assay of glucose uptake. The most potent inhibitors of SGLT2 (IC50 = 9–23 nM) were considerably weaker inhibitors of SGLT1 (IC50 = 10–19 μM). They showed no effect on the sodium independent GLUT family of glucose transporters, and the most potent ones were not acutely toxic to cultured cells. The interaction of a C-glucosyl dihydrochalcone with a POPC membrane was modeled computationally, providing evidence that it is not a pan-assay interference compound. These results point toward the discovery of structures that are potent and highly selective inhibitors o...

  • Targeting Type 2 Diabetes with C‑Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation
    2016
    Co-Authors: Ana R. Jesus, Diogo Vila-viçosa, Miguel Machuqueiro, Ana P. Marques, Timothy M. Dore, Amélia P. Rauter
    Abstract:

    Inhibiting glucose reabsorption by sodium glucose co-transporter proteins (SGLTs) in the kidneys is a relatively new strategy for treating type 2 diabetes. Selective inhibition of SGLT2 over SGLT1 is critical for minimizing adverse side effects associated with SGLT1 inhibition. A library of C-glucosyl Dihydrochalcones and their dihydrochalcone and chalcone precursors was synthesized and tested as SGLT1/SGLT2 inhibitors using a cell-based fluorescence assay of glucose uptake. The most potent inhibitors of SGLT2 (IC50 = 9–23 nM) were considerably weaker inhibitors of SGLT1 (IC50 = 10–19 μM). They showed no effect on the sodium independent GLUT family of glucose transporters, and the most potent ones were not acutely toxic to cultured cells. The interaction of a C-glucosyl dihydrochalcone with a POPC membrane was modeled computationally, providing evidence that it is not a pan-assay interference compound. These results point toward the discovery of structures that are potent and highly selective inhibitors of SGLT2