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Allan D Butterfield - One of the best experts on this subject based on the ideXlab platform.

  • opiate receptor binding properties of morphine Dihydromorphine and codeine 6 o sulfate ester congeners
    Bioorganic & Medicinal Chemistry Letters, 2006
    Co-Authors: Peter A Crooks, Santosh G Kottayil, Abeer M Alghananeem, Stephen R Byrn, Allan D Butterfield
    Abstract:

    Abstract A series of 3-O-acyl-6-O-sulfate esters of morphine, Dihydromorphine, N-methylmorphinium iodide, codeine, and dihydrocodeine were prepared and evaluated for their ability to bind to μ-, δ-, κ1-, κ2-, and κ3-opiate receptors. Several compounds exhibited good affinity for the μ-opiate receptor. Morphine-3-O-propionyl-6-O-sulfate had four times greater affinity than morphine at the μ-opiate receptor and was the most selective compound at this receptor subtype.

  • opiate receptor binding properties of morphine Dihydromorphine and codeine 6 o sulfate ester congeners
    Bioorganic & Medicinal Chemistry Letters, 2006
    Co-Authors: Peter A Crooks, Santosh G Kottayil, Abeer M Alghananeem, Stephen R Byrn, Allan D Butterfield
    Abstract:

    A series of 3-O-acyl-6-O-sulfate esters of morphine, Dihydromorphine, N-methylmorphinium iodide, codeine, and dihydrocodeine were prepared and evaluated for their ability to bind to mu-, delta-, kappa(1)-, kappa(2)-, and kappa(3)-opiate receptors. Several compounds exhibited good affinity for the mu-opiate receptor. Morphine-3-O-propionyl-6-O-sulfate had four times greater affinity than morphine at the mu-opiate receptor and was the most selective compound at this receptor subtype.

Ulrike Kohls - One of the best experts on this subject based on the ideXlab platform.

  • Body Fluids Using One Isolation Procedure and Liquid Chromatography-Atmospheric-Pressure Chemical-Ionization Mass Spectrometry*
    2016
    Co-Authors: Maciej Bogusz J. T, Rolf-dieter Maier, Klaus-dieter Kriiger, Ulrike Kohls
    Abstract:

    Abstract I A method for determining opiate agonists (morphine, morphine-3-glucuronide, morphine-6-glucuronide, 6-monoacetylmorphine, codeine, codeine-6-glucuronide, dihydrocodeine, Dihydromorphine, buprenorphine, methadone, tramadol, and ibogaine), cocaine and its metabolites (benzoylecgonine and ecgonine methyl ester) and lysergic acid diethylamide in serum, blood, urine and other biological matrices is presented. Aliquots (0.5-1.5 mL) of biological fluids were spiked with appropriate deuterated internal standards and extracted using a common solid-phase extraction method (Ct8 cartridges). The extracts were subjected to liquid chromatographic-atmospheric-pressure chemical-ionization mass spectrometric examination using selected ion monitoring procedures. These procedures were developed after analysis of full-scan mass spectra of examined compounds. The extraction method appeared very universal; the recoveries were high for almost all drugs and the extracts were very clean. The procedure was applied for routine forensic casework

  • Determination of Common Drugs of Abuse in Body Fluids Using One Isolation Procedure and Liquid Chromatography-Atmospheric-Pressure Chemical-Ionization Mass Spectrometry
    Journal of Analytical Toxicology, 1998
    Co-Authors: Maciej J. Bogusz, Rolf-dieter Maier, Klaus-dieter Krüger, Ulrike Kohls
    Abstract:

    I A method for determining opiate agonists (morphine, morphine-3-glucuronide, morphine-6-glucuronide, 6-monoacetylmorphine, codeine, codeine-6-glucuronide, dihydrocodeine, Dihydromorphine, buprenorphine, methadone, tramadol, and ibogaine), cocaine and its metabolites (benzoylecgonine and ecgonine methyl ester) and lysergic acid diethylamide in serum, blood, urine and other biological matrices is presented. Aliquots (0.5-1.5 mL) of biological fluids were spiked with appropriate deuterated internal standards and extracted using a common solid-phase extraction method (Ct8 cartridges). The extracts were subjected to liquid chromatographic-atmospheric- pressure chemical-ionization mass spectrometric examination using selected ion monitoring procedures. These procedures were developed after analysis of full-scan mass spectra of examined compounds. The extraction method appeared very universal; the

Peter A Crooks - One of the best experts on this subject based on the ideXlab platform.

  • opiate receptor binding properties of morphine Dihydromorphine and codeine 6 o sulfate ester congeners
    Bioorganic & Medicinal Chemistry Letters, 2006
    Co-Authors: Peter A Crooks, Santosh G Kottayil, Abeer M Alghananeem, Stephen R Byrn, Allan D Butterfield
    Abstract:

    Abstract A series of 3-O-acyl-6-O-sulfate esters of morphine, Dihydromorphine, N-methylmorphinium iodide, codeine, and dihydrocodeine were prepared and evaluated for their ability to bind to μ-, δ-, κ1-, κ2-, and κ3-opiate receptors. Several compounds exhibited good affinity for the μ-opiate receptor. Morphine-3-O-propionyl-6-O-sulfate had four times greater affinity than morphine at the μ-opiate receptor and was the most selective compound at this receptor subtype.

  • opiate receptor binding properties of morphine Dihydromorphine and codeine 6 o sulfate ester congeners
    Bioorganic & Medicinal Chemistry Letters, 2006
    Co-Authors: Peter A Crooks, Santosh G Kottayil, Abeer M Alghananeem, Stephen R Byrn, Allan D Butterfield
    Abstract:

    A series of 3-O-acyl-6-O-sulfate esters of morphine, Dihydromorphine, N-methylmorphinium iodide, codeine, and dihydrocodeine were prepared and evaluated for their ability to bind to mu-, delta-, kappa(1)-, kappa(2)-, and kappa(3)-opiate receptors. Several compounds exhibited good affinity for the mu-opiate receptor. Morphine-3-O-propionyl-6-O-sulfate had four times greater affinity than morphine at the mu-opiate receptor and was the most selective compound at this receptor subtype.

  • a Dihydromorphine 6 o sulfate
    Acta Crystallographica Section C-crystal Structure Communications, 1996
    Co-Authors: C P Brock, Santosh G Kottayil, D A Butterfield, Peter A Crooks
    Abstract:

    The synthesis of 3-O-acetyl-7,8-Dihydromorphine-6-O-sulfate [IUPAC: (5α,6α)-3-acetoxy-4,5-epoxy-17-methyl-6-morphinaniosulfate], C19H23NO7S, which has important analgesic properties, has been confirmed crystallographically. In the solid state, the zwitterions are linked into chains by N—H⋯O hydrogen bonds.

Maciej J. Bogusz - One of the best experts on this subject based on the ideXlab platform.

  • Determination of Common Drugs of Abuse in Body Fluids Using One Isolation Procedure and Liquid Chromatography-Atmospheric-Pressure Chemical-Ionization Mass Spectrometry
    Journal of Analytical Toxicology, 1998
    Co-Authors: Maciej J. Bogusz, Rolf-dieter Maier, Klaus-dieter Krüger, Ulrike Kohls
    Abstract:

    I A method for determining opiate agonists (morphine, morphine-3-glucuronide, morphine-6-glucuronide, 6-monoacetylmorphine, codeine, codeine-6-glucuronide, dihydrocodeine, Dihydromorphine, buprenorphine, methadone, tramadol, and ibogaine), cocaine and its metabolites (benzoylecgonine and ecgonine methyl ester) and lysergic acid diethylamide in serum, blood, urine and other biological matrices is presented. Aliquots (0.5-1.5 mL) of biological fluids were spiked with appropriate deuterated internal standards and extracted using a common solid-phase extraction method (Ct8 cartridges). The extracts were subjected to liquid chromatographic-atmospheric- pressure chemical-ionization mass spectrometric examination using selected ion monitoring procedures. These procedures were developed after analysis of full-scan mass spectra of examined compounds. The extraction method appeared very universal; the

Santosh G Kottayil - One of the best experts on this subject based on the ideXlab platform.

  • opiate receptor binding properties of morphine Dihydromorphine and codeine 6 o sulfate ester congeners
    Bioorganic & Medicinal Chemistry Letters, 2006
    Co-Authors: Peter A Crooks, Santosh G Kottayil, Abeer M Alghananeem, Stephen R Byrn, Allan D Butterfield
    Abstract:

    Abstract A series of 3-O-acyl-6-O-sulfate esters of morphine, Dihydromorphine, N-methylmorphinium iodide, codeine, and dihydrocodeine were prepared and evaluated for their ability to bind to μ-, δ-, κ1-, κ2-, and κ3-opiate receptors. Several compounds exhibited good affinity for the μ-opiate receptor. Morphine-3-O-propionyl-6-O-sulfate had four times greater affinity than morphine at the μ-opiate receptor and was the most selective compound at this receptor subtype.

  • opiate receptor binding properties of morphine Dihydromorphine and codeine 6 o sulfate ester congeners
    Bioorganic & Medicinal Chemistry Letters, 2006
    Co-Authors: Peter A Crooks, Santosh G Kottayil, Abeer M Alghananeem, Stephen R Byrn, Allan D Butterfield
    Abstract:

    A series of 3-O-acyl-6-O-sulfate esters of morphine, Dihydromorphine, N-methylmorphinium iodide, codeine, and dihydrocodeine were prepared and evaluated for their ability to bind to mu-, delta-, kappa(1)-, kappa(2)-, and kappa(3)-opiate receptors. Several compounds exhibited good affinity for the mu-opiate receptor. Morphine-3-O-propionyl-6-O-sulfate had four times greater affinity than morphine at the mu-opiate receptor and was the most selective compound at this receptor subtype.

  • a Dihydromorphine 6 o sulfate
    Acta Crystallographica Section C-crystal Structure Communications, 1996
    Co-Authors: C P Brock, Santosh G Kottayil, D A Butterfield, Peter A Crooks
    Abstract:

    The synthesis of 3-O-acetyl-7,8-Dihydromorphine-6-O-sulfate [IUPAC: (5α,6α)-3-acetoxy-4,5-epoxy-17-methyl-6-morphinaniosulfate], C19H23NO7S, which has important analgesic properties, has been confirmed crystallographically. In the solid state, the zwitterions are linked into chains by N—H⋯O hydrogen bonds.