The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform
Mohammed Abdelkawy - One of the best experts on this subject based on the ideXlab platform.
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Spectrofluorimetric Determination of Diiodohydroxyquinoline in Presence of Metronidazole in Pharmaceutical Formulation and Spiked Human Plasma
gazi university journal of science, 2013Co-Authors: Y Aboul-enein, Nouruddin W. Ali, Mohammed Gamal, Mohammed AbdelkawyAbstract:Accurate and sensitive spectrofluorimetric method was developed for determination of Diiodohydroxyquinoline in presence of metronidazole. In this method the native fluorescence of Diiodohydroxyquinoline in water solvent at λ =495 nm when excitation was at 250 nm is used for its determination. Linear correlation was obtained in theconcentration range of 400 to 900 ng mL-1. The proposed method was successfully applied for determination ofDiiodohydroxyquinoline in bulk powder with mean accuracy of 100.21±1.13 or in spiked human plasma with mean accuracy of 100.53±1.42 without interference of metronidazole. Keywords: spectrofluorimetry, Diiodohydroxyquinoline and Metronidazole.
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Chromatographic methods for simultaneous determination of Diiodohydroxyquinoline and Metronidazole in their binary mixture
Pakistan journal of pharmaceutical sciences, 2013Co-Authors: Nouruddin W. Ali, Mohammed Gamal, Mohammed AbdelkawyAbstract:Two chromatographic methods were developed for analysis ofDiiodohydroxyquinoline (DIHQ) and metronidazole (MTN). In the first method, Diiodohydroxyquinoline and metronidazole were separated on TLC silica gel 60F254 plate using chloroform: acetone: glacial acetic acid (7.5: 2.5: 0.1, by volume) as mobile phase. The obtained bands were then scanned at 254 nm. The second method is a RP-HPLC method in which Diiodohydroxyquinoline and metronidazole were separated on a reversed-phase C18 column using water : methanol (60 :40, V/V, PH=3.6 )as mobile phase at a flow rate of 0.7 mL.min-1 and UV detection at 220 nm. The mentioned methods were successfully used for determination of Diiodohydroxyquinoline and metronidazole in pure form and in their pharmaceutical formulation.
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Original Article Spectrophotometric determination of Diiodohydroxyquinoline in presence of Metronidazole in pharmaceutical formulation.
2013Co-Authors: Mohammed Gamal, Mohammed Abdelkawy, Beni-suef EgyptAbstract:Accurate and selective spectrophotometric method was developed for determination of Diiodohydroxyquinoline (DIHQ) in presence of metronidazole (MTN). In this work, a spectrophotometric method based on reduction of ferric-phenanthroline (ferriin) to ferrous-phenanthroline (ferroin) by DIHQ is used where the absorption of the obtained orange-red color ferroin chelate was measured at λmax 510 nm. Linear correlation was obtained in the concentration range of 2.0 to 10.0 µg.mL -1
Saleh A. Ahmed - One of the best experts on this subject based on the ideXlab platform.
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Mechanistic Studies On The Oxidative Polymerization Of 8-Hydroxyquinoline And Diiodohydroxyquinoline In Anti-Diarrhea Tablets
Physical Chemistry: An Indian Journal, 2007Co-Authors: Saleh A. Ahmed, Seddique M. AhmedAbstract:Mechanistic studies of the oxidative polymerization reaction of 8-hydroxyquinoline(HQ) were studied experimentally using spectrophotometric technique. Molecular mechanics(MM+) calculations showed that the potential energy(PE) and optimum molecular geometric(OMG) energies(kcal/mol) of the proposed structures formed during polymerization process are very low. These calculations supported the proposed mechanism. The oxidation constant(Kox) of the anionic form(HQ-NaOH) is about twice greater than the protonated form(HQ-H2SO4). Molecular mechanics(MM+) calculations showed that the PE (kcal/mol) of the HQ in the anionic(HQ-NaOH) is about two times greater than the PE in the protonated(HQ-HCl) forms. The proposed procedure was followed successfully for the oxidation of HQ in sterptoquin(SQ) (anti-diarrhea) tablets. The oxidation constant(Kox) of HQ in SQ was found also to be lower than the Kox in synthetic(HQ) solution. Kinetic parameters of the oxidative polymerization of the anionic form of HQ(HQ-NaOH) at different concentration were deduced employing a computer-oriented kinetic analysis of the absorbance(A) at 610nm against the time(t/sec) data. The results obtained indicate that the rate controlling process is governed by the Ginstling-Brounshetin-equation three-dimensional diffusion(D4). It is interesting to note from these calculations that the k value calculated by D4 is about eleven, twenty four, and one hindered five times of magnitude lower than the k values obtained by applying first-(F1), second-(F2), and third-order(F3) kinetics under the same conditions. Activation parameters for the rate of oxidation process of HQ have been computed and discussed.
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Oxidative Polymerization Studies of 8-Hydroxyquinoline in Different Media
Polish Journal of Chemistry, 2007Co-Authors: Seddique M. Ahmed, Saleh A. AhmedAbstract:Oxidative polymerization reaction of 8-hydroxyquinoline (HQ) in different media has been studied experimentally by spectrophotometric technique and confirmed computationally by molecular mechanics (MM+) calculations. MM+ calculations showed that the PE of the optimum molecular geometric (OMG) of the anionic HQ (HQ-NaOH) form is about two (1.985) times greater than the PE in the protonated (HQ-HCl) form. PE of the OMG structure of the PHQ was computed (-30.651 kJ mol -1 ). These calculations indicate that the matrix is highly stable. The oxidation constant (K ox ) of the anionic form (HQ-NaOH) is about twice (2.02) greater than that of the protonated (HQ-H 2 SO 4 ) form. The proposed procedure was successfully applied for the oxidation of Diiodohydroxyquinoline in streptoquin (SQ) (anti-diarrhea, tablets). The K ox of HQ in SQ was also found to be lower than the K ox in synthetic (HQ) solution. Kinetic parameters of the oxidative polymerization of the anionic form ofHQ (HQ-NaOH) were deduced on the basis ofabsorbance variations. The results of computer-oriented kinetic analysis indicate that the rate-controlling step of the HQ polymerization is governed by Ginstling-Bronstein equation representing the three-dimensional diffusion (D4). Activation parameters of the oxidative polymerization of the anionic form of HQ (HQ-NaOH) were computed and discussed.
William Arthur Petri - One of the best experts on this subject based on the ideXlab platform.
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Amoebic dysentery.
BMJ clinical evidence, 2013Co-Authors: Chelsea Marie, William Arthur PetriAbstract:Amoebic dysentery is caused by the protozoan parasite Entamoeba histolytica. It is transmitted in areas where poor sanitation allows contamination of drinking water and food with faeces. In these areas, up to 40% of people with diarrhoea may have amoebic dysentery. We conducted a systematic review and aimed to answer the following clinical question: What are the effects of drug treatments for amoebic dysentery in endemic areas? We searched: Medline, Embase, The Cochrane Library, and other important databases up to June 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). We found 6 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. In this systematic review, we present information relating to the effectiveness and safety of the following interventions: Diiodohydroxyquinoline (iodoquinol), diloxanide, emetine, metronidazole, nitazoxanide, ornidazole, paromomycin, secnidazole, and tinidazole.
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Amoebic dysentery.
BMJ clinical evidence, 2011Co-Authors: Nicole M Mackey-lawrence, William Arthur PetriAbstract:Amoebic dysentery is caused by the protozoan parasite Entamoeba histolytica. It is transmitted in areas where poor sanitation allows contamination of drinking water and food with faeces. In these areas, up to 40% of people with diarrhoea may have amoebic dysentery. We conducted a systematic review and aimed to answer the following clinical question: What are the effects of drug treatments for amoebic dysentery in endemic areas? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2010 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). We found 6 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. In this systematic review, we present information relating to the effectiveness and safety of the following interventions: Diiodohydroxyquinoline (iodoquinol), diloxanide, emetine, metronidazole, nitazoxanide, ornidazole, paromomycin, secnidazole, and tinidazole.
Seddique M. Ahmed - One of the best experts on this subject based on the ideXlab platform.
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Mechanistic Studies On The Oxidative Polymerization Of 8-Hydroxyquinoline And Diiodohydroxyquinoline In Anti-Diarrhea Tablets
Physical Chemistry: An Indian Journal, 2007Co-Authors: Saleh A. Ahmed, Seddique M. AhmedAbstract:Mechanistic studies of the oxidative polymerization reaction of 8-hydroxyquinoline(HQ) were studied experimentally using spectrophotometric technique. Molecular mechanics(MM+) calculations showed that the potential energy(PE) and optimum molecular geometric(OMG) energies(kcal/mol) of the proposed structures formed during polymerization process are very low. These calculations supported the proposed mechanism. The oxidation constant(Kox) of the anionic form(HQ-NaOH) is about twice greater than the protonated form(HQ-H2SO4). Molecular mechanics(MM+) calculations showed that the PE (kcal/mol) of the HQ in the anionic(HQ-NaOH) is about two times greater than the PE in the protonated(HQ-HCl) forms. The proposed procedure was followed successfully for the oxidation of HQ in sterptoquin(SQ) (anti-diarrhea) tablets. The oxidation constant(Kox) of HQ in SQ was found also to be lower than the Kox in synthetic(HQ) solution. Kinetic parameters of the oxidative polymerization of the anionic form of HQ(HQ-NaOH) at different concentration were deduced employing a computer-oriented kinetic analysis of the absorbance(A) at 610nm against the time(t/sec) data. The results obtained indicate that the rate controlling process is governed by the Ginstling-Brounshetin-equation three-dimensional diffusion(D4). It is interesting to note from these calculations that the k value calculated by D4 is about eleven, twenty four, and one hindered five times of magnitude lower than the k values obtained by applying first-(F1), second-(F2), and third-order(F3) kinetics under the same conditions. Activation parameters for the rate of oxidation process of HQ have been computed and discussed.
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Oxidative Polymerization Studies of 8-Hydroxyquinoline in Different Media
Polish Journal of Chemistry, 2007Co-Authors: Seddique M. Ahmed, Saleh A. AhmedAbstract:Oxidative polymerization reaction of 8-hydroxyquinoline (HQ) in different media has been studied experimentally by spectrophotometric technique and confirmed computationally by molecular mechanics (MM+) calculations. MM+ calculations showed that the PE of the optimum molecular geometric (OMG) of the anionic HQ (HQ-NaOH) form is about two (1.985) times greater than the PE in the protonated (HQ-HCl) form. PE of the OMG structure of the PHQ was computed (-30.651 kJ mol -1 ). These calculations indicate that the matrix is highly stable. The oxidation constant (K ox ) of the anionic form (HQ-NaOH) is about twice (2.02) greater than that of the protonated (HQ-H 2 SO 4 ) form. The proposed procedure was successfully applied for the oxidation of Diiodohydroxyquinoline in streptoquin (SQ) (anti-diarrhea, tablets). The K ox of HQ in SQ was also found to be lower than the K ox in synthetic (HQ) solution. Kinetic parameters of the oxidative polymerization of the anionic form ofHQ (HQ-NaOH) were deduced on the basis ofabsorbance variations. The results of computer-oriented kinetic analysis indicate that the rate-controlling step of the HQ polymerization is governed by Ginstling-Bronstein equation representing the three-dimensional diffusion (D4). Activation parameters of the oxidative polymerization of the anionic form of HQ (HQ-NaOH) were computed and discussed.
Mohammed Gamal - One of the best experts on this subject based on the ideXlab platform.
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Spectrofluorimetric Determination of Diiodohydroxyquinoline in Presence of Metronidazole in Pharmaceutical Formulation and Spiked Human Plasma
gazi university journal of science, 2013Co-Authors: Y Aboul-enein, Nouruddin W. Ali, Mohammed Gamal, Mohammed AbdelkawyAbstract:Accurate and sensitive spectrofluorimetric method was developed for determination of Diiodohydroxyquinoline in presence of metronidazole. In this method the native fluorescence of Diiodohydroxyquinoline in water solvent at λ =495 nm when excitation was at 250 nm is used for its determination. Linear correlation was obtained in theconcentration range of 400 to 900 ng mL-1. The proposed method was successfully applied for determination ofDiiodohydroxyquinoline in bulk powder with mean accuracy of 100.21±1.13 or in spiked human plasma with mean accuracy of 100.53±1.42 without interference of metronidazole. Keywords: spectrofluorimetry, Diiodohydroxyquinoline and Metronidazole.
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Chromatographic methods for simultaneous determination of Diiodohydroxyquinoline and Metronidazole in their binary mixture
Pakistan journal of pharmaceutical sciences, 2013Co-Authors: Nouruddin W. Ali, Mohammed Gamal, Mohammed AbdelkawyAbstract:Two chromatographic methods were developed for analysis ofDiiodohydroxyquinoline (DIHQ) and metronidazole (MTN). In the first method, Diiodohydroxyquinoline and metronidazole were separated on TLC silica gel 60F254 plate using chloroform: acetone: glacial acetic acid (7.5: 2.5: 0.1, by volume) as mobile phase. The obtained bands were then scanned at 254 nm. The second method is a RP-HPLC method in which Diiodohydroxyquinoline and metronidazole were separated on a reversed-phase C18 column using water : methanol (60 :40, V/V, PH=3.6 )as mobile phase at a flow rate of 0.7 mL.min-1 and UV detection at 220 nm. The mentioned methods were successfully used for determination of Diiodohydroxyquinoline and metronidazole in pure form and in their pharmaceutical formulation.
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Original Article Spectrophotometric determination of Diiodohydroxyquinoline in presence of Metronidazole in pharmaceutical formulation.
2013Co-Authors: Mohammed Gamal, Mohammed Abdelkawy, Beni-suef EgyptAbstract:Accurate and selective spectrophotometric method was developed for determination of Diiodohydroxyquinoline (DIHQ) in presence of metronidazole (MTN). In this work, a spectrophotometric method based on reduction of ferric-phenanthroline (ferriin) to ferrous-phenanthroline (ferroin) by DIHQ is used where the absorption of the obtained orange-red color ferroin chelate was measured at λmax 510 nm. Linear correlation was obtained in the concentration range of 2.0 to 10.0 µg.mL -1