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Raqi M. Shubietah - One of the best experts on this subject based on the ideXlab platform.
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Cathodic Stripping Voltammetric Determination of Dimenhydrinate يئاودلا بكرملا نييعت Dimenhydrinate ةرطق ىلع يرتمتلوفلا يطبھملا عازتنلاا ةقيرطب قبئز
2015Co-Authors: Raqi M. Shubietah, Ali Z. Abu ZuhriAbstract:Dimenhydrinate (DMH) is a derivative of theophylline (diphenhydramine salt of 8-chloro theophylline). Both Dimenhydrinate and theophylline are used as antihistamines in treatment of asthma, in addition to other important pharmaceutical uses. A three-electrode voltammetric system was used, with hanging mercury drop electrode (HMDE) as working electrode. A reduction peak of DMH at -0.2 to -0.3 V in acetate buffer, pH about 4.0 is obtained. The peak height is increased largely (tripled) in presence of Cu 2+ , due to the formation of DMH-Cu (I) complex. The detection limit is as low as 5x10 -9 M DMH. Application of the analysis of two drugs containing Dimenhydrinate was carried out, where a coefficient of variation of about 3% was obtained.
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Cathodic Stripping Voltammetric Determination of Dimenhydrinate
An-Najah University Journal for Research - Natural Sciences, 2014Co-Authors: Raqi M. Shubietah, Ali Z. Abu ZuhriAbstract:Dimenhydrinate (DMH) is a derivative of theophylline (diphenhydramine salt of 8-chloro theophylline). Both Dimenhydrinate and theophylline are used as antihistamines in treatment of asthma, in addition to other important pharmaceutical uses. A three-electrode voltammetric system was used, with hanging mercury drop electrode (HMDE) as working electrode. A reduction peak of DMH at -0.2 to -0.3 V in acetate buffer, pH about 4.0 is obtained. The peak height is increased largely (tripled) in presence of Cu 2+ , due to the formation of DMH-Cu (I) complex. The detection limit is as low as 5x10 -9 M DMH. Application of the analysis of two drugs containing Dimenhydrinate was carried out, where a coefficient of variation of about 3% was obtained.
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Adsorptive stripping voltammetric determination of Dimenhydrinate at a hanging mercury drop electrode
Microchimica Acta, 1999Co-Authors: Raqi M. Shubietah, Ali Z. Abu Zuhri, Arnold G. FoggAbstract:Dimenhydrinate exhibits a single adsorptive stripping peak at a hanging mercury drop electrode after accumulation at 0.0V vs Ag/AgCl electrode at pH 3.8 (acetate buffer). The addition of trace amounts of copper ions enhanced the Dimenhydrinate peak and its height depends on the concentration of each Dimenhydrinate and Cu^2+. The adsorptive stripping response was evaluated with respect to accumulation time and potential, concentration dependence, electrolyte, the presence of other purines, surfactants and other metal ions, and some variables. The calibration graph for Dimenhydrinate determination is linear over the range 2.0×10^−8−2.0×10^−7 M (pre-concentration for 60s). The correlation factor is found to be 0.985 and RSD is 3.2% at 1.0×10^−7 M. Detection limit is 1.0×10^−8 M after 5 min accumulation. The determination of Dimenhydrinate in pharmaceutical formulations by the proposed method is also reported.
Ali Z. Abu Zuhri - One of the best experts on this subject based on the ideXlab platform.
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Cathodic Stripping Voltammetric Determination of Dimenhydrinate يئاودلا بكرملا نييعت Dimenhydrinate ةرطق ىلع يرتمتلوفلا يطبھملا عازتنلاا ةقيرطب قبئز
2015Co-Authors: Raqi M. Shubietah, Ali Z. Abu ZuhriAbstract:Dimenhydrinate (DMH) is a derivative of theophylline (diphenhydramine salt of 8-chloro theophylline). Both Dimenhydrinate and theophylline are used as antihistamines in treatment of asthma, in addition to other important pharmaceutical uses. A three-electrode voltammetric system was used, with hanging mercury drop electrode (HMDE) as working electrode. A reduction peak of DMH at -0.2 to -0.3 V in acetate buffer, pH about 4.0 is obtained. The peak height is increased largely (tripled) in presence of Cu 2+ , due to the formation of DMH-Cu (I) complex. The detection limit is as low as 5x10 -9 M DMH. Application of the analysis of two drugs containing Dimenhydrinate was carried out, where a coefficient of variation of about 3% was obtained.
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Cathodic Stripping Voltammetric Determination of Dimenhydrinate
An-Najah University Journal for Research - Natural Sciences, 2014Co-Authors: Raqi M. Shubietah, Ali Z. Abu ZuhriAbstract:Dimenhydrinate (DMH) is a derivative of theophylline (diphenhydramine salt of 8-chloro theophylline). Both Dimenhydrinate and theophylline are used as antihistamines in treatment of asthma, in addition to other important pharmaceutical uses. A three-electrode voltammetric system was used, with hanging mercury drop electrode (HMDE) as working electrode. A reduction peak of DMH at -0.2 to -0.3 V in acetate buffer, pH about 4.0 is obtained. The peak height is increased largely (tripled) in presence of Cu 2+ , due to the formation of DMH-Cu (I) complex. The detection limit is as low as 5x10 -9 M DMH. Application of the analysis of two drugs containing Dimenhydrinate was carried out, where a coefficient of variation of about 3% was obtained.
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Adsorptive stripping voltammetric determination of Dimenhydrinate at a hanging mercury drop electrode
Microchimica Acta, 1999Co-Authors: Raqi M. Shubietah, Ali Z. Abu Zuhri, Arnold G. FoggAbstract:Dimenhydrinate exhibits a single adsorptive stripping peak at a hanging mercury drop electrode after accumulation at 0.0V vs Ag/AgCl electrode at pH 3.8 (acetate buffer). The addition of trace amounts of copper ions enhanced the Dimenhydrinate peak and its height depends on the concentration of each Dimenhydrinate and Cu^2+. The adsorptive stripping response was evaluated with respect to accumulation time and potential, concentration dependence, electrolyte, the presence of other purines, surfactants and other metal ions, and some variables. The calibration graph for Dimenhydrinate determination is linear over the range 2.0×10^−8−2.0×10^−7 M (pre-concentration for 60s). The correlation factor is found to be 0.985 and RSD is 3.2% at 1.0×10^−7 M. Detection limit is 1.0×10^−8 M after 5 min accumulation. The determination of Dimenhydrinate in pharmaceutical formulations by the proposed method is also reported.
Andreas Bernkop-schnürch - One of the best experts on this subject based on the ideXlab platform.
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In vitro evaluation of a self-emulsifying drug delivery system (SEDDS) for nasal administration of Dimenhydrinate
Drug Delivery and Translational Research, 2019Co-Authors: Christina Leichner, Randi Angela Baus, Melanie Plautz, Sarah Dünnhaupt, Jan Barthelmes, Max Jelkmann, Andreas Bernkop-schnürchAbstract:The objective of the study was the development and in vitro characterization of a self-emulsifying drug delivery system (SEDDS) for the nasal application of Dimenhydrinate. Final composition of SEDDS was established based on drug solubility and stability studies. Dimenhydrinate was loaded into the SEDDS pre-concentrates to 7.5% ( m / v ). The droplet size of the final SEDDS formulations was in a range between 60 and 220 nm. Permeability, as well as tissue toxicity, of the formulations was investigated using bovine nasal mucosa. Enhancement in permeation up to 2.8-fold compared to pure Dimenhydrinate was confirmed. Furthermore, toxicity studies did not reveal any serious tissue damages related to the SEDDS. Additionally, irritation potential of SEDDS was evaluated in ciliary beat frequency measurements. Incorporation of Dimenhydrinate into SEDDS might therefore be considered as a promising approach within the field of nasal delivery of antiemetics by utilizing permeation enhancement strategy.
Mete Kiroglu - One of the best experts on this subject based on the ideXlab platform.
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Original Article The Effects of Betahistine and Dimenhydrinate on Caloric Test Parameters; Slow-Phase Velocity of
2015Co-Authors: Mete KirogluAbstract:OBJECTIVE: The aim of this study is to determine the effects of betahistine and Dimenhydrinate on the slow phase velocity. MATERIALS and METHODS: Forty patients with complaints of vertigo and dizziness volunteered to be included in the study. All patients who were included the study were treated at the other medical centers. The patients were divided into two Groups. Patients in the first Group were given betahistine 24 mg three times per day. During this treatment, caloric testing was performed, and the dose was increased to 48 mg three times a day due to ongoing complaints. The test was then repeated four weeks after using this higher dosage. Patients in the second Group had caloric testing while using and four weeks after stopping Dimenhydrinate. RESULTS: The study Group was comprised of 40 patients; 20 patients (13 female, 7 male, 18-68 years, median age 46) in the betahistine Group and 20 patients (14 female, 6 male, 24-74 years, median age 44.5) in the Dimenhydrinate Group. The average slow phase maximum velocity in the first Group of patients was 18-/+ 8.2 and 21.1-/+ 10.8 deg/s at 24 mg betahistine three times a day and 48 mg three times a day, respectively. In the second Group of patients, the average slow phase velocity was 13.4-/+ 5.1 and 18.2-/+ 7.5 deg/s during and after stopping the treatment of dimen-hydrinate, respectively. The caloric test-induced slow-phase velocity was decreased with Dimenhydrinate and increased with the higher dosage of betahistine. CONCLUSION: To our knowledge, this is the first study to demonstrate that betahistine increases caloric-induced slow-phase velocity in humans. Dimenhydrinate and betahistine should not be used together because of their opposite effects on the vestibular system. Dimenhydrinate can be used to treat acute episodes of vertigo, whereas betahistine should not be used during the episode but may be used in the period between the attacks to stimulate the vestibular system
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The Effects of Betahistine and Dimenhydrinate on Caloric Test Parameters; Slow-Phase Velocity of Nystagmus
The Journal of International Advanced Otology, 2014Co-Authors: Mete Kiroglu, Muhammed Dağkıran, Süleyman Özdemir, Ozgur Surmrlioglu, Özgür TarkanAbstract:OBJECTIVE: The aim of this study is to determine the effects of betahistine and Dimenhydrinate on the slow phase velocity. MATERIALS and METHODS: Forty patients with complaints of vertigo and dizziness volunteered to be included in the study. All patients who were included the study were treated at the other medical centers. The patients were divided into two Groups. Patients in the first Group were given betahistine 24 mg three times per day. During this treatment, caloric testing was performed, and the dose was increased to 48 mg three times a day due to ongoing complaints. The test was then repeated four weeks after using this higher dosage. Patients in the second Group had caloric testing while using and four weeks after stopping Dimenhydrinate. RESULTS: The study Group was comprised of 40 patients; 20 patients (13 female, 7 male, 18-68 years, median age 46) in the betahistine Group and 20 patients (14 female, 6 male, 24-74 years, median age 44.5) in the Dimenhydrinate Group. The average slow phase maximum velocity in the first Group of patients was 18 -/+ 8.2 and 21.1 -/+ 10.8 deg/s at 24 mg betahistine three times a day and 48 mg three times a day, respectively. In the second Group of patients, the average slow phase velocity was 13.4 -/+ 5.1 and 18.2 -/+ 7.5 deg/s during and after stopping the treatment of Dimenhydrinate, respectively. The caloric test-induced slow-phase velocity was decreased with Dimenhydrinate and increased with the higher dosage of betahistine. CONCLUSION: To our knowledge, this is the first study to demonstrate that betahistine increases caloric-induced slow-phase velocity in humans. Dimenhydrinate and betahistine should not be used together because of their opposite effects on the vestibular system. Dimenhydrinate can be used to treat acute episodes of vertigo, whereas betahistine should not be used during the episode but may be used in the period between the attacks to stimulate the vestibular system.
Arnold G. Fogg - One of the best experts on this subject based on the ideXlab platform.
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Adsorptive stripping voltammetric determination of Dimenhydrinate at a hanging mercury drop electrode
Microchimica Acta, 1999Co-Authors: Raqi M. Shubietah, Ali Z. Abu Zuhri, Arnold G. FoggAbstract:Dimenhydrinate exhibits a single adsorptive stripping peak at a hanging mercury drop electrode after accumulation at 0.0V vs Ag/AgCl electrode at pH 3.8 (acetate buffer). The addition of trace amounts of copper ions enhanced the Dimenhydrinate peak and its height depends on the concentration of each Dimenhydrinate and Cu^2+. The adsorptive stripping response was evaluated with respect to accumulation time and potential, concentration dependence, electrolyte, the presence of other purines, surfactants and other metal ions, and some variables. The calibration graph for Dimenhydrinate determination is linear over the range 2.0×10^−8−2.0×10^−7 M (pre-concentration for 60s). The correlation factor is found to be 0.985 and RSD is 3.2% at 1.0×10^−7 M. Detection limit is 1.0×10^−8 M after 5 min accumulation. The determination of Dimenhydrinate in pharmaceutical formulations by the proposed method is also reported.