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Zhengtao Wang - One of the best experts on this subject based on the ideXlab platform.

  • protection of angelica sinensis oliv diels against hepatotoxicity induced by Dioscorea bulbifera l and its mechanism
    BioScience Trends, 2014
    Co-Authors: Chengwei Niu, Junming Wang, Zhengtao Wang
    Abstract:

    Dioscorea bulbifera L., a traditionally used medicinal plant in China, is reported to induce hepatotoxicity. The present study is designed to investigate the protection of an ethanol extract of Angelica sinensis (Oliv) Diels (AE) against an ethyl acetate fraction of D. bulbifera (EF)-induced liver injury and its engaged mechanism. High performance liquid chromatography (HPLC) analysis showed that the amount of diosbulbin B in EF was 16.03% and ferulic acid in AE was 0.18%. EF (350 mg/kg) increased serum alanine/aspartate aminotransferase (ALT/AST), alkaline phosphatase (ALP) activities and total bilirubin (TB) amount, while AE inhibited such an increase. Liver histological evaluation showed that AE prevented development of severe hepatic lesions induced by EF. Further results showed that EF decreased the expression of Bcl-2 and induced the cleaved activation of caspase-9 and -3, and all those effects were reversed by AE. AE also reversed EF-induced decreased expression of the inhibitor of kappa B (IκB), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Taken together, our results demonstrate that AE can prevent EF-induced hepatotoxicity via preventing apoptosis, meanwhile IκB, SOD, and GPx may be involved in such protection.

  • cytokines as potential biomarkers of liver toxicity induced by Dioscorea bulbifera l
    BioScience Trends, 2014
    Co-Authors: Yuchen Sheng, Zhongping Deng, Zhengtao Wang
    Abstract:

    The present study is designed to search for the serum cytokine biomarker for liver injury induced by Dioscorea bulbifera L., which is a traditionally used herbal medicine in China. Mice were orally given various doses of ethyl acetate extract (EF) isolated from D. bulbifera for 12 days. The activity of serum alanine/aspartate transaminases (ALT/AST) was increased in EF (400 mg/kg)-treated mice. Histological assessment further confirmed EF (400 mg/kg)-induced liver injury. Results of a cytokine-antibody array demonstrated that there were 10 cytokines up-regulated and 1 cytokine down-regulated in EF (400 mg/kg)-treated mice. Enzyme-linked immunosorbent assay (ELISA) further confirmed the increased level of CD30 ligand (CD30L) and decreased level of interlukin-3 (IL-3) in EF-treated mice. In conclusion, our results demonstrate that the altered expression of CD30L and IL-3 may be potential biomarkers for hepatotoxicity induced by D. bulbifera.

  • antitumor activity of Dioscorea bulbifera l rhizome in vivo
    Fitoterapia, 2012
    Co-Authors: Hai Liu, Junming Wang, Christopher Branfordwhite, Zaiyong Wang, Kaikai Shen, Zhengtao Wang
    Abstract:

    Antitumor activities of water extract (fraction A), ethanol extract (fraction B), ethyl acetate extract (fraction C), non-ethyl acetate extract (fraction D) and compound diosbulbin B isolated from Dioscorea bulbifera L. (DB) were investigated in vivo in this present study. The results showed that fractions B and C both decreased tumor weight in S180 and H22 tumor cells bearing mice, while fractions A and D had no such effect. Furthermore, fraction C altered the weight of spleen and thymus, and the amounts of total leukocytes, lymphocytes and neutrophils in tumor-bearing mice. Further results showed that compound diosbulbin B demonstrated anti-tumor effects in the dose-dependent manner at the dosage of 2 to 16 mg/kg without significant toxicity in vivo. Furthermore, on the basis of chemical analysis of the above extracts by high-performance liquid chromatography (HPLC) with a diode array detector (DAD), diosbulbin B was found to be the major antitumor bioactive component of DB. These results suggest that DB has potential anti-tumor effects which may be related to influencing the immune system for the first time, and the compound diosbulbin B is the major antitumor component of DB.

  • phenolic compounds from the rhizomes of Dioscorea bulbifera
    Chemistry & Biodiversity, 2011
    Co-Authors: Hai Liu, Guixin Chou, Karl Wah Keung Tsim, Junming Wang, Zhengtao Wang
    Abstract:

    One new bibenzyl, 7, and one new diarylheptanone, diobulbinone A (18), together with sixteen known compounds, 1-6 and 8-17, have been isolated form the rhizomes of Dioscorea bulbifera. Their structures were elucidated by NMR and MS analyses. Compound 7 showed high antioxidant capacity in FRAP assay and DPPH radical-scavenging activity.

  • gender related difference in liver injury induced by Dioscorea bulbifera l rhizome in mice
    Human & Experimental Toxicology, 2011
    Co-Authors: Junming Wang, Chang-hong Wang, Hai Liu, Qingning Liang, Zhengtao Wang
    Abstract:

    The present study was undertaken to investigate the gender-related liver injury induced by Dioscorea bulbifera L. (DB), a traditional medicinal plant, in mice, and further explored its hepatotoxic ...

Rémy Bertrand Teponno - One of the best experts on this subject based on the ideXlab platform.

  • Bafoudiosbulbin H, a new clerodane diterpene from the flowers of Dioscorea bulbifera L. var sativa
    Phytochemistry Letters, 2013
    Co-Authors: Rémy Bertrand Teponno, Beaudelaire K. Ponou, Leon Azefack Tapondjou, Luciano Barboni
    Abstract:

    Abstract A new clerodane diterpenoid, bafoudiosbulbin H (1), was isolated from the flowers of Dioscorea bulbifera L. var sativa. Its acetylation using acetic anhydride-pyridine and catalytic amount of 4-DMAP at 60 °C yielded bafoudiosbulbin H acetate (2) together with a clerodane with an unprecedented acylation pattern (bafoudiosbulbin H1, 3). The reaction of the known bafoudiosbulbin G (4) in the same conditions yielded demethylbafoudiosbulbin G (5). Structural elucidation of 5 led to the revision of the stereochemistry previously assigned to 4. Structures were elucidated using spectroscopic techniques, including 1D and 2D NMR (1H, 13C, HSQC, COSY, HMBC, ROESY, NOESY) and mass spectrometry (HRESIMS).

  • analgesic and anti inflammatory properties of extracts from the bulbils of Dioscorea bulbifera l var sativa Dioscoreaceae in mice and rats
    Evidence-based Complementary and Alternative Medicine, 2011
    Co-Authors: Marius Mbiantcha, Rémy Bertrand Teponno, Albert Kamanyi, A L Tapondjou, Pierre Watcho, Telesphore Benoit Nguelefack
    Abstract:

    The aqueous and methanol extracts from the dry bulbils of Dioscorea bulbifera L. var sativa (Dioscoreaceae)—evaluated orally at the doses of 300 and 600 mg/kg against pain induced by acetic acid, formalin, pressure and against inflammation induced by carrageenan, histamine, serotonin and formalin in mice and rats, showed a dose dependant inhibition of pain and inflammation with a maximum effect of 56.38%, 73.06% and 42.79% produced by the aqueous extract, respectively on pain induced by acetic acid, formalin and pressure while the methanol extract at the same dose respectively inhibited these models of pain by 62.70%, 84.54% and 47.70%. The oral administration of aqueous and methanol extracts caused significant anti-inflammatory activity on paw oedema induced by histamine, serotonin and formalin. The present results show that the bulbils of Dioscorea bulbifera var sativa possess potent analgesic and anti-inflammatory activities. These activities may results from the inhibition of inflammatory mediators such as histamine, serotonin and prostaglandins. Thus, the analgesic activity of the bulbils of Dioscorea bulbifera may be at least partially linked to its anti-inflammatory activity.

  • bafoudiosbulbins f and g further clerodane diterpenoids from Dioscorea bulbifera l var sativa and revised structure of bafoudiosbulbin b
    Phytochemistry, 2008
    Co-Authors: Rémy Bertrand Teponno, Azefack Leon Tapondjou, Pierre Tane, Eliane Aboumansour, Helen Stoecklievans, Luciano Barboni
    Abstract:

    Abstract From the bulbils of Dioscorea bulbifera L. var sativa, two clerodane diterpenoids, Bafoudiosbulbins F (1) and G (2), together with five known compounds: Bafoudiosbulbins A–C, 3,5,4′-trihydroxy-3′-methoxybibenzyl, and kaempferol were isolated. Their structures were established by spectroscopic techniques, including 1H, 13C NMR, NOESY, ROESY, COSY, TOCSY, HSQC, and HMBC. The relative stereochemistry of compounds 1 and 2 was assigned on the basis of X-ray crystallographic diffraction analysis. Furthermore, the structure of Bafoudiosbulbin B was revised using extensive 2D NMR techniques as well as chemical transformation.

  • three new clerodane diterpenoids from the bulbils of Dioscorea bulbifera l var sativa
    Helvetica Chimica Acta, 2007
    Co-Authors: Rémy Bertrand Teponno, Azefack Leon Tapondjou, Pierre Tane, Hyun Jujung, Junghwan Nam, Heejuhn Park
    Abstract:

    From the bulbils of Dioscorea bulbifera L. var. sativa, three new clerodane diterpenoids, bafoudiosbulbin C (=methyl (2β,8α,12S)-17-oxo-2,19 : 8,19 : 12,17 : 15,16-tetraepoxycleroda-3,13(16), 14-triene-18-carboxylate; 1), bafoudiosbulbin D (=methyl (2β,6β,12R)-17,19-dioxo-2,19 : 6,17 :  8,12 : 15,16-tetraepoxycleroda-13(16),14-diene-18-carboxylate; 2), and bafoudiosbulbin E (=methyl (2β,3α,4α,6β,12R)-17,19-dioxo-2,19 : 3,4 : 6,17 : 8,12 : 15,16-pentaepoxycleroda-13(16),14-diene-18-carboxylate; 3) were isolated, together with the known compounds bafoudiosbulbins A and B, 3-O-β-D-glucopyranosyl-β-sitosterol, and 6′-stearoyl-3-O-β-D-glucopyranosyl-β-sitosterol. Their structures were established by high-field NMR techniques (1H,1H-COSY, 13C-DEPT, HSQC, HMBC, and NOESY), MS analyses, as well as by comparison of their spectral data with those of related compounds.

  • bafoudiosbulbins a and b two anti salmonellal clerodane diterpenoids from Dioscorea bulbifera l var sativa
    Phytochemistry, 2006
    Co-Authors: Rémy Bertrand Teponno, Azefack Leon Tapondjou, Jules Desire Djoukeng, Pierre Tane, Eliane Aboumansour, Donatien Gatsing, Raphael Tabacchi, H Stoeklievans, David Lontsi
    Abstract:

    Two clerodane diterpenoids, Bafoudiosbulbins A 1, and B 2, together with five known compounds: tetracosanoic acid, 1-(tetracosanoyl)-glycerol, trans-tetracosanylferulate, beta-sitosterol and 3-O-beta-D-glucopyranosyl-beta-sitosterol were isolated from the tubers of Dioscorea bulbifera L. var sativa. Their structures were established by spectroscopic methods (1D and 2D-NMR, MS) and X-ray crystallographic diffraction analysis of compound 1. The CH2Cl2-soluble portion of the crude extract and the two clerodanes were screened for anti-bacterial activity using both agar diffusion and broth dilution techniques against Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Salmonella typhi, Salmonella paratyphi A and Salmonella paratyphi B. They both showed significant activities against P. aeruginosa, S. typhi, S. paratyphi A and S. paratyphi B.

David Lontsi - One of the best experts on this subject based on the ideXlab platform.

  • bafoudiosbulbins a and b two anti salmonellal clerodane diterpenoids from Dioscorea bulbifera l var sativa
    Phytochemistry, 2006
    Co-Authors: Rémy Bertrand Teponno, Azefack Leon Tapondjou, Jules Desire Djoukeng, Pierre Tane, Eliane Aboumansour, Donatien Gatsing, Raphael Tabacchi, H Stoeklievans, David Lontsi
    Abstract:

    Abstract Two clerodane diterpenoids, Bafoudiosbulbins A 1 , and B 2 , together with five known compounds: tetracosanoic acid, 1-(tetracosanoyl)-glycerol, trans -tetracosanylferulate, β-sitosterol and 3- O -β- d -glucopyranosyl-β-sitosterol were isolated from the tubers of Dioscorea bulbifera L. var sativa . Their structures were established by spectroscopic methods (1D and 2D-NMR, MS) and X-ray crystallographic diffraction analysis of compound 1 . The CH 2 Cl 2 -soluble portion of the crude extract and the two clerodanes were screened for anti-bacterial activity using both agar diffusion and broth dilution techniques against Pseudomonas aeruginosa , Escherichia coli , Klebsiella pneumoniae , Staphylococcus aureus , Salmonella typhi , Salmonella paratyphi A and Salmonella paratyphi B. They both showed significant activities against P. aeruginosa , S. typhi , S. paratyphi A and S. paratyphi B.

  • bafoudiosbulbins a and b two anti salmonellal clerodane diterpenoids from Dioscorea bulbifera l var sativa
    Phytochemistry, 2006
    Co-Authors: Rémy Bertrand Teponno, Azefack Leon Tapondjou, Jules Desire Djoukeng, Pierre Tane, Eliane Aboumansour, Donatien Gatsing, Raphael Tabacchi, H Stoeklievans, David Lontsi
    Abstract:

    Two clerodane diterpenoids, Bafoudiosbulbins A 1, and B 2, together with five known compounds: tetracosanoic acid, 1-(tetracosanoyl)-glycerol, trans-tetracosanylferulate, beta-sitosterol and 3-O-beta-D-glucopyranosyl-beta-sitosterol were isolated from the tubers of Dioscorea bulbifera L. var sativa. Their structures were established by spectroscopic methods (1D and 2D-NMR, MS) and X-ray crystallographic diffraction analysis of compound 1. The CH2Cl2-soluble portion of the crude extract and the two clerodanes were screened for anti-bacterial activity using both agar diffusion and broth dilution techniques against Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Salmonella typhi, Salmonella paratyphi A and Salmonella paratyphi B. They both showed significant activities against P. aeruginosa, S. typhi, S. paratyphi A and S. paratyphi B.

  • isolation and nmr assignment of a pennogenin glycoside from Dioscorea bulbifera l var sativa
    Natural product sciences, 2006
    Co-Authors: Rémy Bertrand Teponno, Azefack Leon Tapondjou, Jules Desire Djoukeng, E A Mansour, Raphael Tabacci, Pierre Tane, David Lontsi
    Abstract:

    A steroidal saponin, ;(1, spiroconazole A) was isolated from the tubers of Dioscorea bulbifera L. var sativa and assignment was completed using HMBC correlation. In addition, four phenolic substances, 2,7-dihydroxy-4-methoxyphenanthrene (2), quercetin (3), (4), and (5) were also isolated.

Balu A Chopade - One of the best experts on this subject based on the ideXlab platform.

  • novel platinum palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera anticancer and antioxidant activities
    International Journal of Nanomedicine, 2015
    Co-Authors: Sougata Ghosh, Rohini Kitture, S N Kale, Jayesh R Bellare, Piyush More, Rahul Nitnavare, Ankush M Dewle, Geetanjali B Tomar, Rohan Chippalkatti, Balu A Chopade
    Abstract:

    Medicinal plants serve as rich sources of diverse bioactive phytochemicals that might even take part in bioreduction and stabilization of phytogenic nanoparticles with immense therapeutic properties. Herein, we report for the first time the rapid efficient synthesis of novel platinum-palladium bimetallic nanoparticles (Pt-PdNPs) along with individual platinum (PtNPs) and palladium (PdNPs) nanoparticles using a medicinal plant, Dioscorea bulbifera tuber extract (DBTE). High-resolution transmission electron microscopy revealed monodispersed PtNPs of size 2-5 nm, while PdNPs and Pt-PdNPs between 10 and 25 nm. Energy dispersive spectroscopy analysis confirmed 30.88% ± 1.73% elemental Pt and 68.96% ± 1.48% elemental Pd in the bimetallic nanoparticles. Fourier transform infrared spectra indicated strong peaks at 3,373 cm(-1), attributed to hydroxyl group of polyphenolic compounds in DBTE that might play a key role in bioreduction in addition to the sharp peaks at 2,937, 1,647, 1,518, and 1,024 cm(-1), associated with C-H stretching, N-H bending in primary amines, N-O stretching in nitro group, and C-C stretch, respectively. Anticancer activity against HeLa cells showed that Pt-PdNPs exhibited more pronounced cell death of 74.25% compared to individual PtNPs (12.6%) or PdNPs (33.15%). Further, Pt-PdNPs showed an enhanced scavenging activity against 2,2-diphenyl-1-picrylhydrazyl, superoxide, nitric oxide, and hydroxyl radicals.

  • Phytochemistry and Therapeutic Potential of Medicinal Plant: Dioscorea bulbifera
    Medicinal Chemistry, 2015
    Co-Authors: Sougata Ghosh, Dilip D Dhavale, Vijay Singh Parihar, Piyush More, Balu A Chopade
    Abstract:

    Dioscorea bulbifera is an immensely important medicinal plant which is extensively used in both Indian and Chinese system of traditional medicine. It is found in many parts of the world and has gained wide attention not only for health care but also as a food crop. It has attracted scientific interest owing to its numerous therapeutic applications in various pathophysiological conditions like ulcers, sores, wound, spasms, dysentery, diabetes and cancer. Spectacular success in extensive research particularly within last two decades has proven that these activities are attributed to its unique phytochemistry. Bioactive components from D. bulbifera have exhibited anti-oxidant, antiinflammatory, antibacterial, plasmid curing, antidiabetic and anticancer activities. It has become a model system in nanobiotechnology as it harbours phytochemicals with reducing, capping and shape modulating efficiencies. Numerous studies, either separately or in association, have aimed to explain the chemical composition and mechanisms behind its pharmacognostic significance. Similarly, many reports have documented and validated the claimed traditional usage by providing a strong scientific rationale. However, there is no review published on its in vitro, in vivo and in silico applications along with detailed phytochemistry. In view of the background, this review elaborates the complete phytochemistry of D. bulbifera with therapeutic importance.

  • antidiabetic activity of gnidia glauca and Dioscorea bulbifera potent amylase and glucosidase inhibitors
    Evidence-based Complementary and Alternative Medicine, 2012
    Co-Authors: Sougata Ghosh, Mehul Ahire, Sumersing Patil, Amit M Jabgunde, Meenakshi Bhat Dusane, Bimba N Joshi, Karishma Pardesi, Sanjay M Jachak, Dilip D Dhavale, Balu A Chopade
    Abstract:

    Diabetes is a metabolic disorder affecting about 220 million people worldwide. One of the most critical complications of diabetes is post-prandial hyper-glycemia (PPHG). Glucosidase inhibitor and α-amylase inhibitors are class of compounds that help in managing PPHG. Low-cost herbal treatment is recommended due to their lesser side effect for treatment of diabetes. Two plants with significant traditional therapeutic potential, namely, Gnidia glauca and Dioscorea bulbifera, were tested for their efficiency to inhibit α-amylase and α-glucosidase. Stem, leaf, and flower of G. glauca and bulb of D. bulbifera were sequentially extracted with petroleum ether, ethyl acetate, and methanol as well as separately with 70% ethanol. Petroleum ether extract of flower of G. glauca was found to inhibit α-amylase significantly (78.56%). Extracts were further tested against crude murine pancreatic, small intestinal, and liver glucosidase enzyme which revealed excellent inhibitory properties. α-glucosidase inhibition provided a strong in vitro evidence for confirmation of both G. glauca and D. bulbifera as excellent antidiabetic remedy. This is the first report of its kind that provides a strong biochemical basis for management of type II diabetes using G. glauca and D. bulbifera. These results provide intense rationale for further in vivo and clinical study.

  • synthesis of gold nanoanisotrops using Dioscorea bulbifera tuber extract
    Journal of Nanomaterials, 2011
    Co-Authors: Sougata Ghosh, Mehul Ahire, Sumersing Patil, Amit M Jabgunde, Karishma Pardesi, Dilip D Dhavale, Rohini Kitture, S N Kale, Jayesh R Bellare, Balu A Chopade
    Abstract:

    Biosynthesis of metal nanoparticles employing plant extracts and thereby development of an environmentally benign process is an important branch of nanotechnology. Here, the synthesis of gold nanoparticles using Dioscorea bulbifera tuber extract (DBTE) as the reducing agent is reported. Field emission scanning electron microscopy (FESEM), energy-dispersive spectroscopy (EDX), X-ray diffraction (XRD), and UV-visible absorption spectroscopy confirmed the reduction of gold ions to AuNPs. The anisotropic nanoparticles consist of a mixture of gold nanotriangles, nanoprisms, nanotrapezoid, and spheres. The kinetics of particle formation was time dependent and was enhanced by the increase of temperature from 6° to 50°, the optimum being 50°. The optimum concentration of chloroauric acid was found to be 1mM. Complete reduction of the metal ions within 5 hours by DBTE highlights the development of a novel ecofriendly route of biological synthesis of gold nanoparticles. This is the first paper on synthesis of gold nanoparticles using DBTE.

Junming Wang - One of the best experts on this subject based on the ideXlab platform.

  • protection of angelica sinensis oliv diels against hepatotoxicity induced by Dioscorea bulbifera l and its mechanism
    BioScience Trends, 2014
    Co-Authors: Chengwei Niu, Junming Wang, Zhengtao Wang
    Abstract:

    Dioscorea bulbifera L., a traditionally used medicinal plant in China, is reported to induce hepatotoxicity. The present study is designed to investigate the protection of an ethanol extract of Angelica sinensis (Oliv) Diels (AE) against an ethyl acetate fraction of D. bulbifera (EF)-induced liver injury and its engaged mechanism. High performance liquid chromatography (HPLC) analysis showed that the amount of diosbulbin B in EF was 16.03% and ferulic acid in AE was 0.18%. EF (350 mg/kg) increased serum alanine/aspartate aminotransferase (ALT/AST), alkaline phosphatase (ALP) activities and total bilirubin (TB) amount, while AE inhibited such an increase. Liver histological evaluation showed that AE prevented development of severe hepatic lesions induced by EF. Further results showed that EF decreased the expression of Bcl-2 and induced the cleaved activation of caspase-9 and -3, and all those effects were reversed by AE. AE also reversed EF-induced decreased expression of the inhibitor of kappa B (IκB), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Taken together, our results demonstrate that AE can prevent EF-induced hepatotoxicity via preventing apoptosis, meanwhile IκB, SOD, and GPx may be involved in such protection.

  • antitumor activity of Dioscorea bulbifera l rhizome in vivo
    Fitoterapia, 2012
    Co-Authors: Hai Liu, Junming Wang, Christopher Branfordwhite, Zaiyong Wang, Kaikai Shen, Zhengtao Wang
    Abstract:

    Antitumor activities of water extract (fraction A), ethanol extract (fraction B), ethyl acetate extract (fraction C), non-ethyl acetate extract (fraction D) and compound diosbulbin B isolated from Dioscorea bulbifera L. (DB) were investigated in vivo in this present study. The results showed that fractions B and C both decreased tumor weight in S180 and H22 tumor cells bearing mice, while fractions A and D had no such effect. Furthermore, fraction C altered the weight of spleen and thymus, and the amounts of total leukocytes, lymphocytes and neutrophils in tumor-bearing mice. Further results showed that compound diosbulbin B demonstrated anti-tumor effects in the dose-dependent manner at the dosage of 2 to 16 mg/kg without significant toxicity in vivo. Furthermore, on the basis of chemical analysis of the above extracts by high-performance liquid chromatography (HPLC) with a diode array detector (DAD), diosbulbin B was found to be the major antitumor bioactive component of DB. These results suggest that DB has potential anti-tumor effects which may be related to influencing the immune system for the first time, and the compound diosbulbin B is the major antitumor component of DB.

  • phenolic compounds from the rhizomes of Dioscorea bulbifera
    Chemistry & Biodiversity, 2011
    Co-Authors: Hai Liu, Guixin Chou, Karl Wah Keung Tsim, Junming Wang, Zhengtao Wang
    Abstract:

    One new bibenzyl, 7, and one new diarylheptanone, diobulbinone A (18), together with sixteen known compounds, 1-6 and 8-17, have been isolated form the rhizomes of Dioscorea bulbifera. Their structures were elucidated by NMR and MS analyses. Compound 7 showed high antioxidant capacity in FRAP assay and DPPH radical-scavenging activity.

  • gender related difference in liver injury induced by Dioscorea bulbifera l rhizome in mice
    Human & Experimental Toxicology, 2011
    Co-Authors: Junming Wang, Chang-hong Wang, Hai Liu, Qingning Liang, Zhengtao Wang
    Abstract:

    The present study was undertaken to investigate the gender-related liver injury induced by Dioscorea bulbifera L. (DB), a traditional medicinal plant, in mice, and further explored its hepatotoxic ...

  • steroidal saponins from the rhizomes of Dioscorea bulbifera and their cytotoxic activity
    Planta Medica, 2011
    Co-Authors: Hai Liu, Guixin Chou, Junming Wang, Zhengtao Wang
    Abstract:

    Two new steroidal saponins, diosbulbisides D (1) and E (2), along with five known saponins (3- 7) were isolated from the rhizomes of Dioscorea bulbifera L. Their structures were elucidated on the basis of spectral data. Compounds 6 and 7, two 3- O-trisaccharides of diosgenin spirostanes, showed moderate cytotoxic activity against human hepatocellular carcinoma cells, with IC₅₀ values of 3.89 µM and 7.47 µM on SMMC7721, and 10.87 µM and 19.10 µM on Bel-7402 cell lines, respectively.