The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Kenji F. Tanaka - One of the best experts on this subject based on the ideXlab platform.
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Chronic social defeat stress impairs goal-Directed Behavior through dysregulation of ventral hippocampal activity in male mice
Neuropsychopharmacology, 2021Co-Authors: Keitaro Yoshida, Michael R. Drew, Norio Takata, Masaru Mimura, Anna Kono, Kenji F. TanakaAbstract:Chronic stress is a risk factor for a variety of psychiatric disorders, including depression. Although impairments to motivated Behavior are a major symptom of clinical depression, little is known about the circuit mechanisms through which stress impairs motivation. Furthermore, research in animal models for depression has focused on impairments to hedonic aspects of motivation, whereas patient studies suggest that impairments to appetitive, goal-Directed motivation contribute significantly to motivational impairments in depression. Here, we characterized goal-Directed motivation in repeated social defeat stress (R-SDS), a well-established mouse model for depression in male mice. R-SDS impaired the ability to sustain and complete goal-Directed Behavior in a food-seeking operant lever-press task. Furthermore, stress-exposed mice segregated into susceptible and resilient subpopulations. Interestingly, susceptibility to stress-induced motivational impairments was unrelated to stress-induced social withdrawal, another prominent effect of R-SDS in mouse models. Based on evidence that ventral hippocampus (vHP) modulates sustainment of goal-Directed Behavior, we monitored vHP activity during the task using fiber photometry. Successful task completion was associated with suppression of ventral hippocampal neural activity. This suppression was diminished after R-SDS in stress-susceptible but not stress-resilient mice. The serotonin selective reuptake inhibitor (SSRI) escitalopram and ketamine both normalized vHP activity during the task and restored motivated Behavior. Furthermore, optogenetic vHP inhibition was sufficient to restore motivated Behavior after stress. These results identify vHP hyperactivity as a circuit mechanism of stress-induced impairments to goal-Directed Behavior and a putative biomarker that is sensitive to antidepressant treatments and that differentiates susceptible and resilient individuals.
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Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-Directed Behavior.
Nature Neuroscience, 2019Co-Authors: Keitaro Yoshida, Michael R. Drew, Masaru Mimura, Kenji F. TanakaAbstract:The ability to sustain goal-Directed action is essential for success in many domains, but little is known about the corresponding neural substrates. Using fiber photometry to monitor population neural activity, we demonstrate that engagement in sustained food- or punishment-motivated Behavior is associated with suppression of ventral but not dorsal hippocampal activity. Using optogenetic stimulation, we demonstrate that this suppression is required for goal-Directed Behavior, whereas optogenetic suppression of the ventral hippocampus (vHP) enhances the ability to sustain goal-Directed Behavior. Suppression of vHP during sustained goal-Directed Behavior was accompanied by increased activity in median but not dorsal raphe, implicating serotonergic signaling through Htr3a as a mechanism of vHP suppression during successful goal-Directed Behavior. Sustainment of goal-Directed action may require suppression of vHP because of the structure’s well-documented role in Behavioral inhibition. Yoshida et al. show in mice that sustained engagement in motivated Behavior requires suppression of ventral hippocampus activity through activation of median raphe serotonin neurons.
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Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-Directed Behavior.
Nature neuroscience, 2019Co-Authors: Keitaro Yoshida, Michael R. Drew, Masaru Mimura, Kenji F. TanakaAbstract:The ability to sustain goal-Directed action is essential for success in many domains, but little is known about the corresponding neural substrates. Using fiber photometry to monitor population neural activity, we demonstrate that engagement in sustained food- or punishment-motivated Behavior is associated with suppression of ventral but not dorsal hippocampal activity. Using optogenetic stimulation, we demonstrate that this suppression is required for goal-Directed Behavior, whereas optogenetic suppression of the ventral hippocampus (vHP) enhances the ability to sustain goal-Directed Behavior. Suppression of vHP during sustained goal-Directed Behavior was accompanied by increased activity in median but not dorsal raphe, implicating serotonergic signaling through Htr3a as a mechanism of vHP suppression during successful goal-Directed Behavior. Sustainment of goal-Directed action may require suppression of vHP because of the structure's well-documented role in Behavioral inhibition.
Keitaro Yoshida - One of the best experts on this subject based on the ideXlab platform.
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Chronic social defeat stress impairs goal-Directed Behavior through dysregulation of ventral hippocampal activity in male mice
Neuropsychopharmacology, 2021Co-Authors: Keitaro Yoshida, Michael R. Drew, Norio Takata, Masaru Mimura, Anna Kono, Kenji F. TanakaAbstract:Chronic stress is a risk factor for a variety of psychiatric disorders, including depression. Although impairments to motivated Behavior are a major symptom of clinical depression, little is known about the circuit mechanisms through which stress impairs motivation. Furthermore, research in animal models for depression has focused on impairments to hedonic aspects of motivation, whereas patient studies suggest that impairments to appetitive, goal-Directed motivation contribute significantly to motivational impairments in depression. Here, we characterized goal-Directed motivation in repeated social defeat stress (R-SDS), a well-established mouse model for depression in male mice. R-SDS impaired the ability to sustain and complete goal-Directed Behavior in a food-seeking operant lever-press task. Furthermore, stress-exposed mice segregated into susceptible and resilient subpopulations. Interestingly, susceptibility to stress-induced motivational impairments was unrelated to stress-induced social withdrawal, another prominent effect of R-SDS in mouse models. Based on evidence that ventral hippocampus (vHP) modulates sustainment of goal-Directed Behavior, we monitored vHP activity during the task using fiber photometry. Successful task completion was associated with suppression of ventral hippocampal neural activity. This suppression was diminished after R-SDS in stress-susceptible but not stress-resilient mice. The serotonin selective reuptake inhibitor (SSRI) escitalopram and ketamine both normalized vHP activity during the task and restored motivated Behavior. Furthermore, optogenetic vHP inhibition was sufficient to restore motivated Behavior after stress. These results identify vHP hyperactivity as a circuit mechanism of stress-induced impairments to goal-Directed Behavior and a putative biomarker that is sensitive to antidepressant treatments and that differentiates susceptible and resilient individuals.
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Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-Directed Behavior.
Nature Neuroscience, 2019Co-Authors: Keitaro Yoshida, Michael R. Drew, Masaru Mimura, Kenji F. TanakaAbstract:The ability to sustain goal-Directed action is essential for success in many domains, but little is known about the corresponding neural substrates. Using fiber photometry to monitor population neural activity, we demonstrate that engagement in sustained food- or punishment-motivated Behavior is associated with suppression of ventral but not dorsal hippocampal activity. Using optogenetic stimulation, we demonstrate that this suppression is required for goal-Directed Behavior, whereas optogenetic suppression of the ventral hippocampus (vHP) enhances the ability to sustain goal-Directed Behavior. Suppression of vHP during sustained goal-Directed Behavior was accompanied by increased activity in median but not dorsal raphe, implicating serotonergic signaling through Htr3a as a mechanism of vHP suppression during successful goal-Directed Behavior. Sustainment of goal-Directed action may require suppression of vHP because of the structure’s well-documented role in Behavioral inhibition. Yoshida et al. show in mice that sustained engagement in motivated Behavior requires suppression of ventral hippocampus activity through activation of median raphe serotonin neurons.
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Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-Directed Behavior.
Nature neuroscience, 2019Co-Authors: Keitaro Yoshida, Michael R. Drew, Masaru Mimura, Kenji F. TanakaAbstract:The ability to sustain goal-Directed action is essential for success in many domains, but little is known about the corresponding neural substrates. Using fiber photometry to monitor population neural activity, we demonstrate that engagement in sustained food- or punishment-motivated Behavior is associated with suppression of ventral but not dorsal hippocampal activity. Using optogenetic stimulation, we demonstrate that this suppression is required for goal-Directed Behavior, whereas optogenetic suppression of the ventral hippocampus (vHP) enhances the ability to sustain goal-Directed Behavior. Suppression of vHP during sustained goal-Directed Behavior was accompanied by increased activity in median but not dorsal raphe, implicating serotonergic signaling through Htr3a as a mechanism of vHP suppression during successful goal-Directed Behavior. Sustainment of goal-Directed action may require suppression of vHP because of the structure's well-documented role in Behavioral inhibition.
Masaru Mimura - One of the best experts on this subject based on the ideXlab platform.
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Chronic social defeat stress impairs goal-Directed Behavior through dysregulation of ventral hippocampal activity in male mice
Neuropsychopharmacology, 2021Co-Authors: Keitaro Yoshida, Michael R. Drew, Norio Takata, Masaru Mimura, Anna Kono, Kenji F. TanakaAbstract:Chronic stress is a risk factor for a variety of psychiatric disorders, including depression. Although impairments to motivated Behavior are a major symptom of clinical depression, little is known about the circuit mechanisms through which stress impairs motivation. Furthermore, research in animal models for depression has focused on impairments to hedonic aspects of motivation, whereas patient studies suggest that impairments to appetitive, goal-Directed motivation contribute significantly to motivational impairments in depression. Here, we characterized goal-Directed motivation in repeated social defeat stress (R-SDS), a well-established mouse model for depression in male mice. R-SDS impaired the ability to sustain and complete goal-Directed Behavior in a food-seeking operant lever-press task. Furthermore, stress-exposed mice segregated into susceptible and resilient subpopulations. Interestingly, susceptibility to stress-induced motivational impairments was unrelated to stress-induced social withdrawal, another prominent effect of R-SDS in mouse models. Based on evidence that ventral hippocampus (vHP) modulates sustainment of goal-Directed Behavior, we monitored vHP activity during the task using fiber photometry. Successful task completion was associated with suppression of ventral hippocampal neural activity. This suppression was diminished after R-SDS in stress-susceptible but not stress-resilient mice. The serotonin selective reuptake inhibitor (SSRI) escitalopram and ketamine both normalized vHP activity during the task and restored motivated Behavior. Furthermore, optogenetic vHP inhibition was sufficient to restore motivated Behavior after stress. These results identify vHP hyperactivity as a circuit mechanism of stress-induced impairments to goal-Directed Behavior and a putative biomarker that is sensitive to antidepressant treatments and that differentiates susceptible and resilient individuals.
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Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-Directed Behavior.
Nature Neuroscience, 2019Co-Authors: Keitaro Yoshida, Michael R. Drew, Masaru Mimura, Kenji F. TanakaAbstract:The ability to sustain goal-Directed action is essential for success in many domains, but little is known about the corresponding neural substrates. Using fiber photometry to monitor population neural activity, we demonstrate that engagement in sustained food- or punishment-motivated Behavior is associated with suppression of ventral but not dorsal hippocampal activity. Using optogenetic stimulation, we demonstrate that this suppression is required for goal-Directed Behavior, whereas optogenetic suppression of the ventral hippocampus (vHP) enhances the ability to sustain goal-Directed Behavior. Suppression of vHP during sustained goal-Directed Behavior was accompanied by increased activity in median but not dorsal raphe, implicating serotonergic signaling through Htr3a as a mechanism of vHP suppression during successful goal-Directed Behavior. Sustainment of goal-Directed action may require suppression of vHP because of the structure’s well-documented role in Behavioral inhibition. Yoshida et al. show in mice that sustained engagement in motivated Behavior requires suppression of ventral hippocampus activity through activation of median raphe serotonin neurons.
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Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-Directed Behavior.
Nature neuroscience, 2019Co-Authors: Keitaro Yoshida, Michael R. Drew, Masaru Mimura, Kenji F. TanakaAbstract:The ability to sustain goal-Directed action is essential for success in many domains, but little is known about the corresponding neural substrates. Using fiber photometry to monitor population neural activity, we demonstrate that engagement in sustained food- or punishment-motivated Behavior is associated with suppression of ventral but not dorsal hippocampal activity. Using optogenetic stimulation, we demonstrate that this suppression is required for goal-Directed Behavior, whereas optogenetic suppression of the ventral hippocampus (vHP) enhances the ability to sustain goal-Directed Behavior. Suppression of vHP during sustained goal-Directed Behavior was accompanied by increased activity in median but not dorsal raphe, implicating serotonergic signaling through Htr3a as a mechanism of vHP suppression during successful goal-Directed Behavior. Sustainment of goal-Directed action may require suppression of vHP because of the structure's well-documented role in Behavioral inhibition.
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Ventrolateral Striatal Medium Spiny Neurons Positively Regulate Food-Incentive, Goal-Directed Behavior Independently of D1 and D2 Selectivity.
The Journal of Neuroscience, 2017Co-Authors: Akiyo Natsubori, Iku Tsutsui-kimura, Youcef Bouchekioua, Alban De Kerchove D'exaerde, Motokazu Uchigashima, Hiroshi Sekiya, Masahiko Watanabe, Hiroshi Nishida, Masaru Mimura, Norio TakataAbstract:The ventral striatum is involved in motivated Behavior. Akin to the dorsal striatum, the ventral striatum contains two parallel pathways: the striatomesencephalic pathway consisting of dopamine receptor Type 1-expressing medium spiny neurons (D1-MSNs) and the striatopallidal pathway consisting of D2-MSNs. These two genetically identified pathways are thought to encode opposing functions in motivated Behavior. It has also been reported that D1/D2 genetic selectivity is not attributed to the anatomical discrimination of two pathways. We wanted to determine whether D1- and D2-MSNs in the ventral striatum functioned in an opposing manner as previous observations claimed, and whether D1/D2 selectivity corresponded to a functional segregation in motivated Behavior of mice. To address this question, we focused on the lateral portion of ventral striatum as a region implicated in food-incentive, goal-Directed Behavior, and recorded D1 or D2-MSN activity by using a gene-encoded ratiometric Ca 2+ indicator and by constructing a fiberphotometry system, and manipulated their activities via optogenetic inhibition during ongoing Behaviors. We observed concurrent event-related compound Ca 2+ elevations in ventrolateral D1- and D2-MSNs, especially at trial start cue-related and first lever press-related times. D1 or D2 selective optogenetic inhibition just after the trial start cue resulted in a reduction of goal-Directed Behavior, indicating a shared coding of motivated Behavior by both populations at this time. Only D1-selective inhibition just after the first lever press resulted in the reduction of Behavior, indicating D1-MSN-specific coding at that specific time. Our data did not support opposing encoding by both populations in food-incentive, goal-Directed Behavior. SIGNIFICANCE STATEMENT An opposing role of dopamine receptor Type 1 or Type 2-expressing medium spiny neurons (D1-MSNs or D2-MSNs) on striatum-mediated Behaviors has been widely accepted. However, this idea has been questioned by recent reports. In the present study, we measured concurrent Ca 2+ activity patterns of D1- and D2-MSNs in the ventrolateral striatum during food-incentive, goal-Directed Behavior in mice. According to Ca 2+ activity patterns, we conducted timing-specific optogenetic inhibition of each type of MSN. We demonstrated that both D1- and D2-MSNs in the ventrolateral striatum commonly and positively encoded action initiation, whereas only D1-MSNs positively encoded sustained motivated Behavior. These findings led us to reconsider the prevailing notion of a functional segregation of MSN activity in the ventral striatum.
Michael R. Drew - One of the best experts on this subject based on the ideXlab platform.
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Chronic social defeat stress impairs goal-Directed Behavior through dysregulation of ventral hippocampal activity in male mice
Neuropsychopharmacology, 2021Co-Authors: Keitaro Yoshida, Michael R. Drew, Norio Takata, Masaru Mimura, Anna Kono, Kenji F. TanakaAbstract:Chronic stress is a risk factor for a variety of psychiatric disorders, including depression. Although impairments to motivated Behavior are a major symptom of clinical depression, little is known about the circuit mechanisms through which stress impairs motivation. Furthermore, research in animal models for depression has focused on impairments to hedonic aspects of motivation, whereas patient studies suggest that impairments to appetitive, goal-Directed motivation contribute significantly to motivational impairments in depression. Here, we characterized goal-Directed motivation in repeated social defeat stress (R-SDS), a well-established mouse model for depression in male mice. R-SDS impaired the ability to sustain and complete goal-Directed Behavior in a food-seeking operant lever-press task. Furthermore, stress-exposed mice segregated into susceptible and resilient subpopulations. Interestingly, susceptibility to stress-induced motivational impairments was unrelated to stress-induced social withdrawal, another prominent effect of R-SDS in mouse models. Based on evidence that ventral hippocampus (vHP) modulates sustainment of goal-Directed Behavior, we monitored vHP activity during the task using fiber photometry. Successful task completion was associated with suppression of ventral hippocampal neural activity. This suppression was diminished after R-SDS in stress-susceptible but not stress-resilient mice. The serotonin selective reuptake inhibitor (SSRI) escitalopram and ketamine both normalized vHP activity during the task and restored motivated Behavior. Furthermore, optogenetic vHP inhibition was sufficient to restore motivated Behavior after stress. These results identify vHP hyperactivity as a circuit mechanism of stress-induced impairments to goal-Directed Behavior and a putative biomarker that is sensitive to antidepressant treatments and that differentiates susceptible and resilient individuals.
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Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-Directed Behavior.
Nature Neuroscience, 2019Co-Authors: Keitaro Yoshida, Michael R. Drew, Masaru Mimura, Kenji F. TanakaAbstract:The ability to sustain goal-Directed action is essential for success in many domains, but little is known about the corresponding neural substrates. Using fiber photometry to monitor population neural activity, we demonstrate that engagement in sustained food- or punishment-motivated Behavior is associated with suppression of ventral but not dorsal hippocampal activity. Using optogenetic stimulation, we demonstrate that this suppression is required for goal-Directed Behavior, whereas optogenetic suppression of the ventral hippocampus (vHP) enhances the ability to sustain goal-Directed Behavior. Suppression of vHP during sustained goal-Directed Behavior was accompanied by increased activity in median but not dorsal raphe, implicating serotonergic signaling through Htr3a as a mechanism of vHP suppression during successful goal-Directed Behavior. Sustainment of goal-Directed action may require suppression of vHP because of the structure’s well-documented role in Behavioral inhibition. Yoshida et al. show in mice that sustained engagement in motivated Behavior requires suppression of ventral hippocampus activity through activation of median raphe serotonin neurons.
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Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-Directed Behavior.
Nature neuroscience, 2019Co-Authors: Keitaro Yoshida, Michael R. Drew, Masaru Mimura, Kenji F. TanakaAbstract:The ability to sustain goal-Directed action is essential for success in many domains, but little is known about the corresponding neural substrates. Using fiber photometry to monitor population neural activity, we demonstrate that engagement in sustained food- or punishment-motivated Behavior is associated with suppression of ventral but not dorsal hippocampal activity. Using optogenetic stimulation, we demonstrate that this suppression is required for goal-Directed Behavior, whereas optogenetic suppression of the ventral hippocampus (vHP) enhances the ability to sustain goal-Directed Behavior. Suppression of vHP during sustained goal-Directed Behavior was accompanied by increased activity in median but not dorsal raphe, implicating serotonergic signaling through Htr3a as a mechanism of vHP suppression during successful goal-Directed Behavior. Sustainment of goal-Directed action may require suppression of vHP because of the structure's well-documented role in Behavioral inhibition.
Henrik Hagtvedt - One of the best experts on this subject based on the ideXlab platform.
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“I Don’t” versus “I Can’t”: When Empowered Refusal Motivates Goal-Directed Behavior
Journal of Consumer Research, 2012Co-Authors: Vanessa M. Patrick, Henrik HagtvedtAbstract:This research is based on the insight that the language we use to describe our choices serves as a feedback mechanism that either enhances or impedes our goal-Directed Behavior. Specifically, we investigate the influence of a linguistic element of self-talk, in which a refusal may be framed as “I don’t” (vs. “I can’t”), on resisting temptation and motivating goal-Directed Behavior. We present a set of four studies to demonstrate the efficacy of the “don’t” (vs. “can’t”) framing (studies 1–3) when the source of the goal is internal (vs. external; studies 2A and 2B), as well as the mediating role of psychological empowerment (studies 1, 2A, and 2B). We demonstrate this novel and effective refusal strategy with actual choice (study 1) and with Behavioral intent (studies 2A and 2B) and also illustrate its applicability in the real world in a longitudinal intervention-based field study (study 3).
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'I Don’t' versus 'I Can’t': When Empowered Refusal Motivates Goal-Directed Behavior
2012Co-Authors: Vanessa M. Patrick, Henrik HagtvedtAbstract:This research is based on the insight that the language we use to describe our choices serves as a feedback mechanism that either enhances or impedes our goal-Directed Behavior. Specifically, we investigate the influence of a linguistic element of self-talk, in which a refusal may be framed as “I don’t” (vs. “I can’t”), on resisting temptation and motivating goal-Directed Behavior. We present a set of four studies to demonstrate the efficacy of the “don’t” (vs. “can’t”) framing (studies 1-3) when the source of the goal is internal (vs. external; studies 2a and 2b), as well as the mediating role of psychological empowerment (studies 1, 2a, and 2b). We demonstrate this novel and effective refusal strategy with actual choice (study 1) and with Behavioral intent (studies 2a and 2b) and also illustrate its applicability in the real world in a longitudinal intervention-based field study (study 3).
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i don t versus i can t when empowered refusal motivates goal Directed Behavior
2012Co-Authors: Vanessa M. Patrick, Henrik HagtvedtAbstract:This research is based on the insight that the language we use to describe our choices serves as a feedback mechanism that either enhances or impedes our goal-Directed Behavior. Specifically, we investigate the influence of a linguistic element of self-talk, in which a refusal may be framed as “I don’t” (vs. “I can’t”), on resisting temptation and motivating goal-Directed Behavior. We present a set of four studies to demonstrate the efficacy of the “don’t” (vs. “can’t”) framing (studies 1-3) when the source of the goal is internal (vs. external; studies 2a and 2b), as well as the mediating role of psychological empowerment (studies 1, 2a, and 2b). We demonstrate this novel and effective refusal strategy with actual choice (study 1) and with Behavioral intent (studies 2a and 2b) and also illustrate its applicability in the real world in a longitudinal intervention-based field study (study 3).