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Yaping Zhang - One of the best experts on this subject based on the ideXlab platform.

  • association of Disease Predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations
    Journal of Pineal Research, 2010
    Co-Authors: Lindan Ji, Jin Xu, Dongdong Wu, Nelson L S Tang, Yaping Zhang
    Abstract:

    Melatonin is predominantly involved in signaling circadian and seasonal rhythms, and its synthesis is regulated by the environmental light/ dark cycle. The selection pressure by geographically different environmental light/dark cycles, which is predominantly determined by sunshine duration, on the global distribution of genetic polymorphisms in the melatonin pathway is not well understood. Recent genetic association studies identified various Disease-Predisposition polymorphisms in this pathway. We investigated the correlations between the prevalence of these clinically important single nucleotide polymorphisms (SNPs) and sunshine duration among worldwide human populations from twelve regions in the CEPH-HGDP database rs4753426, a recently reported Predisposition SNP for type 2 diabetes in the promoter of the MT 2 melatonin receptor gene (MTNR1B), which was not included in the CEPH-HGDP genotyping array, was additionally genotyped. This SNP showed a marginally significant correlation in 760 CEPH-HGDP DNA samples (r = -0.5346, P = 0.0733), and it showed the most prominent association among the candidate melatonin pathway SNPs examined. To control for population structure, which may lead to a false positive correlation, we genotyped this SNP in a replication set of 1792 subjects from China. The correlation was confirmed among Chinese populations (r = -0.8694, P = 0.0002), and was also statistically significant after correction of other climatic and geographical covariants in multiple regression analysis (β = -0.907, P = 1.94 x 10 -5 ). Taken together, it suggests that the human melatonin signaling pathway, particularly MT 2 melatonin receptor may have undergone a selective pressure in response to global variation in sunshine duration.

  • Association of Disease‐Predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations
    Journal of Pineal Research, 2009
    Co-Authors: Lindan Ji, Jin Xu, Dongdong Wu, Nelson L S Tang, Yaping Zhang
    Abstract:

    Melatonin is predominantly involved in signaling circadian and seasonal rhythms, and its synthesis is regulated by the environmental light/ dark cycle. The selection pressure by geographically different environmental light/dark cycles, which is predominantly determined by sunshine duration, on the global distribution of genetic polymorphisms in the melatonin pathway is not well understood. Recent genetic association studies identified various Disease-Predisposition polymorphisms in this pathway. We investigated the correlations between the prevalence of these clinically important single nucleotide polymorphisms (SNPs) and sunshine duration among worldwide human populations from twelve regions in the CEPH-HGDP database rs4753426, a recently reported Predisposition SNP for type 2 diabetes in the promoter of the MT 2 melatonin receptor gene (MTNR1B), which was not included in the CEPH-HGDP genotyping array, was additionally genotyped. This SNP showed a marginally significant correlation in 760 CEPH-HGDP DNA samples (r = -0.5346, P = 0.0733), and it showed the most prominent association among the candidate melatonin pathway SNPs examined. To control for population structure, which may lead to a false positive correlation, we genotyped this SNP in a replication set of 1792 subjects from China. The correlation was confirmed among Chinese populations (r = -0.8694, P = 0.0002), and was also statistically significant after correction of other climatic and geographical covariants in multiple regression analysis (β = -0.907, P = 1.94 x 10 -5 ). Taken together, it suggests that the human melatonin signaling pathway, particularly MT 2 melatonin receptor may have undergone a selective pressure in response to global variation in sunshine duration.

Lindan Ji - One of the best experts on this subject based on the ideXlab platform.

  • association of Disease Predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations
    Journal of Pineal Research, 2010
    Co-Authors: Lindan Ji, Jin Xu, Dongdong Wu, Nelson L S Tang, Yaping Zhang
    Abstract:

    Melatonin is predominantly involved in signaling circadian and seasonal rhythms, and its synthesis is regulated by the environmental light/ dark cycle. The selection pressure by geographically different environmental light/dark cycles, which is predominantly determined by sunshine duration, on the global distribution of genetic polymorphisms in the melatonin pathway is not well understood. Recent genetic association studies identified various Disease-Predisposition polymorphisms in this pathway. We investigated the correlations between the prevalence of these clinically important single nucleotide polymorphisms (SNPs) and sunshine duration among worldwide human populations from twelve regions in the CEPH-HGDP database rs4753426, a recently reported Predisposition SNP for type 2 diabetes in the promoter of the MT 2 melatonin receptor gene (MTNR1B), which was not included in the CEPH-HGDP genotyping array, was additionally genotyped. This SNP showed a marginally significant correlation in 760 CEPH-HGDP DNA samples (r = -0.5346, P = 0.0733), and it showed the most prominent association among the candidate melatonin pathway SNPs examined. To control for population structure, which may lead to a false positive correlation, we genotyped this SNP in a replication set of 1792 subjects from China. The correlation was confirmed among Chinese populations (r = -0.8694, P = 0.0002), and was also statistically significant after correction of other climatic and geographical covariants in multiple regression analysis (β = -0.907, P = 1.94 x 10 -5 ). Taken together, it suggests that the human melatonin signaling pathway, particularly MT 2 melatonin receptor may have undergone a selective pressure in response to global variation in sunshine duration.

  • Association of Disease‐Predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations
    Journal of Pineal Research, 2009
    Co-Authors: Lindan Ji, Jin Xu, Dongdong Wu, Nelson L S Tang, Yaping Zhang
    Abstract:

    Melatonin is predominantly involved in signaling circadian and seasonal rhythms, and its synthesis is regulated by the environmental light/ dark cycle. The selection pressure by geographically different environmental light/dark cycles, which is predominantly determined by sunshine duration, on the global distribution of genetic polymorphisms in the melatonin pathway is not well understood. Recent genetic association studies identified various Disease-Predisposition polymorphisms in this pathway. We investigated the correlations between the prevalence of these clinically important single nucleotide polymorphisms (SNPs) and sunshine duration among worldwide human populations from twelve regions in the CEPH-HGDP database rs4753426, a recently reported Predisposition SNP for type 2 diabetes in the promoter of the MT 2 melatonin receptor gene (MTNR1B), which was not included in the CEPH-HGDP genotyping array, was additionally genotyped. This SNP showed a marginally significant correlation in 760 CEPH-HGDP DNA samples (r = -0.5346, P = 0.0733), and it showed the most prominent association among the candidate melatonin pathway SNPs examined. To control for population structure, which may lead to a false positive correlation, we genotyped this SNP in a replication set of 1792 subjects from China. The correlation was confirmed among Chinese populations (r = -0.8694, P = 0.0002), and was also statistically significant after correction of other climatic and geographical covariants in multiple regression analysis (β = -0.907, P = 1.94 x 10 -5 ). Taken together, it suggests that the human melatonin signaling pathway, particularly MT 2 melatonin receptor may have undergone a selective pressure in response to global variation in sunshine duration.

Nelson L S Tang - One of the best experts on this subject based on the ideXlab platform.

  • association of Disease Predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations
    Journal of Pineal Research, 2010
    Co-Authors: Lindan Ji, Jin Xu, Dongdong Wu, Nelson L S Tang, Yaping Zhang
    Abstract:

    Melatonin is predominantly involved in signaling circadian and seasonal rhythms, and its synthesis is regulated by the environmental light/ dark cycle. The selection pressure by geographically different environmental light/dark cycles, which is predominantly determined by sunshine duration, on the global distribution of genetic polymorphisms in the melatonin pathway is not well understood. Recent genetic association studies identified various Disease-Predisposition polymorphisms in this pathway. We investigated the correlations between the prevalence of these clinically important single nucleotide polymorphisms (SNPs) and sunshine duration among worldwide human populations from twelve regions in the CEPH-HGDP database rs4753426, a recently reported Predisposition SNP for type 2 diabetes in the promoter of the MT 2 melatonin receptor gene (MTNR1B), which was not included in the CEPH-HGDP genotyping array, was additionally genotyped. This SNP showed a marginally significant correlation in 760 CEPH-HGDP DNA samples (r = -0.5346, P = 0.0733), and it showed the most prominent association among the candidate melatonin pathway SNPs examined. To control for population structure, which may lead to a false positive correlation, we genotyped this SNP in a replication set of 1792 subjects from China. The correlation was confirmed among Chinese populations (r = -0.8694, P = 0.0002), and was also statistically significant after correction of other climatic and geographical covariants in multiple regression analysis (β = -0.907, P = 1.94 x 10 -5 ). Taken together, it suggests that the human melatonin signaling pathway, particularly MT 2 melatonin receptor may have undergone a selective pressure in response to global variation in sunshine duration.

  • Association of Disease‐Predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations
    Journal of Pineal Research, 2009
    Co-Authors: Lindan Ji, Jin Xu, Dongdong Wu, Nelson L S Tang, Yaping Zhang
    Abstract:

    Melatonin is predominantly involved in signaling circadian and seasonal rhythms, and its synthesis is regulated by the environmental light/ dark cycle. The selection pressure by geographically different environmental light/dark cycles, which is predominantly determined by sunshine duration, on the global distribution of genetic polymorphisms in the melatonin pathway is not well understood. Recent genetic association studies identified various Disease-Predisposition polymorphisms in this pathway. We investigated the correlations between the prevalence of these clinically important single nucleotide polymorphisms (SNPs) and sunshine duration among worldwide human populations from twelve regions in the CEPH-HGDP database rs4753426, a recently reported Predisposition SNP for type 2 diabetes in the promoter of the MT 2 melatonin receptor gene (MTNR1B), which was not included in the CEPH-HGDP genotyping array, was additionally genotyped. This SNP showed a marginally significant correlation in 760 CEPH-HGDP DNA samples (r = -0.5346, P = 0.0733), and it showed the most prominent association among the candidate melatonin pathway SNPs examined. To control for population structure, which may lead to a false positive correlation, we genotyped this SNP in a replication set of 1792 subjects from China. The correlation was confirmed among Chinese populations (r = -0.8694, P = 0.0002), and was also statistically significant after correction of other climatic and geographical covariants in multiple regression analysis (β = -0.907, P = 1.94 x 10 -5 ). Taken together, it suggests that the human melatonin signaling pathway, particularly MT 2 melatonin receptor may have undergone a selective pressure in response to global variation in sunshine duration.

  • megasnphunter a learning approach to detect Disease Predisposition snps and high level interactions in genome wide association study
    BMC Bioinformatics, 2009
    Co-Authors: Can Yang, Nelson L S Tang, Qiang Yang, Weichuan Yu
    Abstract:

    Background The interactions of multiple single nucleotide polymorphisms (SNPs) are highly hypothesized to affect an individual's susceptibility to complex Diseases. Although many works have been done to identify and quantify the importance of multi-SNP interactions, few of them could handle the genome wide data due to the combinatorial explosive search space and the difficulty to statistically evaluate the high-order interactions given limited samples.

Dongdong Wu - One of the best experts on this subject based on the ideXlab platform.

  • association of Disease Predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations
    Journal of Pineal Research, 2010
    Co-Authors: Lindan Ji, Jin Xu, Dongdong Wu, Nelson L S Tang, Yaping Zhang
    Abstract:

    Melatonin is predominantly involved in signaling circadian and seasonal rhythms, and its synthesis is regulated by the environmental light/ dark cycle. The selection pressure by geographically different environmental light/dark cycles, which is predominantly determined by sunshine duration, on the global distribution of genetic polymorphisms in the melatonin pathway is not well understood. Recent genetic association studies identified various Disease-Predisposition polymorphisms in this pathway. We investigated the correlations between the prevalence of these clinically important single nucleotide polymorphisms (SNPs) and sunshine duration among worldwide human populations from twelve regions in the CEPH-HGDP database rs4753426, a recently reported Predisposition SNP for type 2 diabetes in the promoter of the MT 2 melatonin receptor gene (MTNR1B), which was not included in the CEPH-HGDP genotyping array, was additionally genotyped. This SNP showed a marginally significant correlation in 760 CEPH-HGDP DNA samples (r = -0.5346, P = 0.0733), and it showed the most prominent association among the candidate melatonin pathway SNPs examined. To control for population structure, which may lead to a false positive correlation, we genotyped this SNP in a replication set of 1792 subjects from China. The correlation was confirmed among Chinese populations (r = -0.8694, P = 0.0002), and was also statistically significant after correction of other climatic and geographical covariants in multiple regression analysis (β = -0.907, P = 1.94 x 10 -5 ). Taken together, it suggests that the human melatonin signaling pathway, particularly MT 2 melatonin receptor may have undergone a selective pressure in response to global variation in sunshine duration.

  • Association of Disease‐Predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations
    Journal of Pineal Research, 2009
    Co-Authors: Lindan Ji, Jin Xu, Dongdong Wu, Nelson L S Tang, Yaping Zhang
    Abstract:

    Melatonin is predominantly involved in signaling circadian and seasonal rhythms, and its synthesis is regulated by the environmental light/ dark cycle. The selection pressure by geographically different environmental light/dark cycles, which is predominantly determined by sunshine duration, on the global distribution of genetic polymorphisms in the melatonin pathway is not well understood. Recent genetic association studies identified various Disease-Predisposition polymorphisms in this pathway. We investigated the correlations between the prevalence of these clinically important single nucleotide polymorphisms (SNPs) and sunshine duration among worldwide human populations from twelve regions in the CEPH-HGDP database rs4753426, a recently reported Predisposition SNP for type 2 diabetes in the promoter of the MT 2 melatonin receptor gene (MTNR1B), which was not included in the CEPH-HGDP genotyping array, was additionally genotyped. This SNP showed a marginally significant correlation in 760 CEPH-HGDP DNA samples (r = -0.5346, P = 0.0733), and it showed the most prominent association among the candidate melatonin pathway SNPs examined. To control for population structure, which may lead to a false positive correlation, we genotyped this SNP in a replication set of 1792 subjects from China. The correlation was confirmed among Chinese populations (r = -0.8694, P = 0.0002), and was also statistically significant after correction of other climatic and geographical covariants in multiple regression analysis (β = -0.907, P = 1.94 x 10 -5 ). Taken together, it suggests that the human melatonin signaling pathway, particularly MT 2 melatonin receptor may have undergone a selective pressure in response to global variation in sunshine duration.

Barry Turnbull - One of the best experts on this subject based on the ideXlab platform.

  • familial Disease Predisposition impacts treatment outcome in patients with waldenstrom macroglobulinemia
    Clinical Lymphoma Myeloma & Leukemia, 2012
    Co-Authors: Steven P Treon, Christina Hanzis, Christina K Tripsas, Leukothea Ioakimidis, Christopher J Patterson, Robert Manning, Patricia Sheehy, Barry Turnbull, Zachary R Hunter
    Abstract:

    Abstract Background We examined the impact of familial Predisposition on treatment outcome in 135 patients with Waldenstrom macroglobulinemia (WM), 26.7% of whom had first- or second-degree relatives with a B-cell lymphoproliferative disorder. Patients and Methods All patients were rituximab naive and received a rituximab-containing regimen. There were no significant differences in baseline characteristics between cohorts. Results Overall response (93.9% vs. 75.0%; P = .029) and complete response/very good partial response (CR/VGPR) (23.2% vs. 16.7%; P P = .015) and time to next therapy (TTNT) (50.0 vs. 33.0 months; P = .024) favored patients with sporadic WM. By multivariate analysis, familial Predisposition was an independent marker for Disease progression (hazard ratio, 0.554). Patients with familial but not sporadic Disease exhibited better responses, including CR/VGPR attainment ( P = .0006) and a trend for longer progression-free survival (> 33 vs. 20.6 months; P = .08), with bortezomib-containing therapy. Conclusion The findings convey that familial Predisposition is an important determinant of treatment outcome in WM. Prospective studies to confirm these observations are needed.

  • treatment with a bortezomib containing regimen is associated with better therapeutic outcomes in patients with waldenstrom s macroglobulinemia who have familial Disease Predisposition
    Blood, 2011
    Co-Authors: Steven P Treon, Zachary R Hunter, Christina Hanzis, Christina K Tripsas, Leukothea Ioakimidis, Christopher J Patterson, Robert Manning, Patricia Sheehy, Barry Turnbull
    Abstract:

    Abstract 1643 We examined the impact of familial Predisposition on treatment outcome in 135 Waldenstrom's macroglobulinaemia (WM) patients, 26.7% of whom had first or second degree relative(s) with a B-cell lymphoproliferative disorder. All patients were rituximab-naive and received a rituximab-containing regimen. There were no significant differences in baseline characteristics between cohorts. Overall (93.9% vs. 75.0%; p=0.029) and CR/VGPR (23.2% vs. 16.7%; p 33 versus 20.6 months for bortezomib and non-bortezomib containing therapy, respectively (p=0.08). For sporadic WM patients, the median TTP was estimated at >35 versus 45.5 months for bortezomib and non-bortezomib containing therapy, respectively (p=0.68). The findings of this study convey that familial Disease Predisposition is an important determinant of response, TTP and TTNT in patients with WM. Treatment with a bortezomib-containing regimen is associated with better therapeutic outcomes in patients with WM who have familial Disease Predisposition, and may be revealing of signaling pathways that are present in familial patients and amenable to select targeting by proteasome inhibition. ![Figure 1.][2] Figure 1. Overall, major, and VGPR/CR responses for 135 WM patients with sporadic (A) or familial (B) Disease who received either bortezomib or a non-bortezomib containing regimen. *p=0.05; and **p=0.0006 among familial WM patients who received bortezomib versus non-bortezomib containing therapy. Disclosures: No relevant conflicts of interest to declare. [1]: #F1 [2]: pending:yes