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John P Devincenzo - One of the best experts on this subject based on the ideXlab platform.

  • relating plaque morphology to respiratory syncytial virus subgroup viral load and Disease Severity in children
    Pediatric Research, 2015
    Co-Authors: Youngin Kim, Ryan Murphy, Sirshendu Majumdar, Lisa Harrison, Jody Aitken, John P Devincenzo
    Abstract:

    Relating plaque morphology to respiratory syncytial virus subgroup, viral load, and Disease Severity in children

  • respiratory syncytial virus load viral dynamics and Disease Severity in previously healthy naturally infected children
    The Journal of Infectious Diseases, 2011
    Co-Authors: Chadi El M Saleeby, Lisa Harrison, Andrew J Bush, Jody A Aitken, John P Devincenzo
    Abstract:

    Background. Respiratory syncytial virus (RSV) Disease Severity was thought to be a result of host immunopathology but alternatively may be driven by high-level viral replication. The relationships between RSV load, viral clearance dynamics, and Disease Severity have not been carefully evaluated. Methods. Previously healthy RSV-infected children <2 years old were recruited. RSV load was measured in respiratory secretions by fresh quantitative culture over 3 hospital days. Measures of Disease Severity were hospital admission, duration of hospitalization, requirement for intensive care, and respiratory failure. Results. Multivariate logistic regression models revealed independent predictors of increased duration of hospitalization: male sex, lower weight, and higher viral load on any day. Viral loads at day 3 were more significantly associated with requirement for intensive care and respiratory failure than were viral loads at earlier time points. Faster RSV clearance was independently associated with shorter hospitalization. Discussion. These observations challenge the immunopathology-based pathogenesis paradigm. They also have major therapeutic implications, suggesting that application of antiviral agents early in the Disease course, even at a time when viral replication is at its highest, might improve subsequent morbidity by significantly lowering viral load and direct viral cytopathic effects, and aborting the potential downstream immunopathology.

  • surfactant protein a2 polymorphisms and Disease Severity in a respiratory syncytial virus infected population
    The Journal of Pediatrics, 2010
    Co-Authors: Chadi El M Saleeby, Grant W Somes, Mary K Dahmer, Michael W Quasney, John P Devincenzo
    Abstract:

    Objective To examine whether genetic variations within the surfactant protein A2 (SP-A2) gene are associated with respiratory syncytial virus (RSV) Disease Severity in infected children. Study design Naturally infected children aged ≤24 months were prospectively enrolled in 3 RSV seasons. SP-A2 genotyping was performed. Independent clinical predictors of Disease Severity were analyzed. The association of SP-A2 genetic diversity and Disease Severity was tested by using multivariate logistic regression models and 4 levels of Disease gradation as outcome measures. Results Homozygosity of the 1A 0 allele was protective against hospitalization (odds ratio [OR] = 0.15, P = .0010). This remained significant in African American patients (OR = 0.24, P = .042) and Caucasian patients (OR = 0.05, P  = .021) after adjustment for other co-variates. Hospitalized children with the 1A 2 allele demonstrated significant protection from severe Disease with univariate analyses, but only a trend for protection with multivariate analyses. Patients homozygous or heterozygous for an asparagine at amino acid position 9 were twice or more likely to need intensive care unit admission (OR = 2.15, P = .022), require intubation (OR = 3.04, P = .005), and have a hospitalization lasting ≥4 days (OR = 1.89, P = .02) compared with children homozygous for a threonine at this position. Conclusions SP-A2 polymorphisms are associated with the Severity of RSV infection in infants.

  • natural infection of infants with respiratory syncytial virus subgroups a and b a study of frequency Disease Severity and viral load
    Pediatric Research, 2004
    Co-Authors: John P Devincenzo
    Abstract:

    Heterogeneity in respiratory syncytial virus (RSV) Disease Severity likely is due to a combination of host and viral factors. Infection with RSV subgroup A is thought to produce more severe Disease than RSV-B. Higher RSV loads correlate with greater Disease Severity in hospitalized infants. Whether subgroup-specific variations in Disease Severity result from differences in RSV load has not been studied. A total of 102 RSV-hospitalized infants <2 y of age were studied. Nasal washes were collected in a standardized manner and were cultured in <3 h in parallel with an RSV quantitative standard in a HEp-2 plaque assay. RSV-A (72%) was more frequent than RSV-B. Disease Severity risk factors were similar between subgroups. RSV loads were similar between A and B subgroups (4.77 versus 4.68 log PFU/mL). Measures of Disease Severity were also similar between subgroups.

Lisa Harrison - One of the best experts on this subject based on the ideXlab platform.

  • relating plaque morphology to respiratory syncytial virus subgroup viral load and Disease Severity in children
    Pediatric Research, 2015
    Co-Authors: Youngin Kim, Ryan Murphy, Sirshendu Majumdar, Lisa Harrison, Jody Aitken, John P Devincenzo
    Abstract:

    Relating plaque morphology to respiratory syncytial virus subgroup, viral load, and Disease Severity in children

  • respiratory syncytial virus load viral dynamics and Disease Severity in previously healthy naturally infected children
    The Journal of Infectious Diseases, 2011
    Co-Authors: Chadi El M Saleeby, Lisa Harrison, Andrew J Bush, Jody A Aitken, John P Devincenzo
    Abstract:

    Background. Respiratory syncytial virus (RSV) Disease Severity was thought to be a result of host immunopathology but alternatively may be driven by high-level viral replication. The relationships between RSV load, viral clearance dynamics, and Disease Severity have not been carefully evaluated. Methods. Previously healthy RSV-infected children <2 years old were recruited. RSV load was measured in respiratory secretions by fresh quantitative culture over 3 hospital days. Measures of Disease Severity were hospital admission, duration of hospitalization, requirement for intensive care, and respiratory failure. Results. Multivariate logistic regression models revealed independent predictors of increased duration of hospitalization: male sex, lower weight, and higher viral load on any day. Viral loads at day 3 were more significantly associated with requirement for intensive care and respiratory failure than were viral loads at earlier time points. Faster RSV clearance was independently associated with shorter hospitalization. Discussion. These observations challenge the immunopathology-based pathogenesis paradigm. They also have major therapeutic implications, suggesting that application of antiviral agents early in the Disease course, even at a time when viral replication is at its highest, might improve subsequent morbidity by significantly lowering viral load and direct viral cytopathic effects, and aborting the potential downstream immunopathology.

Youngin Kim - One of the best experts on this subject based on the ideXlab platform.

Chadi El M Saleeby - One of the best experts on this subject based on the ideXlab platform.

  • respiratory syncytial virus load viral dynamics and Disease Severity in previously healthy naturally infected children
    The Journal of Infectious Diseases, 2011
    Co-Authors: Chadi El M Saleeby, Lisa Harrison, Andrew J Bush, Jody A Aitken, John P Devincenzo
    Abstract:

    Background. Respiratory syncytial virus (RSV) Disease Severity was thought to be a result of host immunopathology but alternatively may be driven by high-level viral replication. The relationships between RSV load, viral clearance dynamics, and Disease Severity have not been carefully evaluated. Methods. Previously healthy RSV-infected children <2 years old were recruited. RSV load was measured in respiratory secretions by fresh quantitative culture over 3 hospital days. Measures of Disease Severity were hospital admission, duration of hospitalization, requirement for intensive care, and respiratory failure. Results. Multivariate logistic regression models revealed independent predictors of increased duration of hospitalization: male sex, lower weight, and higher viral load on any day. Viral loads at day 3 were more significantly associated with requirement for intensive care and respiratory failure than were viral loads at earlier time points. Faster RSV clearance was independently associated with shorter hospitalization. Discussion. These observations challenge the immunopathology-based pathogenesis paradigm. They also have major therapeutic implications, suggesting that application of antiviral agents early in the Disease course, even at a time when viral replication is at its highest, might improve subsequent morbidity by significantly lowering viral load and direct viral cytopathic effects, and aborting the potential downstream immunopathology.

  • surfactant protein a2 polymorphisms and Disease Severity in a respiratory syncytial virus infected population
    The Journal of Pediatrics, 2010
    Co-Authors: Chadi El M Saleeby, Grant W Somes, Mary K Dahmer, Michael W Quasney, John P Devincenzo
    Abstract:

    Objective To examine whether genetic variations within the surfactant protein A2 (SP-A2) gene are associated with respiratory syncytial virus (RSV) Disease Severity in infected children. Study design Naturally infected children aged ≤24 months were prospectively enrolled in 3 RSV seasons. SP-A2 genotyping was performed. Independent clinical predictors of Disease Severity were analyzed. The association of SP-A2 genetic diversity and Disease Severity was tested by using multivariate logistic regression models and 4 levels of Disease gradation as outcome measures. Results Homozygosity of the 1A 0 allele was protective against hospitalization (odds ratio [OR] = 0.15, P = .0010). This remained significant in African American patients (OR = 0.24, P = .042) and Caucasian patients (OR = 0.05, P  = .021) after adjustment for other co-variates. Hospitalized children with the 1A 2 allele demonstrated significant protection from severe Disease with univariate analyses, but only a trend for protection with multivariate analyses. Patients homozygous or heterozygous for an asparagine at amino acid position 9 were twice or more likely to need intensive care unit admission (OR = 2.15, P = .022), require intubation (OR = 3.04, P = .005), and have a hospitalization lasting ≥4 days (OR = 1.89, P = .02) compared with children homozygous for a threonine at this position. Conclusions SP-A2 polymorphisms are associated with the Severity of RSV infection in infants.

Ryan Murphy - One of the best experts on this subject based on the ideXlab platform.