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Utkan Demirci - One of the best experts on this subject based on the ideXlab platform.
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advances in developing hiv 1 Viral Load assays for resource limited settings
Biotechnology Advances, 2010Co-Authors: Shuqi Wang, Utkan DemirciAbstract:Commercial HIV-1 RNA Viral Load assays have been routinely used in developed countries to monitor antiretroViral treatment (ART). However, these assays require expensive equipment and reagents, well-trained operators, and established laboratory infrastructure. These requirements restrict their use in resource-limited settings where people are most afflicted with the HIV-1 epidemic. Inexpensive alternatives such as the Ultrasensitive p24 assay, the reverse transcriptase (RT) assay and in-house reverse transcription quantitative polymerase chain reaction (RT-qPCR) have been developed. However, they are still time-consuming, technologically complex and inappropriate for decentralized laboratories as point-of-care (POC) tests. Recent advances in microfluidics and nanotechnology offer new strategies to develop low-cost, rapid, robust and simple HIV-1 Viral Load monitoring systems. We review state-of-the-art technologies used for HIV-1 Viral Load monitoring in both developed and developing settings. Emerging approaches based on microfluidics and nanotechnology, which have potential to be integrated into POC HIV-1 Viral Load assays, are also discussed.
Alexandra Calmy - One of the best experts on this subject based on the ideXlab platform.
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HIV Viral Load Monitoring in Resource-Limited Regions: Optional or Necessary?
Clinical Infectious Diseases, 2007Co-Authors: Alexandra Calmy, Nathan Ford, Lut Lynen, Steven J. Reynolds, Bernard Hirschel, Eric Goemaere, Felipe Garcia De La Vega, Luc Perrin, William RodriguezAbstract:Although it is a standard practice in high-income countries, determination of the human immunodeficiency virus (HIV) Load is not recommended in developing countries because of the costs and technical constraints. As more and more countries establish capacity to provide second-line therapy, and as costs and technological constraints associated with Viral Load testing decrease, the question of whether determination of the Viral Load is necessary deserves attention. Viral Load testing could increase in importance as a guide for clinical decisions on when to switch to second-line treatment and on how to optimize the duration of the first-line treatment regimen. In addition, the Viral Load is a particularly useful tool for monitoring adherence to treatment, performing sentinel surveillance, and diagnosing HIV infection in children aged
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HIV Viral Load Monitoring in Resource-Limited Regions : Optional or Necessary? Commentary
Clinical Infectious Diseases, 2007Co-Authors: Alexandra Calmy, Nathan Ford, Lut Lynen, Steven J. Reynolds, Bernard Hirschel, Eric Goemaere, Felipe Garcia De La Vega, Luc Perrin, William Rodrigvez, Robert T. SchooleyAbstract:Although it is a standard practice in high-income countries, determination of the human immunodeficiency virus (HIV) Load is not recommended in developing countries because of the costs and technical constraints. As more and more countries establish capacity to provide second-line therapy, and as costs and technological constraints associated with Viral Load testing decrease, the question of whether determination of the Viral Load is necessary deserves attention. Viral Load testing could increase in importance as a guide for clinical decisions on when to switch to second-line treatment and on how to optimize the duration of the first-line treatment regimen. In addition, the Viral Load is a particularly useful tool for monitoring adherence to treatment, performing sentinel surveillance, and diagnosing HIV infection in children aged
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hiv Viral Load monitoring in resource limited regions optional or necessary
Clinical Infectious Diseases, 2007Co-Authors: Nathan Ford, Lut Lynen, Steven J. Reynolds, Alexandra Calmy, Bernard Hirschel, Eric Goemaere, Felipe Garcia De La Vega, Luc Perrin, William RodriguezAbstract:Although it is a standard practice in high-income countries, determination of the human immunodeficiency virus (HIV) Load is not recommended in developing countries because of the costs and technical constraints. As more and more countries establish capacity to provide second-line therapy, and as costs and technological constraints associated with Viral Load testing decrease, the question of whether determination of the Viral Load is necessary deserves attention. Viral Load testing could increase in importance as a guide for clinical decisions on when to switch to second-line treatment and on how to optimize the duration of the first-line treatment regimen. In addition, the Viral Load is a particularly useful tool for monitoring adherence to treatment, performing sentinel surveillance, and diagnosing HIV infection in children aged <18 months. Rather than considering Viral Load data to be an unaffordable luxury, efforts should be made to ensure that Viral Load testing becomes affordable, simple, and easy to use in resource-limited settings.
Wame N Mosime - One of the best experts on this subject based on the ideXlab platform.
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Community-driven demand creation for the use of routine Viral Load testing: a model to scale up routine Viral Load testing.
Journal of the International AIDS Society, 2017Co-Authors: Bactrin M Killingo, Trisa B Taro, Wame N MosimeAbstract:INTRODUCTION HIV treatment outcomes are dependent on the use of Viral Load measurement. Despite global and national guidelines recommending the use of routine Viral Load testing, these policies alone have not translated into widespread implementation or sufficiently increased access for people living with HIV (PLHIV). Civil society and communities of PLHIV recognize the need to close this gap and to enable the scale up of routine Viral Load testing. METHODS The International Treatment Preparedness Coalition (ITPC) developed an approach to community-led demand creation for the use of routine Viral Load testing. Using this Community Demand Creation Model, implementers follow a step-wise process to capacitate and empower communities to address their most pressing needs. This includes utlizing a specific toolkit that includes conducting a baseline assessment, developing a treatment education toolkit, organizing mobilization workshops for knowledge building, provision of small grants to support advocacy work and conducting benchmark evaluations. RESULTS AND DISCUSSION The Community Demand Creation Model to increase demand for routine Viral Load testing services by PLHIV has been delivered in diverse contexts including in the sub-Saharan African, Asian, Latin American and the Caribbean regions. Between December 2015 and December 2016, ITPC trained more than 240 PLHIV activists, and disbursed US$90,000 to network partners in support of their national advocacy work. The latter efforts informed a regional, community-driven campaign calling for domestic investment in the expeditious implementation of national Viral Load testing guidelines. CONCLUSIONS HIV treatment education and community mobilization are critical components of demand creation for access to optimal HIV treatment, especially for the use of routine Viral Load testing. ITPC's Community Demand Creation Model offers a novel approach to achieving this goal.
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Community-driven demand creation for the use of routine Viral Load testing: a model to scale up routine Viral Load testing.
Journal of the International AIDS Society, 2017Co-Authors: Bactrin M Killingo, Trisa B Taro, Wame N MosimeAbstract:HIV treatment outcomes are dependent on the use of Viral Load measurement. Despite global and national guidelines recommending the use of routine Viral Load testing, these policies alone have not translated into widespread implementation or sufficiently increased access for people living with HIV (PLHIV). Civil society and communities of PLHIV recognize the need to close this gap and to enable the scale up of routine Viral Load testing. The International Treatment Preparedness Coalition (ITPC) developed an approach to community-led demand creation for the use of routine Viral Load testing. Using this Community Demand Creation Model, implementers follow a step-wise process to capacitate and empower communities to address their most pressing needs. This includes utlizing a specific toolkit that includes conducting a baseline assessment, developing a treatment education toolkit, organizing mobilization workshops for knowledge building, provision of small grants to support advocacy work and conducting benchmark evaluations. The Community Demand Creation Model to increase demand for routine Viral Load testing services by PLHIV has been delivered in diverse contexts including in the sub-Saharan African, Asian, Latin American and the Caribbean regions. Between December 2015 and December 2016, ITPC trained more than 240 PLHIV activists, and disbursed US$90,000 to network partners in support of their national advocacy work. The latter efforts informed a regional, community-driven campaign calling for domestic investment in the expeditious implementation of national Viral Load testing guidelines. HIV treatment education and community mobilization are critical components of demand creation for access to optimal HIV treatment, especially for the use of routine Viral Load testing. ITPC's Community Demand Creation Model offers a novel approach to achieving this goal. © 2017 The Authors. Journal of the International AIDS Society published by John Wiley & sons Ltd on behalf of the International AIDS Society.
Daniel P O'brien - One of the best experts on this subject based on the ideXlab platform.
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Viral Load testing in a resource-limited setting: quality control is critical.
Journal of the International AIDS Society, 2011Co-Authors: Jane Greig, Philipp Du Cros, Derryck Klarkowski, Clair Mills, Steffen Jørgensen, P. Richard Harrigan, Daniel P O'brienAbstract:Background World Health Organization guidelines now recommend routine use of Viral Load testing, where available, for patients receiving antiretroViral treatment (ART). However, its use has not been routinely implemented in many resource-limited settings due to cost, availability and accessibility. Viral Load testing is complex, making its application in resource-limited settings challenging. We describe the issues encountered by Medecins Sans Frontieres (MSF) when using routine Viral Load testing in a large HIV programme in sub-Saharan Africa.
William Rodriguez - One of the best experts on this subject based on the ideXlab platform.
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HIV Viral Load Monitoring in Resource-Limited Regions: Optional or Necessary?
Clinical Infectious Diseases, 2007Co-Authors: Alexandra Calmy, Nathan Ford, Lut Lynen, Steven J. Reynolds, Bernard Hirschel, Eric Goemaere, Felipe Garcia De La Vega, Luc Perrin, William RodriguezAbstract:Although it is a standard practice in high-income countries, determination of the human immunodeficiency virus (HIV) Load is not recommended in developing countries because of the costs and technical constraints. As more and more countries establish capacity to provide second-line therapy, and as costs and technological constraints associated with Viral Load testing decrease, the question of whether determination of the Viral Load is necessary deserves attention. Viral Load testing could increase in importance as a guide for clinical decisions on when to switch to second-line treatment and on how to optimize the duration of the first-line treatment regimen. In addition, the Viral Load is a particularly useful tool for monitoring adherence to treatment, performing sentinel surveillance, and diagnosing HIV infection in children aged
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hiv Viral Load monitoring in resource limited regions optional or necessary
Clinical Infectious Diseases, 2007Co-Authors: Nathan Ford, Lut Lynen, Steven J. Reynolds, Alexandra Calmy, Bernard Hirschel, Eric Goemaere, Felipe Garcia De La Vega, Luc Perrin, William RodriguezAbstract:Although it is a standard practice in high-income countries, determination of the human immunodeficiency virus (HIV) Load is not recommended in developing countries because of the costs and technical constraints. As more and more countries establish capacity to provide second-line therapy, and as costs and technological constraints associated with Viral Load testing decrease, the question of whether determination of the Viral Load is necessary deserves attention. Viral Load testing could increase in importance as a guide for clinical decisions on when to switch to second-line treatment and on how to optimize the duration of the first-line treatment regimen. In addition, the Viral Load is a particularly useful tool for monitoring adherence to treatment, performing sentinel surveillance, and diagnosing HIV infection in children aged <18 months. Rather than considering Viral Load data to be an unaffordable luxury, efforts should be made to ensure that Viral Load testing becomes affordable, simple, and easy to use in resource-limited settings.