The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform

John A. Dodds - One of the best experts on this subject based on the ideXlab platform.

  • Formulation of solid products: two‐component tablets with a Disintegrating Agent
    Polymer International, 2003
    Co-Authors: S Hutin, P Accart, Driss Oulahna, John A. Dodds
    Abstract:

    The formulation of binary tablets containing an insoluble powder and a Disintegrating Agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine-starch, cocoa-ultrafine sugar and cocoa-icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions.

  • formulation of solid products two component tablets with a Disintegrating Agent
    Polymer International, 2003
    Co-Authors: S Hutin, P Accart, Driss Oulahna, John A. Dodds
    Abstract:

    The formulation of binary tablets containing an insoluble powder and a Disintegrating Agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine-starch, cocoa-ultrafine sugar and cocoa-icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions.

  • Formulation of solid products: two-component tablets with a Disintegrating Agent
    Polymer International, 2003
    Co-Authors: S Hutin, P Accart, Driss Oulahna, John A. Dodds
    Abstract:

    The formulation of binary tablets containing an insoluble powder and a Disintegrating Agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine-starch, cocoa-ultrafine sugar and cocoa-icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions. (C) 2003 Society of Chemical Industry.

S Hutin - One of the best experts on this subject based on the ideXlab platform.

  • Formulation of solid products: two‐component tablets with a Disintegrating Agent
    Polymer International, 2003
    Co-Authors: S Hutin, P Accart, Driss Oulahna, John A. Dodds
    Abstract:

    The formulation of binary tablets containing an insoluble powder and a Disintegrating Agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine-starch, cocoa-ultrafine sugar and cocoa-icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions.

  • formulation of solid products two component tablets with a Disintegrating Agent
    Polymer International, 2003
    Co-Authors: S Hutin, P Accart, Driss Oulahna, John A. Dodds
    Abstract:

    The formulation of binary tablets containing an insoluble powder and a Disintegrating Agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine-starch, cocoa-ultrafine sugar and cocoa-icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions.

  • Formulation of solid products: two-component tablets with a Disintegrating Agent
    Polymer International, 2003
    Co-Authors: S Hutin, P Accart, Driss Oulahna, John A. Dodds
    Abstract:

    The formulation of binary tablets containing an insoluble powder and a Disintegrating Agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine-starch, cocoa-ultrafine sugar and cocoa-icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions. (C) 2003 Society of Chemical Industry.

Ralph F. Shangraw - One of the best experts on this subject based on the ideXlab platform.

  • Evaluation of Soy Polysaccharide as a Disintegrating: Agent Part II: Wet Granulation
    Drug Development and Industrial Pharmacy, 2008
    Co-Authors: Sanyasi R. Kalidindi, Ralph F. Shangraw
    Abstract:

    Soy polysaccharide was evaluated as a Disintegrating Agent in tablets made by wet granulation utilizing both lactose and dicalcium phosphate dihydrate as fillers, gelatin as a granulating Agent and hydrochlorothiazide as a model drug. It was found to be more effective than starch but less effective than cross-linked carboxymethylcellulose (Ac-Di-SolR) at equivalent concentrations. Soy polysaccharide appears to reduce the friability of tablets as concentration increases. Tablets containing either Soy polysaccharide or cross-linked carboxymethylcellulose showed no changes in dissolution profiles after storage under ambient conditions for six months.

  • Evaluation of Soy Polysaccharide as a Disintegrating Agent Part I: Direct Compression
    Drug Development and Industrial Pharmacy, 2008
    Co-Authors: Sanyasi R. Kalidindi, Ralph F. Shangraw
    Abstract:

    AbstractSoy polysaccharide, a group of high molecular weight polysaccharides obtained from soy beans, was evaluated as a disintegrant in tablets made by direct compression using lactose and dicalcium phosphate dihydrate as fillers. A cross-linked sodium carboxy-methyl cellulose and corn starch were used as control disintegrants. Parameters studied were compressibility, friability and disintegration times. Dissolution studies were conducted on tablets containing hydrochlorothiazide as a model drug of low water solubility. Soy polysacchardie performs well as a Disintegrating Agent in direct compression formulations with results paralleling those of cross-linked CMC at the 2% level and superior to corn starch at the 8% level. Dissolution rates of the drug from tablets were rapid, particularly at the 5% level and were not adversely affected by aging at room temperatures.

Driss Oulahna - One of the best experts on this subject based on the ideXlab platform.

  • Formulation of solid products: two‐component tablets with a Disintegrating Agent
    Polymer International, 2003
    Co-Authors: S Hutin, P Accart, Driss Oulahna, John A. Dodds
    Abstract:

    The formulation of binary tablets containing an insoluble powder and a Disintegrating Agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine-starch, cocoa-ultrafine sugar and cocoa-icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions.

  • formulation of solid products two component tablets with a Disintegrating Agent
    Polymer International, 2003
    Co-Authors: S Hutin, P Accart, Driss Oulahna, John A. Dodds
    Abstract:

    The formulation of binary tablets containing an insoluble powder and a Disintegrating Agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine-starch, cocoa-ultrafine sugar and cocoa-icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions.

  • Formulation of solid products: two-component tablets with a Disintegrating Agent
    Polymer International, 2003
    Co-Authors: S Hutin, P Accart, Driss Oulahna, John A. Dodds
    Abstract:

    The formulation of binary tablets containing an insoluble powder and a Disintegrating Agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine-starch, cocoa-ultrafine sugar and cocoa-icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions. (C) 2003 Society of Chemical Industry.

P Accart - One of the best experts on this subject based on the ideXlab platform.

  • Formulation of solid products: two‐component tablets with a Disintegrating Agent
    Polymer International, 2003
    Co-Authors: S Hutin, P Accart, Driss Oulahna, John A. Dodds
    Abstract:

    The formulation of binary tablets containing an insoluble powder and a Disintegrating Agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine-starch, cocoa-ultrafine sugar and cocoa-icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions.

  • formulation of solid products two component tablets with a Disintegrating Agent
    Polymer International, 2003
    Co-Authors: S Hutin, P Accart, Driss Oulahna, John A. Dodds
    Abstract:

    The formulation of binary tablets containing an insoluble powder and a Disintegrating Agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine-starch, cocoa-ultrafine sugar and cocoa-icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions.

  • Formulation of solid products: two-component tablets with a Disintegrating Agent
    Polymer International, 2003
    Co-Authors: S Hutin, P Accart, Driss Oulahna, John A. Dodds
    Abstract:

    The formulation of binary tablets containing an insoluble powder and a Disintegrating Agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine-starch, cocoa-ultrafine sugar and cocoa-icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions. (C) 2003 Society of Chemical Industry.