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Steven C. Almo - One of the best experts on this subject based on the ideXlab platform.
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Divergent Evolution in Enolase Superfamily: Strategies for Assigning Functions
The Journal of biological chemistry, 2011Co-Authors: John A. Gerlt, Matthew P Jacobson, Patricia C. Babbitt, Steven C. AlmoAbstract:Nature's strategies for evolving catalytic functions can be deciphered from the information contained in the rapidly expanding protein sequence databases. However, the functions of many proteins in the protein sequence and structure databases are either uncertain (too Divergent to assign function based on homology) or unknown (no homologs), thereby limiting the utility of the databases. The mechanistically diverse enolase superfamily is a paradigm for understanding the structural bases for Evolution of enzymatic function. We describe strategies for assigning functions to members of the enolase superfamily that should be applicable to other superfamilies.
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d-Ribulose 5-Phosphate 3-Epimerase: Functional and Structural Relationships to Members of the Ribulose-Phosphate Binding (β/α)8-Barrel Superfamily†,‡
Biochemistry, 2006Co-Authors: Julie Akana, Alexander A. Fedorov, Elena V. Fedorov, Walter R. P. Novak, Patricia C. Babbitt, Steven C. Almo, John A. GerltAbstract:The “ribulose phosphate binding” superfamily defined by the Structural Classification of Proteins (SCOP) database is considered the result of Divergent Evolution from a common (β/α)8-barrel ancesto...
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d ribulose 5 phosphate 3 epimerase functional and structural relationships to members of the ribulose phosphate binding β α 8 barrel superfamily
Biochemistry, 2006Co-Authors: Julie Akana, Alexander A. Fedorov, Elena V. Fedorov, Walter R. P. Novak, Patricia C. Babbitt, Steven C. Almo, John A. GerltAbstract:The “ribulose phosphate binding” superfamily defined by the Structural Classification of Proteins (SCOP) database is considered the result of Divergent Evolution from a common (β/α)8-barrel ancesto...
John A. Gerlt - One of the best experts on this subject based on the ideXlab platform.
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Divergent Evolution in Enolase Superfamily: Strategies for Assigning Functions
The Journal of biological chemistry, 2011Co-Authors: John A. Gerlt, Matthew P Jacobson, Patricia C. Babbitt, Steven C. AlmoAbstract:Nature's strategies for evolving catalytic functions can be deciphered from the information contained in the rapidly expanding protein sequence databases. However, the functions of many proteins in the protein sequence and structure databases are either uncertain (too Divergent to assign function based on homology) or unknown (no homologs), thereby limiting the utility of the databases. The mechanistically diverse enolase superfamily is a paradigm for understanding the structural bases for Evolution of enzymatic function. We describe strategies for assigning functions to members of the enolase superfamily that should be applicable to other superfamilies.
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d-Ribulose 5-Phosphate 3-Epimerase: Functional and Structural Relationships to Members of the Ribulose-Phosphate Binding (β/α)8-Barrel Superfamily†,‡
Biochemistry, 2006Co-Authors: Julie Akana, Alexander A. Fedorov, Elena V. Fedorov, Walter R. P. Novak, Patricia C. Babbitt, Steven C. Almo, John A. GerltAbstract:The “ribulose phosphate binding” superfamily defined by the Structural Classification of Proteins (SCOP) database is considered the result of Divergent Evolution from a common (β/α)8-barrel ancesto...
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d ribulose 5 phosphate 3 epimerase functional and structural relationships to members of the ribulose phosphate binding β α 8 barrel superfamily
Biochemistry, 2006Co-Authors: Julie Akana, Alexander A. Fedorov, Elena V. Fedorov, Walter R. P. Novak, Patricia C. Babbitt, Steven C. Almo, John A. GerltAbstract:The “ribulose phosphate binding” superfamily defined by the Structural Classification of Proteins (SCOP) database is considered the result of Divergent Evolution from a common (β/α)8-barrel ancesto...
Patricia C. Babbitt - One of the best experts on this subject based on the ideXlab platform.
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Divergent Evolution in Enolase Superfamily: Strategies for Assigning Functions
The Journal of biological chemistry, 2011Co-Authors: John A. Gerlt, Matthew P Jacobson, Patricia C. Babbitt, Steven C. AlmoAbstract:Nature's strategies for evolving catalytic functions can be deciphered from the information contained in the rapidly expanding protein sequence databases. However, the functions of many proteins in the protein sequence and structure databases are either uncertain (too Divergent to assign function based on homology) or unknown (no homologs), thereby limiting the utility of the databases. The mechanistically diverse enolase superfamily is a paradigm for understanding the structural bases for Evolution of enzymatic function. We describe strategies for assigning functions to members of the enolase superfamily that should be applicable to other superfamilies.
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d-Ribulose 5-Phosphate 3-Epimerase: Functional and Structural Relationships to Members of the Ribulose-Phosphate Binding (β/α)8-Barrel Superfamily†,‡
Biochemistry, 2006Co-Authors: Julie Akana, Alexander A. Fedorov, Elena V. Fedorov, Walter R. P. Novak, Patricia C. Babbitt, Steven C. Almo, John A. GerltAbstract:The “ribulose phosphate binding” superfamily defined by the Structural Classification of Proteins (SCOP) database is considered the result of Divergent Evolution from a common (β/α)8-barrel ancesto...
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d ribulose 5 phosphate 3 epimerase functional and structural relationships to members of the ribulose phosphate binding β α 8 barrel superfamily
Biochemistry, 2006Co-Authors: Julie Akana, Alexander A. Fedorov, Elena V. Fedorov, Walter R. P. Novak, Patricia C. Babbitt, Steven C. Almo, John A. GerltAbstract:The “ribulose phosphate binding” superfamily defined by the Structural Classification of Proteins (SCOP) database is considered the result of Divergent Evolution from a common (β/α)8-barrel ancesto...
Julie Akana - One of the best experts on this subject based on the ideXlab platform.
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d-Ribulose 5-Phosphate 3-Epimerase: Functional and Structural Relationships to Members of the Ribulose-Phosphate Binding (β/α)8-Barrel Superfamily†,‡
Biochemistry, 2006Co-Authors: Julie Akana, Alexander A. Fedorov, Elena V. Fedorov, Walter R. P. Novak, Patricia C. Babbitt, Steven C. Almo, John A. GerltAbstract:The “ribulose phosphate binding” superfamily defined by the Structural Classification of Proteins (SCOP) database is considered the result of Divergent Evolution from a common (β/α)8-barrel ancesto...
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d ribulose 5 phosphate 3 epimerase functional and structural relationships to members of the ribulose phosphate binding β α 8 barrel superfamily
Biochemistry, 2006Co-Authors: Julie Akana, Alexander A. Fedorov, Elena V. Fedorov, Walter R. P. Novak, Patricia C. Babbitt, Steven C. Almo, John A. GerltAbstract:The “ribulose phosphate binding” superfamily defined by the Structural Classification of Proteins (SCOP) database is considered the result of Divergent Evolution from a common (β/α)8-barrel ancesto...
Goran Arnqvist - One of the best experts on this subject based on the ideXlab platform.
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Postmating sexual selection and the enigmatic jawed genitalia of Callosobruchus subinnotatus.
Biology open, 2017Co-Authors: Merel M. Van Haren, Johanna Liljestrand Rönn, Menno Schilthuizen, Goran ArnqvistAbstract:Insect genitalia exhibit rapid Divergent Evolution. Truly extraordinary structures have evolved in some groups, presumably as a result of postmating sexual selection. To increase our understanding ...
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Divergent Evolution of life span associated with mitochondrial DNA Evolution.
Evolution; international journal of organic evolution, 2016Co-Authors: Biljana Stojković, Ahmed Sayadi, Mirko Đorđević, Jelena Jović, Uroš Savković, Goran ArnqvistAbstract:Mitochondria play a key role in ageing. The pursuit of genes that regulate variation in life span and ageing have shown that several nuclear-encoded mitochondrial genes are important. However, the role of mitochondrial encoded genes (mtDNA) is more controversial and our appreciation of the role of mtDNA for the Evolution of life span is limited. We use replicated lines of seed beetles that have been artificially selected for long or short life for >190 generations, now showing dramatic phenotypic differences, to test for a possible role of mtDNA in the Divergent Evolution of ageing and life span. We show that these Divergent selection regimes led to the Evolution of significantly different mtDNA haplotype frequencies. Selection for a long life and late reproduction generated positive selection for one specific haplotype, which was fixed in most such lines. In contrast, selection for reproduction early in life led to both positive selection as well as negative frequency-dependent selection on two different haplotypes, which were both present in all such lines. Our findings suggest that the Evolution of life span was in part mediated by mtDNA, providing support for the emerging general tenet that adaptive Evolution of life-history syndromes may involve mtDNA.
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Natural selection hampers divergence of reproductive traits in a seed beetle.
Journal of evolutionary biology, 2010Co-Authors: Claudia Fricke, C. Andersson, Goran ArnqvistAbstract:Speciation is thought to often result from indirect selection for reproductive isolation. This will occur when reproductive traits that cause reproductive isolation evolve (i) as a by-product of natural selection on traits with which they are genetically correlated or (ii) as an indirect result of diversifying sexual selection. Here, we use experimental Evolution to study the degree of Divergent Evolution of reproductive traits by manipulating the intensity of natural and sexual selection in replicated selection lines of seed beetles. Following 40 generations of selection, we assayed the degree of Divergent Evolution of reproductive traits between replicate selection lines experiencing the same selection regime. The Evolution of reproductive traits was significantly Divergent across selection lines within treatments. The Evolution of reproductive traits was both slower and, more importantly, significantly less Divergent among lines experiencing stronger directional natural selection. This suggests that reproductive traits did not evolve as an indirect by-product of adaptation. We discuss several ways in which natural selection may hamper Divergent Evolution among allopatric populations.
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Comparative evidence for the Evolution of genitalia by sexual selection
Nature, 1998Co-Authors: Goran ArnqvistAbstract:Rapid Divergent Evolution of male genitalia is one of the most general Evolutionary trends in animals with internal fertilization; the shapes of genital traits often provide the only reliable characters for species identification1. Yet the Evolutionary processes responsible for this pattern remain obscure. The long-standing lock-and-key hypothesis, still popular among taxonomists, suggests that genitalia evolve by pre-insemination hybridization avoidance; that is, hybrid inferiority drives the Evolution of male genitalia with a proper mechanical fit to female genitalia. The sexual selection hypothesis2,3, in contrast, proposes that Divergent Evolution of genitalia is the result of sexual selection, brought about by variation in postinsemination paternity success among males. Here, by comparing pairs of related clades of insects that differ in mating system, I assess how the opportunity for postmating sexual selection affects the rate of Divergent Evolution of male genitalia. Genital Evolution is more than twice as Divergent in groups in which females mate several times than in groups in which females mate only once. This pattern is not found for other morphological traits. These findings provide strong empirical evidence in favour of a postmating sexual selection mechanism of genital Evolution.