The Experts below are selected from a list of 219 Experts worldwide ranked by ideXlab platform

Arne Klungland - One of the best experts on this subject based on the ideXlab platform.

  • Bases of DNA repair and regulation
    Nature Chemical Biology, 2014
    Co-Authors: Adam B Robertson, John Arne Dahl, Arne Klungland
    Abstract:

    Recent studies have identified the existence of modified cytosine bases in DNA that result from ten eleven translocation (Tet)-mediated oxidation of 5-methylcytosine. The demonstration that Tet oxidizes thymine to 5-hydroxymethyluracil has implications for our current view of DNA Metabolism.

  • DNA Metabolism: Bases of DNA repair and regulation
    Nature Chemical Biology, 2014
    Co-Authors: Adam B Robertson, John Arne Dahl, Arne Klungland
    Abstract:

    Recent studies have identified the existence of modified cytosine bases in DNA that result from ten eleven translocation (Tet)-mediated oxidation of 5-methylcytosine. The demonstration that Tet oxidizes thymine to 5-hydroxymethyluracil has implications for our current view of DNA Metabolism.

Robert M Brosh - One of the best experts on this subject based on the ideXlab platform.

  • mechanisms of recq helicases in pathways of DNA Metabolism and maintenance of genomic stability
    Biochemical Journal, 2006
    Co-Authors: Sudha Sharma, Kevin M Doherty, Robert M Brosh
    Abstract:

    Helicases are molecular motor proteins that couple the hydrolysis of NTP to nucleic acid unwinding. The growing number of DNA helicases implicated in human disease suggests that their vital specialized roles in cellular pathways are important for the maintenance of genome stability. In particular, mutations in genes of the RecQ family of DNA helicases result in chromosomal instability diseases of premature aging and/or cancer predisposition. We will discuss the mechanisms of RecQ helicases in pathways of DNA Metabolism. A review of RecQ helicases from bacteria to human reveals their importance in genomic stability by their participation with other proteins to resolve DNA replication and recombination intermediates. In the light of their known catalytic activities and protein interactions, proposed models for RecQ function will be summarized with an emphasis on how this distinct class of enzymes functions in chromosomal stability maintenance and prevention of human disease and cancer.

Raymond J Monnat - One of the best experts on this subject based on the ideXlab platform.

  • human recq helicases roles in DNA Metabolism mutagenesis and cancer biology
    Seminars in Cancer Biology, 2010
    Co-Authors: Raymond J Monnat
    Abstract:

    Helicases use the energy of ATP hydrolysis to separate double-stranded nucleic acids to facilitate essential processes such as replication, recombination, transcription and repair. This article focuses on the human RECQ helicase gene and protein family. Loss of function of three different members has been shown to cause Bloom syndrome (BS), Werner syndrome (WS) and Rothmund–Thomson syndrome (RTS). This article outlines clinical and cellular features of these cancer predisposition syndromes, and discusses their pathogenesis in light of our understanding of RECQ helicase biochemical activities and in vivo functions. I also discuss the emerging role for RECQ helicases as predictors of disease risk and the response to therapy.

Adam B Robertson - One of the best experts on this subject based on the ideXlab platform.

  • Bases of DNA repair and regulation
    Nature Chemical Biology, 2014
    Co-Authors: Adam B Robertson, John Arne Dahl, Arne Klungland
    Abstract:

    Recent studies have identified the existence of modified cytosine bases in DNA that result from ten eleven translocation (Tet)-mediated oxidation of 5-methylcytosine. The demonstration that Tet oxidizes thymine to 5-hydroxymethyluracil has implications for our current view of DNA Metabolism.

  • DNA Metabolism: Bases of DNA repair and regulation
    Nature Chemical Biology, 2014
    Co-Authors: Adam B Robertson, John Arne Dahl, Arne Klungland
    Abstract:

    Recent studies have identified the existence of modified cytosine bases in DNA that result from ten eleven translocation (Tet)-mediated oxidation of 5-methylcytosine. The demonstration that Tet oxidizes thymine to 5-hydroxymethyluracil has implications for our current view of DNA Metabolism.

Sudha Sharma - One of the best experts on this subject based on the ideXlab platform.

  • mechanisms of recq helicases in pathways of DNA Metabolism and maintenance of genomic stability
    Biochemical Journal, 2006
    Co-Authors: Sudha Sharma, Kevin M Doherty, Robert M Brosh
    Abstract:

    Helicases are molecular motor proteins that couple the hydrolysis of NTP to nucleic acid unwinding. The growing number of DNA helicases implicated in human disease suggests that their vital specialized roles in cellular pathways are important for the maintenance of genome stability. In particular, mutations in genes of the RecQ family of DNA helicases result in chromosomal instability diseases of premature aging and/or cancer predisposition. We will discuss the mechanisms of RecQ helicases in pathways of DNA Metabolism. A review of RecQ helicases from bacteria to human reveals their importance in genomic stability by their participation with other proteins to resolve DNA replication and recombination intermediates. In the light of their known catalytic activities and protein interactions, proposed models for RecQ function will be summarized with an emphasis on how this distinct class of enzymes functions in chromosomal stability maintenance and prevention of human disease and cancer.