The Experts below are selected from a list of 1881519 Experts worldwide ranked by ideXlab platform
David L Becton - One of the best experts on this subject based on the ideXlab platform.
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Nutlin‐3 treatment spares cisplatin‐induced inhibition of bone healing while maintaining osteosarcoma toxicity
Journal of Orthopaedic Research, 2016Co-Authors: Kimo C Stine, Elizabeth C Wahl, Lichu Liu, Robert A Skinner, Jaclyn Vanderschilden, Robert C Bunn, Corey O Montgomery, James Aronson, David L Becton, Richard W. NicholasAbstract:The majority of Osteosarcoma (OS) patients are treated with a combination of chemotherapy, resection, and limb salvage protocols. These protocols include distraction osteogenesis (Do), which is characterized by direct new bone formation. Cisplatin (CDP) is extensively used for OS chemotherapy and recent studies, using a mouse Do Model, have demonstrated that CDP has profound negative effects on bone repair. Recent oncological therapeutic strategies are based on the use of standard cytotoxic drugs plus an assortment of biologic agents. Here we demonstrate that the previously reported CDP-associated inhibition of bone repair can be modulated by the administration of a small molecule p53 inducer (nutlin-3). The effects of nutlin-3 on CDP osteotoxicity were studied using both pre- and post-operative treatment Models. In both cases the addition of nutlin-3, bracketing CDP exposure, demonstrated robust and significant bone sparing activity (p
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nutlin 3 treatment spares cisplatin induced inhibition of bone healing while maintaining osteosarcoma toxicity
Journal of Orthopaedic Research, 2016Co-Authors: Kimo C Stine, Elizabeth C Wahl, Lichu Liu, Robert A Skinner, Jaclyn Vanderschilden, Robert C Bunn, Corey O Montgomery, James Aronson, David L BectonAbstract:The majority of Osteosarcoma (OS) patients are treated with a combination of chemotherapy, resection, and limb salvage protocols. These protocols include distraction osteogenesis (Do), which is characterized by direct new bone formation. Cisplatin (CDP) is extensively used for OS chemotherapy and recent studies, using a mouse Do Model, have demonstrated that CDP has profound negative effects on bone repair. Recent oncological therapeutic strategies are based on the use of standard cytotoxic drugs plus an assortment of biologic agents. Here we demonstrate that the previously reported CDP-associated inhibition of bone repair can be modulated by the administration of a small molecule p53 inducer (nutlin-3). The effects of nutlin-3 on CDP osteotoxicity were studied using both pre- and post-operative treatment Models. In both cases the addition of nutlin-3, bracketing CDP exposure, demonstrated robust and significant bone sparing activity (p < 0.01-0.001). In addition the combination of nutlin-3 and CDP induced equivalent OS tumor killing in a xenograft Model. Collectively, these results demonstrate that the induction of p53 peri-operatively protects bone healing from the toxic effects of CDP, while maintaining OS toxicity. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1716-1724, 2016.
James Aronson - One of the best experts on this subject based on the ideXlab platform.
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Nutlin‐3 treatment spares cisplatin‐induced inhibition of bone healing while maintaining osteosarcoma toxicity
Journal of Orthopaedic Research, 2016Co-Authors: Kimo C Stine, Elizabeth C Wahl, Lichu Liu, Robert A Skinner, Jaclyn Vanderschilden, Robert C Bunn, Corey O Montgomery, James Aronson, David L Becton, Richard W. NicholasAbstract:The majority of Osteosarcoma (OS) patients are treated with a combination of chemotherapy, resection, and limb salvage protocols. These protocols include distraction osteogenesis (Do), which is characterized by direct new bone formation. Cisplatin (CDP) is extensively used for OS chemotherapy and recent studies, using a mouse Do Model, have demonstrated that CDP has profound negative effects on bone repair. Recent oncological therapeutic strategies are based on the use of standard cytotoxic drugs plus an assortment of biologic agents. Here we demonstrate that the previously reported CDP-associated inhibition of bone repair can be modulated by the administration of a small molecule p53 inducer (nutlin-3). The effects of nutlin-3 on CDP osteotoxicity were studied using both pre- and post-operative treatment Models. In both cases the addition of nutlin-3, bracketing CDP exposure, demonstrated robust and significant bone sparing activity (p
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nutlin 3 treatment spares cisplatin induced inhibition of bone healing while maintaining osteosarcoma toxicity
Journal of Orthopaedic Research, 2016Co-Authors: Kimo C Stine, Elizabeth C Wahl, Lichu Liu, Robert A Skinner, Jaclyn Vanderschilden, Robert C Bunn, Corey O Montgomery, James Aronson, David L BectonAbstract:The majority of Osteosarcoma (OS) patients are treated with a combination of chemotherapy, resection, and limb salvage protocols. These protocols include distraction osteogenesis (Do), which is characterized by direct new bone formation. Cisplatin (CDP) is extensively used for OS chemotherapy and recent studies, using a mouse Do Model, have demonstrated that CDP has profound negative effects on bone repair. Recent oncological therapeutic strategies are based on the use of standard cytotoxic drugs plus an assortment of biologic agents. Here we demonstrate that the previously reported CDP-associated inhibition of bone repair can be modulated by the administration of a small molecule p53 inducer (nutlin-3). The effects of nutlin-3 on CDP osteotoxicity were studied using both pre- and post-operative treatment Models. In both cases the addition of nutlin-3, bracketing CDP exposure, demonstrated robust and significant bone sparing activity (p < 0.01-0.001). In addition the combination of nutlin-3 and CDP induced equivalent OS tumor killing in a xenograft Model. Collectively, these results demonstrate that the induction of p53 peri-operatively protects bone healing from the toxic effects of CDP, while maintaining OS toxicity. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1716-1724, 2016.
Kimo C Stine - One of the best experts on this subject based on the ideXlab platform.
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Nutlin‐3 treatment spares cisplatin‐induced inhibition of bone healing while maintaining osteosarcoma toxicity
Journal of Orthopaedic Research, 2016Co-Authors: Kimo C Stine, Elizabeth C Wahl, Lichu Liu, Robert A Skinner, Jaclyn Vanderschilden, Robert C Bunn, Corey O Montgomery, James Aronson, David L Becton, Richard W. NicholasAbstract:The majority of Osteosarcoma (OS) patients are treated with a combination of chemotherapy, resection, and limb salvage protocols. These protocols include distraction osteogenesis (Do), which is characterized by direct new bone formation. Cisplatin (CDP) is extensively used for OS chemotherapy and recent studies, using a mouse Do Model, have demonstrated that CDP has profound negative effects on bone repair. Recent oncological therapeutic strategies are based on the use of standard cytotoxic drugs plus an assortment of biologic agents. Here we demonstrate that the previously reported CDP-associated inhibition of bone repair can be modulated by the administration of a small molecule p53 inducer (nutlin-3). The effects of nutlin-3 on CDP osteotoxicity were studied using both pre- and post-operative treatment Models. In both cases the addition of nutlin-3, bracketing CDP exposure, demonstrated robust and significant bone sparing activity (p
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nutlin 3 treatment spares cisplatin induced inhibition of bone healing while maintaining osteosarcoma toxicity
Journal of Orthopaedic Research, 2016Co-Authors: Kimo C Stine, Elizabeth C Wahl, Lichu Liu, Robert A Skinner, Jaclyn Vanderschilden, Robert C Bunn, Corey O Montgomery, James Aronson, David L BectonAbstract:The majority of Osteosarcoma (OS) patients are treated with a combination of chemotherapy, resection, and limb salvage protocols. These protocols include distraction osteogenesis (Do), which is characterized by direct new bone formation. Cisplatin (CDP) is extensively used for OS chemotherapy and recent studies, using a mouse Do Model, have demonstrated that CDP has profound negative effects on bone repair. Recent oncological therapeutic strategies are based on the use of standard cytotoxic drugs plus an assortment of biologic agents. Here we demonstrate that the previously reported CDP-associated inhibition of bone repair can be modulated by the administration of a small molecule p53 inducer (nutlin-3). The effects of nutlin-3 on CDP osteotoxicity were studied using both pre- and post-operative treatment Models. In both cases the addition of nutlin-3, bracketing CDP exposure, demonstrated robust and significant bone sparing activity (p < 0.01-0.001). In addition the combination of nutlin-3 and CDP induced equivalent OS tumor killing in a xenograft Model. Collectively, these results demonstrate that the induction of p53 peri-operatively protects bone healing from the toxic effects of CDP, while maintaining OS toxicity. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1716-1724, 2016.
Joanna Łachwa - One of the best experts on this subject based on the ideXlab platform.
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thermodynamics of binary mixtures of n methyl 2 pyrrolidinone and ketone experimental results and Modelling of the solid liquid equilibrium and the vapour liquid equilibrium the modified unifac Do Model characterization
The Journal of Chemical Thermodynamics, 2005Co-Authors: Urszula Domanska, Joanna ŁachwaAbstract:Abstract The (solid + liquid) equilibrium (SLE) of eight binary systems containing N-methyl-2-pyrrolidinone (NMP) with (2-propanone, or 2-butanone, or 2-pentanone, or 3-pentanone, or cyclopentanone, or 2-hexanone, or 4-methyl-2-pentanone, or 3-heptanone) were carried out by using a dynamic method from T = 200 K to the melting point of the NMP. The isothermal (vapour + liquid) equilibrium data (VLE) have been measured for three binary mixtures of NMP with 2-propanone, 3-pentanone and 2-hexanone at pressure range from p = 0 kPa to p = 115 kPa. Data were obtained at the temperature T = 333.15 K for the first system and at T = 373.15 K for the second two systems. The experimental results of SLE have been correlated using the binary parameters Wilson, UNIQUAC ASM and two modified NRTL equations. The root-mean-square deviations of the solubility temperatures for all the calculated values vary from (0.32 K to 0.68 K) and depend on the particular equation used. The data of VLE were correlated with one to three parameters in the Redlich–Kister expansion. Binary mixtures of NMP with (2-propanone, or 2-butanone, or 2-pentanone, or 3-pentanone, or cyclopentanone, or 2-hexanone, or 4-methyl-2-pentanone, or 3-heptanone) have been investigated in the framework of the modified UNIFAC (Do) Model. The reported new interaction parameters for NMP-group (c-CONCH3) and carbonyl group ( C O) let the Model consistently described a set of thermodynamic properties, including (solid + liquid) equilibrium, (vapour + liquid) equilibrium, excess Gibbs energy and molar excess enthalpies of mixing. Our experimental and literature data of binary mixtures containing NMP and ketones were compared with the results of prediction with the modified UNIFAC (Do) Model.
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Thermodynamics of binary mixtures of N-methyl-2-pyrrolidinone and ketone. Experimental results and Modelling of the (solid + liquid) equilibrium and the (vapour + liquid) equilibrium. The modified UNIFAC (Do) Model characterization
The Journal of Chemical Thermodynamics, 2005Co-Authors: Urszula Domańska, Joanna ŁachwaAbstract:Abstract The (solid + liquid) equilibrium (SLE) of eight binary systems containing N-methyl-2-pyrrolidinone (NMP) with (2-propanone, or 2-butanone, or 2-pentanone, or 3-pentanone, or cyclopentanone, or 2-hexanone, or 4-methyl-2-pentanone, or 3-heptanone) were carried out by using a dynamic method from T = 200 K to the melting point of the NMP. The isothermal (vapour + liquid) equilibrium data (VLE) have been measured for three binary mixtures of NMP with 2-propanone, 3-pentanone and 2-hexanone at pressure range from p = 0 kPa to p = 115 kPa. Data were obtained at the temperature T = 333.15 K for the first system and at T = 373.15 K for the second two systems. The experimental results of SLE have been correlated using the binary parameters Wilson, UNIQUAC ASM and two modified NRTL equations. The root-mean-square deviations of the solubility temperatures for all the calculated values vary from (0.32 K to 0.68 K) and depend on the particular equation used. The data of VLE were correlated with one to three parameters in the Redlich–Kister expansion. Binary mixtures of NMP with (2-propanone, or 2-butanone, or 2-pentanone, or 3-pentanone, or cyclopentanone, or 2-hexanone, or 4-methyl-2-pentanone, or 3-heptanone) have been investigated in the framework of the modified UNIFAC (Do) Model. The reported new interaction parameters for NMP-group (c-CONCH3) and carbonyl group ( C O) let the Model consistently described a set of thermodynamic properties, including (solid + liquid) equilibrium, (vapour + liquid) equilibrium, excess Gibbs energy and molar excess enthalpies of mixing. Our experimental and literature data of binary mixtures containing NMP and ketones were compared with the results of prediction with the modified UNIFAC (Do) Model.
Thierry Boulard - One of the best experts on this subject based on the ideXlab platform.
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Modelling of micrometeorology, canopy transpiration and photosynthesis in a closed greenhouse using computational fluid dynamics
Biosystems Engineering, 2017Co-Authors: Thierry Boulard, Jean-claude Roy, Jean-baptiste Pouillard, Hicham Fatnassi, Ariane GriseyAbstract:Closed greenhouse systems allow micrometeorological conditions to be optimised for both energy saving and high quality yields. However, micrometeorological parameters need to be accurately monitored as a response to daily environmental conditions changes. A Computational Fluid Dynamics (CFD) Model was developed to predict the distribution of temperature, water vapour and CO2 occurring in a Venlo-type semi-closed glass greenhouse equipped with air conditioners. Sensible and latent heat fluxes in the crop rows were included in the Model along with radiation through a Discrete Ordinates (Do) Model. A Model for photosynthesis was also included to predict the evolution of the CO2 concentrations inside the greenhouse. Comparisons between simulated and measured values showed a good agreement for temperature and humidity. Good agreement was found also between simulated and experimental CO2 concentration values determined during a sunny summer day. Simulations were also performed to investigate the vertical distribution of temperature and humidity for two different Leaf Area Density (LAD) values (2.95 m(-1) and 5.9 m(-1)) and for different arrangements of the air conditioners. Simulation results showed that tall canopies, with high LAD, simultaneously induce a stronger cooling of the interior air. They also enhance temperature stratification providing a substantial decrease at canopy level. Lower suction also enhances stratification of the interior air.
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CFD determination of the climate distribution in a semi closed greenhouse with air cooling
2015Co-Authors: Jean Roy, Thierry Boulard, Hicham Fatnassi, Jean Pouillard, Ariane GriseyAbstract:This paper presents the results of the simulation of the temperature and air humidity distributions in a 960 m2 semi closed greenhouse with a tomato crop and equipped with fourteen air cooling and dehumidifying ducts. These units are distributed between the crop rows and the sucking inlets are alternately located at high or low locations. The computational Model of the aerial Domain was developed using the Fluent Computational Fluid Dynamics code. For simulating radiative exchanges, a Discrete Ordinates (Do) Model was considered. Sensible, latent and radiative heat transfers together with crop activity (stomatal resistance) and induced water vapour transfers were computed within the crop stands using a porous and semi-transparent medium Model. In order to limit both computing time and mesh size, the geometric Domain was limited to the greenhouse walls. Experimental conditions for temperature and humidity conditions were applied to the outlets of the ducts. Air leakages and airflow through the vents during the opening period were simulated with sink terms located on the mesh connected with the roof and the walls. Simulations were performed for a single summer day from 8:00 am to 22:00 pm with a 30 min. time step. A new set of boundary values was applied before each simulation. Simulated and measured values of temperature and water vapour concentration inside the greenhouse are presented and commented together with a sensibility study on the influence of the air conditioning device.
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Experimental and CFD results on the CO2 distribution in a semi closed greenhouse
2013Co-Authors: Jean Roy, Thierry Boulard, Hicham Fatnassi, Jean Pouillard, Ariane GriseyAbstract:This work aims at predicting CO2 concentration inside an experimental energy saving and semi closed greenhouse with a tomato crop. For that purpose, a 3D Model of a cropped greenhouse has been created, including a discrete CO2 injection system and an air-cooling and dehumidifying system. The Model has been developed using the Fluent CFD code. For simulating radiative exchanges, a Discrete Ordinates (Do) Model was enabled, together with sensible, latent and radiative heat transfers related to crop activity and mass transfers (water vapor and CO2) were simulated within the crop rows considered as equivalent porous and semi-transparent media. This approach allows computing the distributed crop photosynthesis. Experimental measurements were performed for the determination of the spatial and dynamic distribution of climate parameters and CO2 distributions within the greenhouse and in its vicinity in order to be used as boundary conditions by the CFD Model. Comparisons between the simulated and the measured values of the CO2 concentration inside the greenhouse are presented for a whole day time. The simulated net CO2 consumption is also determined and presented. Finally, we also analyzed the sensitivity of the distribution of CO2 in the greenhouse vs. the attenuation of solar radiation across the crop rows.
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Dynamic simulation of the distributed radiative and convective climate within a cropped greenhouse
Renewable Energy, 2012Co-Authors: Rezki Nebbali, Thierry BoulardAbstract:This article presents numerical simulations of the distribution of climate parameters within a ventilated tunnel tomato greenhouse during variable outside conditions. The simulations were performed using a computational fluid dynamics (CFD) code that solved the transport equations in a 3D Domain, including the greenhouse and its crop stands, the surrounding ambient air and the soil located directly under the greenhouse. Radiative heat transfers were Modeled using a bi-band discrete ordinates (Do) Model, and the crop was considered to be a porous medium. Sensible and latent heat transfer between leaves and the surrounding air were determined based on the energy balance that included longwave and shortwave radiation fluxes in each crop control volume. The climatic boundary conditions were determined using experimental measurements, and the sun position was calculated for each time interval that was considered. The temperature distribution in the soil was determined based on a preliminary CFD determination of the conductive heat transfer in a 1D soil column. Simulations in the entire 3D Domain were then performed, and 1 h time step and boundary conditions were updated prior to each calculation procedure. Results are presented for the spring equinox and summer solstice. These results highlight the combined influence of sun position, wind direction and intensity on the greenhouse microclimate and especially on the evapotranspiration rate of the crop at the leaf level. We discuss the possibility of using CFD code integration as a conceptual tool for designers or in association with a control climate Model for farmers.
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Dynamic simulation of the distributed radiative and convective climate within a cropped greenhouse
Renewable Energy, 2012Co-Authors: Rezki Nebbali, J. C. Roy, Thierry BoulardAbstract:This article presents numerical simulations of the distribution of climate parameters within a ventilated tunnel tomato greenhouse during variable outside conditions. The simulations were performed using a computational fluid dynamics (CFD) code that solved the transport equations in a 3D Domain, including the greenhouse and its crop stands, the surrounding ambient air and the soil located directly under the greenhouse. Radiative heat transfers were Modeled using a bi-band discrete ordinates (Do) Model, and the crop was considered to be a porous medium. Sensible and latent heat transfer between leaves and the surrounding air were determined based on the energy balance that included longwave and short-wave radiation fluxes in each crop control volume. The climatic boundary conditions were determined using experimental measurements, and the sun position was calculated for each time interval that was considered. The temperature distribution in the soil was determined based on a preliminary CFD determination of the conductive heat transfer in a 1D soil column. Simulations in the entire 3D Domain were then performed, and 1 h time step and boundary conditions were updated prior to each calculation procedure. Results are presented for the spring equinox and summer solstice. These results highlight the combined influence of sun position, wind direction and intensity on the greenhouse microclimate and especially on the evapotranspiration rate of the crop at the leaf level. We discuss the possibility of using CFD code integration as a conceptual tool for designers or in association with a control climate Model for farmers. (C) 2011 Elsevier Ltd. All rights reserved.