The Experts below are selected from a list of 6609 Experts worldwide ranked by ideXlab platform
Li-xin Wang - One of the best experts on this subject based on the ideXlab platform.
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Organocatalytic Enantioselective Michael/Cyclization Domino Reaction between 3-Amideoxindoles and α,β-Unsaturated Aldehydes: One-Pot Preparation of Chiral Spirocyclic Oxindole-γ-lactams
Journal of Organic Chemistry, 2017Co-Authors: Peng Yang, Feng Chen, Lin Peng, Xiao Wang, Zheng-bing Zhang, Chen Chao, Li-xin WangAbstract:The first organocatalytic enantioselective Michael/cyclization Domino Reaction between 3-amideoxindoles and α,β-unsaturated aldehydes is described. After sequential oxidation with pyridinium chlorochromate, a direct and one-pot preparation of highly sterically hindered spirocyclic oxindole-γ-lactams was achieved in 51–81% yields with 75–97% ee and ≤80/20 dr.
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an unexpected metal free dmap catalyzed michael addition elimination Domino Reaction between 2 naphthols and bromomaleimides for the effective construction of 3 arylmaleimides
Tetrahedron Letters, 2016Co-Authors: Yong Zhang, Fang Tian, Feng Chen, Yu Yang, Chaozhe Tang, Lin Peng, Li-xin WangAbstract:Abstract An unexpected novel DMAP catalyzed Michael addition–elimination Domino Reaction between 2-naphthols and bromomaleimides has been reported. This protocol features metal-free catalysis and mild Reaction conditions, which furnished 3-arylmaleimides in moderate to excellent yields (25–89% yields).
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An Unprecedented Base-Promoted Domino Reaction of Methyleneindolinones and N-Tosyloxycarbamates for the Construction of Bispirooxindoles and Spiroaziridine Oxindoles.
ChemInform, 2015Co-Authors: Qi-lin Wang, Tian Cai, Jing Zhou, Fang Tian, Li-xin WangAbstract:The DABCO-mediated Domino Reaction of methyleneindolinones (I) with N-tosyloxycarbamates (II) leads to symmetrical bispirooxindoles (III) in high yields.
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an unprecedented base promoted Domino Reaction of methyleneindolinones and n tosyloxycarbamates for the construction of bispirooxindoles and spiroaziridine oxindoles
Chemical Communications, 2015Co-Authors: Qi-lin Wang, Tian Cai, Jing Zhou, Fang Tian, Li-xin WangAbstract:An efficient and unprecedented Domino Reaction of methyleneindolinones and N-tosyloxycarbamates has been developed to afford structurally complex and diverse bispirooxindoles in excellent yields (up to 98%) and spiroaziridine oxindoles in moderate to good yields (55–91%). Moreover, this protocol could also provide the unsymmetrical bispirooxindoles and various fused spirocyclic pyrrolidines in excellent yields.
Jan K. Maurin - One of the best experts on this subject based on the ideXlab platform.
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Domino Reaction of Pyrrolidinium Ylides: Michael Addition/[1,2]-Stevens Rearrangement
Journal of Organic Chemistry, 2018Co-Authors: Anna Kowalkowska, Andrzej Jończyk, Jan K. MaurinAbstract:A novel Domino Reaction featuring a Michael addition/[1,2]-Stevens rearrangement Reaction of pyrrolidinium ylides with electrophilic alkenes is described. Ylides generated under mild conditions from 2-aryl-N-cyanomethyl-N-methylpyrrolidinium salts entered the Michael addition, followed by a [1,3]-hydrogen shift and finally the [1,2]-Stevens rearrangement to give 3-aryl-2-cyano-2-(2-EWG-ethyl)-1-methylpiperidines.
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Domino Reaction of Pyrrolidinium Ylides: Michael Addition/[1,2]-Stevens Rearrangement
2018Co-Authors: Anna Kowalkowska, Andrzej Jończyk, Jan K. MaurinAbstract:A novel Domino Reaction featuring a Michael addition/[1,2]-Stevens rearrangement Reaction of pyrrolidinium ylides with electrophilic alkenes is described. Ylides generated under mild conditions from 2-aryl-N-cyanomethyl-N-methylpyrrolidinium salts entered the Michael addition, followed by a [1,3]-hydrogen shift and finally the [1,2]-Stevens rearrangement to give 3-aryl-2-cyano-2-(2-EWG-ethyl)-1-methylpiperidines
Fang Tian - One of the best experts on this subject based on the ideXlab platform.
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an unexpected metal free dmap catalyzed michael addition elimination Domino Reaction between 2 naphthols and bromomaleimides for the effective construction of 3 arylmaleimides
Tetrahedron Letters, 2016Co-Authors: Yong Zhang, Fang Tian, Feng Chen, Yu Yang, Chaozhe Tang, Lin Peng, Li-xin WangAbstract:Abstract An unexpected novel DMAP catalyzed Michael addition–elimination Domino Reaction between 2-naphthols and bromomaleimides has been reported. This protocol features metal-free catalysis and mild Reaction conditions, which furnished 3-arylmaleimides in moderate to excellent yields (25–89% yields).
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An Unprecedented Base-Promoted Domino Reaction of Methyleneindolinones and N-Tosyloxycarbamates for the Construction of Bispirooxindoles and Spiroaziridine Oxindoles.
ChemInform, 2015Co-Authors: Qi-lin Wang, Tian Cai, Jing Zhou, Fang Tian, Li-xin WangAbstract:The DABCO-mediated Domino Reaction of methyleneindolinones (I) with N-tosyloxycarbamates (II) leads to symmetrical bispirooxindoles (III) in high yields.
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an unprecedented base promoted Domino Reaction of methyleneindolinones and n tosyloxycarbamates for the construction of bispirooxindoles and spiroaziridine oxindoles
Chemical Communications, 2015Co-Authors: Qi-lin Wang, Tian Cai, Jing Zhou, Fang Tian, Li-xin WangAbstract:An efficient and unprecedented Domino Reaction of methyleneindolinones and N-tosyloxycarbamates has been developed to afford structurally complex and diverse bispirooxindoles in excellent yields (up to 98%) and spiroaziridine oxindoles in moderate to good yields (55–91%). Moreover, this protocol could also provide the unsymmetrical bispirooxindoles and various fused spirocyclic pyrrolidines in excellent yields.
Qi-lin Wang - One of the best experts on this subject based on the ideXlab platform.
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An Unprecedented Base-Promoted Domino Reaction of Methyleneindolinones and N-Tosyloxycarbamates for the Construction of Bispirooxindoles and Spiroaziridine Oxindoles.
ChemInform, 2015Co-Authors: Qi-lin Wang, Tian Cai, Jing Zhou, Fang Tian, Li-xin WangAbstract:The DABCO-mediated Domino Reaction of methyleneindolinones (I) with N-tosyloxycarbamates (II) leads to symmetrical bispirooxindoles (III) in high yields.
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an unprecedented base promoted Domino Reaction of methyleneindolinones and n tosyloxycarbamates for the construction of bispirooxindoles and spiroaziridine oxindoles
Chemical Communications, 2015Co-Authors: Qi-lin Wang, Tian Cai, Jing Zhou, Fang Tian, Li-xin WangAbstract:An efficient and unprecedented Domino Reaction of methyleneindolinones and N-tosyloxycarbamates has been developed to afford structurally complex and diverse bispirooxindoles in excellent yields (up to 98%) and spiroaziridine oxindoles in moderate to good yields (55–91%). Moreover, this protocol could also provide the unsymmetrical bispirooxindoles and various fused spirocyclic pyrrolidines in excellent yields.
Junliang Zhang - One of the best experts on this subject based on the ideXlab platform.
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enantioselective gold catalyzed functionalization of unreactive sp3 c h bonds through a redox neutral Domino Reaction
ChemInform, 2011Co-Authors: Guanghua Zhou, Feng Liu, Junliang ZhangAbstract:A diversity of furan-fused azepines, e.g. (II), (IV), (VI) and (VIII), is smoothly obtained by direct functionalization of unreactive C(sp3)—H bonds via Au(I)-catalyzed asymmetric redox—neutral Domino Reaction.
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enantioselective gold catalyzed functionalization of unreactive sp3 c h bonds through a redox neutral Domino Reaction
Chemistry: A European Journal, 2011Co-Authors: Guanghua Zhou, Feng Liu, Junliang ZhangAbstract:Selectivity is golden: The first asymmetric redox-neutral Domino Reaction catalyzed by gold that results in the direct functionalization of unreactive sp(3) C-H bonds has been reported. This method consists of a heterocyclization/1,5-hydride transfer/cyclization Reaction and provides synthetically valuable azepines with high enantioselectivities and in high yields (Tf = triflate; see scheme).
