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Bao-jie Wang - One of the best experts on this subject based on the ideXlab platform.
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No association between the Ser9Gly polymorphism of the Dopamine Receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies.
BMC Medical Genetics, 2020Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:BACKGROUND: Previous studies found that Ser9Gly (rs6280) might be involved in the occurrence of schizophrenia. However, no consist conclusion has yet been achieved. Compared to the case-control study, the family-based study took into account stratification bias. Thus, we conducted a meta-analysis of family-based studies to measure a pooled effect size of the association between Ser9Gly and the risk of schizophrenia. METHODS: The relevant family-based studies were screened using the electronic databases by the inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to measure the correction between Ser9Gly polymorphism and schizophrenia susceptibility. Subgroup analysis was performed by stratification of ethnicity (i.e., East Asian, Caucasian, and other populations). Additionally, publication bias was evaluated by the funnel plot. RESULTS: After literature searching, a total of 13 family-based association studies were included, which contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HRR) studies. No statistical significance of the heterogeneity was detected in TDT and HRR studies. Thus, the pooled effect size was calculated under the fixed effect model. The results found that the association was significantly protective in East Asian in TDT studies (204 informative meiosis, OR = 0.744, 95% CI = 0.564-0.980, Z-value = - 2.104, p = 0.035). CONCLUSIONS: The meta-analysis based on the family study found a protective association of Ser9Gly in East Asian. In future, large sample molecular epidemiology studies are needed to validate our findings.
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No association between the Ser9Gly polymorphism of the Dopamine Receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies
2020Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:Abstract Background: Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human Dopamine Receptor D3 gene (DRD3). It is still controversial whether Ser9Gly is involved in the occurrence of schizophrenia. While there has been meta-analysis performed previously, that work did not include the family-based studies, which accounted for stratification bias. Thus, we performed a meta-analysis of family-based studies to explore the role of Ser9Gly in the etiology of schizophrenia. Methods: The published family-based association studies were retrieved from the relevant literature databases according to the established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia. Moreover, subgroup analysis was carried out by ethnicity (i.e., East Asian, Caucasian, and other populations). Results: We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HRR) studies. There was no statistical significance for the heterogeneity in TDT and HRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that this association was significantly protective in East Asian in TDT studies (204 informative meiosis, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035). Conclusions: Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. These data provide possible avenues for future family-based studies related to schizophrenia.
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No association between the Ser9Gly polymorphism of the Dopamine Receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies
2020Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:Abstract Background : Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human Dopamine Receptor D3 gene ( DRD 3 ). It is still controversial whether Ser9Gly is involved in the occurrence of schizophrenia. While there has been meta-analysis performed previously, that work did not include the family-based studies, which accounted for stratification bias. Thus, we performed a meta-analysis of family-based studies to explore the role of Ser9Gly in the etiology of schizophrenia. Methods : The published family-based association studies were retrieved from the relevant literature databases according to the established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia. Moreover, subgroup analysis was carried out by ethnicity (i.e., East Asian, Caucasian, and other populations). Results : We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HRR) studies. There was no statistical significance for the heterogeneity in TDT and HRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that neither of the associations between Ser9Gly and the risk of schizophrenia were observed in TDT (1219 informative meiosis, OR=1.005, 95% CI = 0.898-1.125, Z-value = 0.086, p = 0.932) and HRR studies (1704 samples, OR=0.869, 95% CI = 0.713-1.059, Z-value = -1.395, p = 0.163), except for the significantly preferential transmission of DRD3 Ser9 allele in East Asian in TDT studies (204 informative meiosis, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035). Conclusions : Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. These data provide possible avenues for future family-based studies related to schizophrenia.
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No association between the Ser9Gly polymorphism of the Dopamine Receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies
2020Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:Abstract Background : Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human Dopamine Receptor D3 gene ( DRD3 ) that may be involved in the occurrence of schizophrenia. We performed a meta-analysis of family-based studies to explore the role of Ser9Gly in the etiology of schizophrenia. Methods : The published family-based association studies were retrieved from the relevant literature databases according to the established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia. Results : We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HHRR) studies. There was no statistical significance for the heterogeneity in TDT and HHRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that neither of the associations between Ser9Gly and the risk of schizophrenia were observed in TDT (1219 samples, OR=1.005, 95% CI = 0.898-1.125, Z-value = 0.086, p = 0.932) and HHRR studies (1704 samples, OR=0.869, 95% CI = 0.713-1.059, Z-value = -1.395, p = 0.163), except for the significantly preferential transmission of DRD3 Ser9 allele in East Asian in TDT studies (204 samples, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035). Conclusions : Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. These data provide possible avenues for future family-based studies related to schizophrenia.
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No relationship between Dopamine D3 Receptor gene Ser9Gly polymorphism (rs6280) and schizophrenia: a meta-analysis of family-based association studies
2019Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:Abstract Background Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human Dopamine Receptor D3 gene (DRD3). It is still controversial that whether Ser9Gly is involved in the occurrence of schizophrenia. Thus, a meta-analysis of family-based studies was performed to explore the role of Ser9Gly in the etiology of schizophrenia.Methods The published family-based association studies were searched from the relevant literature databases according to the established inclusion criteria. We generated odds ratios and 95% confidence intervals in order to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia.Results We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HHRR) studies. There was no statistical significance for the heterogeneity in TDT and HHRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that neither of the associations between Ser9Gly and the risk of schizophrenia were observed in TDT (1219 samples, OR=1.005, 95% CI = 0.898-1.125, Z-value = 0.086, p = 0.932) and HHRR studies (1704 samples, OR=0.869, 95% CI = 0.713-1.059, Z-value = -1.395, p = 0.163), except for the significantly preferential transmission of DRD3 Ser9 allele in East Asian in TDT studies (204 samples, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035).Conclusions Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. However, more effects need to further confirm the function of DRD3 Ser9Gly SNP in the occurrence of schizophrenia.
Xiao-na Li - One of the best experts on this subject based on the ideXlab platform.
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No association between the Ser9Gly polymorphism of the Dopamine Receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies.
BMC Medical Genetics, 2020Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:BACKGROUND: Previous studies found that Ser9Gly (rs6280) might be involved in the occurrence of schizophrenia. However, no consist conclusion has yet been achieved. Compared to the case-control study, the family-based study took into account stratification bias. Thus, we conducted a meta-analysis of family-based studies to measure a pooled effect size of the association between Ser9Gly and the risk of schizophrenia. METHODS: The relevant family-based studies were screened using the electronic databases by the inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to measure the correction between Ser9Gly polymorphism and schizophrenia susceptibility. Subgroup analysis was performed by stratification of ethnicity (i.e., East Asian, Caucasian, and other populations). Additionally, publication bias was evaluated by the funnel plot. RESULTS: After literature searching, a total of 13 family-based association studies were included, which contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HRR) studies. No statistical significance of the heterogeneity was detected in TDT and HRR studies. Thus, the pooled effect size was calculated under the fixed effect model. The results found that the association was significantly protective in East Asian in TDT studies (204 informative meiosis, OR = 0.744, 95% CI = 0.564-0.980, Z-value = - 2.104, p = 0.035). CONCLUSIONS: The meta-analysis based on the family study found a protective association of Ser9Gly in East Asian. In future, large sample molecular epidemiology studies are needed to validate our findings.
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No association between the Ser9Gly polymorphism of the Dopamine Receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies
2020Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:Abstract Background: Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human Dopamine Receptor D3 gene (DRD3). It is still controversial whether Ser9Gly is involved in the occurrence of schizophrenia. While there has been meta-analysis performed previously, that work did not include the family-based studies, which accounted for stratification bias. Thus, we performed a meta-analysis of family-based studies to explore the role of Ser9Gly in the etiology of schizophrenia. Methods: The published family-based association studies were retrieved from the relevant literature databases according to the established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia. Moreover, subgroup analysis was carried out by ethnicity (i.e., East Asian, Caucasian, and other populations). Results: We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HRR) studies. There was no statistical significance for the heterogeneity in TDT and HRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that this association was significantly protective in East Asian in TDT studies (204 informative meiosis, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035). Conclusions: Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. These data provide possible avenues for future family-based studies related to schizophrenia.
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No association between the Ser9Gly polymorphism of the Dopamine Receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies
2020Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:Abstract Background : Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human Dopamine Receptor D3 gene ( DRD 3 ). It is still controversial whether Ser9Gly is involved in the occurrence of schizophrenia. While there has been meta-analysis performed previously, that work did not include the family-based studies, which accounted for stratification bias. Thus, we performed a meta-analysis of family-based studies to explore the role of Ser9Gly in the etiology of schizophrenia. Methods : The published family-based association studies were retrieved from the relevant literature databases according to the established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia. Moreover, subgroup analysis was carried out by ethnicity (i.e., East Asian, Caucasian, and other populations). Results : We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HRR) studies. There was no statistical significance for the heterogeneity in TDT and HRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that neither of the associations between Ser9Gly and the risk of schizophrenia were observed in TDT (1219 informative meiosis, OR=1.005, 95% CI = 0.898-1.125, Z-value = 0.086, p = 0.932) and HRR studies (1704 samples, OR=0.869, 95% CI = 0.713-1.059, Z-value = -1.395, p = 0.163), except for the significantly preferential transmission of DRD3 Ser9 allele in East Asian in TDT studies (204 informative meiosis, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035). Conclusions : Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. These data provide possible avenues for future family-based studies related to schizophrenia.
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No association between the Ser9Gly polymorphism of the Dopamine Receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies
2020Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:Abstract Background : Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human Dopamine Receptor D3 gene ( DRD3 ) that may be involved in the occurrence of schizophrenia. We performed a meta-analysis of family-based studies to explore the role of Ser9Gly in the etiology of schizophrenia. Methods : The published family-based association studies were retrieved from the relevant literature databases according to the established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia. Results : We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HHRR) studies. There was no statistical significance for the heterogeneity in TDT and HHRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that neither of the associations between Ser9Gly and the risk of schizophrenia were observed in TDT (1219 samples, OR=1.005, 95% CI = 0.898-1.125, Z-value = 0.086, p = 0.932) and HHRR studies (1704 samples, OR=0.869, 95% CI = 0.713-1.059, Z-value = -1.395, p = 0.163), except for the significantly preferential transmission of DRD3 Ser9 allele in East Asian in TDT studies (204 samples, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035). Conclusions : Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. These data provide possible avenues for future family-based studies related to schizophrenia.
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No relationship between Dopamine D3 Receptor gene Ser9Gly polymorphism (rs6280) and schizophrenia: a meta-analysis of family-based association studies
2019Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:Abstract Background Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human Dopamine Receptor D3 gene (DRD3). It is still controversial that whether Ser9Gly is involved in the occurrence of schizophrenia. Thus, a meta-analysis of family-based studies was performed to explore the role of Ser9Gly in the etiology of schizophrenia.Methods The published family-based association studies were searched from the relevant literature databases according to the established inclusion criteria. We generated odds ratios and 95% confidence intervals in order to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia.Results We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HHRR) studies. There was no statistical significance for the heterogeneity in TDT and HHRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that neither of the associations between Ser9Gly and the risk of schizophrenia were observed in TDT (1219 samples, OR=1.005, 95% CI = 0.898-1.125, Z-value = 0.086, p = 0.932) and HHRR studies (1704 samples, OR=0.869, 95% CI = 0.713-1.059, Z-value = -1.395, p = 0.163), except for the significantly preferential transmission of DRD3 Ser9 allele in East Asian in TDT studies (204 samples, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035).Conclusions Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. However, more effects need to further confirm the function of DRD3 Ser9Gly SNP in the occurrence of schizophrenia.
Julio Bobes - One of the best experts on this subject based on the ideXlab platform.
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GENETICS AND CELL BIOLOGY Association Between the STin2 VNTR Polymorphism of the Serotonin Transporter Gene and Treatment Outcome in Alcohol-Dependent Patients
2020Co-Authors: Gerardo Flórez, Pilar A. Saiz, Paz García-portilla, Blanca Morales, Victoria Alvarez, Eliecer Coto, Julio BobesAbstract:Aims: The aim of this study was to investigate the potential association between functional polymorphisms of Dopaminergic (Dopamine Receptor D2 (DRD2), Dopamine Receptor D3 (DRD3) and Dopamine transporter (SLC6A3)) and serotonergic (serotonin 2A Receptor (HTR2A) and serotonin transporter (SLC6A4)) genes and treatment outcome in alcohol-dependent patients. Methods: A total of 90 Spanish Caucasian alcohol-dependent outpatients (ICD-10 criteria) were enrolled in the study. The association between genotypes and drinking outcomes was measured over 6 months of treatment. Biomarkers of alcohol consumption, as well as alcohol consumption and its consequences, craving, disability and quality of life, were assessed. Based on those measures, we created a composite secondary measure to globally assess treatment outcome in alcoholism. Results: No association was found between DRD2, DRD3, SLC6A3 or HTR2A gene variants and treatment outcome. However, SLC6A4 STin2 12/12 carriers showed poor 6-month time point treatment outcome (32.8% in the good outcome group versus 64.0% in the poor outcome group, χ 2 (df) = 7.20 (1), corrected P = 0.042, OR (95% CI) = 0.27 (0.10-0.72)). Nevertheless, independent analysis of each treatment group reveals that the excess of 12/12 carriers in the poor outcome group was only found in the naltrexone-treated group (24.1% versus 64.7% χ 2 (df) = 7.41 (1), corrected P = 0.042, OR (95% CI) = 0.17 (0.05-0.64)). In the whole sample, the L-10 repeats haplotype (5-HTTLPR-STin2 VNTR) is associated with good outcome (LRT = 3.88, df = 1, P = 0.049). Conclusions: Our findings suggest that functional polymorphism of the SLC6A4 gene may have an influence on treatment outcome in alcohol-dependent patients.
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Association Between the Stin2 VNTR Polymorphism of the Serotonin Transporter Gene and Treatment Outcome in Alcohol-Dependent Patients
Alcohol and Alcoholism, 2008Co-Authors: Gerardo Flórez, Pilar A. Saiz, Paz García-portilla, Sandra Álvarez, Luis Nogueiras, Blanca Morales, Victoria Alvarez, Eliecer Coto, Julio BobesAbstract:Aims: The aim of this study was to investigate the potential association between functional polymorphisms of Dopaminergic [Dopamine Receptor D2 (DRD2), Dopamine Receptor D3 (DRD3) and Dopamine transporter (SLC6A3)] and serotonergic [serotonin 2A Receptor (HTR2A) and serotonin transporter (SLC6A4)] genes and treatment outcome in alcohol-dependent patients. Methods: A total of 90 Spanish Caucasian alcohol-dependent outpatients (ICD-10 criteria) were enrolled in the study. The association between genotypes and drinking outcomes was measured over 6 months of treatment. Biomarkers of alcohol consumption, as well as alcohol consumption and its consequences, craving, disability and quality of life, were assessed. Based on those measures, we created a composite secondary measure to globally assess treatment outcome in alcoholism. Results: No association was found between DRD2, DRD3, SLC6A3 or HTR2A gene variants and treatment outcome. However, SLC6A4 STin2 12/12 carriers showed poor 6-month time point treatment outcome [32.8% in the good outcome group versus 64.0% in the poor outcome group, χ2 ( df ) = 7.20 (1), corrected P = 0.042, OR (95% CI) = 0.27 (0.10–0.72)]. Nevertheless, independent analysis of each treatment group reveals that the excess of 12/12 carriers in the poor outcome group was only found in the naltrexone-treated group [24.1% versus 64.7% χ2 ( df ) = 7.41 (1), corrected P = 0.042, OR (95% CI) = 0.17 (0.05–0.64)]. In the whole sample, the L-10 repeats haplotype (5-HTTLPR-STin2 VNTR) is associated with good outcome (LRT = 3.88, df = 1, P = 0.049). Conclusions: Our findings suggest that functional polymorphism of the SLC6A4 gene may have an influence on treatment outcome in alcohol-dependent patients.
Ian P. Everall - One of the best experts on this subject based on the ideXlab platform.
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Dopamine Receptor D3 genetic polymorphism (rs6280TC) is associated with rates of cognitive impairment in methamphetamine-dependent men with HIV: preliminary findings
Journal of NeuroVirology, 2011Co-Authors: Saurabh Gupta, Chad A. Bousman, Gursharan Chana, Mariana Cherner, Robert K. Heaton, Reena Deutsch, Ronald J. Ellis, Igor Grant, Ian P. EverallAbstract:Macrophages are one of HIV-1’s principal targets and chiefly responsible for translocating HIV into the central nervous system (CNS). Previous research suggested an increase in macrophages being infected by HIV in the presence of methamphetamine (METH) or increased extracellular Dopamine (DA). Experimental studies indicate that this is mediated by DA Receptors, including DA Receptor D3 (DRD3), which is expressed in macrophages. A single nucleotide polymorphism (SNP) of the DRD3 gene (rs6280TC) modulates its Dopamine binding affinity, resulting in the possibility that inheriting a variant of this SNP increases macrophage susceptibility to HIV infection in the presence of METH and DA, particularly in the CNS where METH is sequestered, leading to cognitive impairment (CI). Thus, we conducted a retrospective clinical investigation to evaluate whether rs6280TC is associated with CI among HIV-positive METH users. We stratified 310 males by HIV serostatus (HIV-positive, -negative) and METH dependence (METH-positive, -negative) and then by rs6280TC genotype (CC, CT, and TT). Genotypic groups within each of four HIV/METH groups were compared for rates of CI. We hypothesized that only HIV-positive/METH-positive carriers of the C allele, which increases the DRD3’s binding to DA, would be more likely to develop CI. Cochran–Armitage test for trends in proportions yielded significant ( p
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Dopamine Receptor D3 genetic polymorphism (rs6280TC) is associated with rates of cognitive impairment in methamphetamine-dependent men with HIV: preliminary findings
Journal of NeuroVirology, 2011Co-Authors: Saurabh Gupta, Chad A. Bousman, Gursharan Chana, Mariana Cherner, Robert K. Heaton, Reena Deutsch, Ronald J. Ellis, Igor Grant, Ian P. EverallAbstract:Macrophages are one of HIV-1’s principal targets and chiefly responsible for translocating HIV into the central nervous system (CNS). Previous research suggested an increase in macrophages being infected by HIV in the presence of methamphetamine (METH) or increased extracellular Dopamine (DA). Experimental studies indicate that this is mediated by DA Receptors, including DA Receptor D3 (DRD3), which is expressed in macrophages. A single nucleotide polymorphism (SNP) of the DRD3 gene (rs6280TC) modulates its Dopamine binding affinity, resulting in the possibility that inheriting a variant of this SNP increases macrophage susceptibility to HIV infection in the presence of METH and DA, particularly in the CNS where METH is sequestered, leading to cognitive impairment (CI). Thus, we conducted a retrospective clinical investigation to evaluate whether rs6280TC is associated with CI among HIV-positive METH users. We stratified 310 males by HIV serostatus (HIV-positive, -negative) and METH dependence (METH-positive, -negative) and then by rs6280TC genotype (CC, CT, and TT). Genotypic groups within each of four HIV/METH groups were compared for rates of CI. We hypothesized that only HIV-positive/METH-positive carriers of the C allele, which increases the DRD3’s binding to DA, would be more likely to develop CI. Cochran–Armitage test for trends in proportions yielded significant (p < 0.05) association between three genotypes and impairment rates in the hypothesized order, but only among HIV-positive/METH-positive subjects. The results also confirmed that C allele carriers (CC and CT, 53.3%) in this group had higher impairment rates (p = 0.05) than TT carriers (33.3%). These findings support the theory that rs6280TC influences the frequency of CI in HIV-positive/METH-positive males.
Ji-long Zheng - One of the best experts on this subject based on the ideXlab platform.
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No association between the Ser9Gly polymorphism of the Dopamine Receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies.
BMC Medical Genetics, 2020Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:BACKGROUND: Previous studies found that Ser9Gly (rs6280) might be involved in the occurrence of schizophrenia. However, no consist conclusion has yet been achieved. Compared to the case-control study, the family-based study took into account stratification bias. Thus, we conducted a meta-analysis of family-based studies to measure a pooled effect size of the association between Ser9Gly and the risk of schizophrenia. METHODS: The relevant family-based studies were screened using the electronic databases by the inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to measure the correction between Ser9Gly polymorphism and schizophrenia susceptibility. Subgroup analysis was performed by stratification of ethnicity (i.e., East Asian, Caucasian, and other populations). Additionally, publication bias was evaluated by the funnel plot. RESULTS: After literature searching, a total of 13 family-based association studies were included, which contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HRR) studies. No statistical significance of the heterogeneity was detected in TDT and HRR studies. Thus, the pooled effect size was calculated under the fixed effect model. The results found that the association was significantly protective in East Asian in TDT studies (204 informative meiosis, OR = 0.744, 95% CI = 0.564-0.980, Z-value = - 2.104, p = 0.035). CONCLUSIONS: The meta-analysis based on the family study found a protective association of Ser9Gly in East Asian. In future, large sample molecular epidemiology studies are needed to validate our findings.
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No association between the Ser9Gly polymorphism of the Dopamine Receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies
2020Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:Abstract Background: Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human Dopamine Receptor D3 gene (DRD3). It is still controversial whether Ser9Gly is involved in the occurrence of schizophrenia. While there has been meta-analysis performed previously, that work did not include the family-based studies, which accounted for stratification bias. Thus, we performed a meta-analysis of family-based studies to explore the role of Ser9Gly in the etiology of schizophrenia. Methods: The published family-based association studies were retrieved from the relevant literature databases according to the established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia. Moreover, subgroup analysis was carried out by ethnicity (i.e., East Asian, Caucasian, and other populations). Results: We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HRR) studies. There was no statistical significance for the heterogeneity in TDT and HRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that this association was significantly protective in East Asian in TDT studies (204 informative meiosis, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035). Conclusions: Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. These data provide possible avenues for future family-based studies related to schizophrenia.
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No association between the Ser9Gly polymorphism of the Dopamine Receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies
2020Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:Abstract Background : Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human Dopamine Receptor D3 gene ( DRD 3 ). It is still controversial whether Ser9Gly is involved in the occurrence of schizophrenia. While there has been meta-analysis performed previously, that work did not include the family-based studies, which accounted for stratification bias. Thus, we performed a meta-analysis of family-based studies to explore the role of Ser9Gly in the etiology of schizophrenia. Methods : The published family-based association studies were retrieved from the relevant literature databases according to the established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia. Moreover, subgroup analysis was carried out by ethnicity (i.e., East Asian, Caucasian, and other populations). Results : We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HRR) studies. There was no statistical significance for the heterogeneity in TDT and HRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that neither of the associations between Ser9Gly and the risk of schizophrenia were observed in TDT (1219 informative meiosis, OR=1.005, 95% CI = 0.898-1.125, Z-value = 0.086, p = 0.932) and HRR studies (1704 samples, OR=0.869, 95% CI = 0.713-1.059, Z-value = -1.395, p = 0.163), except for the significantly preferential transmission of DRD3 Ser9 allele in East Asian in TDT studies (204 informative meiosis, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035). Conclusions : Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. These data provide possible avenues for future family-based studies related to schizophrenia.
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No association between the Ser9Gly polymorphism of the Dopamine Receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies
2020Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:Abstract Background : Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human Dopamine Receptor D3 gene ( DRD3 ) that may be involved in the occurrence of schizophrenia. We performed a meta-analysis of family-based studies to explore the role of Ser9Gly in the etiology of schizophrenia. Methods : The published family-based association studies were retrieved from the relevant literature databases according to the established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia. Results : We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HHRR) studies. There was no statistical significance for the heterogeneity in TDT and HHRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that neither of the associations between Ser9Gly and the risk of schizophrenia were observed in TDT (1219 samples, OR=1.005, 95% CI = 0.898-1.125, Z-value = 0.086, p = 0.932) and HHRR studies (1704 samples, OR=0.869, 95% CI = 0.713-1.059, Z-value = -1.395, p = 0.163), except for the significantly preferential transmission of DRD3 Ser9 allele in East Asian in TDT studies (204 samples, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035). Conclusions : Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. These data provide possible avenues for future family-based studies related to schizophrenia.
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No relationship between Dopamine D3 Receptor gene Ser9Gly polymorphism (rs6280) and schizophrenia: a meta-analysis of family-based association studies
2019Co-Authors: Xiao-na Li, Ji-long Zheng, Bao-jie WangAbstract:Abstract Background Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human Dopamine Receptor D3 gene (DRD3). It is still controversial that whether Ser9Gly is involved in the occurrence of schizophrenia. Thus, a meta-analysis of family-based studies was performed to explore the role of Ser9Gly in the etiology of schizophrenia.Methods The published family-based association studies were searched from the relevant literature databases according to the established inclusion criteria. We generated odds ratios and 95% confidence intervals in order to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia.Results We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HHRR) studies. There was no statistical significance for the heterogeneity in TDT and HHRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that neither of the associations between Ser9Gly and the risk of schizophrenia were observed in TDT (1219 samples, OR=1.005, 95% CI = 0.898-1.125, Z-value = 0.086, p = 0.932) and HHRR studies (1704 samples, OR=0.869, 95% CI = 0.713-1.059, Z-value = -1.395, p = 0.163), except for the significantly preferential transmission of DRD3 Ser9 allele in East Asian in TDT studies (204 samples, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035).Conclusions Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. However, more effects need to further confirm the function of DRD3 Ser9Gly SNP in the occurrence of schizophrenia.