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Jakob Linnet - One of the best experts on this subject based on the ideXlab platform.
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Dopamine Release in ventral striatum during iowa gambling task performance is associated with increased excitement levels in pathological gambling
Addiction, 2011Co-Authors: Jakob Linnet, Ericka Peterson, Arne Møller, Albert Gjedde, Doris J DoudetAbstract:Aims Gambling excitement is believed to be associated with biological measures of pathological gambling. Here, we tested the hypothesis that Dopamine Release would be associated with increased excitement levels in Pathological Gamblers compared with Healthy Controls. Design Pathological Gamblers and Healthy Controls were experimentally compared in a non-gambling (baseline) and gambling condition. Measurements We used Positron Emission Tomography (PET) with the tracer raclopride to measure Dopamine D 2/3 receptor availability in the ventral striatum during a non-gambling and gambling condition of the Iowa Gambling Task (IGT). After each condition participants rated their excitement level. Setting Laboratory experiment. Participants 18 Pathological Gamblers and 16 Healthy Controls. Findings Pathological Gamblers with Dopamine Release in the ventral striatum had significantly higher excitement levels than Healthy Controls despite lower IGT performance. No differences in excitement levels and IGT performance were found between Pathological Gamblers and Healthy Controls without Dopamine Release. Pathological Gamblers showed a significant correlation between Dopamine Release and excitement level, while no such interaction was found in Healthy Controls. Conclusions In pathological gamblers Dopamine Release in the ventral striatum appears to be associated with increased excitement levels despite lower IGT performance. The results might suggest a ‘double deficit’ function of Dopamine in pathological gambling, where Dopamine Release reinforces maladaptive gambling through increasing excitement levels, reducing inhibition of risky decisions, or a combination of both. These findings may have implications for the understanding of Dopamine in pathological gambling and other forms of addiction.
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Dopamine Release in ventral striatum of pathological gamblers losing money
Acta Psychiatrica Scandinavica, 2010Co-Authors: Jakob Linnet, Ericka Peterson, Doris J Doudet, Albert Gjedde, Arne MøllerAbstract:Linnet J, Peterson E, Doudet DJ, Gjedde A, Moller A. Dopamine Release in ventral striatum of pathological gamblers losing money. Objective: To investigate Dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as ‘chasing one’s losses’. We therefore hypothesized that losing money would be associated with increased Dopamine Release in the ventral striatum of PG compared with healthy controls (HC). Method: We used Positron Emission Tomography (PET) with [11C]raclopride to measure Dopamine Release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT). Results: PG who lost money had significantly increased Dopamine Release in the left ventral striatum compared with HC. PG and HC who won money did not differ in Dopamine Release. Conclusion: Our findings suggest a Dopaminergic basis of monetary losses in pathological gambling, which might explain loss-chasing behavior. The findings may have implications for the understanding of Dopamine dysfunctions and impaired decision-making in pathological gambling and substance-related addictions.
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Dopamine Release in ventral striatum of pathological gamblers losing money
Acta Psychiatrica Scandinavica, 2010Co-Authors: Jakob Linnet, Ericka Peterson, Doris J Doudet, Albert Gjedde, Arne MøllerAbstract:Linnet J, Peterson E, Doudet DJ, Gjedde A, Moller A. Dopamine Release in ventral striatum of pathological gamblers losing money. Objective: To investigate Dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as ‘chasing one’s losses’. We therefore hypothesized that losing money would be associated with increased Dopamine Release in the ventral striatum of PG compared with healthy controls (HC). Method: We used Positron Emission Tomography (PET) with [11C]raclopride to measure Dopamine Release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT). Results: PG who lost money had significantly increased Dopamine Release in the left ventral striatum compared with HC. PG and HC who won money did not differ in Dopamine Release. Conclusion: Our findings suggest a Dopaminergic basis of monetary losses in pathological gambling, which might explain loss-chasing behavior. The findings may have implications for the understanding of Dopamine dysfunctions and impaired decision-making in pathological gambling and substance-related addictions.
Doris J Doudet - One of the best experts on this subject based on the ideXlab platform.
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Dopamine Release in ventral striatum during iowa gambling task performance is associated with increased excitement levels in pathological gambling
Addiction, 2011Co-Authors: Jakob Linnet, Ericka Peterson, Arne Møller, Albert Gjedde, Doris J DoudetAbstract:Aims Gambling excitement is believed to be associated with biological measures of pathological gambling. Here, we tested the hypothesis that Dopamine Release would be associated with increased excitement levels in Pathological Gamblers compared with Healthy Controls. Design Pathological Gamblers and Healthy Controls were experimentally compared in a non-gambling (baseline) and gambling condition. Measurements We used Positron Emission Tomography (PET) with the tracer raclopride to measure Dopamine D 2/3 receptor availability in the ventral striatum during a non-gambling and gambling condition of the Iowa Gambling Task (IGT). After each condition participants rated their excitement level. Setting Laboratory experiment. Participants 18 Pathological Gamblers and 16 Healthy Controls. Findings Pathological Gamblers with Dopamine Release in the ventral striatum had significantly higher excitement levels than Healthy Controls despite lower IGT performance. No differences in excitement levels and IGT performance were found between Pathological Gamblers and Healthy Controls without Dopamine Release. Pathological Gamblers showed a significant correlation between Dopamine Release and excitement level, while no such interaction was found in Healthy Controls. Conclusions In pathological gamblers Dopamine Release in the ventral striatum appears to be associated with increased excitement levels despite lower IGT performance. The results might suggest a ‘double deficit’ function of Dopamine in pathological gambling, where Dopamine Release reinforces maladaptive gambling through increasing excitement levels, reducing inhibition of risky decisions, or a combination of both. These findings may have implications for the understanding of Dopamine in pathological gambling and other forms of addiction.
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Dopamine Release in ventral striatum of pathological gamblers losing money
Acta Psychiatrica Scandinavica, 2010Co-Authors: Jakob Linnet, Ericka Peterson, Doris J Doudet, Albert Gjedde, Arne MøllerAbstract:Linnet J, Peterson E, Doudet DJ, Gjedde A, Moller A. Dopamine Release in ventral striatum of pathological gamblers losing money. Objective: To investigate Dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as ‘chasing one’s losses’. We therefore hypothesized that losing money would be associated with increased Dopamine Release in the ventral striatum of PG compared with healthy controls (HC). Method: We used Positron Emission Tomography (PET) with [11C]raclopride to measure Dopamine Release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT). Results: PG who lost money had significantly increased Dopamine Release in the left ventral striatum compared with HC. PG and HC who won money did not differ in Dopamine Release. Conclusion: Our findings suggest a Dopaminergic basis of monetary losses in pathological gambling, which might explain loss-chasing behavior. The findings may have implications for the understanding of Dopamine dysfunctions and impaired decision-making in pathological gambling and substance-related addictions.
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Dopamine Release in ventral striatum of pathological gamblers losing money
Acta Psychiatrica Scandinavica, 2010Co-Authors: Jakob Linnet, Ericka Peterson, Doris J Doudet, Albert Gjedde, Arne MøllerAbstract:Linnet J, Peterson E, Doudet DJ, Gjedde A, Moller A. Dopamine Release in ventral striatum of pathological gamblers losing money. Objective: To investigate Dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as ‘chasing one’s losses’. We therefore hypothesized that losing money would be associated with increased Dopamine Release in the ventral striatum of PG compared with healthy controls (HC). Method: We used Positron Emission Tomography (PET) with [11C]raclopride to measure Dopamine Release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT). Results: PG who lost money had significantly increased Dopamine Release in the left ventral striatum compared with HC. PG and HC who won money did not differ in Dopamine Release. Conclusion: Our findings suggest a Dopaminergic basis of monetary losses in pathological gambling, which might explain loss-chasing behavior. The findings may have implications for the understanding of Dopamine dysfunctions and impaired decision-making in pathological gambling and substance-related addictions.
Albert Gjedde - One of the best experts on this subject based on the ideXlab platform.
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Dopamine Release in ventral striatum during iowa gambling task performance is associated with increased excitement levels in pathological gambling
Addiction, 2011Co-Authors: Jakob Linnet, Ericka Peterson, Arne Møller, Albert Gjedde, Doris J DoudetAbstract:Aims Gambling excitement is believed to be associated with biological measures of pathological gambling. Here, we tested the hypothesis that Dopamine Release would be associated with increased excitement levels in Pathological Gamblers compared with Healthy Controls. Design Pathological Gamblers and Healthy Controls were experimentally compared in a non-gambling (baseline) and gambling condition. Measurements We used Positron Emission Tomography (PET) with the tracer raclopride to measure Dopamine D 2/3 receptor availability in the ventral striatum during a non-gambling and gambling condition of the Iowa Gambling Task (IGT). After each condition participants rated their excitement level. Setting Laboratory experiment. Participants 18 Pathological Gamblers and 16 Healthy Controls. Findings Pathological Gamblers with Dopamine Release in the ventral striatum had significantly higher excitement levels than Healthy Controls despite lower IGT performance. No differences in excitement levels and IGT performance were found between Pathological Gamblers and Healthy Controls without Dopamine Release. Pathological Gamblers showed a significant correlation between Dopamine Release and excitement level, while no such interaction was found in Healthy Controls. Conclusions In pathological gamblers Dopamine Release in the ventral striatum appears to be associated with increased excitement levels despite lower IGT performance. The results might suggest a ‘double deficit’ function of Dopamine in pathological gambling, where Dopamine Release reinforces maladaptive gambling through increasing excitement levels, reducing inhibition of risky decisions, or a combination of both. These findings may have implications for the understanding of Dopamine in pathological gambling and other forms of addiction.
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Dopamine Release in ventral striatum of pathological gamblers losing money
Acta Psychiatrica Scandinavica, 2010Co-Authors: Jakob Linnet, Ericka Peterson, Doris J Doudet, Albert Gjedde, Arne MøllerAbstract:Linnet J, Peterson E, Doudet DJ, Gjedde A, Moller A. Dopamine Release in ventral striatum of pathological gamblers losing money. Objective: To investigate Dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as ‘chasing one’s losses’. We therefore hypothesized that losing money would be associated with increased Dopamine Release in the ventral striatum of PG compared with healthy controls (HC). Method: We used Positron Emission Tomography (PET) with [11C]raclopride to measure Dopamine Release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT). Results: PG who lost money had significantly increased Dopamine Release in the left ventral striatum compared with HC. PG and HC who won money did not differ in Dopamine Release. Conclusion: Our findings suggest a Dopaminergic basis of monetary losses in pathological gambling, which might explain loss-chasing behavior. The findings may have implications for the understanding of Dopamine dysfunctions and impaired decision-making in pathological gambling and substance-related addictions.
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Dopamine Release in ventral striatum of pathological gamblers losing money
Acta Psychiatrica Scandinavica, 2010Co-Authors: Jakob Linnet, Ericka Peterson, Doris J Doudet, Albert Gjedde, Arne MøllerAbstract:Linnet J, Peterson E, Doudet DJ, Gjedde A, Moller A. Dopamine Release in ventral striatum of pathological gamblers losing money. Objective: To investigate Dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as ‘chasing one’s losses’. We therefore hypothesized that losing money would be associated with increased Dopamine Release in the ventral striatum of PG compared with healthy controls (HC). Method: We used Positron Emission Tomography (PET) with [11C]raclopride to measure Dopamine Release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT). Results: PG who lost money had significantly increased Dopamine Release in the left ventral striatum compared with HC. PG and HC who won money did not differ in Dopamine Release. Conclusion: Our findings suggest a Dopaminergic basis of monetary losses in pathological gambling, which might explain loss-chasing behavior. The findings may have implications for the understanding of Dopamine dysfunctions and impaired decision-making in pathological gambling and substance-related addictions.
Arne Møller - One of the best experts on this subject based on the ideXlab platform.
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Dopamine Release in ventral striatum during iowa gambling task performance is associated with increased excitement levels in pathological gambling
Addiction, 2011Co-Authors: Jakob Linnet, Ericka Peterson, Arne Møller, Albert Gjedde, Doris J DoudetAbstract:Aims Gambling excitement is believed to be associated with biological measures of pathological gambling. Here, we tested the hypothesis that Dopamine Release would be associated with increased excitement levels in Pathological Gamblers compared with Healthy Controls. Design Pathological Gamblers and Healthy Controls were experimentally compared in a non-gambling (baseline) and gambling condition. Measurements We used Positron Emission Tomography (PET) with the tracer raclopride to measure Dopamine D 2/3 receptor availability in the ventral striatum during a non-gambling and gambling condition of the Iowa Gambling Task (IGT). After each condition participants rated their excitement level. Setting Laboratory experiment. Participants 18 Pathological Gamblers and 16 Healthy Controls. Findings Pathological Gamblers with Dopamine Release in the ventral striatum had significantly higher excitement levels than Healthy Controls despite lower IGT performance. No differences in excitement levels and IGT performance were found between Pathological Gamblers and Healthy Controls without Dopamine Release. Pathological Gamblers showed a significant correlation between Dopamine Release and excitement level, while no such interaction was found in Healthy Controls. Conclusions In pathological gamblers Dopamine Release in the ventral striatum appears to be associated with increased excitement levels despite lower IGT performance. The results might suggest a ‘double deficit’ function of Dopamine in pathological gambling, where Dopamine Release reinforces maladaptive gambling through increasing excitement levels, reducing inhibition of risky decisions, or a combination of both. These findings may have implications for the understanding of Dopamine in pathological gambling and other forms of addiction.
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Dopamine Release in ventral striatum of pathological gamblers losing money
Acta Psychiatrica Scandinavica, 2010Co-Authors: Jakob Linnet, Ericka Peterson, Doris J Doudet, Albert Gjedde, Arne MøllerAbstract:Linnet J, Peterson E, Doudet DJ, Gjedde A, Moller A. Dopamine Release in ventral striatum of pathological gamblers losing money. Objective: To investigate Dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as ‘chasing one’s losses’. We therefore hypothesized that losing money would be associated with increased Dopamine Release in the ventral striatum of PG compared with healthy controls (HC). Method: We used Positron Emission Tomography (PET) with [11C]raclopride to measure Dopamine Release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT). Results: PG who lost money had significantly increased Dopamine Release in the left ventral striatum compared with HC. PG and HC who won money did not differ in Dopamine Release. Conclusion: Our findings suggest a Dopaminergic basis of monetary losses in pathological gambling, which might explain loss-chasing behavior. The findings may have implications for the understanding of Dopamine dysfunctions and impaired decision-making in pathological gambling and substance-related addictions.
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Dopamine Release in ventral striatum of pathological gamblers losing money
Acta Psychiatrica Scandinavica, 2010Co-Authors: Jakob Linnet, Ericka Peterson, Doris J Doudet, Albert Gjedde, Arne MøllerAbstract:Linnet J, Peterson E, Doudet DJ, Gjedde A, Moller A. Dopamine Release in ventral striatum of pathological gamblers losing money. Objective: To investigate Dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as ‘chasing one’s losses’. We therefore hypothesized that losing money would be associated with increased Dopamine Release in the ventral striatum of PG compared with healthy controls (HC). Method: We used Positron Emission Tomography (PET) with [11C]raclopride to measure Dopamine Release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT). Results: PG who lost money had significantly increased Dopamine Release in the left ventral striatum compared with HC. PG and HC who won money did not differ in Dopamine Release. Conclusion: Our findings suggest a Dopaminergic basis of monetary losses in pathological gambling, which might explain loss-chasing behavior. The findings may have implications for the understanding of Dopamine dysfunctions and impaired decision-making in pathological gambling and substance-related addictions.
Ericka Peterson - One of the best experts on this subject based on the ideXlab platform.
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Dopamine Release in ventral striatum during iowa gambling task performance is associated with increased excitement levels in pathological gambling
Addiction, 2011Co-Authors: Jakob Linnet, Ericka Peterson, Arne Møller, Albert Gjedde, Doris J DoudetAbstract:Aims Gambling excitement is believed to be associated with biological measures of pathological gambling. Here, we tested the hypothesis that Dopamine Release would be associated with increased excitement levels in Pathological Gamblers compared with Healthy Controls. Design Pathological Gamblers and Healthy Controls were experimentally compared in a non-gambling (baseline) and gambling condition. Measurements We used Positron Emission Tomography (PET) with the tracer raclopride to measure Dopamine D 2/3 receptor availability in the ventral striatum during a non-gambling and gambling condition of the Iowa Gambling Task (IGT). After each condition participants rated their excitement level. Setting Laboratory experiment. Participants 18 Pathological Gamblers and 16 Healthy Controls. Findings Pathological Gamblers with Dopamine Release in the ventral striatum had significantly higher excitement levels than Healthy Controls despite lower IGT performance. No differences in excitement levels and IGT performance were found between Pathological Gamblers and Healthy Controls without Dopamine Release. Pathological Gamblers showed a significant correlation between Dopamine Release and excitement level, while no such interaction was found in Healthy Controls. Conclusions In pathological gamblers Dopamine Release in the ventral striatum appears to be associated with increased excitement levels despite lower IGT performance. The results might suggest a ‘double deficit’ function of Dopamine in pathological gambling, where Dopamine Release reinforces maladaptive gambling through increasing excitement levels, reducing inhibition of risky decisions, or a combination of both. These findings may have implications for the understanding of Dopamine in pathological gambling and other forms of addiction.
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Dopamine Release in ventral striatum of pathological gamblers losing money
Acta Psychiatrica Scandinavica, 2010Co-Authors: Jakob Linnet, Ericka Peterson, Doris J Doudet, Albert Gjedde, Arne MøllerAbstract:Linnet J, Peterson E, Doudet DJ, Gjedde A, Moller A. Dopamine Release in ventral striatum of pathological gamblers losing money. Objective: To investigate Dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as ‘chasing one’s losses’. We therefore hypothesized that losing money would be associated with increased Dopamine Release in the ventral striatum of PG compared with healthy controls (HC). Method: We used Positron Emission Tomography (PET) with [11C]raclopride to measure Dopamine Release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT). Results: PG who lost money had significantly increased Dopamine Release in the left ventral striatum compared with HC. PG and HC who won money did not differ in Dopamine Release. Conclusion: Our findings suggest a Dopaminergic basis of monetary losses in pathological gambling, which might explain loss-chasing behavior. The findings may have implications for the understanding of Dopamine dysfunctions and impaired decision-making in pathological gambling and substance-related addictions.
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Dopamine Release in ventral striatum of pathological gamblers losing money
Acta Psychiatrica Scandinavica, 2010Co-Authors: Jakob Linnet, Ericka Peterson, Doris J Doudet, Albert Gjedde, Arne MøllerAbstract:Linnet J, Peterson E, Doudet DJ, Gjedde A, Moller A. Dopamine Release in ventral striatum of pathological gamblers losing money. Objective: To investigate Dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as ‘chasing one’s losses’. We therefore hypothesized that losing money would be associated with increased Dopamine Release in the ventral striatum of PG compared with healthy controls (HC). Method: We used Positron Emission Tomography (PET) with [11C]raclopride to measure Dopamine Release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT). Results: PG who lost money had significantly increased Dopamine Release in the left ventral striatum compared with HC. PG and HC who won money did not differ in Dopamine Release. Conclusion: Our findings suggest a Dopaminergic basis of monetary losses in pathological gambling, which might explain loss-chasing behavior. The findings may have implications for the understanding of Dopamine dysfunctions and impaired decision-making in pathological gambling and substance-related addictions.