The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Erik Florvaag - One of the best experts on this subject based on the ideXlab platform.
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rocuronium and cisatracurium positive skin tests in non allergic volunteers determination of Drug Concentration thresholds using a dilution titration technique
Acta Anaesthesiologica Scandinavica, 2003Co-Authors: C M Berg, Tom Heier, V Wilhelmsen, Erik FlorvaagAbstract:Background: Muscle relaxants are believed to be responsible for 2/3 of the cases of anaphylactic reactions during anesthesia. This assumption is based mainly on positive skin tests obtained in individuals that have experienced anesthesia-related anaphylaxis. A positive skin test is supposed to be associated with mast cell degranulation of vasoactive amines. In the present study we tested the frequency of positive skin tests with two commonly used muscle relaxants, rocuronium and cisatracurium, in a selected group of volunteers with low potential for allergic reactions. Methods: Thirty healthy volunteers without known allergy or previous exposure to muscle relaxants were studied. Low potential for allergic reactions was determined prior to inclusion in the study, using various allergy tests. Each individual was tested with intradermal and skin prick tests, and molar Drug Concentration thresholds for positive skin reactions were determined using a dilution titration technique. The presence or absence of mast cell degranulation was tested by electron microscopic investigation of skin biopsies obtained from positive and negative skin reactions. Results: None of the volunteers had a positive skin prick test. More than 90% of the volunteers had a positive intradermal test with both rocuronium and cisatracurium. The highest molar Drug Concentration that was not associated with a positive intradermal test was 10−6 M (rocuronium) and 10−7 M (cisatracurium), equivalent to vial dilution 1 : 1000 for both Drugs. In none of the volunteers was mast cell degranulation detected. Conclusion: Non-mast-cell-mediated positive intradermal skin reactions are frequently occurring with rocuronium and cisatracurium, even at vial dilution 1 : 1000. A clinically applicable test technique is needed that is able to separate positive skin tests associated with mast cell degranulation from non-mast-cell-mediated reactions.
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Rocuronium and cisatracurium‐positive skin tests in non‐allergic volunteers: determination of Drug Concentration thresholds using a dilution titration technique
Acta anaesthesiologica Scandinavica, 2003Co-Authors: C M Berg, Tom Heier, V Wilhelmsen, Erik FlorvaagAbstract:Background: Muscle relaxants are believed to be responsible for 2/3 of the cases of anaphylactic reactions during anesthesia. This assumption is based mainly on positive skin tests obtained in individuals that have experienced anesthesia-related anaphylaxis. A positive skin test is supposed to be associated with mast cell degranulation of vasoactive amines. In the present study we tested the frequency of positive skin tests with two commonly used muscle relaxants, rocuronium and cisatracurium, in a selected group of volunteers with low potential for allergic reactions. Methods: Thirty healthy volunteers without known allergy or previous exposure to muscle relaxants were studied. Low potential for allergic reactions was determined prior to inclusion in the study, using various allergy tests. Each individual was tested with intradermal and skin prick tests, and molar Drug Concentration thresholds for positive skin reactions were determined using a dilution titration technique. The presence or absence of mast cell degranulation was tested by electron microscopic investigation of skin biopsies obtained from positive and negative skin reactions. Results: None of the volunteers had a positive skin prick test. More than 90% of the volunteers had a positive intradermal test with both rocuronium and cisatracurium. The highest molar Drug Concentration that was not associated with a positive intradermal test was 10−6 M (rocuronium) and 10−7 M (cisatracurium), equivalent to vial dilution 1 : 1000 for both Drugs. In none of the volunteers was mast cell degranulation detected. Conclusion: Non-mast-cell-mediated positive intradermal skin reactions are frequently occurring with rocuronium and cisatracurium, even at vial dilution 1 : 1000. A clinically applicable test technique is needed that is able to separate positive skin tests associated with mast cell degranulation from non-mast-cell-mediated reactions.
P. Campi - One of the best experts on this subject based on the ideXlab platform.
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skin test Concentrations for systemically administered Drugs an enda eaaci Drug allergy interest group position paper
Allergy, 2013Co-Authors: Knut Brockow, Marina Atanaskovicmarkovic, L H Garvey, B Bonadonna, Annick Barbaud, M. Beatrice Bilò, Miguel Blanca, Werner Aberer, Andreas J. Bircher, P. CampiAbstract:Skin tests are of paramount importance for the evaluation of Drug hypersensitivity reactions. Drug skin tests are often not carried out because of lack of concise information on specific test Concentrations. The diagnosis of Drug allergy is often based on history alone, which is an unreliable indicator of true hypersensitivity.To promote and standardize reproducible skin testing with safe and nonirritant Drug Concentrations in the clinical practice, the European Network and European Academy of Allergy and Clinical Immunology (EAACI) Interest Group on Drug Allergy has performed a literature search on skin test Drug Concentration in MEDLINE and EMBASE, reviewed and evaluated the literature in five languages using the GRADE system for quality of evidence and strength of recommendation. Where the literature is poor, we have taken into consideration the collective experience of the group.We recommend Drug Concentration for skin testing aiming to achieve a specificity of at least 95%. It has been possible to recommend specific Drug Concentration for betalactam antibiotics, perioperative Drugs, heparins, platinum salts and radiocontrast media. For many other Drugs, there is insufficient evidence to recommend appropriate Drug Concentration. There
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skin test Concentrations for systemically administered Drugs an enda eaaci Drug allergy interest group position paper
Allergy, 2013Co-Authors: Knut Brockow, Marina Atanaskovicmarkovic, L H Garvey, B Bonadonna, Annick Barbaud, M. Beatrice Bilò, Miguel Blanca, Werner Aberer, Andreas J. Bircher, P. CampiAbstract:Skin tests are of paramount importance for the evaluation of Drug hypersensitivity reactions. Drug skin tests are often not carried out because of lack of concise information on specific test Concentrations. The diagnosis of Drug allergy is often based on history alone, which is an unreliable indicator of true hypersensitivity.To promote and standardize reproducible skin testing with safe and nonirritant Drug Concentrations in the clinical practice, the European Network and European Academy of Allergy and Clinical Immunology (EAACI) Interest Group on Drug Allergy has performed a literature search on skin test Drug Concentration in MEDLINE and EMBASE, reviewed and evaluated the literature in five languages using the GRADE system for quality of evidence and strength of recommendation. Where the literature is poor, we have taken into consideration the collective experience of the group.We recommend Drug Concentration for skin testing aiming to achieve a specificity of at least 95%. It has been possible to recommend specific Drug Concentration for betalactam antibiotics, perioperative Drugs, heparins, platinum salts and radiocontrast media. For many other Drugs, there is insufficient evidence to recommend appropriate Drug Concentration. There is urgent need for multicentre studies designed to establish and validate Drug skin test Concentration using standard protocols. For most Drugs, sensitivity of skin testing is higher in immediate hypersensitivity compared to nonimmediate hypersensitivity.
C M Berg - One of the best experts on this subject based on the ideXlab platform.
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rocuronium and cisatracurium positive skin tests in non allergic volunteers determination of Drug Concentration thresholds using a dilution titration technique
Acta Anaesthesiologica Scandinavica, 2003Co-Authors: C M Berg, Tom Heier, V Wilhelmsen, Erik FlorvaagAbstract:Background: Muscle relaxants are believed to be responsible for 2/3 of the cases of anaphylactic reactions during anesthesia. This assumption is based mainly on positive skin tests obtained in individuals that have experienced anesthesia-related anaphylaxis. A positive skin test is supposed to be associated with mast cell degranulation of vasoactive amines. In the present study we tested the frequency of positive skin tests with two commonly used muscle relaxants, rocuronium and cisatracurium, in a selected group of volunteers with low potential for allergic reactions. Methods: Thirty healthy volunteers without known allergy or previous exposure to muscle relaxants were studied. Low potential for allergic reactions was determined prior to inclusion in the study, using various allergy tests. Each individual was tested with intradermal and skin prick tests, and molar Drug Concentration thresholds for positive skin reactions were determined using a dilution titration technique. The presence or absence of mast cell degranulation was tested by electron microscopic investigation of skin biopsies obtained from positive and negative skin reactions. Results: None of the volunteers had a positive skin prick test. More than 90% of the volunteers had a positive intradermal test with both rocuronium and cisatracurium. The highest molar Drug Concentration that was not associated with a positive intradermal test was 10−6 M (rocuronium) and 10−7 M (cisatracurium), equivalent to vial dilution 1 : 1000 for both Drugs. In none of the volunteers was mast cell degranulation detected. Conclusion: Non-mast-cell-mediated positive intradermal skin reactions are frequently occurring with rocuronium and cisatracurium, even at vial dilution 1 : 1000. A clinically applicable test technique is needed that is able to separate positive skin tests associated with mast cell degranulation from non-mast-cell-mediated reactions.
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Rocuronium and cisatracurium‐positive skin tests in non‐allergic volunteers: determination of Drug Concentration thresholds using a dilution titration technique
Acta anaesthesiologica Scandinavica, 2003Co-Authors: C M Berg, Tom Heier, V Wilhelmsen, Erik FlorvaagAbstract:Background: Muscle relaxants are believed to be responsible for 2/3 of the cases of anaphylactic reactions during anesthesia. This assumption is based mainly on positive skin tests obtained in individuals that have experienced anesthesia-related anaphylaxis. A positive skin test is supposed to be associated with mast cell degranulation of vasoactive amines. In the present study we tested the frequency of positive skin tests with two commonly used muscle relaxants, rocuronium and cisatracurium, in a selected group of volunteers with low potential for allergic reactions. Methods: Thirty healthy volunteers without known allergy or previous exposure to muscle relaxants were studied. Low potential for allergic reactions was determined prior to inclusion in the study, using various allergy tests. Each individual was tested with intradermal and skin prick tests, and molar Drug Concentration thresholds for positive skin reactions were determined using a dilution titration technique. The presence or absence of mast cell degranulation was tested by electron microscopic investigation of skin biopsies obtained from positive and negative skin reactions. Results: None of the volunteers had a positive skin prick test. More than 90% of the volunteers had a positive intradermal test with both rocuronium and cisatracurium. The highest molar Drug Concentration that was not associated with a positive intradermal test was 10−6 M (rocuronium) and 10−7 M (cisatracurium), equivalent to vial dilution 1 : 1000 for both Drugs. In none of the volunteers was mast cell degranulation detected. Conclusion: Non-mast-cell-mediated positive intradermal skin reactions are frequently occurring with rocuronium and cisatracurium, even at vial dilution 1 : 1000. A clinically applicable test technique is needed that is able to separate positive skin tests associated with mast cell degranulation from non-mast-cell-mediated reactions.
Knut Brockow - One of the best experts on this subject based on the ideXlab platform.
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skin test Concentrations for systemically administered Drugs an enda eaaci Drug allergy interest group position paper
Allergy, 2013Co-Authors: Knut Brockow, Marina Atanaskovicmarkovic, L H Garvey, B Bonadonna, Annick Barbaud, M. Beatrice Bilò, Miguel Blanca, Werner Aberer, Andreas J. Bircher, P. CampiAbstract:Skin tests are of paramount importance for the evaluation of Drug hypersensitivity reactions. Drug skin tests are often not carried out because of lack of concise information on specific test Concentrations. The diagnosis of Drug allergy is often based on history alone, which is an unreliable indicator of true hypersensitivity.To promote and standardize reproducible skin testing with safe and nonirritant Drug Concentrations in the clinical practice, the European Network and European Academy of Allergy and Clinical Immunology (EAACI) Interest Group on Drug Allergy has performed a literature search on skin test Drug Concentration in MEDLINE and EMBASE, reviewed and evaluated the literature in five languages using the GRADE system for quality of evidence and strength of recommendation. Where the literature is poor, we have taken into consideration the collective experience of the group.We recommend Drug Concentration for skin testing aiming to achieve a specificity of at least 95%. It has been possible to recommend specific Drug Concentration for betalactam antibiotics, perioperative Drugs, heparins, platinum salts and radiocontrast media. For many other Drugs, there is insufficient evidence to recommend appropriate Drug Concentration. There
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skin test Concentrations for systemically administered Drugs an enda eaaci Drug allergy interest group position paper
Allergy, 2013Co-Authors: Knut Brockow, Marina Atanaskovicmarkovic, L H Garvey, B Bonadonna, Annick Barbaud, M. Beatrice Bilò, Miguel Blanca, Werner Aberer, Andreas J. Bircher, P. CampiAbstract:Skin tests are of paramount importance for the evaluation of Drug hypersensitivity reactions. Drug skin tests are often not carried out because of lack of concise information on specific test Concentrations. The diagnosis of Drug allergy is often based on history alone, which is an unreliable indicator of true hypersensitivity.To promote and standardize reproducible skin testing with safe and nonirritant Drug Concentrations in the clinical practice, the European Network and European Academy of Allergy and Clinical Immunology (EAACI) Interest Group on Drug Allergy has performed a literature search on skin test Drug Concentration in MEDLINE and EMBASE, reviewed and evaluated the literature in five languages using the GRADE system for quality of evidence and strength of recommendation. Where the literature is poor, we have taken into consideration the collective experience of the group.We recommend Drug Concentration for skin testing aiming to achieve a specificity of at least 95%. It has been possible to recommend specific Drug Concentration for betalactam antibiotics, perioperative Drugs, heparins, platinum salts and radiocontrast media. For many other Drugs, there is insufficient evidence to recommend appropriate Drug Concentration. There is urgent need for multicentre studies designed to establish and validate Drug skin test Concentration using standard protocols. For most Drugs, sensitivity of skin testing is higher in immediate hypersensitivity compared to nonimmediate hypersensitivity.
V Wilhelmsen - One of the best experts on this subject based on the ideXlab platform.
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rocuronium and cisatracurium positive skin tests in non allergic volunteers determination of Drug Concentration thresholds using a dilution titration technique
Acta Anaesthesiologica Scandinavica, 2003Co-Authors: C M Berg, Tom Heier, V Wilhelmsen, Erik FlorvaagAbstract:Background: Muscle relaxants are believed to be responsible for 2/3 of the cases of anaphylactic reactions during anesthesia. This assumption is based mainly on positive skin tests obtained in individuals that have experienced anesthesia-related anaphylaxis. A positive skin test is supposed to be associated with mast cell degranulation of vasoactive amines. In the present study we tested the frequency of positive skin tests with two commonly used muscle relaxants, rocuronium and cisatracurium, in a selected group of volunteers with low potential for allergic reactions. Methods: Thirty healthy volunteers without known allergy or previous exposure to muscle relaxants were studied. Low potential for allergic reactions was determined prior to inclusion in the study, using various allergy tests. Each individual was tested with intradermal and skin prick tests, and molar Drug Concentration thresholds for positive skin reactions were determined using a dilution titration technique. The presence or absence of mast cell degranulation was tested by electron microscopic investigation of skin biopsies obtained from positive and negative skin reactions. Results: None of the volunteers had a positive skin prick test. More than 90% of the volunteers had a positive intradermal test with both rocuronium and cisatracurium. The highest molar Drug Concentration that was not associated with a positive intradermal test was 10−6 M (rocuronium) and 10−7 M (cisatracurium), equivalent to vial dilution 1 : 1000 for both Drugs. In none of the volunteers was mast cell degranulation detected. Conclusion: Non-mast-cell-mediated positive intradermal skin reactions are frequently occurring with rocuronium and cisatracurium, even at vial dilution 1 : 1000. A clinically applicable test technique is needed that is able to separate positive skin tests associated with mast cell degranulation from non-mast-cell-mediated reactions.
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Rocuronium and cisatracurium‐positive skin tests in non‐allergic volunteers: determination of Drug Concentration thresholds using a dilution titration technique
Acta anaesthesiologica Scandinavica, 2003Co-Authors: C M Berg, Tom Heier, V Wilhelmsen, Erik FlorvaagAbstract:Background: Muscle relaxants are believed to be responsible for 2/3 of the cases of anaphylactic reactions during anesthesia. This assumption is based mainly on positive skin tests obtained in individuals that have experienced anesthesia-related anaphylaxis. A positive skin test is supposed to be associated with mast cell degranulation of vasoactive amines. In the present study we tested the frequency of positive skin tests with two commonly used muscle relaxants, rocuronium and cisatracurium, in a selected group of volunteers with low potential for allergic reactions. Methods: Thirty healthy volunteers without known allergy or previous exposure to muscle relaxants were studied. Low potential for allergic reactions was determined prior to inclusion in the study, using various allergy tests. Each individual was tested with intradermal and skin prick tests, and molar Drug Concentration thresholds for positive skin reactions were determined using a dilution titration technique. The presence or absence of mast cell degranulation was tested by electron microscopic investigation of skin biopsies obtained from positive and negative skin reactions. Results: None of the volunteers had a positive skin prick test. More than 90% of the volunteers had a positive intradermal test with both rocuronium and cisatracurium. The highest molar Drug Concentration that was not associated with a positive intradermal test was 10−6 M (rocuronium) and 10−7 M (cisatracurium), equivalent to vial dilution 1 : 1000 for both Drugs. In none of the volunteers was mast cell degranulation detected. Conclusion: Non-mast-cell-mediated positive intradermal skin reactions are frequently occurring with rocuronium and cisatracurium, even at vial dilution 1 : 1000. A clinically applicable test technique is needed that is able to separate positive skin tests associated with mast cell degranulation from non-mast-cell-mediated reactions.
