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Claude Ponvert - One of the best experts on this subject based on the ideXlab platform.

  • non immediate reading Skin Tests and prolonged challenges in non immediate hypersensitivity to beta lactams in children
    Applied Immunohistochemistry & Molecular Morphology, 2018
    Co-Authors: Claude Ponvert, Pierre Scheinmann, Jacques De Blic, Guillaume Lezmi, F Alrowaishdi, A Badosalbiero
    Abstract:

    BACKGROUND A minority of children reporting non-immediate reactions to beta-lactams (BLs) are allergic. Allergy workup usually includes late-reading (48-72 hours) Skin Tests (ST) and short (1-3 days) drug provocation Tests (DPT), regardless of the chronology of the index reaction. The sensitivity of hyper-late-reading (≥6-7 days) ST and of prolonged DPT for the diagnosis of non-immediate hypersensitivity to BLs is yet to be determined. OBJECTIVES To establish the diagnostic values of late-reading ST and hyper-late-reading ST and of prolonged DPT in children reporting non-immediate reactions to BLs. METHODS Prospective assessment of children reporting non-immediate reactions to BLs with late- and additional hyper-late-reading intradermal (ID) and patch Tests, and if negative, with prolonged DPT. RESULTS Five hundred and fifty children reporting reactions to a single or several BLs (674 suspected BLs) were included. Non-immediate hypersensitivity to BLs was diagnosed in 63 children (11.5%), reporting 66 reactions (9.8%), based on responses in ST (n = 17, 25.8%: 5 to ID, 8 to patch Tests, and 4 to both Tests), DPT (n = 43, 65.2%), and clinical history (n = 6, 9.1%), including 3/9 children with severe cutaneous adverse reactions. Skin test positivity was observed after the 6-7th day in 14/17 children, and DPT positivity after a median time of 3 days. No severe reaction was observed after ST or during prolonged DPT. CONCLUSION Additional hyper-late-reading of ST enhanced their positivity. However, their overall sensitivity remained weak, especially in non-severe cases. Prolonged DPT are safe and may improve the performance of DPT in the diagnosis of non-immediate hypersensitivity to BLs.

  • Anaphylaxis to the 23-valent pneumococcal vaccine: a second explored case by means of immediate-reading Skin Tests with pneumococcal vaccines.
    Vaccine, 2010
    Co-Authors: Claude Ponvert, Pierre Scheinmann, Jacques De Blic
    Abstract:

    Abstract Anaphylaxis to pneumococcal vaccines is rare. In the only one child with anaphylaxis to a first injection of the 23-valent pneumococcal vaccine that has been explored, Skin Tests and specific IgE determination diagnosed immediate-type hypersensitivity to pneumococcal antigens. We report the case of a child who tolerated three injections of the 7-valent pneumococcal vaccine, but experienced anaphylaxis to a fourth injection of the 23-valent vaccine. Immediate responses in Skin Tests diagnosed immediate-type hypersensitivity to the two vaccines. Immunizations with the 7-valent pneumococcal vaccine may induce IgE-dependent sensitization to pneumococcal antigens, responsible for anaphylaxis to subsequent injections of pneumococcal vaccines.

  • anaphylaxis to the 23 valent pneumococcal vaccine in child a case control study based on immediate responses in Skin Tests and specific ige determination
    Vaccine, 2001
    Co-Authors: Claude Ponvert, Jacques De Blic, Delia Ardeleanjaby, Annemarie Colingorski, Bruno Soufflet, Christine Hamberger, Pierre Scheinmann
    Abstract:

    Injections of the 23-valent pneumococcal vaccine are usually well tolerated. Skin Tests (prick and intradermal) and a self-made RAST with pneumococcal vaccine and phenol were performed in a child reporting a severe anaphylactic reaction induced by a 23-valent pneumococcal vaccine, and in ten control children, including one child with a well-tolerated vaccination, and nine non-vaccinated children. Skin Tests and RAST with the vaccine were positive in the child reporting anaphylaxis, and negative in nine of the control children. Intradermal test with the vaccine was slightly positive in a non-vaccinated child with negative RAST. Skin Tests and RAST with phenol were negative in all the children. These results suggest that immediate responses in Skin Tests and specific IgE determination have a good diagnostic value in children reporting severe reactions suggestive of IgE-dependent hypersensitivity to pneumococcal vaccine.

  • Allergy to β-Lactam Antibiotics in Children
    Pediatrics, 1999
    Co-Authors: Claude Ponvert, Pierre Scheinmann, Jacques De Blic, Laurence Le Clainche, Muriel Le Bourgeois, J. Paupe
    Abstract:

    Background. Skin Tests with soluble b-lactams can be used to diagnose immediate and de- layed hypersensitivity (HS) reactions to b-lactam antibi- otics. Very few studies have been performed with chil- dren with suspected b-lactam allergy. In these studies, immediate HS to b-lactams was diagnosed by Skin Tests in 4.9% to 40% of children. The diagnostic and predictive values of immediate responses in Skin Tests are good, because very few children with negative Skin test results have positive oral challenge (OC) test results. Delayed responses in Skin Tests (intradermal and patch Tests) have been reported in adult patients and children suffering with urticaria, angioedema, and maculopapular rashes during treatments with b-lactam antibiotics. However, the diagnostic and predictive values of late responses are unknown. Semi-late responses in Skin Tests with b-lac- tams have never been studied in adults or children. Objectives. The aims of this study were to confirm or rule out the diagnosis of allergy to b-lactams in children with histories of adverse reactions to these antibiotics, to determine whether allergic children were sensitized to one or several classes of b-lactams, and to evaluate the frequency and diagnostic value of immediate, acceler- ated, and delayed responses in Skin Tests with b-lactam antibiotics in children. Methods. We studied 325 children with suspected b-lactam allergy. Skin Tests (prick and intradermal) were performed with soluble forms of the suspected (or very similar) b-lactams and with one or several b-lactams from other classes. The reaction was assessed after 20 minutes (immediate), 8 hours (accelerated), and 48 to 72 hours (delayed). OCs with the suspected b-lactams were performed in patients with negative Skin test results, except those with severe serum sickness-like reactions and potentially harmful toxidermias. Results. Skin Tests and OCs led to the diagnosis of b-lactam allergy in 24 (7.4%) and 15 (4.6%) of the chil- dren, respectively. Thus, only 12% of the children were diagnosed as allergic to b-lactams by means of Skin Tests and OC. HS to b-lactams was suspected from clinical history in 30 (9.2%) children reporting serum sickness- like reactions and potentially harmful toxidermias. In a few children, we diagnosed food allergy and intolerance to excipients or nonsteroidal antiinflammatory drugs. No cause was found in the other children. Based on Skin Tests and OC, the prevalences of immu- noglobulin E-dependent and of semi-late or delayed sen- sitizations to b-lactam assessed were similar (6.8% vs 5.2%, respectively). Most immunoglobulin E-dependent sensitizations were diagnosed by means of Skin Tests (86.4%). In contrast, most semi-late and delayed sensiti- zations were diagnosed by OC (70.6%). The likelihood of b-lactam allergy was significantly higher for anaphylaxis (42.9% vs 8.3% in other reactions) and immediate reac- tions (25% vs 10% in accelerated and delayed reactions). Of the children diagnosed as allergic to b-lactam by means of Skin Tests, OC, and clinical history, 11.7% were sensitized to several classes of b-lactams. The risk was significantly higher in children with anaphylaxis (26.7% vs 7.5% of the children with other reactions) and in children reporting immediate reactions (33.3% vs 8.5% of the children with accelerated and delayed reactions). Finally, age, sex, personal history of atopy, number of reactions to b-lactams, and number of reactions to other drugs were not significant risk factors for b-lactam al- lergy. Conclusion. The Skin Tests were safe, and the imme- diate reaction to Skin Tests successfully diagnosed allergy to b-lactam antibiotics in children reporting reactions suggestive of immediate HS. In contrast, most acceler- ated and delayed reactions were diagnosed by OC. Thus, our results suggest that the diagnostic and predictive values of Skin Tests for nonimmediate HS to b-lactams in children are low. They also strongly suggest that most reactions reported in children are attributable to infec- tious diseases or interactions between drugs and infec- tious agents rather than to b-lactam HS. Pediatrics 1999; 104(4). URL: http://www.pediatrics.org/cgi/content/full/ 104/4/e45; b-lactams, allergy, Skin Tests, oral challenge, child.

Jacques De Blic - One of the best experts on this subject based on the ideXlab platform.

  • non immediate reading Skin Tests and prolonged challenges in non immediate hypersensitivity to beta lactams in children
    Applied Immunohistochemistry & Molecular Morphology, 2018
    Co-Authors: Claude Ponvert, Pierre Scheinmann, Jacques De Blic, Guillaume Lezmi, F Alrowaishdi, A Badosalbiero
    Abstract:

    BACKGROUND A minority of children reporting non-immediate reactions to beta-lactams (BLs) are allergic. Allergy workup usually includes late-reading (48-72 hours) Skin Tests (ST) and short (1-3 days) drug provocation Tests (DPT), regardless of the chronology of the index reaction. The sensitivity of hyper-late-reading (≥6-7 days) ST and of prolonged DPT for the diagnosis of non-immediate hypersensitivity to BLs is yet to be determined. OBJECTIVES To establish the diagnostic values of late-reading ST and hyper-late-reading ST and of prolonged DPT in children reporting non-immediate reactions to BLs. METHODS Prospective assessment of children reporting non-immediate reactions to BLs with late- and additional hyper-late-reading intradermal (ID) and patch Tests, and if negative, with prolonged DPT. RESULTS Five hundred and fifty children reporting reactions to a single or several BLs (674 suspected BLs) were included. Non-immediate hypersensitivity to BLs was diagnosed in 63 children (11.5%), reporting 66 reactions (9.8%), based on responses in ST (n = 17, 25.8%: 5 to ID, 8 to patch Tests, and 4 to both Tests), DPT (n = 43, 65.2%), and clinical history (n = 6, 9.1%), including 3/9 children with severe cutaneous adverse reactions. Skin test positivity was observed after the 6-7th day in 14/17 children, and DPT positivity after a median time of 3 days. No severe reaction was observed after ST or during prolonged DPT. CONCLUSION Additional hyper-late-reading of ST enhanced their positivity. However, their overall sensitivity remained weak, especially in non-severe cases. Prolonged DPT are safe and may improve the performance of DPT in the diagnosis of non-immediate hypersensitivity to BLs.

  • Anaphylaxis to the 23-valent pneumococcal vaccine: a second explored case by means of immediate-reading Skin Tests with pneumococcal vaccines.
    Vaccine, 2010
    Co-Authors: Claude Ponvert, Pierre Scheinmann, Jacques De Blic
    Abstract:

    Abstract Anaphylaxis to pneumococcal vaccines is rare. In the only one child with anaphylaxis to a first injection of the 23-valent pneumococcal vaccine that has been explored, Skin Tests and specific IgE determination diagnosed immediate-type hypersensitivity to pneumococcal antigens. We report the case of a child who tolerated three injections of the 7-valent pneumococcal vaccine, but experienced anaphylaxis to a fourth injection of the 23-valent vaccine. Immediate responses in Skin Tests diagnosed immediate-type hypersensitivity to the two vaccines. Immunizations with the 7-valent pneumococcal vaccine may induce IgE-dependent sensitization to pneumococcal antigens, responsible for anaphylaxis to subsequent injections of pneumococcal vaccines.

  • anaphylaxis to the 23 valent pneumococcal vaccine in child a case control study based on immediate responses in Skin Tests and specific ige determination
    Vaccine, 2001
    Co-Authors: Claude Ponvert, Jacques De Blic, Delia Ardeleanjaby, Annemarie Colingorski, Bruno Soufflet, Christine Hamberger, Pierre Scheinmann
    Abstract:

    Injections of the 23-valent pneumococcal vaccine are usually well tolerated. Skin Tests (prick and intradermal) and a self-made RAST with pneumococcal vaccine and phenol were performed in a child reporting a severe anaphylactic reaction induced by a 23-valent pneumococcal vaccine, and in ten control children, including one child with a well-tolerated vaccination, and nine non-vaccinated children. Skin Tests and RAST with the vaccine were positive in the child reporting anaphylaxis, and negative in nine of the control children. Intradermal test with the vaccine was slightly positive in a non-vaccinated child with negative RAST. Skin Tests and RAST with phenol were negative in all the children. These results suggest that immediate responses in Skin Tests and specific IgE determination have a good diagnostic value in children reporting severe reactions suggestive of IgE-dependent hypersensitivity to pneumococcal vaccine.

  • Allergy to β-Lactam Antibiotics in Children
    Pediatrics, 1999
    Co-Authors: Claude Ponvert, Pierre Scheinmann, Jacques De Blic, Laurence Le Clainche, Muriel Le Bourgeois, J. Paupe
    Abstract:

    Background. Skin Tests with soluble b-lactams can be used to diagnose immediate and de- layed hypersensitivity (HS) reactions to b-lactam antibi- otics. Very few studies have been performed with chil- dren with suspected b-lactam allergy. In these studies, immediate HS to b-lactams was diagnosed by Skin Tests in 4.9% to 40% of children. The diagnostic and predictive values of immediate responses in Skin Tests are good, because very few children with negative Skin test results have positive oral challenge (OC) test results. Delayed responses in Skin Tests (intradermal and patch Tests) have been reported in adult patients and children suffering with urticaria, angioedema, and maculopapular rashes during treatments with b-lactam antibiotics. However, the diagnostic and predictive values of late responses are unknown. Semi-late responses in Skin Tests with b-lac- tams have never been studied in adults or children. Objectives. The aims of this study were to confirm or rule out the diagnosis of allergy to b-lactams in children with histories of adverse reactions to these antibiotics, to determine whether allergic children were sensitized to one or several classes of b-lactams, and to evaluate the frequency and diagnostic value of immediate, acceler- ated, and delayed responses in Skin Tests with b-lactam antibiotics in children. Methods. We studied 325 children with suspected b-lactam allergy. Skin Tests (prick and intradermal) were performed with soluble forms of the suspected (or very similar) b-lactams and with one or several b-lactams from other classes. The reaction was assessed after 20 minutes (immediate), 8 hours (accelerated), and 48 to 72 hours (delayed). OCs with the suspected b-lactams were performed in patients with negative Skin test results, except those with severe serum sickness-like reactions and potentially harmful toxidermias. Results. Skin Tests and OCs led to the diagnosis of b-lactam allergy in 24 (7.4%) and 15 (4.6%) of the chil- dren, respectively. Thus, only 12% of the children were diagnosed as allergic to b-lactams by means of Skin Tests and OC. HS to b-lactams was suspected from clinical history in 30 (9.2%) children reporting serum sickness- like reactions and potentially harmful toxidermias. In a few children, we diagnosed food allergy and intolerance to excipients or nonsteroidal antiinflammatory drugs. No cause was found in the other children. Based on Skin Tests and OC, the prevalences of immu- noglobulin E-dependent and of semi-late or delayed sen- sitizations to b-lactam assessed were similar (6.8% vs 5.2%, respectively). Most immunoglobulin E-dependent sensitizations were diagnosed by means of Skin Tests (86.4%). In contrast, most semi-late and delayed sensiti- zations were diagnosed by OC (70.6%). The likelihood of b-lactam allergy was significantly higher for anaphylaxis (42.9% vs 8.3% in other reactions) and immediate reac- tions (25% vs 10% in accelerated and delayed reactions). Of the children diagnosed as allergic to b-lactam by means of Skin Tests, OC, and clinical history, 11.7% were sensitized to several classes of b-lactams. The risk was significantly higher in children with anaphylaxis (26.7% vs 7.5% of the children with other reactions) and in children reporting immediate reactions (33.3% vs 8.5% of the children with accelerated and delayed reactions). Finally, age, sex, personal history of atopy, number of reactions to b-lactams, and number of reactions to other drugs were not significant risk factors for b-lactam al- lergy. Conclusion. The Skin Tests were safe, and the imme- diate reaction to Skin Tests successfully diagnosed allergy to b-lactam antibiotics in children reporting reactions suggestive of immediate HS. In contrast, most acceler- ated and delayed reactions were diagnosed by OC. Thus, our results suggest that the diagnostic and predictive values of Skin Tests for nonimmediate HS to b-lactams in children are low. They also strongly suggest that most reactions reported in children are attributable to infec- tious diseases or interactions between drugs and infec- tious agents rather than to b-lactam HS. Pediatrics 1999; 104(4). URL: http://www.pediatrics.org/cgi/content/full/ 104/4/e45; b-lactams, allergy, Skin Tests, oral challenge, child.

Pierre Scheinmann - One of the best experts on this subject based on the ideXlab platform.

  • non immediate reading Skin Tests and prolonged challenges in non immediate hypersensitivity to beta lactams in children
    Applied Immunohistochemistry & Molecular Morphology, 2018
    Co-Authors: Claude Ponvert, Pierre Scheinmann, Jacques De Blic, Guillaume Lezmi, F Alrowaishdi, A Badosalbiero
    Abstract:

    BACKGROUND A minority of children reporting non-immediate reactions to beta-lactams (BLs) are allergic. Allergy workup usually includes late-reading (48-72 hours) Skin Tests (ST) and short (1-3 days) drug provocation Tests (DPT), regardless of the chronology of the index reaction. The sensitivity of hyper-late-reading (≥6-7 days) ST and of prolonged DPT for the diagnosis of non-immediate hypersensitivity to BLs is yet to be determined. OBJECTIVES To establish the diagnostic values of late-reading ST and hyper-late-reading ST and of prolonged DPT in children reporting non-immediate reactions to BLs. METHODS Prospective assessment of children reporting non-immediate reactions to BLs with late- and additional hyper-late-reading intradermal (ID) and patch Tests, and if negative, with prolonged DPT. RESULTS Five hundred and fifty children reporting reactions to a single or several BLs (674 suspected BLs) were included. Non-immediate hypersensitivity to BLs was diagnosed in 63 children (11.5%), reporting 66 reactions (9.8%), based on responses in ST (n = 17, 25.8%: 5 to ID, 8 to patch Tests, and 4 to both Tests), DPT (n = 43, 65.2%), and clinical history (n = 6, 9.1%), including 3/9 children with severe cutaneous adverse reactions. Skin test positivity was observed after the 6-7th day in 14/17 children, and DPT positivity after a median time of 3 days. No severe reaction was observed after ST or during prolonged DPT. CONCLUSION Additional hyper-late-reading of ST enhanced their positivity. However, their overall sensitivity remained weak, especially in non-severe cases. Prolonged DPT are safe and may improve the performance of DPT in the diagnosis of non-immediate hypersensitivity to BLs.

  • Anaphylaxis to the 23-valent pneumococcal vaccine: a second explored case by means of immediate-reading Skin Tests with pneumococcal vaccines.
    Vaccine, 2010
    Co-Authors: Claude Ponvert, Pierre Scheinmann, Jacques De Blic
    Abstract:

    Abstract Anaphylaxis to pneumococcal vaccines is rare. In the only one child with anaphylaxis to a first injection of the 23-valent pneumococcal vaccine that has been explored, Skin Tests and specific IgE determination diagnosed immediate-type hypersensitivity to pneumococcal antigens. We report the case of a child who tolerated three injections of the 7-valent pneumococcal vaccine, but experienced anaphylaxis to a fourth injection of the 23-valent vaccine. Immediate responses in Skin Tests diagnosed immediate-type hypersensitivity to the two vaccines. Immunizations with the 7-valent pneumococcal vaccine may induce IgE-dependent sensitization to pneumococcal antigens, responsible for anaphylaxis to subsequent injections of pneumococcal vaccines.

  • anaphylaxis to the 23 valent pneumococcal vaccine in child a case control study based on immediate responses in Skin Tests and specific ige determination
    Vaccine, 2001
    Co-Authors: Claude Ponvert, Jacques De Blic, Delia Ardeleanjaby, Annemarie Colingorski, Bruno Soufflet, Christine Hamberger, Pierre Scheinmann
    Abstract:

    Injections of the 23-valent pneumococcal vaccine are usually well tolerated. Skin Tests (prick and intradermal) and a self-made RAST with pneumococcal vaccine and phenol were performed in a child reporting a severe anaphylactic reaction induced by a 23-valent pneumococcal vaccine, and in ten control children, including one child with a well-tolerated vaccination, and nine non-vaccinated children. Skin Tests and RAST with the vaccine were positive in the child reporting anaphylaxis, and negative in nine of the control children. Intradermal test with the vaccine was slightly positive in a non-vaccinated child with negative RAST. Skin Tests and RAST with phenol were negative in all the children. These results suggest that immediate responses in Skin Tests and specific IgE determination have a good diagnostic value in children reporting severe reactions suggestive of IgE-dependent hypersensitivity to pneumococcal vaccine.

  • Allergy to β-Lactam Antibiotics in Children
    Pediatrics, 1999
    Co-Authors: Claude Ponvert, Pierre Scheinmann, Jacques De Blic, Laurence Le Clainche, Muriel Le Bourgeois, J. Paupe
    Abstract:

    Background. Skin Tests with soluble b-lactams can be used to diagnose immediate and de- layed hypersensitivity (HS) reactions to b-lactam antibi- otics. Very few studies have been performed with chil- dren with suspected b-lactam allergy. In these studies, immediate HS to b-lactams was diagnosed by Skin Tests in 4.9% to 40% of children. The diagnostic and predictive values of immediate responses in Skin Tests are good, because very few children with negative Skin test results have positive oral challenge (OC) test results. Delayed responses in Skin Tests (intradermal and patch Tests) have been reported in adult patients and children suffering with urticaria, angioedema, and maculopapular rashes during treatments with b-lactam antibiotics. However, the diagnostic and predictive values of late responses are unknown. Semi-late responses in Skin Tests with b-lac- tams have never been studied in adults or children. Objectives. The aims of this study were to confirm or rule out the diagnosis of allergy to b-lactams in children with histories of adverse reactions to these antibiotics, to determine whether allergic children were sensitized to one or several classes of b-lactams, and to evaluate the frequency and diagnostic value of immediate, acceler- ated, and delayed responses in Skin Tests with b-lactam antibiotics in children. Methods. We studied 325 children with suspected b-lactam allergy. Skin Tests (prick and intradermal) were performed with soluble forms of the suspected (or very similar) b-lactams and with one or several b-lactams from other classes. The reaction was assessed after 20 minutes (immediate), 8 hours (accelerated), and 48 to 72 hours (delayed). OCs with the suspected b-lactams were performed in patients with negative Skin test results, except those with severe serum sickness-like reactions and potentially harmful toxidermias. Results. Skin Tests and OCs led to the diagnosis of b-lactam allergy in 24 (7.4%) and 15 (4.6%) of the chil- dren, respectively. Thus, only 12% of the children were diagnosed as allergic to b-lactams by means of Skin Tests and OC. HS to b-lactams was suspected from clinical history in 30 (9.2%) children reporting serum sickness- like reactions and potentially harmful toxidermias. In a few children, we diagnosed food allergy and intolerance to excipients or nonsteroidal antiinflammatory drugs. No cause was found in the other children. Based on Skin Tests and OC, the prevalences of immu- noglobulin E-dependent and of semi-late or delayed sen- sitizations to b-lactam assessed were similar (6.8% vs 5.2%, respectively). Most immunoglobulin E-dependent sensitizations were diagnosed by means of Skin Tests (86.4%). In contrast, most semi-late and delayed sensiti- zations were diagnosed by OC (70.6%). The likelihood of b-lactam allergy was significantly higher for anaphylaxis (42.9% vs 8.3% in other reactions) and immediate reac- tions (25% vs 10% in accelerated and delayed reactions). Of the children diagnosed as allergic to b-lactam by means of Skin Tests, OC, and clinical history, 11.7% were sensitized to several classes of b-lactams. The risk was significantly higher in children with anaphylaxis (26.7% vs 7.5% of the children with other reactions) and in children reporting immediate reactions (33.3% vs 8.5% of the children with accelerated and delayed reactions). Finally, age, sex, personal history of atopy, number of reactions to b-lactams, and number of reactions to other drugs were not significant risk factors for b-lactam al- lergy. Conclusion. The Skin Tests were safe, and the imme- diate reaction to Skin Tests successfully diagnosed allergy to b-lactam antibiotics in children reporting reactions suggestive of immediate HS. In contrast, most acceler- ated and delayed reactions were diagnosed by OC. Thus, our results suggest that the diagnostic and predictive values of Skin Tests for nonimmediate HS to b-lactams in children are low. They also strongly suggest that most reactions reported in children are attributable to infec- tious diseases or interactions between drugs and infec- tious agents rather than to b-lactam HS. Pediatrics 1999; 104(4). URL: http://www.pediatrics.org/cgi/content/full/ 104/4/e45; b-lactams, allergy, Skin Tests, oral challenge, child.

Arnon Goldberg - One of the best experts on this subject based on the ideXlab platform.

  • Variability of venom Skin Tests
    Current Opinion in Allergy and Clinical Immunology, 2007
    Co-Authors: Arnon Goldberg
    Abstract:

    Purpose of review Venom Skin Tests constitute the cornerstone in establishing the diagnosis of venom allergy. In spite of their fundamental role, data regarding their reproducibility and variability are rather sparse. This paper is an overview of our current knowledge on the extent of variability in venom Skin testing, the possible causes for this phenomenon and its clinical implications. It points out certain clinical situations in which this possible variability should be taken into account and anticipates potential venues of expanding our understanding of this debatable subject. Recent findings A single recent study addressed the reproducibility of Skin Tests and serum venom-specific ιmmunoglobulin E levels. Using a simple positive-negative or vice versa criterion for all three venoms examined on two different sessions, this study showed an overall 66% reproducibility of the Skin test reactions and 59% reproducibility of the venom-specific immunoglobulin E assay results. According to an accompanying editorial, however, the validity of these results needs to be confirmed. Determination of the real magnitude of venom Skin test variability is required. At present, in specific clinical situations, repeated Skin Tests and measurement of serum venom-specific immunoglobulin E should be considered before the initiation of venom immunotherapy.

  • timing of venom Skin Tests and ige determinations after insect sting anaphylaxis
    The Journal of Allergy and Clinical Immunology, 1997
    Co-Authors: Arnon Goldberg, Ronit Confinocohen
    Abstract:

    Determinat ion of venom-specific IgE either by Skin testing or by RAST is a prerequisite for the correct diagnosis and t reatment of patients who have had a systemic reaction (SR) caused by an insect sting. Over the past 30 years the routine recommendat ion has been to postpone Tests for specific IgE determinat ion for varying periods of time after the SR. TM Initially, delay in testing was recommended because of the expectation of false-negative results from testing with whole-body insect extract soon after anaphylaxis. This recommendation has not been revised, since testing with venoms became available. To assess whether venom Skin Tests (STs) and serum venom-specific (SVS)-IgE determinations have any value when performed shortly after the insect sting and to determine possible kinetics of these Tests in other clinical situations of venom hypersensitivity, we investigated patients with insect sting-induced SR or large local reaction (LLR). Patients were evaluated twice: within i week of and 4 to 6 weeks after the sting.

D Papaioannou - One of the best experts on this subject based on the ideXlab platform.

  • Insect‐venom allergy in Greek adults
    Allergy, 2007
    Co-Authors: Ch Grigoreas, I D Galatas, Ch Kiamouris, D Papaioannou
    Abstract:

    : Relatively few studies have investigated the prevalence of insect-sting allergy and the results of diagnostic procedures in unselected populations. The prevalence of insect-sting reactions and of venom sensitization in Greece is unknown. We report the results from a stratified random sample of 480 subjects (404 men, 76 women), aged 20-60 years. They all belonged to the ground personnel of the Hellenic Air Force. A detailed history particularly focused on the reactions to Hymenoptera stings was taken in all subjects. Intradermal Skin Tests (concentration: 1 microgram/ml) with three venoms (honeybee, paper wasp, common wasp) were performed. The prevalence of venom sensitization (one or more positive Skin Tests) was 32.7%. Sensitization appears to be more common (2.69 times) in those living in rural areas than in those living in the capital (Athens). The prevalence of systemic reactions was 3.1% (86.7% of them had positive Skin Tests). Large local reactions were reported by 4.6% of the subjects (77.3% of them had positive Skin Tests). Asymptomatic sensitization (positive Skin Tests to venoms) was observed in 28.7% of subjects with no history of an allergic sting reaction. We concluded that the prevalence of Hymenoptera allergy and venom sensitization in Greece is rather high compared to that of other countries.

  • insect venom allergy in greek adults
    Allergy, 1997
    Co-Authors: Ch Grigoreas, I D Galatas, Ch Kiamouris, D Papaioannou
    Abstract:

    : Relatively few studies have investigated the prevalence of insect-sting allergy and the results of diagnostic procedures in unselected populations. The prevalence of insect-sting reactions and of venom sensitization in Greece is unknown. We report the results from a stratified random sample of 480 subjects (404 men, 76 women), aged 20-60 years. They all belonged to the ground personnel of the Hellenic Air Force. A detailed history particularly focused on the reactions to Hymenoptera stings was taken in all subjects. Intradermal Skin Tests (concentration: 1 microgram/ml) with three venoms (honeybee, paper wasp, common wasp) were performed. The prevalence of venom sensitization (one or more positive Skin Tests) was 32.7%. Sensitization appears to be more common (2.69 times) in those living in rural areas than in those living in the capital (Athens). The prevalence of systemic reactions was 3.1% (86.7% of them had positive Skin Tests). Large local reactions were reported by 4.6% of the subjects (77.3% of them had positive Skin Tests). Asymptomatic sensitization (positive Skin Tests to venoms) was observed in 28.7% of subjects with no history of an allergic sting reaction. We concluded that the prevalence of Hymenoptera allergy and venom sensitization in Greece is rather high compared to that of other countries.