The Experts below are selected from a list of 258 Experts worldwide ranked by ideXlab platform
M. Mcgue - One of the best experts on this subject based on the ideXlab platform.
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alcohol and illicit Drug Dependence among parents associations with offspring externalizing disorders
Psychological Medicine, 2009Co-Authors: Naomi R. Marmorstein, William G. Iacono, M. McgueAbstract:Background Previous research indicates that alcohol and Drug Dependence constitute aspects of a general vulnerability to externalizing disorders that accounts for much of the parent-offspring resemblance for these and related disorders. This study examined how adolescent offspring risk for externalizing psychopathology varies with respect to parental alcoholism and illicit Drug Dependence. Method Data from the Minnesota Twin Family Study, a community-based investigation of adolescents (age 17 years, n =1252) and their parents, were used. Lifetime diagnoses of alcohol and Drug Dependence (among both parents and offspring) and offspring attention deficit hyperactivity disorder, oppositional defiant disorder, conduct disorder, adult antisocial behavior, and nicotine Dependence were assessed via structured interviews. Results Parental alcohol Dependence and parental Drug Dependence were similarly associated with increased risk for nearly all offspring disorders, with offspring of alcohol and Drug-dependent parents having approximately 2–3 times the odds for developing a disorder by late adolescence compared to low-risk offspring. Compared to parental Dependence on other illicit Drugs, parental cannabis Dependence was associated with weaker increased risk for offspring externalizing disorders. Conclusions Both parental alcohol and Drug Dependence are independently associated with an increased risk for a broad range of externalizing psychopathology among late-adolescent offspring.
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Alcohol and illicit Drug Dependence among parents: associations with offspring externalizing disorders.
Psychological medicine, 2008Co-Authors: Naomi R. Marmorstein, William G. Iacono, M. McgueAbstract:Previous research indicates that alcohol and Drug Dependence constitute aspects of a general vulnerability to externalizing disorders that accounts for much of the parent-offspring resemblance for these and related disorders. This study examined how adolescent offspring risk for externalizing psychopathology varies with respect to parental alcoholism and illicit Drug Dependence. Data from the Minnesota Twin Family Study, a community-based investigation of adolescents (age 17 years, n=1252) and their parents, were used. Lifetime diagnoses of alcohol and Drug Dependence (among both parents and offspring) and offspring attention deficit hyperactivity disorder, oppositional defiant disorder, conduct disorder, adult antisocial behavior, and nicotine Dependence were assessed via structured interviews. Parental alcohol Dependence and parental Drug Dependence were similarly associated with increased risk for nearly all offspring disorders, with offspring of alcohol and Drug-dependent parents having approximately 2-3 times the odds for developing a disorder by late adolescence compared to low-risk offspring. Compared to parental Dependence on other illicit Drugs, parental cannabis Dependence was associated with weaker increased risk for offspring externalizing disorders. Both parental alcohol and Drug Dependence are independently associated with an increased risk for a broad range of externalizing psychopathology among late-adolescent offspring.
James C. Anthony - One of the best experts on this subject based on the ideXlab platform.
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early onset Drug use and risk for Drug Dependence problems
Addictive Behaviors, 2009Co-Authors: Chuanyu Chen, Carla L Storr, James C. AnthonyAbstract:There is substantial evidence that alcohol, tobacco, and cannabis Dependence problems surface more quickly when use of these Drugs starts before adulthood, but the evidence based on other internationally regulated Drugs (e.g., cocaine) is meager. With focus on an interval of up to 24 months following first Drug use, we examine Drug-specific and age-specific variation in profiles of early-emerging clinical features associated with Drug Dependence. Based upon the United States National Surveys on Drug Use and Health (NSDUH) conducted in 2000-2002, the risk of experiencing Drug Dependence problems was robustly greater for adolescent recent-onset users of cocaine, psychostimulant Drugs other than cocaine, analgesics, anxiolytic medicines, inhalants Drugs, and cannabis, as compared to adult recent-onset users (odds ratio=1.5-4.3, p<0.05). This was not the case for the NSDUH hallucinogens group (e.g., LSD). The adolescent onset associated excess risk was not constant across all clinical features. Our evidence suggests promoting earlier detection and interventions, as well as greater parent and peer awareness of Drug Dependence clinical features that may develop early among young people who have just started using Drugs.
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Early-onset Drug use and risk for Drug Dependence problems.
Addictive behaviors, 2008Co-Authors: Chuanyu Chen, Carla L Storr, James C. AnthonyAbstract:There is substantial evidence that alcohol, tobacco, and cannabis Dependence problems surface more quickly when use of these Drugs starts before adulthood, but the evidence based on other internationally regulated Drugs (e.g., cocaine) is meager. With focus on an interval of up to 24 months following first Drug use, we examine Drug-specific and age-specific variation in profiles of early-emerging clinical features associated with Drug Dependence. Based upon the United States National Surveys on Drug Use and Health (NSDUH) conducted in 2000-2002, the risk of experiencing Drug Dependence problems was robustly greater for adolescent recent-onset users of cocaine, psychostimulant Drugs other than cocaine, analgesics, anxiolytic medicines, inhalants Drugs, and cannabis, as compared to adult recent-onset users (odds ratio=1.5-4.3, p
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Epidemiologic differences in Drug Dependence
Social psychiatry and psychiatric epidemiology, 2003Co-Authors: Carolyn D. M. Furr-holden, James C. AnthonyAbstract:Background: Published epidemiologic survey statistics do not allow direct cross-national comparison of Drug Dependence in the US and the UK, primarily because of a lack of uniformity across case definitions and methods of case ascertainment. Aims: The current study sought to re-estimate these prevalence values after calibration of case definitions (i. e., imposing methodological constraints to unify case definitions), to identify suspected determinants, and also to investigate symptom profiles among active cases. Method: Analyses of data from the US National Household Survey on Drug Abuse and the UK Survey of Psychiatric Morbidity were conducted. Prevalence of active Drug Dependence symptoms was estimated. Logistic regression analysis was used to estimate the magnitude of the association between suspected socio-demographic variables and Drug Dependence. Results: The prevalence of Drug Dependence was an estimated 1.4 % in the US and 0.5 % in the UK. This difference was somewhat attenuated when the effect of living in an urban setting was controlled. Symptom profiles among active cases were very similar. In both countries, being male, non-married, of a low socio-economic status (SES), and living in an urban setting were associated with an increased occurrence of Drug Dependence. Conclusion: There are US–UK differences in prevalence of active Drug Dependence beyond what available statistics imply and some of this difference can be explained by variations associated with living in urban and rural conditions.
Naomi R. Marmorstein - One of the best experts on this subject based on the ideXlab platform.
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alcohol and illicit Drug Dependence among parents associations with offspring externalizing disorders
Psychological Medicine, 2009Co-Authors: Naomi R. Marmorstein, William G. Iacono, M. McgueAbstract:Background Previous research indicates that alcohol and Drug Dependence constitute aspects of a general vulnerability to externalizing disorders that accounts for much of the parent-offspring resemblance for these and related disorders. This study examined how adolescent offspring risk for externalizing psychopathology varies with respect to parental alcoholism and illicit Drug Dependence. Method Data from the Minnesota Twin Family Study, a community-based investigation of adolescents (age 17 years, n =1252) and their parents, were used. Lifetime diagnoses of alcohol and Drug Dependence (among both parents and offspring) and offspring attention deficit hyperactivity disorder, oppositional defiant disorder, conduct disorder, adult antisocial behavior, and nicotine Dependence were assessed via structured interviews. Results Parental alcohol Dependence and parental Drug Dependence were similarly associated with increased risk for nearly all offspring disorders, with offspring of alcohol and Drug-dependent parents having approximately 2–3 times the odds for developing a disorder by late adolescence compared to low-risk offspring. Compared to parental Dependence on other illicit Drugs, parental cannabis Dependence was associated with weaker increased risk for offspring externalizing disorders. Conclusions Both parental alcohol and Drug Dependence are independently associated with an increased risk for a broad range of externalizing psychopathology among late-adolescent offspring.
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Alcohol and illicit Drug Dependence among parents: associations with offspring externalizing disorders.
Psychological medicine, 2008Co-Authors: Naomi R. Marmorstein, William G. Iacono, M. McgueAbstract:Previous research indicates that alcohol and Drug Dependence constitute aspects of a general vulnerability to externalizing disorders that accounts for much of the parent-offspring resemblance for these and related disorders. This study examined how adolescent offspring risk for externalizing psychopathology varies with respect to parental alcoholism and illicit Drug Dependence. Data from the Minnesota Twin Family Study, a community-based investigation of adolescents (age 17 years, n=1252) and their parents, were used. Lifetime diagnoses of alcohol and Drug Dependence (among both parents and offspring) and offspring attention deficit hyperactivity disorder, oppositional defiant disorder, conduct disorder, adult antisocial behavior, and nicotine Dependence were assessed via structured interviews. Parental alcohol Dependence and parental Drug Dependence were similarly associated with increased risk for nearly all offspring disorders, with offspring of alcohol and Drug-dependent parents having approximately 2-3 times the odds for developing a disorder by late adolescence compared to low-risk offspring. Compared to parental Dependence on other illicit Drugs, parental cannabis Dependence was associated with weaker increased risk for offspring externalizing disorders. Both parental alcohol and Drug Dependence are independently associated with an increased risk for a broad range of externalizing psychopathology among late-adolescent offspring.
Parmananda Kulhara - One of the best experts on this subject based on the ideXlab platform.
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Cellular and molecular mechanisms of Drug Dependence: An overview and update.
Indian journal of psychiatry, 2007Co-Authors: Swapnil Gupta, Parmananda KulharaAbstract:Drug Dependence is a major cause of morbidity and loss of productivity. Various theories ranging from economic to psychological have been invoked in an attempt to explain this condition. With the advent of research at the cellular and subcellular levels, perspectives on the etiology of Drug Dependence have also changed. Perhaps the greatest advance has been in the identification of specific receptors for each of the Drugs, their target neurotransmitter systems and the intracellular changes produced by them. These receptors also provide potential targets for treatment strategies of Drug Dependence. This overview attempts to present the mechanisms in the development of Dependence and the newer treatment strategies for the major Drugs of abuse like alcohol, opioids, cannabis, nicotine and cocaine.
William G. Iacono - One of the best experts on this subject based on the ideXlab platform.
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alcohol and illicit Drug Dependence among parents associations with offspring externalizing disorders
Psychological Medicine, 2009Co-Authors: Naomi R. Marmorstein, William G. Iacono, M. McgueAbstract:Background Previous research indicates that alcohol and Drug Dependence constitute aspects of a general vulnerability to externalizing disorders that accounts for much of the parent-offspring resemblance for these and related disorders. This study examined how adolescent offspring risk for externalizing psychopathology varies with respect to parental alcoholism and illicit Drug Dependence. Method Data from the Minnesota Twin Family Study, a community-based investigation of adolescents (age 17 years, n =1252) and their parents, were used. Lifetime diagnoses of alcohol and Drug Dependence (among both parents and offspring) and offspring attention deficit hyperactivity disorder, oppositional defiant disorder, conduct disorder, adult antisocial behavior, and nicotine Dependence were assessed via structured interviews. Results Parental alcohol Dependence and parental Drug Dependence were similarly associated with increased risk for nearly all offspring disorders, with offspring of alcohol and Drug-dependent parents having approximately 2–3 times the odds for developing a disorder by late adolescence compared to low-risk offspring. Compared to parental Dependence on other illicit Drugs, parental cannabis Dependence was associated with weaker increased risk for offspring externalizing disorders. Conclusions Both parental alcohol and Drug Dependence are independently associated with an increased risk for a broad range of externalizing psychopathology among late-adolescent offspring.
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Alcohol and illicit Drug Dependence among parents: associations with offspring externalizing disorders.
Psychological medicine, 2008Co-Authors: Naomi R. Marmorstein, William G. Iacono, M. McgueAbstract:Previous research indicates that alcohol and Drug Dependence constitute aspects of a general vulnerability to externalizing disorders that accounts for much of the parent-offspring resemblance for these and related disorders. This study examined how adolescent offspring risk for externalizing psychopathology varies with respect to parental alcoholism and illicit Drug Dependence. Data from the Minnesota Twin Family Study, a community-based investigation of adolescents (age 17 years, n=1252) and their parents, were used. Lifetime diagnoses of alcohol and Drug Dependence (among both parents and offspring) and offspring attention deficit hyperactivity disorder, oppositional defiant disorder, conduct disorder, adult antisocial behavior, and nicotine Dependence were assessed via structured interviews. Parental alcohol Dependence and parental Drug Dependence were similarly associated with increased risk for nearly all offspring disorders, with offspring of alcohol and Drug-dependent parents having approximately 2-3 times the odds for developing a disorder by late adolescence compared to low-risk offspring. Compared to parental Dependence on other illicit Drugs, parental cannabis Dependence was associated with weaker increased risk for offspring externalizing disorders. Both parental alcohol and Drug Dependence are independently associated with an increased risk for a broad range of externalizing psychopathology among late-adolescent offspring.
