The Experts below are selected from a list of 126 Experts worldwide ranked by ideXlab platform
Bodil Weng - One of the best experts on this subject based on the ideXlab platform.
-
Extraction and Analysis by High-PerFormance Liquid Chromatography of Antibiotics in a Drug Delivery System for Farmed Fish
Journal of Pharmaceutical Sciences, 1993Co-Authors: Astri Rogstad, Bodil WengAbstract:Abstract Simple assays for extraction and determination of the concentrations of the antibiotics oxytetracycline, oxolinic acid, and flumequine in a Drug Dosage Form for farmed fish are described. HPLC with UV detection was used in the analyses. The recovery of all three Drugs was —100%, and the precision varied from 0.5-3.0%. The methods are applicable to the production control, quality control, and stability control of the products.
-
Extraction and Analysis by High-PerFormance Liquid Chromatography of Antibiotics in a Drug Delivery System for Farmed Fish
Journal of pharmaceutical sciences, 1993Co-Authors: Astri Rogstad, Bodil WengAbstract:Simple assays for extraction and determination of the concentrations of the antibiotics oxytetracycline, oxolinic acid, and flumequine in a Drug Dosage Form for farmed fish are described. HPLC with UV detection was used in the analyses. The recovery of all three Drugs was approximately 100%, and the precision varied from 0.5-3.0%. The methods are applicable to the production control, quality control, and stability control of the products.
Ian A. Nicholls - One of the best experts on this subject based on the ideXlab platform.
-
Theophylline molecularly imprinted polymer dissociation kinetics: a novel sustained release Drug Dosage mechanism.
Journal of molecular recognition : JMR, 1998Co-Authors: Mikael C. Norell, Håkan S. Andersson, Ian A. NichollsAbstract:The template release kinetics of theophylline molecularly imprinted polymers has been examined with a view to determining their potential as a controlled release Drug Dosage Form. The basis for the ligand selectivity of these polymers has been shown through the demonstration of pre-polymerization template-monomer complexation and HPLC studies of the product polymer ligand selectivities. The release kinetics shows a dependence upon template loading and pH. Small differences in release characteristics between imprinted and non-imprinted (reference) polymers have been observed.
Astri Rogstad - One of the best experts on this subject based on the ideXlab platform.
-
Extraction and Analysis by High-PerFormance Liquid Chromatography of Antibiotics in a Drug Delivery System for Farmed Fish
Journal of Pharmaceutical Sciences, 1993Co-Authors: Astri Rogstad, Bodil WengAbstract:Abstract Simple assays for extraction and determination of the concentrations of the antibiotics oxytetracycline, oxolinic acid, and flumequine in a Drug Dosage Form for farmed fish are described. HPLC with UV detection was used in the analyses. The recovery of all three Drugs was —100%, and the precision varied from 0.5-3.0%. The methods are applicable to the production control, quality control, and stability control of the products.
-
Extraction and Analysis by High-PerFormance Liquid Chromatography of Antibiotics in a Drug Delivery System for Farmed Fish
Journal of pharmaceutical sciences, 1993Co-Authors: Astri Rogstad, Bodil WengAbstract:Simple assays for extraction and determination of the concentrations of the antibiotics oxytetracycline, oxolinic acid, and flumequine in a Drug Dosage Form for farmed fish are described. HPLC with UV detection was used in the analyses. The recovery of all three Drugs was approximately 100%, and the precision varied from 0.5-3.0%. The methods are applicable to the production control, quality control, and stability control of the products.
Monique Alric - One of the best experts on this subject based on the ideXlab platform.
-
Investigation of the biopharmaceutical behavior of theophylline hydrophilic matrix tablets using USP methods and an artificial digestive system.
Drug development and industrial pharmacy, 2007Co-Authors: Sabah Souliman, Eric Beyssac, Jean-michel Cardot, Sylvain Denis, Monique AlricAbstract:This work aimed to investigate the biopharmaceutical behavior of hydrophilic matrix tablets of theophylline using different in vitro methods: USP II, USP IV, and a novel in vitro system simulating the gastrointestinal tract in man called the artificial digestive system (ADS). The potentiality of each method was evaluated by establishing in vitro/in vivo correlation. Using USP methods, the Drug release was pH-independent and dependent on agitation intensity. Level A IVIVCs could be established using the different in vitro methods but one to one correlation was established only when the ADS method was used. For the prediction of in vivo Drug Dosage Form behavior based on in vitro methods, the ADS showed a high predictability when compared to USP in vitro methods.
Gerhard Zifferer - One of the best experts on this subject based on the ideXlab platform.
-
molecular dynamics simulations for Drug Dosage Form development thermal and solubility characteristics for hot melt extrusion
Molecular Simulation, 2008Co-Authors: Martin Maus, Karl G. Wagner, Andreas Kornherr, Gerhard ZiffererAbstract:Properties of pharmaceutical Drug polymer mixtures like miscibility, stability and Drug release are determined by the interactions of active pharmaceutical ingredients (APIs) and excipients (e.g. plasticisers) with functional polymers. Molecular dynamics (MD) simulations (Materials Studio®, COMPASS force field) are used to predict the principal behaviour of such Drug products, especially miscibility and glass transition temperature (T g). Different mixtures containing APIs (theophylline or ibuprofen (IBU)) and water-soluble (triethyl citrate, (TEC)) or water-insoluble plasticiser (acetyl tributyl citrate (ATBC) or dibutyl sebacate (DBS)) dissolved/dispersed in a cationic polymethacrylate (EUDRAGIT® RS) were studied. Force field-based calculations of the cohesive energy densities of single constituents led to a qualitative approach according to Hanson describing the solid state of the mixture, while further calculations on the basis of the theory of free energy of mixing facilitated a semi-quantitative pre...
-
Molecular dynamics simulations for Drug Dosage Form development: thermal and solubility characteristics for hot-melt extrusion
Molecular Simulation, 2008Co-Authors: Martin Maus, Karl G. Wagner, Andreas Kornherr, Gerhard ZiffererAbstract:International audienceProperties of pharmaceutical Drug polymer mixtures like miscibility, stability and Drug release are determined by the interactions of active pharmaceutical ingredients (APIs) and excipients (e.g. plasticizers) with functional polymers. Molecular dynamics simulations (Materials Studio, compass force field) are used to predict the principal behaviour of such Drug products, especially miscibility and glass transition temperature (Tg). Different mixtures containing APIs (theophylline or ibuprofen) and water soluble (triethyl citrate) or water insoluble plasticizer (acetyltributyl citrate or dibutyl sebacate) dissolved/dispersed in a cationic polymethacrylate (Eudragit® RS) were studied. Force field based calculations of the cohesive energy densities of single constituents led to a qualitative approach according to Hanson describing the solid state of the mixture while further calculations on the basis of the theory of free energy of mixing facilitated a semi quantitative prediction. In case of miscibility also calculation of Tg was possible via modelling specific volumes of amorphous cells at various temperatures. The simulated data correlated well with the experimental data obtained from differential scanning calorimetry of Drug products processed via hotmelt extrusion. Accordingly, the described method facilitates a good estimate of pharmaceutical polymer Drug mixtures thus decreasing product development time as well as the consumption of active ingredients
