The Experts below are selected from a list of 116553 Experts worldwide ranked by ideXlab platform
Marc E Grossman - One of the best experts on this subject based on the ideXlab platform.
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pustular eruption after Drug Exposure is it pustular psoriasis or a pustular Drug eruption
British Journal of Dermatology, 1994Co-Authors: J M Spencer, D N Silvers, Marc E GrossmanAbstract:Summary Generalized pustular eruptions with fever present a diagnostic challenge. A history of preceding Drug Exposure, and rapid disappearance of the eruption after the Drug is stopped, suggest a Drug-induced aetiology rather than pustular psoriasis. We describe and evaluate the clinical and histological features of four patients who developed a generalized pustular eruption following Drug administration. The history of preceding Drug Exposure and the presence of a variable number of eosinophils in the inflammatory infiltrate in the lesions of these cases suggested that the generalized pustular eruptions were Drug-induced.
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Pustular eruption after Drug Exposure : is it pustular psoriasis or a pustular Drug eruption ?
British Journal of Dermatology, 1994Co-Authors: J M Spencer, D N Silvers, Marc E GrossmanAbstract:Summary Generalized pustular eruptions with fever present a diagnostic challenge. A history of preceding Drug Exposure, and rapid disappearance of the eruption after the Drug is stopped, suggest a Drug-induced aetiology rather than pustular psoriasis. We describe and evaluate the clinical and histological features of four patients who developed a generalized pustular eruption following Drug administration. The history of preceding Drug Exposure and the presence of a variable number of eosinophils in the inflammatory infiltrate in the lesions of these cases suggested that the generalized pustular eruptions were Drug-induced.
J M Spencer - One of the best experts on this subject based on the ideXlab platform.
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pustular eruption after Drug Exposure is it pustular psoriasis or a pustular Drug eruption
British Journal of Dermatology, 1994Co-Authors: J M Spencer, D N Silvers, Marc E GrossmanAbstract:Summary Generalized pustular eruptions with fever present a diagnostic challenge. A history of preceding Drug Exposure, and rapid disappearance of the eruption after the Drug is stopped, suggest a Drug-induced aetiology rather than pustular psoriasis. We describe and evaluate the clinical and histological features of four patients who developed a generalized pustular eruption following Drug administration. The history of preceding Drug Exposure and the presence of a variable number of eosinophils in the inflammatory infiltrate in the lesions of these cases suggested that the generalized pustular eruptions were Drug-induced.
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Pustular eruption after Drug Exposure : is it pustular psoriasis or a pustular Drug eruption ?
British Journal of Dermatology, 1994Co-Authors: J M Spencer, D N Silvers, Marc E GrossmanAbstract:Summary Generalized pustular eruptions with fever present a diagnostic challenge. A history of preceding Drug Exposure, and rapid disappearance of the eruption after the Drug is stopped, suggest a Drug-induced aetiology rather than pustular psoriasis. We describe and evaluate the clinical and histological features of four patients who developed a generalized pustular eruption following Drug administration. The history of preceding Drug Exposure and the presence of a variable number of eosinophils in the inflammatory infiltrate in the lesions of these cases suggested that the generalized pustular eruptions were Drug-induced.
Michel Vidal - One of the best experts on this subject based on the ideXlab platform.
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Early sorafenib-induced toxicity is associated with Drug Exposure and UGTIA9 genetic polymorphism in patients with solid tumors: a preliminary study.
PLOS ONE, 2012Co-Authors: Pascaline Boudou-rouquette, Céline Narjoz, Jean Louis Golmard, Audrey Thomas-schoemann, Fabrice Taieb, Jean-philippe Durand, Romain Coriat, Alain Dauphin, Michel VidalAbstract:BACKGROUND: Identifying predictive biomarkers of Drug response is of key importance to improve therapy management and Drug selection in cancer therapy. To date, the influence of Drug Exposure and pharmacogenetic variants on sorafenib-induced toxicity remains poorly documented. The aim of this pharmacokinetic/pharmacodynamic (PK/PD) study was to investigate the relationship between early toxicity and Drug Exposure or pharmacogenetic variants in unselected adult outpatients treated with single-agent sorafenib for advanced solid tumors. METHODS: Toxicity was recorded in 54 patients on days 15 and 30 after treatment initiation and sorafenib Exposure was assessed in 51 patients. The influence of polymorphisms in CYP3A5, UGT1A9, ABCB1 and ABCG2 was examined in relation to sorafenib Exposure and toxicity. Clinical characteristics, Drug Exposure and pharmacogenetic variants were tested univariately for association with toxicities. Candidate variables with p
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early sorafenib induced toxicity is associated with Drug Exposure and ugtia9 genetic polymorphism in patients with solid tumors a preliminary study
PLOS ONE, 2012Co-Authors: Pascaline Boudourouquette, Céline Narjoz, Jean Louis Golmard, Fabrice Taieb, Jean-philippe Durand, Romain Coriat, Alain Dauphin, Audrey Thomasschoemann, Olivier Mir, Michel VidalAbstract:Background: Identifying predictive biomarkers of Drug response is of key importance to improve therapy management and Drug selection in cancer therapy. To date, the influence of Drug Exposure and pharmacogenetic variants on sorafenibinduced toxicity remains poorly documented. The aim of this pharmacokinetic/pharmacodynamic (PK/PD) study was to investigate the relationship between early toxicity and Drug Exposure or pharmacogenetic variants in unselected adult outpatients treated with single-agent sorafenib for advanced solid tumors. Methods: Toxicity was recorded in 54 patients on days 15 and 30 after treatment initiation and sorafenib Exposure was assessed in 51 patients. The influence of polymorphisms in CYP3A5, UGT1A9, ABCB1 and ABCG2 was examined in relation to sorafenib Exposure and toxicity. Clinical characteristics, Drug Exposure and pharmacogenetic variants were tested univariately for association with toxicities. Candidate variables with p,0.1 were analyzed in a multivariate analysis. Results: Gender was the sole parameter independently associated with sorafenib Exposure (p=0.0008). Multivariate analysis showed that increased cumulated sorafenib (AUCcum) was independently associated with any grade $3 toxicity (p=0.037); UGT1A9 polymorphism (rs17868320) with grade $2 diarrhea (p=0.015) and female gender with grade $2 hand-foot skin reaction (p=0.018). Using ROC curve, the threshold AUCcum value of 3,161 mg/L.h was associated with the highest risk to develop any grade $3 toxicity (p=0.018). Conclusion: In this preliminary study, increased cumulated Drug Exposure and UGT1A9 polymorphism (rs17868320) identified patients at high risk for early sorafenib-induced severe toxicity. Further PK/PD studies on larger population are warranted to confirm these preliminary results.
D N Silvers - One of the best experts on this subject based on the ideXlab platform.
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pustular eruption after Drug Exposure is it pustular psoriasis or a pustular Drug eruption
British Journal of Dermatology, 1994Co-Authors: J M Spencer, D N Silvers, Marc E GrossmanAbstract:Summary Generalized pustular eruptions with fever present a diagnostic challenge. A history of preceding Drug Exposure, and rapid disappearance of the eruption after the Drug is stopped, suggest a Drug-induced aetiology rather than pustular psoriasis. We describe and evaluate the clinical and histological features of four patients who developed a generalized pustular eruption following Drug administration. The history of preceding Drug Exposure and the presence of a variable number of eosinophils in the inflammatory infiltrate in the lesions of these cases suggested that the generalized pustular eruptions were Drug-induced.
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Pustular eruption after Drug Exposure : is it pustular psoriasis or a pustular Drug eruption ?
British Journal of Dermatology, 1994Co-Authors: J M Spencer, D N Silvers, Marc E GrossmanAbstract:Summary Generalized pustular eruptions with fever present a diagnostic challenge. A history of preceding Drug Exposure, and rapid disappearance of the eruption after the Drug is stopped, suggest a Drug-induced aetiology rather than pustular psoriasis. We describe and evaluate the clinical and histological features of four patients who developed a generalized pustular eruption following Drug administration. The history of preceding Drug Exposure and the presence of a variable number of eosinophils in the inflammatory infiltrate in the lesions of these cases suggested that the generalized pustular eruptions were Drug-induced.
Michael Privitera - One of the best experts on this subject based on the ideXlab platform.
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Foetal antiepileptic Drug Exposure and verbal versus non-verbal abilities at three years of age
Brain, 2011Co-Authors: Kimford J. Meador, Nancy Browning, Laura A. Kalayjian, Andres Kanner, Joyce D. Liporace, Gus A. Baker, Jill Clayton-smith, Page B Pennell, Morris J. Cohen, Michael PriviteraAbstract:We previously reported that foetal valproate Exposure impairs intelligence quotient. In this follow-up investigation, we examined dose-related effects of foetal antiepileptic Drug Exposure on verbal and non-verbal cognitive measures. This investigation is an ongoing prospective observational multi-centre study in the USA and UK, which has enrolled pregnant females with epilepsy on monotherapy from 1999 to 2004. The study seeks to determine if differential long-term neurodevelopmental effects exist across four commonly used Drugs (carbamazepine, lamotrigine, phenytoin and valproate). This report compares verbal versus non-verbal cognitive outcomes in 216 children who completed testing at the age of three years. Verbal and non-verbal index scores were calculated from the Differential Ability Scales, Preschool Language Scale, Peabody Picture Vocabulary Test and Developmental Test of Visual-Motor Integration. Verbal abilities were lower than non-verbal in children exposed in utero to each Drug. Preconceptional folate use was associated with higher verbal outcomes. Valproate was associated with poorer cognitive outcomes. Performance was negatively associated with valproate dose for both verbal and non-verbal domains and negatively associated with carbamazepine dose for verbal performance. No dose effects were seen for lamotrigine and phenytoin. Since foetal antiepileptic Drug Exposure is associated with lower verbal than non-verbal abilities, language may be particularly susceptible to foetal Exposure. We hypothesize that foetal Drug Exposure may alter normal cerebral lateralization. Further, a dose-dependent relationship is present for both lower verbal and non-verbal abilities with valproate and for lower verbal abilities with carbamazepine. Preconceptional folate may improve cognitive outcomes. Additional research is needed to confirm these findings, extend the study to other Drugs, define the risks associated with Drug treatment for seizures in the neonates, and understand the underlying mechanisms.
