The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Chun-xia Zhao - One of the best experts on this subject based on the ideXlab platform.
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A numerical investigation of Drug Extravasation using a tumour–vasculature microfluidic device
Microfluidics and Nanofluidics, 2018Co-Authors: Hao-fei Wang, Sahan T. W. Kuruneru, Tong Wang, Emilie Sauret, Chun-xia ZhaoAbstract:Understanding Drug Extravasation from the leaky vasculature to tumour sites based on the enhanced permeability and retention effect (EPR) is of critical importance for designing and improving Drug delivery efficiency. This paper reports a tumour–vasculature microfluidic device consisting of two microchannels (top channel and bottom channel) separated by a porous membrane. To investigate Drug Extravasation, a numerical two-phase mixture model was developed and validated using experimental results. This is the first time that a two-phase mixture model is used to investigate Drug Extravasation through the simulated leaky vasculature in a microfluidic device. After the flow structures and Drug distribution were numerically examined, the effects of parameters including the velocity of blood flow, Drug concentration, and the degree of blood vessel leakiness as represented by the membrane porosity were systematically investigated. This numerical model offers a powerful tool to study Drug Extravasation through leaky vasculature, and the simulated results provide useful insights into Drug Extravasation and Drug accumulation at tumour sites.
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a numerical investigation of Drug Extravasation using a tumour vasculature microfluidic device
Microfluidics and Nanofluidics, 2018Co-Authors: Hao-fei Wang, Sahan T. W. Kuruneru, Tong Wang, Emilie Sauret, Chun-xia ZhaoAbstract:Understanding Drug Extravasation from the leaky vasculature to tumour sites based on the enhanced permeability and retention effect (EPR) is of critical importance for designing and improving Drug delivery efficiency. This paper reports a tumour–vasculature microfluidic device consisting of two microchannels (top channel and bottom channel) separated by a porous membrane. To investigate Drug Extravasation, a numerical two-phase mixture model was developed and validated using experimental results. This is the first time that a two-phase mixture model is used to investigate Drug Extravasation through the simulated leaky vasculature in a microfluidic device. After the flow structures and Drug distribution were numerically examined, the effects of parameters including the velocity of blood flow, Drug concentration, and the degree of blood vessel leakiness as represented by the membrane porosity were systematically investigated. This numerical model offers a powerful tool to study Drug Extravasation through leaky vasculature, and the simulated results provide useful insights into Drug Extravasation and Drug accumulation at tumour sites.
Majid Bazargan - One of the best experts on this subject based on the ideXlab platform.
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Effect of tumor shape, size, and tissue transport properties on Drug delivery to solid tumors
Journal of biological engineering, 2014Co-Authors: Mostafa Sefidgar, Madjid Soltani, Hossein Bazmara, Kaamran Raahemifar, Seyed Mojtaba Mousavi Nayinian, Majid BazarganAbstract:The computational methods provide condition for investigation related to the process of Drug delivery, such as convection and diffusion of Drug in extracellular matrices, Drug Extravasation from microvessels or to lymphatic vessels. The information of this process clarifies the mechanisms of Drug delivery from the injection site to absorption by a solid tumor. In this study, an advanced numerical method is used to solve fluid flow and solute transport equations simultaneously to investigate the effect of tumor shape and size on Drug delivery to solid tumor. The advanced mathematical model used in our previous work is further developed by adding solute transport equation to the governing equations. After applying appropriate boundary and initial conditions on tumor and surrounding tissue geometry, the element-based finite volume method is used for solving governing equations of Drug delivery in solid tumor. Also, the effects of size and shape of tumor and some of tissue transport parameters such as effective pressure and hydraulic conductivity on interstitial fluid flow and Drug delivery are investigated. Sensitivity analysis shows that Drug delivery in prolate shape is significantly better than other tumor shapes. Considering size effect, increasing tumor size decreases Drug concentration in interstitial fluid. This study shows that dependency of Drug concentration in interstitial fluid to osmotic and intravascular pressure is negligible. This study shows that among diffusion and convection mechanisms of Drug transport, diffusion is dominant in most different tumor shapes and sizes. In tumors in which the convection has considerable effect, the Drug concentration is larger than that of other tumors at the same time post injection.
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Effect of tumor shape, size, and tissue transport properties on Drug delivery to solid tumors
Journal of Biological Engineering, 2014Co-Authors: Mostafa Sefidgar, Madjid Soltani, Hossein Bazmara, Kaamran Raahemifar, Seyed Mojtaba Mousavi Nayinian, Majid BazarganAbstract:Background The computational methods provide condition for investigation related to the process of Drug delivery, such as convection and diffusion of Drug in extracellular matrices, Drug Extravasation from microvessels or to lymphatic vessels. The information of this process clarifies the mechanisms of Drug delivery from the injection site to absorption by a solid tumor. In this study, an advanced numerical method is used to solve fluid flow and solute transport equations simultaneously to investigate the effect of tumor shape and size on Drug delivery to solid tumor. Methods The advanced mathematical model used in our previous work is further developed by adding solute transport equation to the governing equations. After applying appropriate boundary and initial conditions on tumor and surrounding tissue geometry, the element-based finite volume method is used for solving governing equations of Drug delivery in solid tumor. Also, the effects of size and shape of tumor and some of tissue transport parameters such as effective pressure and hydraulic conductivity on interstitial fluid flow and Drug delivery are investigated. Results Sensitivity analysis shows that Drug delivery in prolate shape is significantly better than other tumor shapes. Considering size effect, increasing tumor size decreases Drug concentration in interstitial fluid. This study shows that dependency of Drug concentration in interstitial fluid to osmotic and intravascular pressure is negligible. Conclusions This study shows that among diffusion and convection mechanisms of Drug transport, diffusion is dominant in most different tumor shapes and sizes. In tumors in which the convection has considerable effect, the Drug concentration is larger than that of other tumors at the same time post injection.
Hao-fei Wang - One of the best experts on this subject based on the ideXlab platform.
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A numerical investigation of Drug Extravasation using a tumour–vasculature microfluidic device
Microfluidics and Nanofluidics, 2018Co-Authors: Hao-fei Wang, Sahan T. W. Kuruneru, Tong Wang, Emilie Sauret, Chun-xia ZhaoAbstract:Understanding Drug Extravasation from the leaky vasculature to tumour sites based on the enhanced permeability and retention effect (EPR) is of critical importance for designing and improving Drug delivery efficiency. This paper reports a tumour–vasculature microfluidic device consisting of two microchannels (top channel and bottom channel) separated by a porous membrane. To investigate Drug Extravasation, a numerical two-phase mixture model was developed and validated using experimental results. This is the first time that a two-phase mixture model is used to investigate Drug Extravasation through the simulated leaky vasculature in a microfluidic device. After the flow structures and Drug distribution were numerically examined, the effects of parameters including the velocity of blood flow, Drug concentration, and the degree of blood vessel leakiness as represented by the membrane porosity were systematically investigated. This numerical model offers a powerful tool to study Drug Extravasation through leaky vasculature, and the simulated results provide useful insights into Drug Extravasation and Drug accumulation at tumour sites.
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a numerical investigation of Drug Extravasation using a tumour vasculature microfluidic device
Microfluidics and Nanofluidics, 2018Co-Authors: Hao-fei Wang, Sahan T. W. Kuruneru, Tong Wang, Emilie Sauret, Chun-xia ZhaoAbstract:Understanding Drug Extravasation from the leaky vasculature to tumour sites based on the enhanced permeability and retention effect (EPR) is of critical importance for designing and improving Drug delivery efficiency. This paper reports a tumour–vasculature microfluidic device consisting of two microchannels (top channel and bottom channel) separated by a porous membrane. To investigate Drug Extravasation, a numerical two-phase mixture model was developed and validated using experimental results. This is the first time that a two-phase mixture model is used to investigate Drug Extravasation through the simulated leaky vasculature in a microfluidic device. After the flow structures and Drug distribution were numerically examined, the effects of parameters including the velocity of blood flow, Drug concentration, and the degree of blood vessel leakiness as represented by the membrane porosity were systematically investigated. This numerical model offers a powerful tool to study Drug Extravasation through leaky vasculature, and the simulated results provide useful insights into Drug Extravasation and Drug accumulation at tumour sites.
Puneet Goyal - One of the best experts on this subject based on the ideXlab platform.
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Morbidity of Chemotherapy Administration and Satisfaction in Breast Cancer Patients: A Comparative Study of Totally Implantable Venous Access Device (TIVAD) Versus Peripheral Venous Access Usage
World Journal of Surgery, 2014Co-Authors: Kul Ranjan Singh, Gaurav Agarwal, Gitika Nanda, Gyan Chand, Anjali Mishra, Amit Agarwal, Ashok K. Verma, Saroj K. Mishra, Puneet GoyalAbstract:Background This prospective, non-randomized, comparative study evaluated morbidity of chemotherapy administration via a totally implantable venous access device (TIVAD) versus peripheral intravenous access (PIVA), and satisfaction in breast cancer patients in a limited-resource setting. Methods Consecutive patients receiving chemotherapy via TIVAD ( n = 114) or PIVA ( n = 159) were studied. Venous access-related events were recorded. Morbidity and satisfaction with TIVAD or PIVA as perceived by the patients were assessed using a specifically designed questionnaire, which patients filled after 1st cycle of, and after completion of all chemotherapy. Results Patients in the two groups were of comparable age, body mass index, and disease stage. Acceptance of TIVAD was higher in literate patients. TIVAD did not interfere with sleep or activities in 90 % of patients. The majority (81.2 %) were satisfied with the cosmetic outcome, 91.5 % would have TIVAD re-inserted if the need arose, and 89.6 % would recommend it to others. Non-fatal complications occurred in 16 patients, and TIVAD had to be removed prematurely in five patients. In the PIVA group, 40 % needed multiple needle pricks and 55.8 % developed thrombophlebitis or staining of arms. Drug Extravasation and ulceration were suffered by 8.3 and 4.2 %, respectively. However, 78.3 % of patients reported no interference with daily activities and only 26 % would prefer a TIVAD. Those receiving more than six chemotherapy cycles were dissatisfied to a greater extent with PIVA ( p
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Morbidity of chemotherapy administration and satisfaction in breast cancer patients: a comparative study of totally implantable venous access device (TIVAD) versus peripheral venous access usage.
World journal of surgery, 2013Co-Authors: Kul Ranjan Singh, Gaurav Agarwal, Gitika Nanda, Gyan Chand, Anjali Mishra, Amit Agarwal, Ashok K. Verma, Saroj K. Mishra, Puneet GoyalAbstract:This prospective, non-randomized, comparative study evaluated morbidity of chemotherapy administration via a totally implantable venous access device (TIVAD) versus peripheral intravenous access (PIVA), and satisfaction in breast cancer patients in a limited-resource setting. Consecutive patients receiving chemotherapy via TIVAD (n = 114) or PIVA (n = 159) were studied. Venous access-related events were recorded. Morbidity and satisfaction with TIVAD or PIVA as perceived by the patients were assessed using a specifically designed questionnaire, which patients filled after 1st cycle of, and after completion of all chemotherapy. Patients in the two groups were of comparable age, body mass index, and disease stage. Acceptance of TIVAD was higher in literate patients. TIVAD did not interfere with sleep or activities in 90 % of patients. The majority (81.2 %) were satisfied with the cosmetic outcome, 91.5 % would have TIVAD re-inserted if the need arose, and 89.6 % would recommend it to others. Non-fatal complications occurred in 16 patients, and TIVAD had to be removed prematurely in five patients. In the PIVA group, 40 % needed multiple needle pricks and 55.8 % developed thrombophlebitis or staining of arms. Drug Extravasation and ulceration were suffered by 8.3 and 4.2 %, respectively. However, 78.3 % of patients reported no interference with daily activities and only 26 % would prefer a TIVAD. Those receiving more than six chemotherapy cycles were dissatisfied to a greater extent with PIVA (p < 0.05). Breast cancer chemotherapy via TIVAD is safe and convenient and results in high satisfaction levels, although it involves additional expenditure. Chemotherapy via PIVA is acceptable, albeit with lower satisfaction, more so in those receiving more than six chemotherapy cycles.
Mostafa Sefidgar - One of the best experts on this subject based on the ideXlab platform.
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Effect of tumor size on Drug delivery to lung tumors
2015 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS MIC), 2015Co-Authors: Madjid Soltani, Mostafa Sefidgar, Hossein Bazmara, Charles Marcus, Rathan M. Subramaniam, Arman RahmimAbstract:Drug delivery to solid tumors can be expressed physically using biomechanical phenomena such as convection, diffusion of Drug in extracellular matrices, and Drug Extravasation from microvessels. Applying computational methods to solve governing conservation equations clarifies the mechanisms of Drug delivery from the injection site to a solid tumor. In this study, multiple tumor geometries were obtained from PET/CT images. An advanced numerical method was used to solve fluid flow and solute transport equations simultaneously to investigate the effect of tumor size on Drug delivery to lung tumors. Data from 20 patients with lung tumors were analyzed and the tumor geometrical information including size, shape, and aspect ratios were classified. In order to investigate effect of tumor size, tumors with similar shapes but different sizes ranging from 1 to 28.6 cm3 were selected and analyzed. A hypothetical tumor, similar to one of the analyzed tumors but scaled to reduce its size to 0.2 cm3, was also analyzed. An ideal bolus injection was considered for the model. The effects of two transport mechanisms, namely convection and diffusion, were considered in this study. The results show because of size of considered lung tumor, the diffusion transport rate is higher than convection transport rate. Based on governing equations, the diffusion transport is only depended on concentration gradient and independent of size of tumor, therefore the predicted concentration profile for considered tumors are similar. When size of tumor is decreased significantly, the Drug concentration is also significantly increased.
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Effect of tumor shape, size, and tissue transport properties on Drug delivery to solid tumors
Journal of biological engineering, 2014Co-Authors: Mostafa Sefidgar, Madjid Soltani, Hossein Bazmara, Kaamran Raahemifar, Seyed Mojtaba Mousavi Nayinian, Majid BazarganAbstract:The computational methods provide condition for investigation related to the process of Drug delivery, such as convection and diffusion of Drug in extracellular matrices, Drug Extravasation from microvessels or to lymphatic vessels. The information of this process clarifies the mechanisms of Drug delivery from the injection site to absorption by a solid tumor. In this study, an advanced numerical method is used to solve fluid flow and solute transport equations simultaneously to investigate the effect of tumor shape and size on Drug delivery to solid tumor. The advanced mathematical model used in our previous work is further developed by adding solute transport equation to the governing equations. After applying appropriate boundary and initial conditions on tumor and surrounding tissue geometry, the element-based finite volume method is used for solving governing equations of Drug delivery in solid tumor. Also, the effects of size and shape of tumor and some of tissue transport parameters such as effective pressure and hydraulic conductivity on interstitial fluid flow and Drug delivery are investigated. Sensitivity analysis shows that Drug delivery in prolate shape is significantly better than other tumor shapes. Considering size effect, increasing tumor size decreases Drug concentration in interstitial fluid. This study shows that dependency of Drug concentration in interstitial fluid to osmotic and intravascular pressure is negligible. This study shows that among diffusion and convection mechanisms of Drug transport, diffusion is dominant in most different tumor shapes and sizes. In tumors in which the convection has considerable effect, the Drug concentration is larger than that of other tumors at the same time post injection.
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Effect of tumor shape, size, and tissue transport properties on Drug delivery to solid tumors
Journal of Biological Engineering, 2014Co-Authors: Mostafa Sefidgar, Madjid Soltani, Hossein Bazmara, Kaamran Raahemifar, Seyed Mojtaba Mousavi Nayinian, Majid BazarganAbstract:Background The computational methods provide condition for investigation related to the process of Drug delivery, such as convection and diffusion of Drug in extracellular matrices, Drug Extravasation from microvessels or to lymphatic vessels. The information of this process clarifies the mechanisms of Drug delivery from the injection site to absorption by a solid tumor. In this study, an advanced numerical method is used to solve fluid flow and solute transport equations simultaneously to investigate the effect of tumor shape and size on Drug delivery to solid tumor. Methods The advanced mathematical model used in our previous work is further developed by adding solute transport equation to the governing equations. After applying appropriate boundary and initial conditions on tumor and surrounding tissue geometry, the element-based finite volume method is used for solving governing equations of Drug delivery in solid tumor. Also, the effects of size and shape of tumor and some of tissue transport parameters such as effective pressure and hydraulic conductivity on interstitial fluid flow and Drug delivery are investigated. Results Sensitivity analysis shows that Drug delivery in prolate shape is significantly better than other tumor shapes. Considering size effect, increasing tumor size decreases Drug concentration in interstitial fluid. This study shows that dependency of Drug concentration in interstitial fluid to osmotic and intravascular pressure is negligible. Conclusions This study shows that among diffusion and convection mechanisms of Drug transport, diffusion is dominant in most different tumor shapes and sizes. In tumors in which the convection has considerable effect, the Drug concentration is larger than that of other tumors at the same time post injection.
