The Experts below are selected from a list of 285 Experts worldwide ranked by ideXlab platform
J.r. Jacobs - One of the best experts on this subject based on the ideXlab platform.
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Algorithm to control "effect compartment" Drug concentrations in pharmacokinetic model-driven Drug delivery
IEEE Transactions on Biomedical Engineering, 1993Co-Authors: J.r. Jacobs, E.a. WilliamsAbstract:In most computer-controlled pharmacokinetic model-driven Drug Infusion pumps, simulation of a linear compartmental pharmacokinetic model is used to compute the rate of intravenous Drug Infusion required to achieve setpoint central compartment (plasma) Drug concentrations. For many Drugs, it has been suggested that it is the Drug concentration in a hypothetical "effect" compartment, rather than in the plasma, that should be manipulated to achieve maximum control over pharmacologic action. Controlling the effect compartment Drug concentration is algorithmically more difficult than controlling the central compartment Drug concentration because of the time delay between administration of Drug into the central compartment and its subsequent appearance in the effect compartment. The authors present a model-based dosing algorithm for use in pharmacokinetic model-driven Drug Infusion devices that target the theoretical effect compartment Drug concentration.
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Accuracy of Drug Infusion pumps under computer control
IEEE Transactions on Biomedical Engineering, 1992Co-Authors: S.b. Connor, T.j. Quill, J.r. JacobsAbstract:Infusion rates demanded of the Infusion pump in many computer-controlled Drug delivery applications are made to change at intervals much shorter than those encountered under routine clinical use. The purpose of this study was to validate the volumetric accuracy of three commercially available Infusion pumps operating in a demanding computer-controlled application. In independent 2-h evaluations, the Infusion rate demanded of each pump changed as often as every 5, 10, or 15 s using an algorithm for computer-controlled pharmacokinetic model-driven intravenous Infusion. Accuracy of the Infusion devices was determined gravimetrically. At all measurement times, each of the Infusion pumps was accurate to within approximately +or-5% of the expected volumetric output under each of the Infusion rate intervals tested. Flow rate accuracy of +or-5% is equal to the nominal expected accuracy of these Infusion pumps in conventional clinical use.
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Algorithm for optimal linear model-based control with application to pharmacokinetic model-driven Drug delivery
IEEE Transactions on Biomedical Engineering, 1990Co-Authors: J.r. JacobsAbstract:Computerized pharmacokinetic-model-driven administration of intravenous anesthetic agents has been implemented using a variety of algorithms to control the Drug Infusion regimen. All such algorithms are similar to the extent that they use a linear pharmacokinetic model of the Drug being administered to determine Drug Infusion rates that theoretically achieve and maintain plasma Drug concentrations (setpoints) specified by the physician. Since the behavior of the pharmacokinetic model can be computed for any input, it should be possible to achieve regulation of the Drug Infusion rates that is flexible (i.e. the physician can interactively adjust the setpoint), practical, and analytically optimized; these objectives are realized by the algorithm described.
Karolos Grigoriadis - One of the best experts on this subject based on the ideXlab platform.
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SMC - Bayesian Estimation for Model Parameters and Time Delay of Blood Pressure Response to Phenylephrine Drug Infusion
2018 IEEE International Conference on Systems Man and Cybernetics (SMC), 2018Co-Authors: Feisheng Yang, Karolos GrigoriadisAbstract:Patient blood pressure response to phenylephrine (PHP) Drug Infusion is modeled as intra-and-inter-variability model with time delay. This paper proposes a novel Bayesian-filtering-based approach for real-time estimating the model parameters variability and Drug transport delay (time delay). From data-driven perspective, cross-correlation (XCF) of mean arterial pressure (MAP) measurement with Drug Infusion provides prior knowledge of time delay estimation, and cubature Kalman filter (CKF) supplies nonlinearity estimation of model parameters and posterior knowledge of time delay. The Bayesian-filtering-based approach was validated in sequential mechanism with animal experimental data. Real-time experimental test convinced the superiority of the proposed approach than multiple-model EKF (MMEKF) in both estimation accuracy of MAP and Drug transport delay estimation and sensitivity analysis of model parameters and Drug transportation delay estimation.
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Bayesian Estimation for Model Parameters and Time Delay of Blood Pressure Response to Phenylephrine Drug Infusion
2018 IEEE International Conference on Systems Man and Cybernetics (SMC), 2018Co-Authors: Feisheng Yang, Karolos GrigoriadisAbstract:Patient blood pressure response to phenylephrine (PHP) Drug Infusion is modeled as intra-and-inter-variability model with time delay. This paper proposes a novel Bayesian-filtering-based approach for real-time estimating the model parameters variability and Drug transport delay (time delay). From data-driven perspective, cross-correlation (XCF) of mean arterial pressure (MAP) measurement with Drug Infusion provides prior knowledge of time delay estimation, and cubature Kalman filter (CKF) supplies nonlinearity estimation of model parameters and posterior knowledge of time delay. The Bayesian-filtering-based approach was validated in sequential mechanism with animal experimental data. Real-time experimental test convinced the superiority of the proposed approach than multiple-model EKF (MMEKF) in both estimation accuracy of MAP and Drug transport delay estimation and sensitivity analysis of model parameters and Drug transportation delay estimation.
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Adaptive Parameter Estimation of Blood Pressure Dynamics Subject to Vasoactive Drug Infusion
IEEE Transactions on Control Systems Technology, 2016Co-Authors: Tamás Luspay, Karolos GrigoriadisAbstract:Dynamic modeling of arterial blood pressure change subject to vasoactive Drug Infusion can be a valuable tool for computerized decision support of Drug administration as well as for automated closed-loop Drug delivery to treat hypotension in emergency trauma care. A time-varying time-delayed first-order dynamic model is considered to describe blood pressure response due to continuous injection of the vasorestrictive Drug phenylephrine (PHP). The patient-to-patient as well as intrapatient variability of the dynamic response is taken into account by online identification of the varying model parameters. A multiple-model extended Kalman filter (MMEKF) structure is developed for the real-time estimation of mean arterial pressure and the dynamic blood pressure response model to PHP Infusion to assist treatment. Convergence analysis is carried out, along with comparison with offline identification methods. Static Drug-response curves for dosage recommendation are obtained from the estimation of the model sensitivity parameter. Finally, a detection algorithm is proposed to identify abrupt model variations caused by sudden physiological changes, such as hemorrhage. The proposed MMEKF parameter estimation method and the hemorrhage detection algorithm are tested and validated using data from animal experiments on anesthetized healthy and hemorrhagic swine that are subject to PHP Infusion.
Nikola Blazevic - One of the best experts on this subject based on the ideXlab platform.
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time dependent diuretic response in rats treated with juniper berry preparations
Phytotherapy Research, 1998Co-Authors: Gordana Stanic, Ita Samaržija, Nikola BlazevicAbstract:The Infusion and the essential oil of juniper berries (Juniperus communis L.) as well as terpinen-4-ol were tested for diuresis response in rats. GC analysis of the oil obtained from the Drug sample revealed that the ratio between the pinene fraction and terpinen-4-ol was 5:1. In a 1 day experiment the effect of diuresis reduction was observed and compared with the effect of vasopressin (ADH). The effect of the smallest dose of ADH (0.004 IU/100 g b.w.) intraperitoneally administered was comparable to the effect of a 10% Drug Infusion and 0.1% essential oil solution, while the effect of 0.4 IU/100 g b.w. of ADH was comparable to that of a 0.01% solution of terpinen-4-ol. During a 3 day experiment diuresis was stimulated after the second application and especially after the third application of test solutions. Among tested preparations a 10% Drug Infusion exerted the most considerable diuretic activity. After 72 h, i.e. three oral doses of 5 mL/100 g b.w. of Drug Infusion, the cumulative urine volume was 44% above the control value. The results suggest that the diuretic activity of juniper berries cannot be attributed only to the essential oil but also to hydrophilic Drug constituents. Copyright © 1998 John Wiley & Sons, Ltd.
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Time‐dependent diuretic response in rats treated with Juniper berry preparations
Phytotherapy Research, 1998Co-Authors: Gordana Stanic, Ita Samaržija, Nikola BlazevicAbstract:The Infusion and the essential oil of juniper berries (Juniperus communis L.) as well as terpinen-4-ol were tested for diuresis response in rats. GC analysis of the oil obtained from the Drug sample revealed that the ratio between the pinene fraction and terpinen-4-ol was 5:1. In a 1 day experiment the effect of diuresis reduction was observed and compared with the effect of vasopressin (ADH). The effect of the smallest dose of ADH (0.004 IU/100 g b.w.) intraperitoneally administered was comparable to the effect of a 10% Drug Infusion and 0.1% essential oil solution, while the effect of 0.4 IU/100 g b.w. of ADH was comparable to that of a 0.01% solution of terpinen-4-ol. During a 3 day experiment diuresis was stimulated after the second application and especially after the third application of test solutions. Among tested preparations a 10% Drug Infusion exerted the most considerable diuretic activity. After 72 h, i.e. three oral doses of 5 mL/100 g b.w. of Drug Infusion, the cumulative urine volume was 44% above the control value. The results suggest that the diuretic activity of juniper berries cannot be attributed only to the essential oil but also to hydrophilic Drug constituents. Copyright © 1998 John Wiley & Sons, Ltd.
E.a. Williams - One of the best experts on this subject based on the ideXlab platform.
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Algorithm to control "effect compartment" Drug concentrations in pharmacokinetic model-driven Drug delivery
IEEE Transactions on Biomedical Engineering, 1993Co-Authors: J.r. Jacobs, E.a. WilliamsAbstract:In most computer-controlled pharmacokinetic model-driven Drug Infusion pumps, simulation of a linear compartmental pharmacokinetic model is used to compute the rate of intravenous Drug Infusion required to achieve setpoint central compartment (plasma) Drug concentrations. For many Drugs, it has been suggested that it is the Drug concentration in a hypothetical "effect" compartment, rather than in the plasma, that should be manipulated to achieve maximum control over pharmacologic action. Controlling the effect compartment Drug concentration is algorithmically more difficult than controlling the central compartment Drug concentration because of the time delay between administration of Drug into the central compartment and its subsequent appearance in the effect compartment. The authors present a model-based dosing algorithm for use in pharmacokinetic model-driven Drug Infusion devices that target the theoretical effect compartment Drug concentration.
Gordana Stanic - One of the best experts on this subject based on the ideXlab platform.
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time dependent diuretic response in rats treated with juniper berry preparations
Phytotherapy Research, 1998Co-Authors: Gordana Stanic, Ita Samaržija, Nikola BlazevicAbstract:The Infusion and the essential oil of juniper berries (Juniperus communis L.) as well as terpinen-4-ol were tested for diuresis response in rats. GC analysis of the oil obtained from the Drug sample revealed that the ratio between the pinene fraction and terpinen-4-ol was 5:1. In a 1 day experiment the effect of diuresis reduction was observed and compared with the effect of vasopressin (ADH). The effect of the smallest dose of ADH (0.004 IU/100 g b.w.) intraperitoneally administered was comparable to the effect of a 10% Drug Infusion and 0.1% essential oil solution, while the effect of 0.4 IU/100 g b.w. of ADH was comparable to that of a 0.01% solution of terpinen-4-ol. During a 3 day experiment diuresis was stimulated after the second application and especially after the third application of test solutions. Among tested preparations a 10% Drug Infusion exerted the most considerable diuretic activity. After 72 h, i.e. three oral doses of 5 mL/100 g b.w. of Drug Infusion, the cumulative urine volume was 44% above the control value. The results suggest that the diuretic activity of juniper berries cannot be attributed only to the essential oil but also to hydrophilic Drug constituents. Copyright © 1998 John Wiley & Sons, Ltd.
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Time‐dependent diuretic response in rats treated with Juniper berry preparations
Phytotherapy Research, 1998Co-Authors: Gordana Stanic, Ita Samaržija, Nikola BlazevicAbstract:The Infusion and the essential oil of juniper berries (Juniperus communis L.) as well as terpinen-4-ol were tested for diuresis response in rats. GC analysis of the oil obtained from the Drug sample revealed that the ratio between the pinene fraction and terpinen-4-ol was 5:1. In a 1 day experiment the effect of diuresis reduction was observed and compared with the effect of vasopressin (ADH). The effect of the smallest dose of ADH (0.004 IU/100 g b.w.) intraperitoneally administered was comparable to the effect of a 10% Drug Infusion and 0.1% essential oil solution, while the effect of 0.4 IU/100 g b.w. of ADH was comparable to that of a 0.01% solution of terpinen-4-ol. During a 3 day experiment diuresis was stimulated after the second application and especially after the third application of test solutions. Among tested preparations a 10% Drug Infusion exerted the most considerable diuretic activity. After 72 h, i.e. three oral doses of 5 mL/100 g b.w. of Drug Infusion, the cumulative urine volume was 44% above the control value. The results suggest that the diuretic activity of juniper berries cannot be attributed only to the essential oil but also to hydrophilic Drug constituents. Copyright © 1998 John Wiley & Sons, Ltd.
