The Experts below are selected from a list of 24615 Experts worldwide ranked by ideXlab platform
Jun Lin - One of the best experts on this subject based on the ideXlab platform.
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dna hybrid gated photothermal mesoporous silica nanoparticles for nir responsive and aptamer targeted Drug delivery
ACS Applied Materials & Interfaces, 2015Co-Authors: Yuanxin Zhang, Zhiyao Hou, Ziyong Cheng, Kerong Deng, Bei Liu, Jun LinAbstract:Near-infrared light is an attractive stimulus due to its noninvasive and deep tissue penetration. Particularly, NIR light is utilized for cancer thermotherapy and on-demand release of Drugs by the disruption of the delivery carriers. Here we have prepared a novel NIR-responsive DNA-hybrid-gated nanocarrier based on mesoporous silica-coated Cu1.8S nanoparticles. Cu1.8S nanoparticles, possessing high photothermal conversion efficiency under a 980 nm laser, were chosen as photothermal agents. The mesoporous silica structure could be used for Drug Storage/delivery and modified with aptamer-modified GC-rich DNA-helix as gatekeepers, Drug vectors, and targeting ligand. Simultaneously, the as-produced photothermal effect caused denaturation of DNA double strands, which triggered the Drug release of the DNA-helix-loaded hydrophilic Drug doxorubicin and mesopore-loaded hydrophobic Drug curcumin, resulting in a synergistic therapeutic effect. The Cu1.8S@mSiO2 nanocomposites endocytosed by cancer cells through the a...
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aptamer mediated up conversion core mof shell nanocomposites for targeted Drug delivery and cell imaging
Scientific Reports, 2015Co-Authors: Kerong Deng, Zhiyao Hou, Ziyong Cheng, Yuanxin Zhang, Chunxia Li, Xuejiao Li, Xiaoran Deng, Jun LinAbstract:Multifunctional nanocarriers for targeted bioimaging and Drug delivery have attracted much attention in early diagnosis and therapy of cancer. In this work, we develop a novel aptamer-guided nanocarrier based on the mesoporous metal-organic framework (MOF) shell and up-conversion luminescent NaYF4:Yb3+/Er3+ nanoparticles (UCNPs) core for the first time to achieve these goals. These UCNPs, chosen as optical labels in biological assays and medical imaging, could emit strong green emission under 980 nm laser. The MOF structure based on iron (III) carboxylate materials [MIL-100 (Fe)] possesses high porosity and non-toxicity, which is of great value as nanocarriers for Drug Storage/delivery. As a unique nanoplatform, the hybrid inorganic-organic Drug delivery vehicles show great promising for simultaneous targeted labeling and therapy of cancer cells.
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hollow structured upconversion luminescent nayf4 yb3 er3 nanospheres for cell imaging and targeted anti cancer Drug delivery
Biomaterials, 2013Co-Authors: Dongmei Yang, Zhiyao Hou, Ziyong Cheng, Chunxia Li, Xiaojiao Kang, Yunlu Dai, Jun LinAbstract:Uniform alpha-NaYF4:Yb3+, Er3+ nanospheres (similar to 130 nm) with mesoporous shell and hollow interior structure were synthesized by using Y(OH)CO3:Yb3+, Er3+ nanospheres (NPs) as sacrificial templates via a surface-protected "etching" and hydrothermal ion-exchange process. In this process, polyethylenimine (PEI) ligands played a key role in formation of the hollow structured alpha-NaYF4 nanospheres, i.e., they can effectively protect the surface of the Y(OH)CO3 from rapid dissolution by H+. Moreover, folic acid (FA), a commonly used cancer-targeting agent was conjugated on the surface of NPs based on the presence of free amine groups. The as-prepared FA-modified hollow NPs can be performed as anti-cancer Drug carriers for the investigation of Drug Storage/release properties, which exhibit greater cytotoxicity than DOX-loaded alpha-NaYF4 NPs due to the specific cell uptake by HeLa cells via FA receptor-mediate endocytosis. Furthermore, upconversion (UC) luminescence images of FA-modified alpha-NaYF4:Yb3+, Er3+ NPs uptaken by cells shows bright green emission without background noise under 980 nm infrared laser excitation. Thus, these multifunctional nanospheres combining UC luminescent property and hollow and mesoporous structure have potential for simultaneous targeted anti-cancer Drug delivery and cell imaging. (C) 2012 Elsevier Ltd. All rights reserved.
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self activated luminescent and mesoporous strontium hydroxyapatite nanorods for Drug delivery
Biomaterials, 2010Co-Authors: Cuimiao Zhang, Zhiyao Hou, Piaoping Yang, Ziyong Cheng, Chong Peng, Shanshan Huang, Jun LinAbstract:Multifunctional strontium hydroxyapatite (SrHAp) nanorods with luminescent and mesoporous properties have been successfully synthesized by a hydrothermal method. SEM and TEM images indicate that the mesoporous SrHAp samples consist of monodiperse nanorods with lengths of 120-150 nm, diameters of around 20 nm, and the mesopore size of 3-5 nm. The as-obtained SrHAp nanorods show an intense bright blue emission (centered at 432 nm, lifetime 11.6 ns, quantum efficiency: 22%), which might arise from CO2 center dot(-) radical impurities in the crystal lattice under long-wavelength UV-light irradiation. Furthermore, the amount of trisodium citrate has an obvious impact on the particle size and the luminescence properties of the products, respectively. The Drug Storage/release test indicates that the luminescent SrHAp nanorods show a Drug loading and controlled release properties for ibuprofen (IBU). Additionally, the emission intensity of SrHAp in the Drug carrier system increases with the cumulative released amount of IBU, making the Drug release might be easily tracked and monitored by the change of the luminescence intensity. This luminescent material may be potentially applied in the Drug delivery and disease therapy fields. (C) 2010 Elsevier Ltd. All rights reserved.
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bioactive luminescent and mesoporous europium doped hydroxyapatite as a Drug carrier
Biomaterials, 2008Co-Authors: Piaoping Yang, Hongzhou Lian, Zewei Quan, Xiaojiao Kang, Jun LinAbstract:Bioactive, luminescent and mesoporous europium-doped hydroxyapatite (Eu:HAp) was successfully prepared through a simple one-step route using cationic surfactant as template. The obtained multifunctional hydroxyapatite was performed as a Drug delivery carrier to investigate the Drug Storage/release properties using ibuprofen (IBU) as a model Drug. The structural, morphological, textural and optical properties were well characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectra (XPS), Fourier transform infrared spectroscopy (FT-IR), N(2) adsorption/desorption, and photoluminescence (PL) spectra, respectively. The results reveal that the multifunctional hydroxyapatites exhibit the typical ordered characteristics of the hexagonal mesostructure, and have rod-like morphology with the particle size of 20-40 nm in width and 100-200 nm in length. The Drug Storage/release test indicates that the luminescent HAp shows much similar Drug loading amount and cumulative release rate to those of pure HAp. Interestingly, the IBU-loaded samples still show red luminescence of Eu(3+) ((5)D(0)-(7)F(1),(2)) under UV irradiation, and the emission intensities of Eu(3+) in the Drug carrier system vary with the released amount of IBU, thus making the Drug release be easily tracked and monitored by the change of the luminescence intensity.
Piaoping Yang - One of the best experts on this subject based on the ideXlab platform.
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electrospinning preparation and Drug delivery properties of an up conversion luminescent porous nayf4 yb3 er3 silica fiber nanocomposite
Advanced Functional Materials, 2011Co-Authors: Zhiyao Hou, Dongmei Yang, Ziyong Cheng, Chong Peng, Piaoping YangAbstract:Up-conversion (UC) luminescent porous silica fibers decorated with NaYF(4):Yb(3+), Er(3+) nanocrystals (NCs) (denoted as NaYF(4):Yb(3+), Er(3+)@silica fiber) are prepared by the electrospinning process using cationic surfactant P123 as a template. Monodisperse and hydrophobic oleic acid capped beta-NaYF(4): Yb(3+), Er(3+) NCs are prepared by thermal decomposition methodology. Then, these NCs are transferred into aqueous solution by employing cetyltrimethylammonium bromide (CTAB) as secondary surfactant. The water-dispersible beta-NaYF(4):Yb(3+), Er(3+) NCs are dispersed into precursor electrospinning solution containing P123 and tetraethyl orthosilicate (TEOS), followed by preparation of precursor fibers via electrospinning. Finally, porous alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber nanocomposites are obtained after annealing the precursor fibers containing beta-NaYF(4):Yb(3+), Er(3+) at 550 degrees C. The as-prepared alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber possesses porous structure and UC luminescence properties simultaneously. Furthermore, the obtained nanocomposites can be used as a Drug delivery host carrier and Drug Storage/release properties are investigated, using ibuprofen (IBU) as a model Drug. The results indicate that the IBU-loaded alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber nanocomposites show UC emission of Er(3+) under 980 nm NIR laser excitation and a controlled release property for IBU. Meanwhile, the UC emission intensity of IBU-alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber system varies with the released amount of IBU.
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luminescent mesoporous and bioactive europium doped calcium silicate mcs eu3 as a Drug carrier
Journal of Colloid and Interface Science, 2011Co-Authors: Shanshan Huang, Piaoping Yang, Hongzhou Lian, Jinhua Jiang, Guogang Li, Ziyong ChengAbstract:Abstract Luminescent, mesoporous, and bioactive europium-doped calcium silicate (MCS: Eu) was successfully synthesized. The obtained MCS: Eu3+ was performed as a Drug delivery carrier to investigate the Drug Storage/release properties using ibuprofen (IBU) as the model Drug. The structural, morphological, textural, and optical properties were well characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), N2 adsorption/desorption, and photoluminescence (PL) spectra, respectively. The results reveal that the MCS: Eu exhibits the typical ordered characteristics of the mesostructure. This composite shows a sustained release profile with IBU as the model Drug. The IBU-loaded samples still present red luminescence of Eu3+ (5D0–7F1,2) under UV irradiation. The emission intensities of Eu3+ in the Drug carrier system vary with the amount of released IBU, making the Drug release easily tracked and monitored. The system demonstrates a great potential for Drug delivery and disease therapy.
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self activated luminescent and mesoporous strontium hydroxyapatite nanorods for Drug delivery
Biomaterials, 2010Co-Authors: Cuimiao Zhang, Zhiyao Hou, Piaoping Yang, Ziyong Cheng, Chong Peng, Shanshan Huang, Jun LinAbstract:Multifunctional strontium hydroxyapatite (SrHAp) nanorods with luminescent and mesoporous properties have been successfully synthesized by a hydrothermal method. SEM and TEM images indicate that the mesoporous SrHAp samples consist of monodiperse nanorods with lengths of 120-150 nm, diameters of around 20 nm, and the mesopore size of 3-5 nm. The as-obtained SrHAp nanorods show an intense bright blue emission (centered at 432 nm, lifetime 11.6 ns, quantum efficiency: 22%), which might arise from CO2 center dot(-) radical impurities in the crystal lattice under long-wavelength UV-light irradiation. Furthermore, the amount of trisodium citrate has an obvious impact on the particle size and the luminescence properties of the products, respectively. The Drug Storage/release test indicates that the luminescent SrHAp nanorods show a Drug loading and controlled release properties for ibuprofen (IBU). Additionally, the emission intensity of SrHAp in the Drug carrier system increases with the cumulative released amount of IBU, making the Drug release might be easily tracked and monitored by the change of the luminescence intensity. This luminescent material may be potentially applied in the Drug delivery and disease therapy fields. (C) 2010 Elsevier Ltd. All rights reserved.
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luminescent and mesoporous europium doped bioactive glasses mbg as a Drug carrier
Journal of Physical Chemistry C, 2009Co-Authors: Piaoping Yang, Shanshan Huang, Jinhua Jiang, Hongzhou LianAbstract:Luminescent and mesoporous europium-doped bioactive glasses (MBG:Eu) were successfully synthesized by a two-step acid-catalyzed self-assembly process combined with hydrothermal treatment in an inorganic−organic system. The obtained MBG was performed as a Drug delivery carrier to investigate the Drug Storage/release properties using ibuprofen (IBU) as a model Drug. The structural, morphological, textural and optical properties were well characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), N2 adsorption/desorption, and photoluminescence (PL) spectra, respectively. The results reveal that the MBG exhibit the typical ordered characteristics of the hexagonal mesostructure. This composite shows sustained release profile with ibuprofen as the model Drug. The IBU-loaded samples still show red luminescence of Eu3+ (5D0-7F1, 2) under UV irradiation, and the emission intensities of Eu3+ in the Drug carrier system vary with the released amount of IBU, thus making the Drug release be easil...
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bioactive luminescent and mesoporous europium doped hydroxyapatite as a Drug carrier
Biomaterials, 2008Co-Authors: Piaoping Yang, Hongzhou Lian, Zewei Quan, Xiaojiao Kang, Jun LinAbstract:Bioactive, luminescent and mesoporous europium-doped hydroxyapatite (Eu:HAp) was successfully prepared through a simple one-step route using cationic surfactant as template. The obtained multifunctional hydroxyapatite was performed as a Drug delivery carrier to investigate the Drug Storage/release properties using ibuprofen (IBU) as a model Drug. The structural, morphological, textural and optical properties were well characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectra (XPS), Fourier transform infrared spectroscopy (FT-IR), N(2) adsorption/desorption, and photoluminescence (PL) spectra, respectively. The results reveal that the multifunctional hydroxyapatites exhibit the typical ordered characteristics of the hexagonal mesostructure, and have rod-like morphology with the particle size of 20-40 nm in width and 100-200 nm in length. The Drug Storage/release test indicates that the luminescent HAp shows much similar Drug loading amount and cumulative release rate to those of pure HAp. Interestingly, the IBU-loaded samples still show red luminescence of Eu(3+) ((5)D(0)-(7)F(1),(2)) under UV irradiation, and the emission intensities of Eu(3+) in the Drug carrier system vary with the released amount of IBU, thus making the Drug release be easily tracked and monitored by the change of the luminescence intensity.
Ziyong Cheng - One of the best experts on this subject based on the ideXlab platform.
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dna hybrid gated photothermal mesoporous silica nanoparticles for nir responsive and aptamer targeted Drug delivery
ACS Applied Materials & Interfaces, 2015Co-Authors: Yuanxin Zhang, Zhiyao Hou, Ziyong Cheng, Kerong Deng, Bei Liu, Jun LinAbstract:Near-infrared light is an attractive stimulus due to its noninvasive and deep tissue penetration. Particularly, NIR light is utilized for cancer thermotherapy and on-demand release of Drugs by the disruption of the delivery carriers. Here we have prepared a novel NIR-responsive DNA-hybrid-gated nanocarrier based on mesoporous silica-coated Cu1.8S nanoparticles. Cu1.8S nanoparticles, possessing high photothermal conversion efficiency under a 980 nm laser, were chosen as photothermal agents. The mesoporous silica structure could be used for Drug Storage/delivery and modified with aptamer-modified GC-rich DNA-helix as gatekeepers, Drug vectors, and targeting ligand. Simultaneously, the as-produced photothermal effect caused denaturation of DNA double strands, which triggered the Drug release of the DNA-helix-loaded hydrophilic Drug doxorubicin and mesopore-loaded hydrophobic Drug curcumin, resulting in a synergistic therapeutic effect. The Cu1.8S@mSiO2 nanocomposites endocytosed by cancer cells through the a...
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aptamer mediated up conversion core mof shell nanocomposites for targeted Drug delivery and cell imaging
Scientific Reports, 2015Co-Authors: Kerong Deng, Zhiyao Hou, Ziyong Cheng, Yuanxin Zhang, Chunxia Li, Xuejiao Li, Xiaoran Deng, Jun LinAbstract:Multifunctional nanocarriers for targeted bioimaging and Drug delivery have attracted much attention in early diagnosis and therapy of cancer. In this work, we develop a novel aptamer-guided nanocarrier based on the mesoporous metal-organic framework (MOF) shell and up-conversion luminescent NaYF4:Yb3+/Er3+ nanoparticles (UCNPs) core for the first time to achieve these goals. These UCNPs, chosen as optical labels in biological assays and medical imaging, could emit strong green emission under 980 nm laser. The MOF structure based on iron (III) carboxylate materials [MIL-100 (Fe)] possesses high porosity and non-toxicity, which is of great value as nanocarriers for Drug Storage/delivery. As a unique nanoplatform, the hybrid inorganic-organic Drug delivery vehicles show great promising for simultaneous targeted labeling and therapy of cancer cells.
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upconversion luminescent core mesoporous silica shell structured β nayf4 yb3 er3 sio2 msio2 composite nanospheres fabrication and Drug Storage release properties
European Journal of Inorganic Chemistry, 2014Co-Authors: Chunxia Li, Dongmei Yang, Ziyong Cheng, Hongzhou Lian, Shanshan HuangAbstract:We present the fabrication, upconversion-luminescence cell imaging, and Drug-Storage/release properties of upconversion-luminescent core/mesoporous-silica-shell-structured -nayf4:yb3+,er3+@sio2@msio(2) composite nanospheres with a size of 80 nm. the biocompatibility test on l929 fibroblast cells using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay reveals the low cytotoxicity of the system. the Drug-Storage and in vitro release tests indicate that these multifunctional nanomaterials have controlled Drug-loading and -release properties for ibuprofen (ibu). moreover, the upconversion (uc) emission intensity of ibu--nayf4:yb3+,er3+@sio2@msio(2) composite nanospheres increases gradually along with the released amount of ibu. additionally, upconversion luminescence images of -nayf4:yb3+,er3+@sio2@msio(2) uptaken by cells show clear green emission under 980 nm infrared laser excitation. these findings make these material promising for applications in the bioimaging, Drug delivery, and disease therapy fields on the basis of its upconversion-luminescent and mesoporous properties.
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hollow structured upconversion luminescent nayf4 yb3 er3 nanospheres for cell imaging and targeted anti cancer Drug delivery
Biomaterials, 2013Co-Authors: Dongmei Yang, Zhiyao Hou, Ziyong Cheng, Chunxia Li, Xiaojiao Kang, Yunlu Dai, Jun LinAbstract:Uniform alpha-NaYF4:Yb3+, Er3+ nanospheres (similar to 130 nm) with mesoporous shell and hollow interior structure were synthesized by using Y(OH)CO3:Yb3+, Er3+ nanospheres (NPs) as sacrificial templates via a surface-protected "etching" and hydrothermal ion-exchange process. In this process, polyethylenimine (PEI) ligands played a key role in formation of the hollow structured alpha-NaYF4 nanospheres, i.e., they can effectively protect the surface of the Y(OH)CO3 from rapid dissolution by H+. Moreover, folic acid (FA), a commonly used cancer-targeting agent was conjugated on the surface of NPs based on the presence of free amine groups. The as-prepared FA-modified hollow NPs can be performed as anti-cancer Drug carriers for the investigation of Drug Storage/release properties, which exhibit greater cytotoxicity than DOX-loaded alpha-NaYF4 NPs due to the specific cell uptake by HeLa cells via FA receptor-mediate endocytosis. Furthermore, upconversion (UC) luminescence images of FA-modified alpha-NaYF4:Yb3+, Er3+ NPs uptaken by cells shows bright green emission without background noise under 980 nm infrared laser excitation. Thus, these multifunctional nanospheres combining UC luminescent property and hollow and mesoporous structure have potential for simultaneous targeted anti-cancer Drug delivery and cell imaging. (C) 2012 Elsevier Ltd. All rights reserved.
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electrospinning preparation and Drug delivery properties of an up conversion luminescent porous nayf4 yb3 er3 silica fiber nanocomposite
Advanced Functional Materials, 2011Co-Authors: Zhiyao Hou, Dongmei Yang, Ziyong Cheng, Chong Peng, Piaoping YangAbstract:Up-conversion (UC) luminescent porous silica fibers decorated with NaYF(4):Yb(3+), Er(3+) nanocrystals (NCs) (denoted as NaYF(4):Yb(3+), Er(3+)@silica fiber) are prepared by the electrospinning process using cationic surfactant P123 as a template. Monodisperse and hydrophobic oleic acid capped beta-NaYF(4): Yb(3+), Er(3+) NCs are prepared by thermal decomposition methodology. Then, these NCs are transferred into aqueous solution by employing cetyltrimethylammonium bromide (CTAB) as secondary surfactant. The water-dispersible beta-NaYF(4):Yb(3+), Er(3+) NCs are dispersed into precursor electrospinning solution containing P123 and tetraethyl orthosilicate (TEOS), followed by preparation of precursor fibers via electrospinning. Finally, porous alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber nanocomposites are obtained after annealing the precursor fibers containing beta-NaYF(4):Yb(3+), Er(3+) at 550 degrees C. The as-prepared alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber possesses porous structure and UC luminescence properties simultaneously. Furthermore, the obtained nanocomposites can be used as a Drug delivery host carrier and Drug Storage/release properties are investigated, using ibuprofen (IBU) as a model Drug. The results indicate that the IBU-loaded alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber nanocomposites show UC emission of Er(3+) under 980 nm NIR laser excitation and a controlled release property for IBU. Meanwhile, the UC emission intensity of IBU-alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber system varies with the released amount of IBU.
Zhiyao Hou - One of the best experts on this subject based on the ideXlab platform.
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dna hybrid gated photothermal mesoporous silica nanoparticles for nir responsive and aptamer targeted Drug delivery
ACS Applied Materials & Interfaces, 2015Co-Authors: Yuanxin Zhang, Zhiyao Hou, Ziyong Cheng, Kerong Deng, Bei Liu, Jun LinAbstract:Near-infrared light is an attractive stimulus due to its noninvasive and deep tissue penetration. Particularly, NIR light is utilized for cancer thermotherapy and on-demand release of Drugs by the disruption of the delivery carriers. Here we have prepared a novel NIR-responsive DNA-hybrid-gated nanocarrier based on mesoporous silica-coated Cu1.8S nanoparticles. Cu1.8S nanoparticles, possessing high photothermal conversion efficiency under a 980 nm laser, were chosen as photothermal agents. The mesoporous silica structure could be used for Drug Storage/delivery and modified with aptamer-modified GC-rich DNA-helix as gatekeepers, Drug vectors, and targeting ligand. Simultaneously, the as-produced photothermal effect caused denaturation of DNA double strands, which triggered the Drug release of the DNA-helix-loaded hydrophilic Drug doxorubicin and mesopore-loaded hydrophobic Drug curcumin, resulting in a synergistic therapeutic effect. The Cu1.8S@mSiO2 nanocomposites endocytosed by cancer cells through the a...
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aptamer mediated up conversion core mof shell nanocomposites for targeted Drug delivery and cell imaging
Scientific Reports, 2015Co-Authors: Kerong Deng, Zhiyao Hou, Ziyong Cheng, Yuanxin Zhang, Chunxia Li, Xuejiao Li, Xiaoran Deng, Jun LinAbstract:Multifunctional nanocarriers for targeted bioimaging and Drug delivery have attracted much attention in early diagnosis and therapy of cancer. In this work, we develop a novel aptamer-guided nanocarrier based on the mesoporous metal-organic framework (MOF) shell and up-conversion luminescent NaYF4:Yb3+/Er3+ nanoparticles (UCNPs) core for the first time to achieve these goals. These UCNPs, chosen as optical labels in biological assays and medical imaging, could emit strong green emission under 980 nm laser. The MOF structure based on iron (III) carboxylate materials [MIL-100 (Fe)] possesses high porosity and non-toxicity, which is of great value as nanocarriers for Drug Storage/delivery. As a unique nanoplatform, the hybrid inorganic-organic Drug delivery vehicles show great promising for simultaneous targeted labeling and therapy of cancer cells.
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hollow structured upconversion luminescent nayf4 yb3 er3 nanospheres for cell imaging and targeted anti cancer Drug delivery
Biomaterials, 2013Co-Authors: Dongmei Yang, Zhiyao Hou, Ziyong Cheng, Chunxia Li, Xiaojiao Kang, Yunlu Dai, Jun LinAbstract:Uniform alpha-NaYF4:Yb3+, Er3+ nanospheres (similar to 130 nm) with mesoporous shell and hollow interior structure were synthesized by using Y(OH)CO3:Yb3+, Er3+ nanospheres (NPs) as sacrificial templates via a surface-protected "etching" and hydrothermal ion-exchange process. In this process, polyethylenimine (PEI) ligands played a key role in formation of the hollow structured alpha-NaYF4 nanospheres, i.e., they can effectively protect the surface of the Y(OH)CO3 from rapid dissolution by H+. Moreover, folic acid (FA), a commonly used cancer-targeting agent was conjugated on the surface of NPs based on the presence of free amine groups. The as-prepared FA-modified hollow NPs can be performed as anti-cancer Drug carriers for the investigation of Drug Storage/release properties, which exhibit greater cytotoxicity than DOX-loaded alpha-NaYF4 NPs due to the specific cell uptake by HeLa cells via FA receptor-mediate endocytosis. Furthermore, upconversion (UC) luminescence images of FA-modified alpha-NaYF4:Yb3+, Er3+ NPs uptaken by cells shows bright green emission without background noise under 980 nm infrared laser excitation. Thus, these multifunctional nanospheres combining UC luminescent property and hollow and mesoporous structure have potential for simultaneous targeted anti-cancer Drug delivery and cell imaging. (C) 2012 Elsevier Ltd. All rights reserved.
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electrospinning preparation and Drug delivery properties of an up conversion luminescent porous nayf4 yb3 er3 silica fiber nanocomposite
Advanced Functional Materials, 2011Co-Authors: Zhiyao Hou, Dongmei Yang, Ziyong Cheng, Chong Peng, Piaoping YangAbstract:Up-conversion (UC) luminescent porous silica fibers decorated with NaYF(4):Yb(3+), Er(3+) nanocrystals (NCs) (denoted as NaYF(4):Yb(3+), Er(3+)@silica fiber) are prepared by the electrospinning process using cationic surfactant P123 as a template. Monodisperse and hydrophobic oleic acid capped beta-NaYF(4): Yb(3+), Er(3+) NCs are prepared by thermal decomposition methodology. Then, these NCs are transferred into aqueous solution by employing cetyltrimethylammonium bromide (CTAB) as secondary surfactant. The water-dispersible beta-NaYF(4):Yb(3+), Er(3+) NCs are dispersed into precursor electrospinning solution containing P123 and tetraethyl orthosilicate (TEOS), followed by preparation of precursor fibers via electrospinning. Finally, porous alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber nanocomposites are obtained after annealing the precursor fibers containing beta-NaYF(4):Yb(3+), Er(3+) at 550 degrees C. The as-prepared alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber possesses porous structure and UC luminescence properties simultaneously. Furthermore, the obtained nanocomposites can be used as a Drug delivery host carrier and Drug Storage/release properties are investigated, using ibuprofen (IBU) as a model Drug. The results indicate that the IBU-loaded alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber nanocomposites show UC emission of Er(3+) under 980 nm NIR laser excitation and a controlled release property for IBU. Meanwhile, the UC emission intensity of IBU-alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber system varies with the released amount of IBU.
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self activated luminescent and mesoporous strontium hydroxyapatite nanorods for Drug delivery
Biomaterials, 2010Co-Authors: Cuimiao Zhang, Zhiyao Hou, Piaoping Yang, Ziyong Cheng, Chong Peng, Shanshan Huang, Jun LinAbstract:Multifunctional strontium hydroxyapatite (SrHAp) nanorods with luminescent and mesoporous properties have been successfully synthesized by a hydrothermal method. SEM and TEM images indicate that the mesoporous SrHAp samples consist of monodiperse nanorods with lengths of 120-150 nm, diameters of around 20 nm, and the mesopore size of 3-5 nm. The as-obtained SrHAp nanorods show an intense bright blue emission (centered at 432 nm, lifetime 11.6 ns, quantum efficiency: 22%), which might arise from CO2 center dot(-) radical impurities in the crystal lattice under long-wavelength UV-light irradiation. Furthermore, the amount of trisodium citrate has an obvious impact on the particle size and the luminescence properties of the products, respectively. The Drug Storage/release test indicates that the luminescent SrHAp nanorods show a Drug loading and controlled release properties for ibuprofen (IBU). Additionally, the emission intensity of SrHAp in the Drug carrier system increases with the cumulative released amount of IBU, making the Drug release might be easily tracked and monitored by the change of the luminescence intensity. This luminescent material may be potentially applied in the Drug delivery and disease therapy fields. (C) 2010 Elsevier Ltd. All rights reserved.
Chunxia Li - One of the best experts on this subject based on the ideXlab platform.
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aptamer mediated up conversion core mof shell nanocomposites for targeted Drug delivery and cell imaging
Scientific Reports, 2015Co-Authors: Kerong Deng, Zhiyao Hou, Ziyong Cheng, Yuanxin Zhang, Chunxia Li, Xuejiao Li, Xiaoran Deng, Jun LinAbstract:Multifunctional nanocarriers for targeted bioimaging and Drug delivery have attracted much attention in early diagnosis and therapy of cancer. In this work, we develop a novel aptamer-guided nanocarrier based on the mesoporous metal-organic framework (MOF) shell and up-conversion luminescent NaYF4:Yb3+/Er3+ nanoparticles (UCNPs) core for the first time to achieve these goals. These UCNPs, chosen as optical labels in biological assays and medical imaging, could emit strong green emission under 980 nm laser. The MOF structure based on iron (III) carboxylate materials [MIL-100 (Fe)] possesses high porosity and non-toxicity, which is of great value as nanocarriers for Drug Storage/delivery. As a unique nanoplatform, the hybrid inorganic-organic Drug delivery vehicles show great promising for simultaneous targeted labeling and therapy of cancer cells.
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upconversion luminescent core mesoporous silica shell structured β nayf4 yb3 er3 sio2 msio2 composite nanospheres fabrication and Drug Storage release properties
European Journal of Inorganic Chemistry, 2014Co-Authors: Chunxia Li, Dongmei Yang, Ziyong Cheng, Hongzhou Lian, Shanshan HuangAbstract:We present the fabrication, upconversion-luminescence cell imaging, and Drug-Storage/release properties of upconversion-luminescent core/mesoporous-silica-shell-structured -nayf4:yb3+,er3+@sio2@msio(2) composite nanospheres with a size of 80 nm. the biocompatibility test on l929 fibroblast cells using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay reveals the low cytotoxicity of the system. the Drug-Storage and in vitro release tests indicate that these multifunctional nanomaterials have controlled Drug-loading and -release properties for ibuprofen (ibu). moreover, the upconversion (uc) emission intensity of ibu--nayf4:yb3+,er3+@sio2@msio(2) composite nanospheres increases gradually along with the released amount of ibu. additionally, upconversion luminescence images of -nayf4:yb3+,er3+@sio2@msio(2) uptaken by cells show clear green emission under 980 nm infrared laser excitation. these findings make these material promising for applications in the bioimaging, Drug delivery, and disease therapy fields on the basis of its upconversion-luminescent and mesoporous properties.
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hollow structured upconversion luminescent nayf4 yb3 er3 nanospheres for cell imaging and targeted anti cancer Drug delivery
Biomaterials, 2013Co-Authors: Dongmei Yang, Zhiyao Hou, Ziyong Cheng, Chunxia Li, Xiaojiao Kang, Yunlu Dai, Jun LinAbstract:Uniform alpha-NaYF4:Yb3+, Er3+ nanospheres (similar to 130 nm) with mesoporous shell and hollow interior structure were synthesized by using Y(OH)CO3:Yb3+, Er3+ nanospheres (NPs) as sacrificial templates via a surface-protected "etching" and hydrothermal ion-exchange process. In this process, polyethylenimine (PEI) ligands played a key role in formation of the hollow structured alpha-NaYF4 nanospheres, i.e., they can effectively protect the surface of the Y(OH)CO3 from rapid dissolution by H+. Moreover, folic acid (FA), a commonly used cancer-targeting agent was conjugated on the surface of NPs based on the presence of free amine groups. The as-prepared FA-modified hollow NPs can be performed as anti-cancer Drug carriers for the investigation of Drug Storage/release properties, which exhibit greater cytotoxicity than DOX-loaded alpha-NaYF4 NPs due to the specific cell uptake by HeLa cells via FA receptor-mediate endocytosis. Furthermore, upconversion (UC) luminescence images of FA-modified alpha-NaYF4:Yb3+, Er3+ NPs uptaken by cells shows bright green emission without background noise under 980 nm infrared laser excitation. Thus, these multifunctional nanospheres combining UC luminescent property and hollow and mesoporous structure have potential for simultaneous targeted anti-cancer Drug delivery and cell imaging. (C) 2012 Elsevier Ltd. All rights reserved.
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bioactive luminescent and mesoporous europium doped hydroxyapatite as a Drug carrier
Biomaterials, 2008Co-Authors: Piaoping Yang, Chunxia Li, Hongzhou Lian, Zewei Quan, Xiaojiao Kang, Jun LinAbstract:Bioactive, luminescent and mesoporous europium-doped hydroxyapatite (Eu:HAp) was successfully prepared through a simple one-step route using cationic surfactant as template. The obtained multifunctional hydroxyapatite was performed as a Drug delivery carrier to investigate the Drug Storage/release properties using ibuprofen (IBU) as a model Drug
